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The Reliability Of The N400 In Single Subjects: Implications For Patients With Disorders Of Consciousness, Damian Cruse, Steve Beukema, Srivas Chennu, Jeffrey G. Malins, Adrian M. Owen, Ken Mcrae Jan 2014

The Reliability Of The N400 In Single Subjects: Implications For Patients With Disorders Of Consciousness, Damian Cruse, Steve Beukema, Srivas Chennu, Jeffrey G. Malins, Adrian M. Owen, Ken Mcrae

Psychology Publications

Functional neuroimaging assessments of residual cognitive capacities, including those that support language, can improve diagnostic and prognostic accuracy in patients with disorders of consciousness. Due to the portability and relative inexpensiveness of electroencephalography, the N400 event-related potential component has been proposed as a clinically valid means to identify preserved linguistic function in non-communicative patients. Across three experiments, we show that changes in both stimuli and task demands significantly influence the probability of detecting statistically significant N400 effects — that is, the difference in N400 amplitudes caused by the experimental manipulation. In terms of task demands, passively heard linguistic stimuli were …

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Introduction To The Special Issue: Cognitive Mechanisms Of Change In The Treatment Of Depression, David J. A. Dozois, Lena C. Quilty Jan 2014

Introduction To The Special Issue: Cognitive Mechanisms Of Change In The Treatment Of Depression, David J. A. Dozois, Lena C. Quilty

Psychology Publications

Depression is a highly debilitating and recurrent mental health condition. Efforts to understand the mechanisms of cognitive change in the treatment of depression are important to optimize psychotherapy outcome and to prevent relapse and recurrence. The articles in this special issue examine cognitive change in cognitive behavioral therapy by incorporating clinical samples and clinical settings, utilizing empirically supported assessment instruments and protocolized psychotherapy techniques, and employing methodologies and statistical strategies designed to address questions related to cognitive mechanisms in treatment outcome. These articles examine the role of cognitive processing, structure, and content over the course of cognitive therapy for depression …

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Changes In Core Beliefs (Early Maladaptive Schemas) And Self-Representation In Cognitive Therapy And Pharmacotherapy For Depression, David J. A. Dozois, Peter J. Bieling, Lyndsay E. Evraire, Irene Patelis-Siotis, Lori Hoar, Susan Chudzik, Katie Mccabe, Henny A. Westra Jan 2014

Changes In Core Beliefs (Early Maladaptive Schemas) And Self-Representation In Cognitive Therapy And Pharmacotherapy For Depression, David J. A. Dozois, Peter J. Bieling, Lyndsay E. Evraire, Irene Patelis-Siotis, Lori Hoar, Susan Chudzik, Katie Mccabe, Henny A. Westra

Psychology Publications

Randomized clinical trials suggest that cognitive therapy (CT) is comparable to antidepressant medication for the acute treatment of depression. Compelling data also indicate that CT has an added prophylactic benefit relative to pharmacotherapy (PT). The purpose of this study was to examine cognitive change in CT for depression. Participants (N = 42) met diagnostic criteria for a current major depressive episode and were randomly assigned to CT + PT or PT. Participants completed indices of depressive symptomatology, core beliefs (i.e., early maladaptive schemas), and self-attribute redundancy before and after therapy. Self-attribute redundancy was conceptualized as a form of schema …

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Cognitive Structure And Processing During Cognitive Behavioral Therapy Vs. Pharmacotherapy For Depression, Lena C. Quilty, David J. A. Dozois, Daniela S.S. Lobo, Lakshmi N. Ravindran, Michael L. Bagby Jan 2014

Cognitive Structure And Processing During Cognitive Behavioral Therapy Vs. Pharmacotherapy For Depression, Lena C. Quilty, David J. A. Dozois, Daniela S.S. Lobo, Lakshmi N. Ravindran, Michael L. Bagby

Psychology Publications

Background: Evidence has converged to suggest that cognitive processing and content covary with depression severity, whereas indices of cognitive structure exhibit greater stability and promise as markers of vulnerability for depression. The objective of the current study was to investigate the temporal dynamics and causal role of cognitive structure and processing in treatment for depression. Method: A total of 104 patients with major depressive disorder were randomized to receive cognitive behavioral therapy (CBT; n = 54) or pharmacotherapy (n = 50). Patients completed the Hamilton Depression Rating Scale (HAM-D), Beck Depression Inventory-II (BDI-II), Psychological Distance Scaling Task (PDST), Redundancy …

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Influence Of Priming Attachment Styles On Excessive Reassurance Seeking And Negative Feedback Seeking In Depression, Lyndsay E. Evraire, Jaclyn A. Ludmer, David J.A. Dozois Jan 2014

Influence Of Priming Attachment Styles On Excessive Reassurance Seeking And Negative Feedback Seeking In Depression, Lyndsay E. Evraire, Jaclyn A. Ludmer, David J.A. Dozois

Psychology Publications

Two studies examined the associations among attachment styles, excessive reassurance seeking (ERS) and negative feedback seeking (NFS) in depression. In Study 1 (n = 303), undergraduate students completed measures assessing attachment style, depressive symptoms, and ERS following either an imaginary interpersonal (friend and partner) or achievement prime. In Study 2 (n = 202), undergraduates completed the same measures in addition to completing an index of NFS following an imaginary interpersonal (partner) and achievement prime. Controlling for symptoms of depression, anxious attachment was positively related to ERS, and avoidant attachment was negatively related to ERS and positively associated with …

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The Impact Of Multisensory Integration Deficits On Speech Perception In Children With Autism Spectrum Disorders., Ryan A Stevenson, Magali Segers, Susanne Ferber, Morgan D Barense, Mark T Wallace Jan 2014

The Impact Of Multisensory Integration Deficits On Speech Perception In Children With Autism Spectrum Disorders., Ryan A Stevenson, Magali Segers, Susanne Ferber, Morgan D Barense, Mark T Wallace

Brain and Mind Institute Researchers' Publications

Speech perception is an inherently multisensory process. When having a face-to-face conversation, a listener not only hears what a speaker is saying, but also sees the articulatory gestures that accompany those sounds. Speech signals in visual and auditory modalities provide complementary information to the listener (Kavanagh and Mattingly, 1974), and when both are perceived in unison, behavioral gains in in speech perception are observed (Sumby and Pollack, 1954). Notably, this benefit is accentuated when speech is perceived in a noisy environment (Sumby and Pollack, 1954). To achieve a behavioral gain from multisensory processing of speech, however, the auditory and visual …

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Diffusion Tensor Imaging And White Matter Abnormalities In Patients With Disorders Of Consciousness., Carlo Cavaliere, Marco Aiello, Carol Di Perri, Davinia Fernandez-Espejo, Adrian M Owen, Andrea Soddu Jan 2014

Diffusion Tensor Imaging And White Matter Abnormalities In Patients With Disorders Of Consciousness., Carlo Cavaliere, Marco Aiello, Carol Di Perri, Davinia Fernandez-Espejo, Adrian M Owen, Andrea Soddu

Brain and Mind Institute Researchers' Publications

Progress in neuroimaging has yielded new powerful tools which, potentially, can be applied to clinical populations, improve the diagnosis of neurological disorders and predict outcome. At present, the diagnosis of consciousness disorders is limited to subjective assessment and objective measurements of behavior, with an emerging role for neuroimaging techniques. In this review we focus on white matter alterations measured using Diffusion Tensor Imaging on patients with consciousness disorders, examining the most common diffusion imaging acquisition protocols and considering the main issues related to diffusion imaging analyses. We conclude by considering some of the remaining challenges to overcome, the existing knowledge …

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Bilateral Saccadic Deficits Following Large And Reversible Inactivation Of Unilateral Frontal Eye Field., Tyler R Peel, Kevin Johnston, Stephen G Lomber, Brian D Corneil Jan 2014

Bilateral Saccadic Deficits Following Large And Reversible Inactivation Of Unilateral Frontal Eye Field., Tyler R Peel, Kevin Johnston, Stephen G Lomber, Brian D Corneil

Brain and Mind Institute Researchers' Publications

Inactivation permits direct assessment of the functional contribution of a given brain area to behavior. Previous inactivation studies of the frontal eye field (FEF) have either used large permanent ablations or reversible pharmacological techniques that only inactivate a small volume of tissue. Here we evaluated the impact of large, yet reversible, FEF inactivation on visually guided, delayed, and memory-guided saccades, using cryoloops implanted in the arcuate sulcus. While FEF inactivation produced the expected triad of contralateral saccadic deficits (increased reaction time, decreased accuracy and peak velocity) and performance errors (neglect or misdirected saccades), we also found consistent increases in reaction …

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Short-Duration Stimulation Of The Supplementary Eye Fields Perturbs Anti-Saccade Performance While Potentiating Contralateral Head Orienting., Brendan B Chapman, Brian D Corneil Jan 2014

Short-Duration Stimulation Of The Supplementary Eye Fields Perturbs Anti-Saccade Performance While Potentiating Contralateral Head Orienting., Brendan B Chapman, Brian D Corneil

Brain and Mind Institute Researchers' Publications

Many forms of brain stimulation utilize the notion of state dependency, whereby greater influences are observed when a given area is more engaged at the time of stimulation. Here, by delivering intracortical microstimulation (ICMS) to the supplementary eye fields (SEF) of monkeys performing interleaved pro- and anti-saccades, we show a surprising diversity of state-dependent effects of ICMS-SEF. Short-duration ICMS-SEF passed around cue presentation selectively disrupted anti-saccades by increasing reaction times and error rates bilaterally, and also recruited neck muscles, favoring contralateral head turning to a greater degree on anti-saccade trials. These results are consistent with the functional relevance of the …

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An Invitation To The Study Of Brain Networks, With Some Statistical Analysis Of Thresholding Techniques, Mark Daley Jan 2014

An Invitation To The Study Of Brain Networks, With Some Statistical Analysis Of Thresholding Techniques, Mark Daley

Brain and Mind Institute Researchers' Publications

We provide a brief introduction to the nascent application of network theory to mesoscale networks in the human brain. Following an overview of the typical data-gathering, processing, and analysis methods employed in this field, we describe the process for inferring a graph from neural time series. A crucial step in the construction of a graph from time series is the thresholding of graph edges to ensure that the graphs represent physiological relationships rather than artifactual noise. We discuss the most popular currently employed methodologies and then introduce one of our own, based on the theory of random matrices. Finally, we …

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Observing Object Lifting Errors Modulates Cortico-Spinal Excitability And Improves Object Lifting Performance., Gavin Buckingham, Jeremy D Wong, Minnie Tang, Paul L Gribble, Melvyn A Goodale Jan 2014

Observing Object Lifting Errors Modulates Cortico-Spinal Excitability And Improves Object Lifting Performance., Gavin Buckingham, Jeremy D Wong, Minnie Tang, Paul L Gribble, Melvyn A Goodale

Brain and Mind Institute Researchers' Publications

Observing the actions of others has been shown to modulate cortico-spinal excitability and affect behaviour. However, the sensorimotor consequences of observing errors are not well understood. Here, participants watched actors lift identically weighted large and small cubes which typically elicit expectation-based fingertip force errors. One group of participants observed the standard overestimation and underestimation-style errors that characterise early lifts with these cubes (Error video--EV). Another group watched the same actors performing the well-adapted error-free lifts that characterise later, well-practiced lifts with these cubes (No error video--NEV). We then examined actual object lifting performance in the subjects who watched the EV …

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Sign Language Ability In Young Deaf Signers Predicts Comprehension Of Written Sentences In English., Kathy N Andrew, Jennifer Hoshooley, Marc F Joanisse Jan 2014

Sign Language Ability In Young Deaf Signers Predicts Comprehension Of Written Sentences In English., Kathy N Andrew, Jennifer Hoshooley, Marc F Joanisse

Brain and Mind Institute Researchers' Publications

We investigated the robust correlation between American Sign Language (ASL) and English reading ability in 51 young deaf signers ages 7;3 to 19;0. Signers were divided into 'skilled' and 'less-skilled' signer groups based on their performance on three measures of ASL. We next assessed reading comprehension of four English sentence structures (actives, passives, pronouns, reflexive pronouns) using a sentence-to-picture-matching task. Of interest was the extent to which ASL proficiency provided a foundation for lexical and syntactic processes of English. Skilled signers outperformed less-skilled signers overall. Error analyses further indicated greater single-word recognition difficulties in less-skilled signers marked by a higher …

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Links Between White Matter Microstructure And Cortisol Reactivity To Stress In Early Childhood: Evidence For Moderation By Parenting., Haroon I Sheikh, Marc F Joanisse, Sarah M Mackrell, Katie R Kryski, Heather J Smith, Shiva M Singh, Elizabeth P Hayden Jan 2014

Links Between White Matter Microstructure And Cortisol Reactivity To Stress In Early Childhood: Evidence For Moderation By Parenting., Haroon I Sheikh, Marc F Joanisse, Sarah M Mackrell, Katie R Kryski, Heather J Smith, Shiva M Singh, Elizabeth P Hayden

Brain and Mind Institute Researchers' Publications

Activity of the hypothalamic-pituitary-adrenal axis (measured via cortisol reactivity) may be a biological marker of risk for depression and anxiety, possibly even early in development. However, the structural neural correlates of early cortisol reactivity are not well known, although these would potentially inform broader models of mechanisms of risk, especially if the early environment further shapes these relationships. Therefore, we examined links between white matter architecture and young girls' cortisol reactivity and whether early caregiving moderated these links. We recruited 45 6-year-old girls based on whether they had previously shown high or low cortisol reactivity to a stress task at …

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Sensitivity Of Human Auditory Cortex To Rapid Frequency Modulation Revealed By Multivariate Representational Similarity Analysis., Marc F Joanisse, Diedre D Desouza Jan 2014

Sensitivity Of Human Auditory Cortex To Rapid Frequency Modulation Revealed By Multivariate Representational Similarity Analysis., Marc F Joanisse, Diedre D Desouza

Brain and Mind Institute Researchers' Publications

Functional Magnetic Resonance Imaging (fMRI) was used to investigate the extent, magnitude, and pattern of brain activity in response to rapid frequency-modulated sounds. We examined this by manipulating the direction (rise vs. fall) and the rate (fast vs. slow) of the apparent pitch of iterated rippled noise (IRN) bursts. Acoustic parameters were selected to capture features used in phoneme contrasts, however the stimuli themselves were not perceived as speech per se. Participants were scanned as they passively listened to sounds in an event-related paradigm. Univariate analyses revealed a greater level and extent of activation in bilateral auditory cortex in response …

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Dopaminergic Medication Impairs Feedback-Based Stimulus-Response Learning But Not Response Selection In Parkinson's Disease., Andrew Vo, Nole M Hiebert, Ken N Seergobin, Stephanie Solcz, Allison Partridge, Penny A Macdonald Jan 2014

Dopaminergic Medication Impairs Feedback-Based Stimulus-Response Learning But Not Response Selection In Parkinson's Disease., Andrew Vo, Nole M Hiebert, Ken N Seergobin, Stephanie Solcz, Allison Partridge, Penny A Macdonald

Brain and Mind Institute Researchers' Publications

Cognitive dysfunction is a feature of Parkinson's Disease (PD). Some cognitive functions are impaired by dopaminergic medications prescribed to address the movement symptoms that typify PD. Learning appears to be the cognitive function most frequently worsened by dopaminergic therapy. However, this result could reflect either impairments in learning (i.e., acquisition of associations among stimuli, responses, and outcomes) or deficits in performance based on learning (e.g., selecting responses). We sought to clarify the specific effects of dopaminergic medication on (a) stimulus-response association learning from outcome feedback and (b) response selection based on learning, in PD. We tested 28 PD patients on …

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Rule-Based Category Learning In Children: The Role Of Age And Executive Functioning., Rahel Rabi, John Paul Minda Jan 2014

Rule-Based Category Learning In Children: The Role Of Age And Executive Functioning., Rahel Rabi, John Paul Minda

Brain and Mind Institute Researchers' Publications

Rule-based category learning was examined in 4-11 year-olds and adults. Participants were asked to learn a set of novel perceptual categories in a classification learning task. Categorization performance improved with age, with younger children showing the strongest rule-based deficit relative to older children and adults. Model-based analyses provided insight regarding the type of strategy being used to solve the categorization task, demonstrating that the use of the task appropriate strategy increased with age. When children and adults who identified the correct categorization rule were compared, the performance deficit was no longer evident. Executive functions were also measured. While both working …

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Failure To Replicate Retrocausal Recall, Imants Barušs, Vanille Rabier Jan 2014

Failure To Replicate Retrocausal Recall, Imants Barušs, Vanille Rabier

Psychology

In two temporally inverted memory experiments, Daryl Bem found that participants had better recall for words that were practiced after the recall task than for control words that were not practiced after the recall task. We attempted to replicate the second of Bem’s two experiments with the addition of a personality measure. After completing the Six Factor Personality Questionnaire, participants (n = 102) interacted with a computer on which they were shown 48 nouns, one at a time, then asked to type as many of the words as they could recall, and then asked to practice a random selection …

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Questions About Interacting With Invisible Intelligences, Imants Barušs Jan 2014

Questions About Interacting With Invisible Intelligences, Imants Barušs

Psychology

So little of the physical universe is made up of the sort of material of which we think reality is made. Indeed 96% of it consists of dark matter and dark energy. And of the 4% made of “matter” as we ordinarily understand it, only a tiny sliver reflects visible light. Yet our ideas about what can or cannot be “out there” are often based on our minuscule exposure to the visible part of the universe. And we assume that whatever might be “out there,” where we cannot see anything, surely must be insentient. But what if we are wrong? …

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Acceptable Casualties, Richard Philp Jan 2014

Acceptable Casualties, Richard Philp

Data and Test Instruments

Military euphemisms have been around for a long time. The current "collateral damage" is one used to describe civilian casualties resulting from military action. The terms "acceptable losses" and "acceptable damage" are euphemisms used to refer to a casualty rate that is deemed justifiable, in the view of the high command, by virtue of the nature of the objective. I have opted to use the more honest term "Acceptable Casualties" as my title. In the Great War, very high casualty rates were often accepted to achieve objectives of trivial importance. This book is dedicated to the memory of my father's …

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Parental Depression And Child Cognitive Vulnerability Predict Children's Cortisol Reactivity, Elizabeth P. Hayden, Benjamin L. Hankin, Sarah V.M. Mackrell, Haroon I. Sheikh, Patricia L. Jordan, David J. A. Dozois, Shiva M. Singh, Thomas M. Olino, Lisa S. Badanes Jan 2014

Parental Depression And Child Cognitive Vulnerability Predict Children's Cortisol Reactivity, Elizabeth P. Hayden, Benjamin L. Hankin, Sarah V.M. Mackrell, Haroon I. Sheikh, Patricia L. Jordan, David J. A. Dozois, Shiva M. Singh, Thomas M. Olino, Lisa S. Badanes

Psychology Publications

Risk for depression is expressed across multiple levels of analysis. For example, parental depression and cognitive vulnerability are known markers of depression risk, but no study has examined their interactive effects on children's cortisol reactivity, a likely mediator of early depression risk. We examined relations across these different levels of vulnerability using cross-sectional and longitudinal methods in two community samples of children. Children were assessed for cognitive vulnerability using self-reports (Study 1; n = 244) and tasks tapping memory and attentional bias (Study 2; n = 205), and their parents were assessed for depression history using structured clinical interviews. In …

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Polish Version Of The Cognitive Distortions Scale (Cds): Preliminary Validation And Personality Correlates, Tomasz Besta, Agata Barczak, Aleksandra Lewandowska-Walter, David J. A. Dozois Jan 2014

Polish Version Of The Cognitive Distortions Scale (Cds): Preliminary Validation And Personality Correlates, Tomasz Besta, Agata Barczak, Aleksandra Lewandowska-Walter, David J. A. Dozois

Psychology Publications

Background
The aim of the two research studies presented in this article was to test the reliability and validity of the Polish version of the Cognitive Distortions Scale (CDS). The relation of the CDS to psychological measures of well-being and other theoretically relevant variables was also explored.

Participants and procedure
Two correlational studies were conducted with psychology undergraduate students and their family members (n = 196 and n = 90, respectively). Participants completed a paper-pencil set of questionnaires that contained measures of cognitive errors (study 1) and scales related to perceived quality of life and psychological well-being (study 2).

Results …

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If It Be Love Indeed Tell Me How Much: Early Core Beliefs Associated With Excessive Reassurance Seeking In Depression., Lyndsay E. Evraire, David J. A. Dozois Jan 2014

If It Be Love Indeed Tell Me How Much: Early Core Beliefs Associated With Excessive Reassurance Seeking In Depression., Lyndsay E. Evraire, David J. A. Dozois

Psychology Publications

This study explored core beliefs associated with excessive reassurance seeking (ERS) in depression. Undergraduate students (n = 303) completed measures of early maladaptive schemas, attachment styles, ERS, and depression, along with a subsequent measure of depressive symptoms 6 weeks later. Anxious attachment, avoidant attachment, and an abandonment/instability schema each added to the prediction of ERS beyond the effects of depression. Moreover, avoidant attachment and the abandonment/instability schema moderated the relationship between ERS and depression over time. These results are consistent with the idea that individuals with early core beliefs reflecting insecurity in relationships seek reassurance. The findings also suggest …

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Approche Des Représentations D’Avenirs Des Lycéens Handicapés Visuels Comparées À Celles Des Lycéens Valides Du Burkina Faso, Issa Abdou Moumoula Dec 2013

Approche Des Représentations D’Avenirs Des Lycéens Handicapés Visuels Comparées À Celles Des Lycéens Valides Du Burkina Faso, Issa Abdou Moumoula

Comparative and International Education / Éducation Comparée et Internationale

Alors que de nombreux travaux portent sur les représentations d’avenir des adolescents, peu d’études rendent compte de l’impact du handicap dans l’élaboration de ces représentations. Nous proposons à travers la conduite d’entretiens individuels semi directifs avec 26 lycéens dont 13 en situation d’handicap visuel, de réaliser un travail exploratoire sur ce thème en vue de faire des propositions en termes de dispositifs d’accompagnement de ces jeunes dans le domaine du conseil en orientation au Burkina Faso. A l’issue de l’analyse de nos données, nous observons que les discours des jeunes adolescents handicapés visuels sont similaires à ceux des élèves valides. …

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The Relation Between Finger Gnosis And Mathematical Ability: Why Redeployment Of Neural Circuits Best Explains The Finding, Marcie Penner-Wilger, Michael L. Anderson Dec 2013

The Relation Between Finger Gnosis And Mathematical Ability: Why Redeployment Of Neural Circuits Best Explains The Finding, Marcie Penner-Wilger, Michael L. Anderson

Brain and Mind Institute Researchers' Publications

This paper elaborates a novel hypothesis regarding the observed predictive relation between finger gnosis and mathematical ability. In brief, we suggest that these two cognitive phenomena have overlapping neural substrates, as the result of the re-use ("redeployment") of part of the finger gnosis circuit for the purpose of representing numbers. We offer some background on the relation and current explanations for it; an outline of our alternate hypothesis; some evidence supporting redeployment over current views; and a plan for further research.

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Functional And Structural Changes Throughout The Auditory System Following Congenital And Early-Onset Deafness: Implications For Hearing Restoration, Blake E. Butler, Stephen G. Lombar Nov 2013

Functional And Structural Changes Throughout The Auditory System Following Congenital And Early-Onset Deafness: Implications For Hearing Restoration, Blake E. Butler, Stephen G. Lombar

Brain and Mind Institute Researchers' Publications

The absence of auditory input, particularly during development, causes widespread changes in the structure and function of the auditory system, extending from peripheral structures into auditory cortex. In humans, the consequences of these changes are far-reaching and often include detriments to language acquisition, and associated psychosocial issues.Much of what is currently known about the nature of deafness-related changes to auditory structures comes from studies of congenitally deaf or early-deafened animal models. Fortunately, the mammalian auditory system shows a high degree of preservation among species, allowing for generalization from these models to the human auditory system. This review begins with a …

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Bdnf In The Dentate Gyrus Is Required For Consolidation Of "Pattern-Separated" Memories., Pedro Bekinschtein, Brianne A Kent, Charlotte A Oomen, Gregory D Clemenson, Fred H Gage, Lisa M Saksida, Timothy J Bussey Nov 2013

Bdnf In The Dentate Gyrus Is Required For Consolidation Of "Pattern-Separated" Memories., Pedro Bekinschtein, Brianne A Kent, Charlotte A Oomen, Gregory D Clemenson, Fred H Gage, Lisa M Saksida, Timothy J Bussey

Brain and Mind Institute Researchers' Publications

Successful memory involves not only remembering information over time, but also keeping memories distinct and less confusable. The computational process for making representations for similar input patterns more distinct from each other has been referred to as "pattern separation." In this work, we developed a set of behavioral conditions that allowed us to manipulate the load for pattern separation at different stages of memory. Thus, we provide experimental evidence that a brain-derived neurotrophic factor (BDNF)-dependent pattern separation process occurs during the encoding/storage/consolidation, but not the retrieval stage of memory processing. We also found that a spontaneous increase in BDNF in …

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Reducing Risk With E-Based Support For Adherence To Lifestyle Change In Hypertension (Reach): Protocol For A Multicentred Randomised Controlled Trial, Robert P. Nolan, Sam Liu, Ross Feldman, Martin Dawes, Susan Barr, Hazel Lynn, Femida Gwardy-Sridhar, Scott G. Thomas, Jack Goodman, Paul Oh, Janusz Kaczorowski, Caroline Chessex, Vladimir Hachinski, Kevin Shoemaker Oct 2013

Reducing Risk With E-Based Support For Adherence To Lifestyle Change In Hypertension (Reach): Protocol For A Multicentred Randomised Controlled Trial, Robert P. Nolan, Sam Liu, Ross Feldman, Martin Dawes, Susan Barr, Hazel Lynn, Femida Gwardy-Sridhar, Scott G. Thomas, Jack Goodman, Paul Oh, Janusz Kaczorowski, Caroline Chessex, Vladimir Hachinski, Kevin Shoemaker

Paediatrics Publications

Introduction: Web-based lifestyle counselling designed to improve adherence to self-management behaviours for diet, exercise and medication has been shown to reduce blood pressure (BP). However, the long-term clinical outcome of these interventions is not established. Our aim was to establish whether an e-counselling program is independently associated with improved clinical outcomes over a 12-month period, as defined by the following criteria: (1) reduction of systolic BP, diastolic BP, pulse pressure and associated risk factors for cardiovascular events; and (2) adherence to self-management behaviour (diet, exercise, smoke-free living and prescribed medication). Methods and analysis: Reducing risk with e-based support for adherence …

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The Touchscreen Operant Platform For Testing Learning And Memory In Rats And Mice., Alexa E Horner, Christopher J Heath, Martha Hvoslef-Eide, Brianne A Kent, Chi Hun Kim, Simon R O Nilsson, Johan Alsiö, Charlotte A Oomen, Andrew Holmes, Lisa M Saksida, Timothy J Bussey Oct 2013

The Touchscreen Operant Platform For Testing Learning And Memory In Rats And Mice., Alexa E Horner, Christopher J Heath, Martha Hvoslef-Eide, Brianne A Kent, Chi Hun Kim, Simon R O Nilsson, Johan Alsiö, Charlotte A Oomen, Andrew Holmes, Lisa M Saksida, Timothy J Bussey

Brain and Mind Institute Researchers' Publications

An increasingly popular method of assessing cognitive functions in rodents is the automated touchscreen platform, on which a number of different cognitive tests can be run in a manner very similar to touchscreen methods currently used to test human subjects. This methodology is low stress (using appetitive rather than aversive reinforcement), has high translational potential and lends itself to a high degree of standardization and throughput. Applications include the study of cognition in rodent models of psychiatric and neurodegenerative diseases (e.g., Alzheimer's disease, schizophrenia, Huntington's disease, frontotemporal dementia), as well as the characterization of the role of select brain regions, …

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The Touchscreen Operant Platform For Testing Working Memory And Pattern Separation In Rats And Mice., Charlotte A Oomen, Martha Hvoslef-Eide, Christopher J Heath, Adam C Mar, Alexa E Horner, Timothy J Bussey, Lisa M Saksida Oct 2013

The Touchscreen Operant Platform For Testing Working Memory And Pattern Separation In Rats And Mice., Charlotte A Oomen, Martha Hvoslef-Eide, Christopher J Heath, Adam C Mar, Alexa E Horner, Timothy J Bussey, Lisa M Saksida

Brain and Mind Institute Researchers' Publications

The automated touchscreen operant chamber for rats and mice allows for the assessment of multiple cognitive domains within the same testing environment. This protocol presents the location discrimination (LD) task and the trial-unique delayed nonmatching-to-location (TUNL) task, which both assess memory for location. During these tasks, animals are trained to a predefined criterion during ∼20-40 daily sessions. In LD sessions, touching the same location on the screen is rewarded on consecutive trials, followed by a reversal of location-reward contingencies. TUNL, a working memory task, requires animals to 'nonmatch' to a sample location after a delay. In both the LD and …

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The Touchscreen Operant Platform For Assessing Executive Function In Rats And Mice., Adam C Mar, Alexa E Horner, Simon R O Nilsson, Johan Alsiö, Brianne A Kent, Chi Hun Kim, Andrew Holmes, Lisa M Saksida, Timothy J Bussey Oct 2013

The Touchscreen Operant Platform For Assessing Executive Function In Rats And Mice., Adam C Mar, Alexa E Horner, Simon R O Nilsson, Johan Alsiö, Brianne A Kent, Chi Hun Kim, Andrew Holmes, Lisa M Saksida, Timothy J Bussey

Brain and Mind Institute Researchers' Publications

This protocol details a subset of assays developed within the touchscreen platform to measure various aspects of executive function in rodents. Three main procedures are included: extinction, measuring the rate and extent of curtailing a response that was previously, but is no longer, associated with reward; reversal learning, measuring the rate and extent of switching a response toward a visual stimulus that was previously not, but has become, associated with reward (and away from a visual stimulus that was previously, but is no longer, rewarded); and the 5-choice serial reaction time (5-CSRT) task, gauging the ability to selectively detect and …

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