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Should Suicide Behaviour Be An Outcome Parameter For Mental Disorder, Amresh Srivastava

Data and Test Instruments

Suicide and mental illness are closely related to each other. A high number of people who commit suicide suffer from a mental illness, and a high number of mentally ill patients exhibit suicide behavior. Suicide behavior is a significant aspect of mental illness. It is consistently observed throughout the course of illness, seen in the prodromal stage, during acute phase of remission, in residual phase and whenever illness relapses. A number of times, mental disorder improves but suicide behavior persists. 10-15% patients attempt suicide in the initial phase of an illness. More than half of the patients get hospitalized due …

Neighbourhood Context And Youth Mental Health: The Role Of Local Community Programming In A Mid-Sized Ontario Urban Centre, Monica Christine Bochus

MA Research Paper

Existing research indicates that neighbourhood disadvantage takes a cumulative toll on mental health across the life course beginning in childhood. This study used a qualitative approach to explore the role of local community resources on buffering the harmful effects of adversity for youth in a mid-sized Ontario urban centre. The following questions were addressed: 1) What role do youth-centered community resources play in child and adolescent mental health promotion and awareness, particularly for at-risk children? 2) How can they serve to improve child and adolescent well-being? By interviewing key informants, the study found that affordable youth-centred programming has the potential …

Contrasting Styles In Cognition And Behaviour In Bumblebees And Honeybees., David F Sherry, Caroline G Strang

Psychology Publications

Bumblebees and honeybees have been the subjects of a great deal of recent research in animal cognition. Many of the major topics in cognition, including memory, attention, concept learning, numerosity, spatial cognition, timing, social learning, and metacognition have been examined in bumblebees, honeybees, or both. Although bumblebees and honeybees are very closely related, they also differ in important ways, including social organization, development, and foraging behaviour. We examine whether differences between bumblebees and honeybees in cognitive processes are related to differences in their natural history and behaviour. There are differences in some cognitive traits, such as serial reversal learning and …

Implicit And Explicit Contributions To Statistical Learning., Laura J Batterink, Paul J Reber, Helen J Neville, Ken A Paller

Brain and Mind Institute Researchers' Publications

Statistical learning allows learners to detect regularities in the environment and appears to emerge automatically as a consequence of experience. Statistical learning paradigms bear many similarities to those of artificial grammar learning and other types of implicit learning. However, whether learning effects in statistical learning tasks are driven by implicit knowledge has not been thoroughly examined. The present study addressed this gap by examining the role of implicit and explicit knowledge within the context of a typical auditory statistical learning paradigm. Learners were exposed to a continuous stream of repeating nonsense words. Learning was tested (a) directly via a forced-choice …

Tract-Based Spatial Statistics In Preterm-Born Neonates Predicts Cognitive And Motor Outcomes At 18 Months., E G Duerden, J Foong, V Chau, H Branson, K J Poskitt, R E Grunau, A Synnes, J G Zwicker, S P Miller

Brain and Mind Institute Researchers' Publications

BACKGROUND AND PURPOSE: Adverse neurodevelopmental outcome is common in children born preterm. Early sensitive predictors of neurodevelopmental outcome such as MR imaging are needed. Tract-based spatial statistics, a diffusion MR imaging analysis method, performed at term-equivalent age (40 weeks) is a promising predictor of neurodevelopmental outcomes in children born very preterm. We sought to determine the association of tract-based spatial statistics findings before term-equivalent age with neurodevelopmental outcome at 18-months corrected age.

MATERIALS AND METHODS: Of 180 neonates (born at 24-32-weeks' gestation) enrolled, 153 had DTI acquired early at 32 weeks' postmenstrual age and 105 had DTI acquired later at …

Transient Visual Responses Reset The Phase Of Low-Frequency Oscillations In The Skeletomotor Periphery., Daniel K Wood, Chao Gu, Brian D Corneil, Paul L Gribble, Melvyn A Goodale

Brain and Mind Institute Researchers' Publications

We recorded muscle activity from an upper limb muscle while human subjects reached towards peripheral targets. We tested the hypothesis that the transient visual response sweeps not only through the central nervous system, but also through the peripheral nervous system. Like the transient visual response in the central nervous system, stimulus-locked muscle responses (< 100 ms) were sensitive to stimulus contrast, and were temporally and spatially dissociable from voluntary orienting activity. Also, the arrival of visual responses reduced the variability of muscle activity by resetting the phase of ongoing low-frequency oscillations. This latter finding critically extends the emerging evidence that the feedforward visual sweep reduces neural variability via phase resetting. We conclude that, when sensory information is relevant to a particular effector, detailed information about the sensorimotor transformation, even from the earliest stages, is found in the peripheral nervous system.

Halting The Hallmarks: A Cellular Automaton Model Of Early Cancer Growth Inhibition, Jenna Butler, Frances Mackay, Colin Denniston, Mark Daley

Brain and Mind Institute Researchers' Publications

Cancer treatment is a fragmented and varied process, as ‘‘cancer’’ is really hundreds of different diseases. The ‘‘hallmarks of cancer’’ proposed by Hanahan and Weinberg (Cell 100(1):57–70, 2000) are a framework for viewing cancer within a common set of underlying principles—ten properties that are common to almost all cancers, allowing them to grow uncontrollably and ravage the body. We used a cellular automaton model of tumour growth paired with lattice Boltzmann methods modelling oxygen flow to simulate combination drugs targeted at knocking out pairs of hallmarks. We found that knocking out some pairs of cancer-enabling hallmarks did not prevent tumour …

Severe Mental Illnesses: Training And Education, Amresh Srivastava

Psychiatry Publications

Amresh Srivastava

MD,MRCPsych,FRCPC

Associate Professore of Psychiatry

Western University

London.ON

Severe Mental Illnesses: Training and Education

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About 4% patients in the community suffer from severe mental illness and about 16% from ‘any mental disorder’

Maximum financial and human resource allocations for mental health is consumed in managing severe mental disorders, leaving very little for treatment of early phase of illness and for developing preventive program.

All of us, psychiatrists, family physicians, other mental health professionals like, nurse, psychologists, socal workers, occupational therapists, counsellors, and members of advocacy groups and mental health organisations, face the challenge for managing patients who …

Purchasing And Using Personal Emergency Response Systems (Pers): How Decisions Are Made By Community-Dwelling Seniors In Canada, Alexandra C. Mckenna, Marita Kloseck, Richard Crilly, Jan Polgar

Bone and Joint Institute

© 2015 McKenna et al. Background: As the demographic of older people continues to grow, health services that support independence among community-dwelling seniors have become increasingly important. Personal Emergency Response Systems (PERS) are medical alert systems, designed to serve as a safety net for seniors living alone. Health care professionals often recommend that seniors in danger of falls or other medical emergencies obtain a PERS. The purpose of the study was to investigate the experience of seniors living with and using a PERS in their daily lives, using a qualitative grounded theory approach. Methods: Five focus groups and 10 semi-structured …

Genomic Copy Number Variation In Mus Musculus., M Elizabeth O Locke, Maja Milojevic, Susan T Eitutis, Nisha Patel, Andrea E Wishart, Mark Daley, Kathleen A. Hill

Brain and Mind Institute Researchers' Publications

BACKGROUND: Copy number variation is an important dimension of genetic diversity and has implications in development and disease. As an important model organism, the mouse is a prime candidate for copy number variant (CNV) characterization, but this has yet to be completed for a large sample size. Here we report CNV analysis of publicly available, high-density microarray data files for 351 mouse tail samples, including 290 mice that had not been characterized for CNVs previously.

RESULTS: We found 9634 putative autosomal CNVs across the samples affecting 6.87% of the mouse reference genome. We find significant differences in the degree of …

Hand Use Predicts The Structure Of Representations In Sensorimotor Cortex., Naveed Ejaz, Masashi Hamada, Jörn Diedrichsen

Brain and Mind Institute Researchers' Publications

Fine finger movements are controlled by the population activity of neurons in the hand area of primary motor cortex. Experiments using microstimulation and single-neuron electrophysiology suggest that this area represents coordinated multi-joint, rather than single-finger movements. However, the principle by which these representations are organized remains unclear. We analyzed activity patterns during individuated finger movements using functional magnetic resonance imaging (fMRI). Although the spatial layout of finger-specific activity patterns was variable across participants, the relative similarity between any pair of activity patterns was well preserved. This invariant organization was better explained by the correlation structure of everyday hand movements than …

Changes In Visual And Sensory-Motor Resting-State Functional Connectivity Support Motor Learning By Observing., Heather R Mcgregor, Paul L Gribble

Brain and Mind Institute Researchers' Publications

Motor learning occurs not only through direct first-hand experience but also through observation (Mattar AA, Gribble PL. Neuron 46: 153-160, 2005). When observing the actions of others, we activate many of the same brain regions involved in performing those actions ourselves (Malfait N, Valyear KF, Culham JC, Anton JL, Brown LE, Gribble PL. J Cogn Neurosci 22: 1493-1503, 2010). Links between neural systems for vision and action have been reported in neurophysiological (Strafella AP, Paus T. Neuroreport 11: 2289-2292, 2000; Watkins KE, Strafella AP, Paus T. Neuropsychologia 41: 989-994, 2003), brain imaging (Buccino G, Binkofski F, Fink GR, Fadiga L, …

Dual Commitment To Organization And Supervisor: A Person-Centered Approach, John P. Meyer, Alexandre J. S. Morin, Christian Vandenberghe

Psychology Publications

A recent trend in commitment research has been to use person-centered analytic strategies to identify homogeneous subgroups with varying configurations of commitment mindsets (affective, normative, continuance) or targets (e.g., organization, supervisor, team). A person-centered approach takes a more holistic perspective than the traditional variable-centered approach and can reflect potentially complex interactions among commitment mindsets and/or targets. We extend application of the person-centered approach to investigate profiles of commitment to two interrelated targets, the organization and supervisor, in two studies (Ns = 481 and 264) involving Belgian university graduates. Using latent profile analyses, we found that a similar 5-profile model fit …

La Nouvelle Immigration Et L’Identité Ethnique, Christoph Schimmele, Zheng Wu

Population Change and Lifecourse Strategic Knowledge Cluster Discussion Paper Series/ Un Réseau stratégique de connaissances Changements de population et parcours de vie Document de travail

Cette synthèse des connaissances fournit une évaluation à jour de l’influence de l’acculturation des enfants sur leur identité sociale. Bien que d’autres facteurs aient un impact sur le développement de l’identité, cette synthèse met l’accent sur le point de rencontre entre l’identité et les relations intergroupes. La plupart des immigrants arrivés après 1965 se heurtent à des circonstances économiques et à une barrière de « couleur » qui compliquent le processus d’acculturation. Comment ces forces structurelles affectent-elles le parcours qui mène à devenir un Canadien ou un Américain est une question dont la portée est étendue. Dans les groupes qui …

Fusion Analysis Of Functional Mri Data For Classification Of Individuals Based On Patterns Of Activation., Mahdi Ramezani, Purang Abolmaesumi, Kris Marble, Heather Trang, Ingrid Johnsrude

Brain and Mind Institute Researchers' Publications

Classification of individuals based on patterns of brain activity observed in functional MRI contrasts may be helpful for diagnosis of neurological disorders. Prior work for classification based on these patterns have primarily focused on using a single contrast, which does not take advantage of complementary information that may be available in multiple contrasts. Where multiple contrasts are used, the objective has been only to identify the joint, distinct brain activity patterns that differ between groups of subjects; not to use the information to classify individuals. Here, we use joint Independent Component Analysis (jICA) within a Support Vector Machine (SVM) classification …

Identification Of Risk Factors For Suicide Amongst Psychiatric Patients: Can Structured Measurement Tools Be More Specific?, Amresh Shrivastava, Robbie Campbell, Megan Johnston, Coralee Berlmont, Miky Kaushal, Avinash Desousa, Larry Stitt, Charles Nelson

Data and Test Instruments

Background One of the main challenges in suicide prevention is that it cannot be predicted. Significant number of patients attempt suicide while being under psychiatric treatment. Lethality and intent of each risk factor varies and remains inconsistent. Though structured instruments have also been useful with limited success search for newer methods remains an urgent clinical need. We believe risk is multifactorial and a scale based upon fundamental domains of biological, psychological, social, environmental, spiritual and clinical origin can elucidate more specific factors. Scale for impact of suicidality- Management, Assessment and Planning of care-brief screener (SISMAP-bcs) is 23 item scale which …

Expression Of Executive Control In Situational Context: Effects Of Facilitating Versus Restraining Cues On Snack Food Consumption, Peter Hall, Betty Tran, Cassandra Lowe, Corita Vincent, Marina Mourtzakis, Teresa Liu-Ambrose, Harry Prapavessis, Yori Gidron

Paediatrics Publications

Objectives: To examine the effects of executive function (EF) on objectively measured high-calorie snack food consumption in 2 age groups and to explore the moderating influence of environmental cues. Methods: In Study 1, 43 older adults (Mage = 74.81) and in Study 2, 79 younger adults (Mage = 18.71) completed measures of EF and subsequently participated in a bogus taste-test paradigm wherein they were required to rate 3 highly appetitive (but high-calorie) snack foods on taste and texture. Grams of snack food consumed was measured covertly in the presence randomly assigned contextual cues (explicit semantic cues in Study 1; implicit …

Psychological Interventions For Needle-Related Procedural Pain And Distress In Children And Adolescents, Anna Taddio, C. Meghan Mcmurtry

Paediatrics Publications

No abstract provided.

Connectionist Perspectives On Language Learning, Representation And Processing., Marc F Joanisse, James L Mcclelland

Brain and Mind Institute Researchers' Publications

The field of formal linguistics was founded on the premise that language is mentally represented as a deterministic symbolic grammar. While this approach has captured many important characteristics of the world's languages, it has also led to a tendency to focus theoretical questions on the correct formalization of grammatical rules while also de-emphasizing the role of learning and statistics in language development and processing. In this review we present a different approach to language research that has emerged from the parallel distributed processing or 'connectionist' enterprise. In the connectionist framework, mental operations are studied by simulating learning and processing within …

The Flip-Side To Readmission: Focused After-Care, Amresh Srivastava

Data and Test Instruments

paper 1. Suicidality in hospitalized early psychosis patients at time of discharge The purpose of this study was to investigate the presence and nature of suicidal risk among early psychosis patients at the time of discharge from hospital. Is it only related to the involvement of a suicidal attempt at admission? Thirty such patients, who were admitted after a suicide attempt were compared with 30 patients similarly diagnosed, but admitted for clinical reasons not involving a suicide attempt. Dependent measures of psychopathology, adjustment and suicidality were used. It was found that the two groups did not differ in suicidality, which …

Tracking The Brain’S Functional Coupling Dynamics Over Development, R. Matthew Hutchison, J. Bruce Morton

Paediatrics Publications

The transition from childhood to adulthood is marked by pronounced functional and structural brain transformations that impact cognition and behavior. Here, we use a functional imaging approach to reveal dynamic changes in coupling strength between networks and the expression of discrete brain configurations over human development during rest and a cognitive control task. Although the brain’s repertoire of functional states was generally preserved across ages, state-specific temporal features, such as the frequency of expression and the amount of time spent in select states, varied by age in ways that were dependent on condition. Increasing age was associated with greater variability …

Motor Skill Learning Between Selection And Execution., Jörn Diedrichsen, Katja Kornysheva

Brain and Mind Institute Researchers' Publications

Learning motor skills evolves from the effortful selection of single movement elements to their combined fast and accurate production. We review recent trends in the study of skill learning which suggest a hierarchical organization of the representations that underlie such expert performance, with premotor areas encoding short sequential movement elements (chunks) or particular component features (timing/spatial organization). This hierarchical representation allows the system to utilize elements of well-learned skills in a flexible manner. One neural correlate of skill development is the emergence of specialized neural circuits that can produce the required elements in a stable and invariant fashion. We discuss …

The Human Motor System Alters Its Reaching Movement Plan For Task-Irrelevant, Positional Forces., Joshua G A Cashaback, Heather R Mcgregor, Paul L Gribble

Brain and Mind Institute Researchers' Publications

The minimum intervention principle and the uncontrolled manifold hypothesis state that our nervous system only responds to force perturbations and sensorimotor noise if they affect task success. This idea has been tested in muscle and joint coordinate frames and more recently using workspace redundancy (e.g., reaching to large targets). However, reaching studies typically involve spatial and or temporal constraints. Constrained reaches represent a small proportion of movements we perform daily and may limit the emergence of natural behavior. Using more relaxed constraints, we conducted two reaching experiments to test the hypothesis that humans respond to task-relevant forces and ignore task-irrelevant …

Seasonal Change In The Avian Hippocampus., David F Sherry, Scott A Macdougall-Shackleton

Brain and Mind Institute Researchers' Publications

The hippocampus plays an important role in cognitive processes, including memory and spatial orientation, in birds. The hippocampus undergoes seasonal change in food-storing birds and brood parasites, there are changes in the hippocampus during breeding, and further changes occur in some species in association with migration. In food-storing birds, seasonal change in the hippocampus occurs in fall and winter when the cognitively demanding behaviour of caching and retrieving food occurs. The timing of annual change in the hippocampus of food-storing birds is quite variable, however, and appears not to be under photoperiod control. A variety of factors, including cognitive performance, …

Developmental Specialization Of The Left Parietal Cortex For The Semantic Representation Of Arabic Numerals: An Fmr-Adaptation Study, Stephan E. Vogel, Celia Goffin, Daniel Ansari

Brain and Mind Institute Researchers' Publications

The way the human brain constructs representations of numerical symbols is poorly understood. While increasing evidence from neuroimaging studies has indicated that the intraparietal sulcus (IPS) becomes increasingly specialized for symbolic numerical magnitude representation over developmental time, the extent to which these changes are associated with age-related differences in symbolic numerical magnitude representation or with developmental changes in non-numerical processes, such as response selection, remains to be uncovered. To address these outstanding questions we investigated developmental changes in the cortical representation of symbolic numerical magnitude in 6- to 14-year-old children using a passive functional magnetic resonance imaging adaptation design, thereby …

Bridging The Literature On Education Migration, Ann H. Kim, Gunjan Sondhi

Population Change and Lifecourse Strategic Knowledge Cluster Discussion Paper Series/ Un Réseau stratégique de connaissances Changements de population et parcours de vie Document de travail

This research synthesis examines key themes and findings on international students and education migrants in Canada. Our review focuses on research related to the first wave of international student mobility (ISM), and we define the literature broadly to include studies on international students, foreign students, visa students, study abroad students, sojourning students, unaccompanied minors for educational purposes, and education migrants at all educational levels and legal statuses. ISM to Canada can be divided into roughly two periods, pre‐1990 and post‐1990. Studies are drawn from across the social sciences with a focus on literature from the perspectives of sociology, geography, economics, …

Historical Analysis In Pediatric Psychology: The Influence Of Societal And Professional Conditions On Two Early Pediatric Psychology Articles And The Field's Subsequent Development, Lara M. Genik, Jeffery Yen, C. Meghan Mcmurtry

Paediatrics Publications

The field of pediatric psychology arose in the 1960s in response to a variety of societal and professional needs. 2 seminal articles written during this time, by Jerome Kagan (1965) and Logan Wright (1967), played key roles in the field's development. However, their efficacy in galvanizing a response from medical professionals and psychologists had much to do with broad-ranging developments in pediatric public health, intraprofessional changes among medical specialties, and a growing preoccupation with ''psychosocial'' and parenting issues. The purpose of this paper is to situate Kagan's (1965) and Wright's (1967) contributions within their social and historical contexts, and thereby …

The Dissociable Effects Of Punishment And Reward On Motor Learning, Joseph M. Galea, Elizabeth Mallia, John Rothwell, Jorn Diedrichsen

Brain and Mind Institute Researchers' Publications

A common assumption regarding error-based motor learning (motor adaptation) in humans is that its underlying mechanism is automatic and insensitive to reward- or punishment-based feedback. Contrary to this hypothesis, we show in a double dissociation that the two have independent effects on the learning and retention components of motor adaptation. Negative feedback, whether graded or binary, accelerated learning. While it was not necessary for the negative feedback to be coupled to monetary loss, it had to be clearly related to the actual performance on the preceding movement. Positive feedback did not speed up learning, but it increased retention of the …

The New Immigration And Ethnic Identity, Christoph Schimmele, Zheng Wu

Population Change and Lifecourse Strategic Knowledge Cluster Discussion Paper Series/ Un Réseau stratégique de connaissances Changements de population et parcours de vie Document de travail

This knowledge synthesis provides an up-to-date assessment of how the acculturation experiences of the children of immigrants influences their social identities. While other factors affect identity development, this synthesis focuses on the interface between identity and intergroup relations. Most post-1965 immigrants encounter economic circumstances and a “color” barrier that complicate the acculturation process. How these structural forces affect the pathway towards becoming a Canadian or an American is a far-reaching issue. For groups that are able to achieve economic parity with Whites and encounter little racism, their “ethnicity” could recede across generations. Hence, recent immigrants could eventually adopt unhyphenated identities …

Attentional Filtering Of Visual Information By Neuronal Ensembles In The Primate Lateral Prefrontal Cortex., Sébastien Tremblay, Florian Pieper, Adam Sachs, Julio Martinez-Trujillo

Brain and Mind Institute Researchers' Publications

The activity of neurons in the primate lateral prefrontal cortex (LPFC) is strongly modulated by visual attention. Such a modulation has mostly been documented by averaging the activity of independently recorded neurons over repeated experimental trials. However, in realistic settings, ensembles of simultaneously active LPFC neurons must generate attentional signals on a single-trial basis, despite the individual and correlated variability of neuronal responses. Whether, under these circumstances, the LPFC can reliably generate attentional signals is unclear. Here, we show that the simultaneous activity of neuronal ensembles in the primate LPFC can be reliably decoded to predict the allocation of attention …