Digital Commons Network^™

Context-Dependent Egr1 Expression In The Avian Hippocampus., Stephanie L Grella, Mélanie F Guigueno, David J White, David F Sherry, Diano F Marrone

Brain and Mind Institute Researchers' Publications

In mammals, episodic memory and spatial cognition involve context-specific recruitment of unique ensembles in the hippocampal formation (HF). Despite their capacity for sophisticated spatial (e.g., for migration) and episodic-like (e.g., for food-caching) memory, the mechanisms underlying contextual representation in birds is not well understood. Here we demonstrate environment-specific Egr1 expression as male brown-headed cowbirds (Molothrus ater) navigate environments for food reward, showing that the avian HF, like its mammalian counterpart, recruits distinct neuronal ensembles to represent different contexts.

Distinct Visual Processing Of Real Objects And Pictures Of Those Objects In 7- To 9-Month-Old Infants., Theresa M Gerhard, Jody C Culham, Gudrun Schwarzer

Brain and Mind Institute Researchers' Publications

The present study examined 7- and 9-month-old infants' visual habituation to real objects and pictures of the same objects and their preferences between real and pictorial versions of the same objects following habituation. Different hypotheses would predict that infants may habituate faster to pictures than real objects (based on proposed theoretical links between behavioral habituation in infants and neuroimaging adaptation in adults) or to real objects vs. pictures (based on past infant electrophysiology data). Sixty-one 7-month-old infants and fifty-nine 9-month-old infants were habituated to either a real object or a picture of the same object and afterward preference tested with …

Equal-Magnitude Size-Weight Illusions Experienced Within And Between Object Categories., Gavin Buckingham, Melvyn A Goodale, Justin A White, David A Westwood

Brain and Mind Institute Researchers' Publications

In the size-weight illusion (SWI), small objects feel heavier than larger objects of the same mass. This effect is typically thought to be a consequence of the lifter's expectation that the large object will outweigh the small object, because objects of the same type typically get heavier as they get larger. Here, we show that this perceptual effect can occur across object category, where there are no strong expectations about the correspondence between size and mass. One group of participants lifted same-colored large and small cubes with the same mass as one another, while another group lifted differently-colored large and …

Working Memory Training And Speech In Noise Comprehension In Older Adults., Rachel V Wayne, Cheryl Hamilton, Julia Jones Huyck, Ingrid S Johnsrude

Brain and Mind Institute Researchers' Publications

Understanding speech in the presence of background sound can be challenging for older adults. Speech comprehension in noise appears to depend on working memory and executive-control processes (e.g., Heald and Nusbaum, 2014), and their augmentation through training may have rehabilitative potential for age-related hearing loss. We examined the efficacy of adaptive working-memory training (Cogmed; Klingberg et al., 2002) in 24 older adults, assessing generalization to other working-memory tasks (near-transfer) and to other cognitive domains (far-transfer) using a cognitive test battery, including the Reading Span test, sensitive to working memory (e.g., Daneman and Carpenter, 1980). We also assessed far transfer to …

Medial Prefrontal And Anterior Insular Connectivity In Early Schizophrenia And Major Depressive Disorder: A Resting Functional Mri Evaluation Of Large-Scale Brain Network Models., Jacob Penner, Kristen A Ford, Reggie Taylor, Betsy Schaefer, Jean Théberge, Richard W J Neufeld, Elizabeth A Osuch, Ravi S Menon, Nagalingam Rajakumar, John M Allman, Peter C Williamson

Brain and Mind Institute Researchers' Publications

Anomalies in the medial prefrontal cortex, anterior insulae, and large-scale brain networks associated with them have been proposed to underlie the pathophysiology of schizophrenia and major depressive disorder (MDD). In this study, we examined the connectivity of the medial prefrontal cortices and anterior insulae in 24 healthy controls, 24 patients with schizophrenia, and 24 patients with MDD early in illness with seed-based resting state functional magnetic resonance imaging analysis using Statistical Probability Mapping. As hypothesized, reduced connectivity was found between the medial prefrontal cortex and the dorsal anterior cingulate cortex and other nodes associated with directed effort in patients with …

Acc Neuro-Over-Connectivity Is Associated With Mathematically Modeled Additional Encoding Operations Of Schizophrenia Stroop-Task Performance, Reggie Taylor, Jean Theberge, Peter C Williamson, Maria Densmore, Richard W J Neufeld

Department of Medicine Publications

Functional magnetic resonance imaging at 7.0 Tesla was undertaken among Schizophrenia participants (Sz), and clinical (major mood disorder; MDD) and healthy controls (HC), during performance of the Stoop task. Stroop conditions included congruent and incongruent word color items, color-only items, and word-only items. Previous modeling results extended to this most widely used selective-attention task. All groups executed item-encoding operations (subprocesses of the item encoding process) at the same rate (performance accuracy being similarly high throughout), thus displaying like processing capacity; Sz participants, however, employed more subprocesses for item completions than did the MDD participants, who in turn used more subprocesses …

Repetitive Behavior In Children With Down Syndrome: Functional Analysis And Intervention, Nicole Neil, Emily A. Jones

Education Publications

Children with Down syndrome frequently display repetitive behavior including unusual routines, rituals, and stereotypy. Literature on intervention for repetitive behavior in individuals with Down syndrome frequently includes aversive procedures and interventions not informed by functional assessments. We used an analogue functional analysis to evaluate reinforcers maintaining repetitive behavior in 3 children with Down syndrome. Following identification of automatic functions, we used an ABAB design and a multiple-baseline design to demonstrate the effectiveness of differential reinforcement of other behavior in reducing repetitive behavior. DRO was effective in decreasing repetitive behavior and, for one participant, repetitive behavior remained low at 1, 2, …

Direct And Indirect Forms Of Childhood Maltreatment And Nonsuicidal-Self-Injury Among Clinically-Referred Children And Youth, Jenna Armiento, Cloe Hamza, Shannon Stewart, Alan Leschied

Education Publications

Importance: Although exposure to direct forms of childhood maltreatment is among the most widely studied risk factors for nonsuicidal self-injury (NSSI), research on NSSI has largely neglected the role of exposure to indirect forms of child maltreatment (i.e., exposure to intimate partner violence).

Objective: To address this gap in the literature, the present study examined associations among both direct and indirect forms of maltreatment and NSSI among clinically referred children and youth. It was expected that exposure to both forms of maltreatment would be associated with increased risk for NSSI engagement.

Design: Data was collected from September 2014 – August …

London’S First Summer Resort The Waterworks Region In Springbank Park, Marvin L. Simner

Psychology Publications

No abstract provided.

Cognitive Distortions, Humor Styles, And Depression, Katerina Rnic, David J.A. Dozois, Rod A. Martin

Psychology Publications

Cognitive distortions are negative biases in thinking that are theorized to represent vulnerability factors for depression and dysphoria. Despite the emphasis placed on cognitive distortions in the context of cognitive behavioural theory and practice, a paucity of research has examined the mechanisms through which they impact depressive symptomatology. Both adaptive and maladaptive styles of humor represent coping strategies that may mediate the relation between cognitive distortions and depressive symptoms. The current study examined the correlations between the frequency and impact of cognitive distortions across both social and achievement-related contexts and types of humor. Cognitive distortions were associated with reduced use …

The Act-I-Pass Study Protocol: How Does Free Access To Recreation Opportunities Impact Children’S Physical Activity Levels?, Jason A. Gilliland, Andrew F. Clark, Patricia Tucker, Harry Prapavessis, William R. Avison, Piotr Wilk

Human Environments Analysis Lab (HEAL)

Background: Physical activity during childhood is associated with a multitude of physical, behavioural, and psychological health benefits. Identification of effective population level strategies for increasing children’s physical activity levels is critical for improving the overall health of Canadians. The overall objective of this study is to assess how a naturally-occurring, community-level intervention which offers Grade 5 children in London, Canada a free access pass to physical activity opportunities (facilities and programs) for an entire school year can lead to increased physical activity among recipients.

Methods/Design: This study adopts a longitudinal cohort study design to assess the effectiveness of improving children’s …

Greater Magnocellular Saccadic Suppression In High Versus Low Autistic Tendency Suggests A Causal Path To Local Perceptual Style., David P Crewther, Daniel Crewther, Stephanie Bevan, Melvyn A Goodale, Sheila G Crewther

Brain and Mind Institute Researchers' Publications

Saccadic suppression-the reduction of visual sensitivity during rapid eye movements-has previously been proposed to reflect a specific suppression of the magnocellular visual system, with the initial neural site of that suppression at or prior to afferent visual information reaching striate cortex. Dysfunction in the magnocellular visual pathway has also been associated with perceptual and physiological anomalies in individuals with autism spectrum disorder or high autistic tendency, leading us to question whether saccadic suppression is altered in the broader autism phenotype. Here we show that individuals with high autistic tendency show greater saccadic suppression of low versus high spatial frequency gratings …

Trends In Psychotropic Dispensing Among Older Adults With Dementia Living In Long-Term Care Facilities: 2004-2013., Akshya Vasudev, Salimah Z Shariff, Kuan Liu, Amer M Burhan, Nathan Herrmann, Sean Leonard, Muhammad Mamdani

Psychiatry Publications

OBJECTIVE: Guidelines worldwide have cautioned against the use of antipsychotics as first-line agents to treat neuropsychiatric symptoms of dementia. We aimed to investigate the changes over time in the dispensing of antipsychotics and other psychotropics among older adults with dementia living in long-term care facilities.

METHODS: We used drug claims data from Ontario, Canada, to calculate quarterly rates of prescription dispensing of six psychotropic drug classes among all elderly (≥65 years of age) long-term care residents with dementia from January 1, 2004, to March 31, 2013. Psychotropic drugs were classified into the following categories: atypical and conventional antipsychotics, non-sedative and …

Behavioral, Perceptual, And Neural Alterations In Sensory And Multisensory Function In Autism Spectrum Disorder., Sarah H Baum, Ryan A Stevenson, Mark T Wallace

Brain and Mind Institute Researchers' Publications

Although sensory processing challenges have been noted since the first clinical descriptions of autism, it has taken until the release of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) in 2013 for sensory problems to be included as part of the core symptoms of autism spectrum disorder (ASD) in the diagnostic profile. Because sensory information forms the building blocks for higher-order social and cognitive functions, we argue that sensory processing is not only an additional piece of the puzzle, but rather a critical cornerstone for characterizing and understanding ASD. In this review we discuss what …

Functional Differences Between Statistical Learning With And Without Explicit Training., Laura J Batterink, Paul J Reber, Ken A Paller

Brain and Mind Institute Researchers' Publications

Humans are capable of rapidly extracting regularities from environmental input, a process known as statistical learning. This type of learning typically occurs automatically, through passive exposure to environmental input. The presumed function of statistical learning is to optimize processing, allowing the brain to more accurately predict and prepare for incoming input. In this study, we ask whether the function of statistical learning may be enhanced through supplementary explicit training, in which underlying regularities are explicitly taught rather than simply abstracted through exposure. Learners were randomly assigned either to an explicit group or an implicit group. All learners were exposed to …

Dual Optimization Method Of Radiofrequency And Quasistatic Field Simulations For Reduction Of Eddy Currents Generated On 7t Radiofrequency Coil Shielding., Yujuan Zhao, Tiejun Zhao, Shailesh B Raval, Narayanan Krishnamurthy, Hai Zheng, Chad T Harris, William B Handler, Blaine A Chronik, Tamer S Ibrahim

Brain and Mind Institute Researchers' Publications

PURPOSE: To optimize the design of radiofrequency (RF) shielding of transmit coils at 7T and reduce eddy currents generated on the RF shielding when imaging with rapid gradient waveforms.

METHODS: One set of a four-element, 2 × 2 Tic-Tac-Toe head coil structure was selected and constructed to study eddy currents on the RF coil shielding. The generated eddy currents were quantitatively studied in the time and frequency domains. The RF characteristics were studied using the finite difference time domain method. Five different kinds of RF shielding were tested on a 7T MRI scanner with phantoms and in vivo human subjects. …

Social Exclusion And Resilience: Newer Targets For Intervention, Amresh Srivastava

Data and Test Instruments

Targets of therapeutic intervention for prevention of repeated hospitalization: need for developing ‘personalised care model’ Amresh Srivastava1, Coralee Belmont 2, Miky Kaushal 3, Avinash DeSouza 4 Robbie Campbell 5 and Larry Stitt 6 1. Associate Professor of Psychiatry, The Western University, Associate Scientist, and Lawson Health research Institute. Consultant psychiatrist Adult Ambulatory and Psychosis Program. Parkwood Institute Wellington Road. London. ON, N6C 0A7 2. Psychiatric Social worker southwest forensic mental health. St. Thomas 3. Research Fellow, Regional mental health St. Thomas 4. Research Fellow, LTMG Medical College and mental Health Resource Foundation, Mumbai, India 5. Emeritus Professor of Psychiatry. The …

Differential Modification Of Cortical And Thalamic Projections To Cat Primary Auditory Cortex Following Early- And Late-Onset Deafness., Nicole Chabot, Blake E Butler, Stephen G Lomber

Brain and Mind Institute Researchers' Publications

Following sensory deprivation, primary somatosensory and visual cortices undergo crossmodal plasticity, which subserves the remaining modalities. However, controversy remains regarding the neuroplastic potential of primary auditory cortex (A1). To examine this, we identified cortical and thalamic projections to A1 in hearing cats and those with early- and late-onset deafness. Following early deafness, inputs from second auditory cortex (A2) are amplified, whereas the number originating in the dorsal zone (DZ) decreases. In addition, inputs from the dorsal medial geniculate nucleus (dMGN) increase, whereas those from the ventral division (vMGN) are reduced. In late-deaf cats, projections from the anterior auditory field (AAF) …

Methane Exchange In A Coastal Fen In The First Year After Flooding--A Systems Shift, Stefan Köhler

Brain and Mind Institute Researchers' Publications

Peatland restoration can have several objectives, for example re-establishing the natural habitat, supporting unique biodiversity attributes or re-initiating key biogeochemical processes, which can ultimately lead to a reduction in greenhouse gas (GHG) emissions. Every restoration measure, however, is itself a disturbance to the ecosystem.

Preserved Haptic Shape Processing After Bilateral Loc Lesions., Jacqueline C Snow, Melvyn A Goodale, Jody C Culham

Brain and Mind Institute Researchers' Publications

UNLABELLED: The visual and haptic perceptual systems are understood to share a common neural representation of object shape. A region thought to be critical for recognizing visual and haptic shape information is the lateral occipital complex (LOC). We investigated whether LOC is essential for haptic shape recognition in humans by studying behavioral responses and brain activation for haptically explored objects in a patient (M.C.) with bilateral lesions of the occipitotemporal cortex, including LOC. Despite severe deficits in recognizing objects using vision, M.C. was able to accurately recognize objects via touch. M.C.'s psychophysical response profile to haptically explored shapes was also …

Positive Psychiatry, Amresh Srivastava

Data and Test Instruments

Revolutionary advances in understanding mental disorders and in providing novel treatments have enhanced the expectations of patients and relatives. There is a growing demand on newer research in providing interventions that allow patients to live a normal life. Of late, concept of the illness itself has undergone significant change. It is now proposed that expected outcome from treatment of mental disorder is to achieve a state of ‚ ‘wellness.’ Positive psychiatry is a newer branch of psychological medicine that seeks to promote understanding of wellness and examines its application in intervention and prevention of mental disorders. The concept of positive …

Interventions For Individuals With High Levels Of Needle Fear: Systematic Review Of Randomized Controlled Trials And Quasi-Randomized Controlled Trials, C. Meghan Mcmurtry, Melanie Noel, Anna Taddio, Martin M. Antony, Gordon J.G. Asmundson, Rebecca Pillai Riddell, Christine T. Chambers, Vibhuti Shah, N. E. Macdonald, J. Rogers, L. Bucci, P. Mousmanis, E. Lang, S. A. Halperin, S. Bowles, C. Halpert, M. Ipp, M. Rieder, K. Robson, E. Uleryk, V. Dubey, A. Hanrahan, D. Lockett, J. Scott, E. Votta Bleeker

Paediatrics Publications

Background: This systematic review evaluated the effectiveness of exposure-based psychological and physical interventions for the management of high levels of needle fear and/or phobia and fainting in children and adults. Design/Methods: A systematic review identified relevant randomized and quasi-randomized controlled trials of children, adults, or both with high levels of needle fear, including phobia (if not available, then populations with other specific phobias were included). Critically important outcomes were self-reported fear specific to the feared situation and stimulus (psychological interventions) or fainting (applied muscle tension). Data were pooled using standardized mean difference (SMD) or relative risk with 95% confidence intervals. …

Psychological Interventions For Vaccine Injections In Children And Adolescents: Systematic Review Of Randomized And Quasi-Randomized Controlled Trials, Kathryn A. Birnie, Christine T. Chambers, Anna Taddio, C. Meghan Mcmurtry, Melanie Noel, Rebecca Pillai Riddell, Vibhuti Shah, N. E. Macdonald, J. Rogers, L. Bucci, E. Lang, P. Mousmanis, S. A. Halperin, S. Bowles, C. Halpert, M. Ipp, M. Rieder, K. Robson, G. J.G. Asmundson, E. Uleryk, M. Antony, D. Alexander, M. Appleton, V. Dubey, A. Hanrahan, D. Lockett

Paediatrics Publications

Background: This systematic review evaluated the effectiveness of psychological interventions for reducing vaccination pain and related outcomes in children and adolescents. Design/Methods: Database searches identified relevant randomized and quasi-randomized controlled trials. Data were extracted and pooled using established methods. Pain, fear, and distress were considered critically important outcomes. Results: Twenty-two studies were included; 2 included adolescents. Findings showed no benefit of false suggestion (n=240) for pain (standardized mean difference [SMD] -0.21 [-0.47, 0.05]) or distress (SMD -0.28 [-0.59, 0.11]), or for use of repeated reassurance (n=82) for pain (SMD -0.18 [-0.92, 0.56]), fear (SMD -0.18 [-0.71, 0.36]), or distress (SMD …

Psychological Interventions For Vaccine Injections In Young Children 0 To 3 Years: Systematic Review Of Randomized Controlled Trials And Quasi-Randomized Controlled Trials, Rebecca Pillai Riddell, Anna Taddio, C. Meghan Mcmurtry, Christine Chambers, Vibhuti Shah, Melanie Noel

Paediatrics Publications

Background: This systematic review evaluated the effectiveness of distraction for reducing infant distress during vaccinations in young children aged 0 to 3 years. Design/Methods: Database searches identified relevant randomized and quasi-randomized controlled trials. Three separate clinical questions related to variants of the psychological strategy of distraction (directed video; directed toy; nondirected toy) were pursued. Distress was identified as the critical outcome to assess the benefits of distraction and extracted from relevant trials. Distress was analyzed by phase of procedure (distress preprocedure; distress acute; distress recovery; idiosyncratic phases based on some or all of the 3 aforementioned phases). Results: Ten studies …

Simple Psychological Interventions For Reducing Pain From Common Needle Procedures In Adults: Systematic Review Of Randomized And Quasi-Randomized Controlled Trials, Katelynn E. Boerner, Kathryn A. Birnie, Christine T. Chambers, Anna Taddio, C. Meghan Mcmurtry, Melanie Noel, Vibhuti Shah, Rebecca Pillai Riddell, N. E. Macdonald, J. Rogers, L. Bucci, P. Mousmanis, E. Lang, S. A. Halperin, S. Bowles, C. Halpert, M. Ipp, G. J.G. Asmundson, M. Rieder, K. Robson, E. Uleryk, M. M. Antony, V. Dubey, A. Hanrahan, D. Lockett, J. Scott

Paediatrics Publications

Background: This systematic review evaluated the effectiveness of simple psychological interventions for managing pain and fear in adults undergoing vaccination or related common needle procedures (ie, venipuncture/venous cannulation). Design/Methods: Databases were searched to identify relevant randomized and quasi-randomized controlled trials. Self-reported pain and fear were prioritized as critically important outcomes. Data were combined using standardized mean difference (SMD) or relative risk (RR) with 95% confidence intervals (CI). Results: No studies involving vaccination met inclusion criteria; evidence was drawn from 8 studies of other common needle procedures (eg, venous cannulation, venipuncture) in adults. Two trials evaluating the impact of neutral signaling …

Maternal Postsecondary Education Associated With Improved Cerebellar Growth After Preterm Birth., Mikaela L Stiver, Daphne Kamino, Ting Guo, Angela Thompson, Emma G Duerden, Margot J Taylor, Emily W Y Tam

Brain and Mind Institute Researchers' Publications

The preterm cerebellum is vulnerable to impaired development impacting long-term outcome. Preterm newborns (<32 >weeks) underwent serial magnetic resonance imaging (MRI) scans. The association between parental education and cerebellar volume at each time point was assessed, adjusting for age at scan. In 26 infants, cerebellar volumes at term (P = .001), but not birth (P = .4), were associated with 2-year volumes. For 1 cm(3) smaller cerebellar volume (4% total volume) at term, the cerebellum was 3.18 cm(3) smaller (3% total volume) by 2 years. Maternal postsecondary education was not associated with cerebellar volume at term (P = .16). Maternal …

Behavioural Charactertics Of Patients Vulnerable For Repeated Hospitalisation, Amresh Srivastava, Coralee Berlmont, Miky Kaushal, Avinash Desouza, Robbie Campbell, Larry Stitt

Data and Test Instruments

Background Re-hospitalization which takes place in about 30 to 50% postdischarge patienst, leads to poor outcome, increased rate of mortality and consumes more than 2/3 of budgetary allocations. Inability to identify vulnerable candidates for repeated admissions limits our options for strategic treatment. Methods In this prospective study conducted at Regional Mental Health Care ( Presently Parkwood Institute) 101 patienst ( 51 feamles, mean age 43 years), were examined using standard psychometric tools on parameters of clinical, psychopathological, suicide behaviour and resiliency for their risk and preventive characerstics. Results We assessed 101 subjects (51 females) with mean age of 42 years. …

Brain Maturation, Poverty And Social Exclusion: Shifting Paradigms Of Psychopathology, Amresh Srivastava

Psychiatry Presentations

Abstract for lecture

Poverty is a major risk factor for mental disorders. Neuroimaging studies show path are breaking findings to explain why ppeople living in poverty suffer from improper development and maturation of brain due to neuronal loss. It sets in much before the child is born and leads to increased vulnerability for mental disorders.

Recent findings show that changes in brain structure and function due to lack of brain maturation is directly related to poverty. A number of these changes are end result of neuronal survival in the most fundamental neuronal matrix. These findings along with other biological correlates …

Reducing Pain During Vaccine Injections: Clinicalpractice Guideline, Anna Taddio, C. Meghan Mcmurtry, Vibhuti Shah, Rebecca Pillai Riddell, Christine T. Chambers, Melanie Noel, Noni E. Macdonald, Jess Rogers, Lucie M. Bucci, Patricia Mousmanis, Eddy Lang, Scott A. Halperin, Susan Bowles, Christine Halpert, Moshe Ipp, Gordon J.G. Asmundson, Michael J. Rieder, Kate Robson, Elizabeth Uleryk, Martin M. Antony, Vinita Dubey, Anita Hanrahan, Donna Lockett, Jeffrey Scott, Elizabeth Votta Bleeker

Paediatrics Publications

No abstract provided.

Finding The Engram., Sheena A Josselyn, Stefan Köhler, Paul W Frankland

Brain and Mind Institute Researchers' Publications

Many attempts have been made to localize the physical trace of a memory, or engram, in the brain. However, until recently, engrams have remained largely elusive. In this Review, we develop four defining criteria that enable us to critically assess the recent progress that has been made towards finding the engram. Recent 'capture' studies use novel approaches to tag populations of neurons that are active during memory encoding, thereby allowing these engram-associated neurons to be manipulated at later times. We propose that findings from these capture studies represent considerable progress in allowing us to observe, erase and express the engram.