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Exercise Training Attenuates Cd8 T Cell Exhaustion, But Not Glucose Intolerance, Following Weight Cycling, Okechukwu K. Oforka, Emily C. Lavoy, Heather L. Caslin Feb 2026

Exercise Training Attenuates Cd8 T Cell Exhaustion, But Not Glucose Intolerance, Following Weight Cycling, Okechukwu K. Oforka, Emily C. Lavoy, Heather L. Caslin

International Journal of Exercise Science: Conference Proceedings

Obesity increases the risk of glucose intolerance and CD8 T cell exhaustion, which indicates an impaired immune function. While weight loss mitigates these risks, most individuals regain weight (weight cycling), which worsens both conditions. Exercise training protects against glucose intolerance and attenuates T cell exhaustion, but its protective role during weight cycling remains unclear. PURPOSE: The purpose of this study was to examine whether exercise training can prevent glucose intolerance and attenuate CD8 T cell exhaustion following weight cycling in mice. METHODS: Forty-eight C57Bl/6 mice were used for the study. Lean and obese groups were elicited using diet. …

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Effects Of Passive Heating And Treadmill Walking On Core Body Temperature, Protein Expression, And Nonmotor Symptoms In Women With Parkinson’S Disease: A Preliminary Analysis, Cayla E. Clark, Tatiana Gaibor Verdezoto, Starr I. Davis, Garin Varjian, Candela Fidalgo Garcia, Savannah Innes, Kyle Biggerstaff, George A. King, Brandon R. Rigby Feb 2026

Effects Of Passive Heating And Treadmill Walking On Core Body Temperature, Protein Expression, And Nonmotor Symptoms In Women With Parkinson’S Disease: A Preliminary Analysis, Cayla E. Clark, Tatiana Gaibor Verdezoto, Starr I. Davis, Garin Varjian, Candela Fidalgo Garcia, Savannah Innes, Kyle Biggerstaff, George A. King, Brandon R. Rigby

International Journal of Exercise Science: Conference Proceedings

Parkinson’s disease (PD) is an idiopathic, neurological disorder with impairments in motor and nonmotor physiological functions. Although heat shock proteins (HSPs) may reduce α-synuclein aggregation, central to PD pathology, HSP responses to elevated core temperature and heat-based interventions in PD remain unexplored. PURPOSE: To observe HSP expression, α-synuclein concentration, core body temperature (TC), and nonmotor symptoms of PD following acute aerobic exercise and passive heating in older women with PD. METHODS: Nine women (67.1±4.7 yrs, 27.5±9.4 kg/m2), clinically diagnosed with PD prior to the start of the study, completed a randomized, crossover design including one …

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Comparison Between Actual And Predicted Sweat Rates In Burn Survivors Using A Predictive Model For Fluid Replacement, Timothy P. Schaefer, Elizabeth A. Gideon, Erin M. Harper, Zachary J. Mckenna, Rachel M. Cottle, Ollie Jay, Craig G. Crandall Feb 2026

Comparison Between Actual And Predicted Sweat Rates In Burn Survivors Using A Predictive Model For Fluid Replacement, Timothy P. Schaefer, Elizabeth A. Gideon, Erin M. Harper, Zachary J. Mckenna, Rachel M. Cottle, Ollie Jay, Craig G. Crandall

International Journal of Exercise Science: Conference Proceedings

Sweating is a primary physiological response necessary to regulate body temperature in hot environments. Recent literature identifies a correlation between multiple variables (i.e., height and weight, environmental temperature, humidity, intensity and duration of exercise, and venue of exercise) and the rate of sweat loss during physical activity in healthy participants. These findings were then used to create a model to predict fluid loss via sweat, and thus the fluid replacement necessary to rehydrate during and following exercise (sweatratecalculator.com). Importantly, this calculator was modeled with data from uninjured, healthy individuals and therefore may not be accurate for burn survivors. Grafted skin …

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Habitual Physical Activity Moderates The Association Between Psychological Stress And Nocturnal Heart Rate In Young Adults, Joelle Becker, Jeremy A. Bigalke, Jason R. Carter Feb 2026

Habitual Physical Activity Moderates The Association Between Psychological Stress And Nocturnal Heart Rate In Young Adults, Joelle Becker, Jeremy A. Bigalke, Jason R. Carter

International Journal of Exercise Science: Conference Proceedings

Psychological stress can lead to nocturnal hyperarousal and sleep disruption. However, the extent to which habitual physical activity buffers stress-related effects on sleep and hyperarousal remains unclear. PURPOSE: The purpose of this study was to examine whether habitual physical activity moderates the relationship between habitual stress, sleep duration, and nocturnal heart rate (HR). We hypothesized that habitual physical activity would moderate the relationship between stress, sleep, and HR. Specifically, higher stress would be associated with shorter total sleep time and elevated HR primarily among individuals with lower physical activity, whereas more physically active individuals would experience smaller stress-related reductions in …

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Boxing For Fitness And Parkinson's Disease, Kaitlyn E. Rzasnicki, Elaina M. Seeley, Vanessa Mikan Phd Feb 2026

Boxing For Fitness And Parkinson's Disease, Kaitlyn E. Rzasnicki, Elaina M. Seeley, Vanessa Mikan Phd

International Journal of Exercise Science: Conference Proceedings

Parkinson’s Disease (PD) is a neurodegenerative disorder that affects over 6 million people every year and has diverse cognitive and physical symptoms, such as tremors, postural instability, depression, etc. Exercise is known as a valuable intervention for maintaining and alleviating some motor symptoms in PD. Specifically, boxing classes are becoming an increasingly popular treatment for PD due to its ability to combine aerobic training, coordination, strength training, and cognitive engagement. PURPOSE: To evaluate the effects of a 4-week boxing program on balance, gait, and quality of life in individuals diagnosed with Parkinson’s Disease. METHODS: This study consisted of two components. …

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Chronic Exercise And Its Effect On Happiness And Anxiety, Daylah Vega, London K. Suarez, Adriana N. Guerrero, Michael V. Maspero, Daiana M. Jones, Emily J. Sauers Feb 2026

Chronic Exercise And Its Effect On Happiness And Anxiety, Daylah Vega, London K. Suarez, Adriana N. Guerrero, Michael V. Maspero, Daiana M. Jones, Emily J. Sauers

International Journal of Exercise Science: Conference Proceedings

Physical activity has been widely researched and demonstrated to play a crucial role in benefiting individuals' mental health.  As sedentary behaviors begin to rise with upcoming generations, it is important to understand the effects chronic exercise has on an individual's physiological process in order to enhance overall wellbeing.  PURPOSE: The purpose of this study was to evaluate the impact of a 6-week Exercise is Medicine on Campus program on happiness and anxiety. METHODS: Sixty-seven participants from OLLU agreed to participate in this endeavor; all participants were placed in 18 fitness teams for the duration of the challenge. Thirty …

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Efficacy Of A Health Coaching Intervention, Hannah K. Hutson, Alison Phillips Reichter, Katherine E. Riley Feb 2026

Efficacy Of A Health Coaching Intervention, Hannah K. Hutson, Alison Phillips Reichter, Katherine E. Riley

International Journal of Exercise Science: Conference Proceedings

Health coaching is an evidence-based, humanistic intervention that involves individualized goal setting and accountability to improve a client’s lifestyle behaviors, such as physical activity (PA). Health coaching integrates tenets of Self-Determination Theory, a commonly utilized theory to support behavior change interventions; it posits that humans have three basic psychological needs – competence, autonomy, and relatedness – which facilitate self-determined motivation and positive health and well-being outcomes. In particular, perceived competence indicates the need to feel skilled and develop mastery over tasks. This influences overall motivation, well-being outcomes, and health behaviors. Low levels of perceived competence may undermine health behaviors and …

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Reliability, Variability And Reproducibility Of Non-Invasive Blood Pressure Measurements In Rats, Paulo Engelke, Milena Samora Feb 2026

Reliability, Variability And Reproducibility Of Non-Invasive Blood Pressure Measurements In Rats, Paulo Engelke, Milena Samora

International Journal of Exercise Science: Conference Proceedings

Accurate blood pressure measurement is essential for advancing research in cardiovascular and exercise physiology. The most commonly used indirect method to measure blood pressure in animals is the tail-cuff system. In addition to requiring less expensive equipment and offering a non-invasive alternative to surgical blood pressure measurements, this technique allows for repeated assessments in conscious animals during both short- and long-term studies. Despite prior validation against the gold-standard methods (i.e., radiotelemetry and arterial catheterization), the reliability, variability and reproducibility of this technique have not been fully established. PURPOSE: The aim of the study was to evaluate the intra- and …

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Kicking And Pulling: Are Propulsive Forces The Secret To Peak Swimming Performance?, Parker A. Hughes, Peter G. Weyand Dr. Feb 2026

Kicking And Pulling: Are Propulsive Forces The Secret To Peak Swimming Performance?, Parker A. Hughes, Peter G. Weyand Dr.

International Journal of Exercise Science: Conference Proceedings

Although swimming is a widely popular, well-researched global sport, the determinates of maximum sprint swimming forces across the four competitive strokes, and their relation to maximal sprint velocity are not known.  PURPOSE: The purpose of this study is to establish the relationship between short duration sprint velocity and maximal force production across the four competitive swimming strokes in elite athletes.  Further, this study will also assess relative lower body kicking contributions to total stroke propulsion forces in each of the four strokes.  METHODS: This study was conducted with 65 NCAA Division 1 caliber swimmers across two universities and …

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What Are Active People Made Of? Identifying Key Biological Correlates Of Physical Activity In Nationally Representative Databases, Isaac R. Ramos, Pratik Patil, Ayland C. Letsinger Feb 2026

What Are Active People Made Of? Identifying Key Biological Correlates Of Physical Activity In Nationally Representative Databases, Isaac R. Ramos, Pratik Patil, Ayland C. Letsinger

International Journal of Exercise Science: Conference Proceedings

Despite widespread awareness of the health benefits of physical activity, more than three-quarters of U.S. adults fail to meet national physical activity guidelines. Biological correlates may contribute to persistent differences in physical activity engagement beyond sociodemographic factors. PURPOSE: To identify biological correlates of physical activity levels in nationally representative U.S. adults. METHODS: Data were collected from the National Health and Nutrition Examination Survey (NHANES) 2021-2023 cycle. Physical activity was assessed using the Global Physical Activity Questionnaire and was expressed as minutes per week of leisure time moderate to vigorous physical activity (MVPA), with vigorous activity weighted by a …

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The Relationship Between Physical Activity And Quality Of Life, Body Mass Index, And Muscular Strength In Patients Following Sleeve Gastrectomy, Kim Ngan Phung, Brett W. Crossland, Michael Olson Feb 2026

The Relationship Between Physical Activity And Quality Of Life, Body Mass Index, And Muscular Strength In Patients Following Sleeve Gastrectomy, Kim Ngan Phung, Brett W. Crossland, Michael Olson

International Journal of Exercise Science: Conference Proceedings

Obesity is a major public health issue in the United States. Sleeve gastrectomy has become one of the most frequently performed bariatric procedures due to its effectiveness in achieving substantial and sustained weight loss in patients with severe obesity. Despite these benefits, postoperative outcomes, such as quality of life, body mass index maintenance, and muscular strength, are significantly influenced by lifestyle factors, especially physical activity. PURPOSE: The purpose of this study is to examine the relationship between physical activity and quality of life, body mass index, and muscular strength in patients following sleeve gastrectomy. METHODS: This cross-sectional study …

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Adipose Tissue Dysfunction As A Novel Contributor To Heart Failure Following Recovery From Doxorubicin Treatment, Quinten W. Pigg, Dillon Harris, Daniela Sayuri Inoue, Mariana Janini Gomes Feb 2026

Adipose Tissue Dysfunction As A Novel Contributor To Heart Failure Following Recovery From Doxorubicin Treatment, Quinten W. Pigg, Dillon Harris, Daniela Sayuri Inoue, Mariana Janini Gomes

International Journal of Exercise Science: Conference Proceedings

Doxorubicin (DOX) remains a cornerstone of cancer treatment but is limited by its dose-dependent cardiotoxicity, and clinical care for cancer survivors has not yet overcome the poor prognosis of DOX-induced heart failure (HF). PURPOSE: To identify early events that are associated with HF development in rats treated with DOX. METHODS: 42 Male Wistar rats received either DOX (4 weekly I.P. injections of 2.5mg/Kg; D, n=24) or equal volume of saline solution (C, n=18). Rats were evaluated after DOX treatment – baseline timepoint (CB or DB) and following 6 weeks of recovery – final timepoint (CF or DF). RESULTS …

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Cardiovascular Reactivity To A Psychosocial Stress In Individuals Who Use E-Cigarettes And Healthy Controls, Kaeda B. Reamer, Kimberly M. Jacob, Summer R. Franklin, Erika M. Filep Dr., Amiee M. Griffis, Joshua E. Gonzalez Dr. Feb 2026

Cardiovascular Reactivity To A Psychosocial Stress In Individuals Who Use E-Cigarettes And Healthy Controls, Kaeda B. Reamer, Kimberly M. Jacob, Summer R. Franklin, Erika M. Filep Dr., Amiee M. Griffis, Joshua E. Gonzalez Dr.

International Journal of Exercise Science: Conference Proceedings

E-cigarette use has increased, especially among young adults. It is known that smoking cigarettes can impact stress reactivity. Cardiovascular reactivity to stress is an independent predictor of hypertension development. However, the effects of regular e-cigarette use on cardiovascular reactivity to stress are unclear. PURPOSE: Investigate cardiovascular reactivity to psychosocial stress in individuals who use e-cigarettes. METHODS: 29 healthy adult participants (8 individuals who use e-cigarettes and 21 healthy controls) were instrumented with an ECG vest and an automated brachial blood pressure cuff. Our protocol consisted of a 5-min baseline, followed by Trier social stress test (TSST) (5-min speech preparation, followed …

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The Effect Of Stress On Skin Temperature In Individuals Who Regularly Use E-Cigarettes Compared To Healthy Controls, Kimberly M. Jacob, Kaeda B. Reamer, Summer R. Franklin, Erica M. Filep Dr., Amiee M. Griffis, Joshua E. Gonzalez Dr. Feb 2026

The Effect Of Stress On Skin Temperature In Individuals Who Regularly Use E-Cigarettes Compared To Healthy Controls, Kimberly M. Jacob, Kaeda B. Reamer, Summer R. Franklin, Erica M. Filep Dr., Amiee M. Griffis, Joshua E. Gonzalez Dr.

International Journal of Exercise Science: Conference Proceedings

Stress influences thermoeffector responses through neuroendocrine and autonomic pathways in humans. Previous studies have reported that regular nicotine use increases thermal strain during exercise by reducing skin blood flow. However, regular e-cigarette use, stress, and their impacts on thermoeffector responses are unclear. PURPOSE: Investigate the effect of a psychosocial stress on skin temperature in individuals who use e-cigarettes: 29 participants (8 individuals who use e-cigarettes, 21 healthy controls) were exposed to the Trier Social Stress Test (TSST). Skin temperature data was collected using a 9-site thermocouple configuration using iButtons. Skin Temperature was recorded every minute throughout the protocol. iButtons were …

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Differences In Sport Performance Anxiety Between Male And Female Competitive Bodybuilders, Christian O. Quintero, Samantha S. Dardaman, Stephen E. Rowden, Rafael E. Cachutt, Scott B. Martin Feb 2026

Differences In Sport Performance Anxiety Between Male And Female Competitive Bodybuilders, Christian O. Quintero, Samantha S. Dardaman, Stephen E. Rowden, Rafael E. Cachutt, Scott B. Martin

International Journal of Exercise Science: Conference Proceedings

In the sport of bodybuilding, high pressures for perfect performances cultivate extreme levels of restriction and discipline in the domains of eating behaviors, physical training, and aesthetic presentation. These pressures potentially put competitive bodybuilders at risk for anxiety. However, research regarding performance anxiety remains limited in bodybuilding literature. PURPOSE: The aim of this study is to examine the differences in sport performance anxiety between male and female bodybuilders. METHODS: Competitive bodybuilders (N = 283; 106 females, 176 males) between the ages of 19 and 68 years old (M = 34.75, SD = 9.83) were recruited to …

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Influence Of Standing Versus Prone Posture On Strength And Stabilizing Activation During The Athletic Shoulder Test, Benjamin P. Doyle, Mattie Higgins, Austin J. Burmeier, John D. Tebbetts, Faith N. Gage, Jennifer M. Yentes, Steven E. Riechman, J Bryan Mann Feb 2026

Influence Of Standing Versus Prone Posture On Strength And Stabilizing Activation During The Athletic Shoulder Test, Benjamin P. Doyle, Mattie Higgins, Austin J. Burmeier, John D. Tebbetts, Faith N. Gage, Jennifer M. Yentes, Steven E. Riechman, J Bryan Mann

International Journal of Exercise Science: Conference Proceedings

The Athletic Shoulder (ASH) test is a well-established tool for assessing long-lever anterior shoulder strength in athletic populations to monitor strength imbalances, fatigue, and screen for injuries. A Standing ASH (STASH) test may be more ecologically valid for assessing full kinetic chain function under postural and joint stabilization demands not captured in the prone position. PURPOSE: To evaluate inter-test agreement and neuromuscular activation differences between the ASH and STASH tests to understand how different stabilization demands impact test performance. METHODS: Forty-two active adults (19M, 23F; 22 ± 2.5 years) performed two maximal repetitions of each abduction position (T=90°, Y=135°, I=~180°) …

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Ready, Set, Stretch: Comparing Static And Dynamic Stretching Effects On Performance, Grace Findeisen, Jonathan Faxigue, Denise V. Gobert Feb 2026

Ready, Set, Stretch: Comparing Static And Dynamic Stretching Effects On Performance, Grace Findeisen, Jonathan Faxigue, Denise V. Gobert

International Journal of Exercise Science: Conference Proceedings

Many studies have been conducted on static and dynamic stretching effects on performance, analyzing factors such as strength and power, speed and agility, and endurance-dominant activities. However, the results have been inconclusive; some studies report significant effects from a stretching style while some reporting no noticeable differences. PURPOSE: This study aims to investigate both the physiological and performance-related effects of static versus dynamic stretching by monitoring participants' heart rates and physical performance across two stretching conditions. METHODS: 13 adult participants consisting of 5 females and 8 males in the experiment was conducted over 3 consecutive days, with the second day …

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The Difference In Muscle Quality And Torque Production Between Sprinters And Jumpers In Ncaa Division I Track Athletes, Ciriany Arrazola, Alexandra Brojanac, Ryan Dunn, Marcos Keefe, Mario I. Hernandez, Ty Palmer, Yasuki Sekiguchi Feb 2026

The Difference In Muscle Quality And Torque Production Between Sprinters And Jumpers In Ncaa Division I Track Athletes, Ciriany Arrazola, Alexandra Brojanac, Ryan Dunn, Marcos Keefe, Mario I. Hernandez, Ty Palmer, Yasuki Sekiguchi

International Journal of Exercise Science: Conference Proceedings

Jumping and sprinting events place mechanical demand on the neuromuscular system, which may result in event-specific differences in muscle quality and strength. Purpose: This study investigated differences in muscle quality, measured by echo intensity (EI), and strength, measured by peak torque (PT), between NCAA Division I jumpers and sprinters. Methods: Twenty-three NCAA Division I jumpers and short sprinters (15 females, 8 males; mean±SD, age: 20±1.5 years, body mass 64.3±10.4 kg, height 172.9±9.0 cm) completed the assessment of EI for the rectus femoris (RF) and hamstrings using ultrasound and isometric maximal voluntary contraction to measure PT for knee extensor and flexor. …

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Gender And Geographic Differences In Grip Strength And Static Balance Among Special Olympics Athletes, Madeline Gose, Phil Esposito Feb 2026

Gender And Geographic Differences In Grip Strength And Static Balance Among Special Olympics Athletes, Madeline Gose, Phil Esposito

International Journal of Exercise Science: Conference Proceedings

Individuals with intellectual and developmental disabilities often experience deficits in muscular strength and balance, which can impact functional independence, injury risk, and sport participation. Grip strength and balance are core components of the Special Olympics FUNfitness screening program and serve as practical indicators of overall functional health. PURPOSE: The purpose of this study is to examine gender (male/female) and geographic region (Africa, Asia/Pacific, Europe, Middle East, North America, South America) based differences in grip strength and balance performance among Special Olympics Athletes. METHODS: A retrospective secondary data analysis was conducted using FUNfitness data collected between 2019-2024. Eyes-open balance performance and …

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Evaluating Self-Reported Dietary Habits And Barriers Among Rotc Cadets Across Training Type And Frequency, Olivia J. Haskell, Sarah E. Johnson, Sheyla Leon, Michael Conner, Lisa C. Colvin, Steven E. Martin, Drew E. Gonzalez Feb 2026

Evaluating Self-Reported Dietary Habits And Barriers Among Rotc Cadets Across Training Type And Frequency, Olivia J. Haskell, Sarah E. Johnson, Sheyla Leon, Michael Conner, Lisa C. Colvin, Steven E. Martin, Drew E. Gonzalez

International Journal of Exercise Science: Conference Proceedings

Reserve Officer Training Corps (ROTC) cadets are emerging tactical athletes balancing academics and physical training. While physical readiness is emphasized, little is known about how cadets’ food-choice values and dietary habits vary across training modes and frequency. Understanding these patterns is vital, as diet influences body composition, performance, recovery, and long-term health in early military career development. PURPOSE: To investigate the dietary habits and food-choice values of ROTC cadets based on their weekly resistance, aerobic, and concurrent training frequency. METHODS: Cross-sectional data were obtained from 184 ROTC and Corps of Cadets regarding the following validated questionnaires: Food Choice …

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Speg Activation To Regulate Sarcoplasmic Reticulum In Muscle Disease, Lauren Nguyen, Sara Kondamadugula, Ting Chang, Susan Hamilton Feb 2026

Speg Activation To Regulate Sarcoplasmic Reticulum In Muscle Disease, Lauren Nguyen, Sara Kondamadugula, Ting Chang, Susan Hamilton

International Journal of Exercise Science: Conference Proceedings

Sarcoplasmic reticulum (SR) Ca2+ leak contributes to many muscle diseases, including Duchenne Muscle Dystrophy (DMD) and Malignant Hyperthermia (MH) with enhanced sensitivity to heat stroke. Recently, we demonstrated that the striated muscle preferentially expressed protein kinase, SPEG, decreases SR Ca2+ leak by phosphorylating Ser2902 on the Ca2+ release channel (also known as the ryanodine receptor 1, RYR1). While SPEG is activated in response to increased leak, the mechanisms of this activation are unknown. In addition, this compensatory mechanism is overwhelmed in the disease states associated with excessive Ca2+ leak. Increasing SPEG activation could potentially be beneficial …

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Exercise Commitment And Dependence, But Not Self-Efficacy, Differentiate Physically Active Hispanic Adults, Hannah E. Farley, Amber W. Kinsey, Stephanie L. Silveira, Sarah E. Deemer, Megan E. Ware Feb 2026

Exercise Commitment And Dependence, But Not Self-Efficacy, Differentiate Physically Active Hispanic Adults, Hannah E. Farley, Amber W. Kinsey, Stephanie L. Silveira, Sarah E. Deemer, Megan E. Ware

International Journal of Exercise Science: Conference Proceedings

Hispanic adults are less likely to meet physical activity (PA) guidelines than other racial and ethnic groups and have a high prevalence of obesity and metabolic syndrome, health outcomes that may be mitigated by engagement in optimal levels of PA. Psychological factors associated with optimal PA engagement in this population have been under studied, and could provide key insight into behavioral patterns. PURPOSE: To explore psychological factors associated with optimal PA engagement (meeting both aerobic and resistance training guidelines) in physically active Hispanic adults. METHODS: Participants who provided information to determine aerobic and resistance activity levels from an online questionnaire …

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Comparison Of Bimanual Force And Movement Coordination In Parkinson’S Disease, Ananya Luthria, Madison M. Weinrich, Deanna M. Kennedy Feb 2026

Comparison Of Bimanual Force And Movement Coordination In Parkinson’S Disease, Ananya Luthria, Madison M. Weinrich, Deanna M. Kennedy

International Journal of Exercise Science: Conference Proceedings

Visually guided bimanual coordination requires precise temporal coupling and accurate scaling of motor output to meet task-specific demands. In Parkinson’s disease (PD), impairments in sensorimotor integration may limit the ability to generate correct force- or movement-based outputs, particularly under multi-frequency coordination constraints. Differences in neural and mechanical control requirements between force-based and movement-based tasks may differentially impact performance in this population. PURPOSE: The purpose of this study was to determine whether individuals with PD can meet the accuracy demands imposed by Lissajous-guided multi-frequency (1:2) bimanual coordination, and to compare temporal and output accuracy between force-based and movement-based task conditions. …

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The Role Of Mkp-5 In Mitochondrial Protection Against Doxorubicin-Induced Cardiotoxicity, Dziedzorm Wormenor, Kisuk Min Feb 2026

The Role Of Mkp-5 In Mitochondrial Protection Against Doxorubicin-Induced Cardiotoxicity, Dziedzorm Wormenor, Kisuk Min

International Journal of Exercise Science: Conference Proceedings

Doxorubicin (DOX) is a highly effective chemotherapeutic drug used to treat various cancers. Unfortunately, the clinical application of DOX is limited by its cardiotoxic effects, which can result in heart failure in cancer patients. PURPOSE: This study aims to investigate whether MAP kinase phosphatase-5 (MKP-5) deficiency promotes mitochondrial protection against doxorubicin-Induced cardiotoxicity (DIC). METHODS: To determine the role of MKP-5 in DIC, DOX was administered intraperitoneally to wild-type (Mkp-5+/+) and MKP-5-deficient (Mkp-5-/-) mice. Following DOX administration, the survival rate was assessed, and transcription factors involved in mitochondrial biogenesis in cardiac muscle were analysed through qRT-PCR or immunoblotting. RESULTS …

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Surviving The Cure: Modeling The Long-Term Consequences Of Chemotherapy, Rachel R. Chiella, Jaden Wells, Sajedeh B. Tabrizi, Savannah V. Rauschendorfer, Cory Dungan, Michael P. Wiggs Feb 2026

Surviving The Cure: Modeling The Long-Term Consequences Of Chemotherapy, Rachel R. Chiella, Jaden Wells, Sajedeh B. Tabrizi, Savannah V. Rauschendorfer, Cory Dungan, Michael P. Wiggs

International Journal of Exercise Science: Conference Proceedings

Due to advances in treatment protocols, survival rates for childhood cancers have improved significantly over the past several decades, with five-year survival now reaching 85%. However, survivorship often comes at a cost, as exposure to intensive chemotherapy impairs skeletal muscle health, reducing quality of life and increasing the risk of early mortality. The CHOP regimen, comprising cyclophosphamide, doxorubicin, vincristine, and prednisone, is a backbone combination used in the treatment of childhood non-Hodgkin lymphoma. Previous data from our lab demonstrates that CHOP causes acute and reductions in growth and muscle size in juvenile mice, yet data on long-term outcomes remain limited. …

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Age And Cognitive Load Alter Joint Work Distribution And Postural Stability During Single Limb Support, Emery E. Nuner, Telicia Appleton, Ibrahim Burghul Feb 2026

Age And Cognitive Load Alter Joint Work Distribution And Postural Stability During Single Limb Support, Emery E. Nuner, Telicia Appleton, Ibrahim Burghul

International Journal of Exercise Science: Conference Proceedings

Age‑related declines in neuromuscular control increase fall risk during single‑limb stance, especially under cognitive load. Altered joint‑work distribution and reduced coordination precision may contribute to this instability, yet dual‑task effects on these mechanisms remain unclear. PURPOSE: To examine age‑related differences in joint eccentric work, inter‑joint coordination (FWHM), and postural stability during single‑limb support under normal and cognitive dual‑task conditions. METHODS: Eight adults (Young: n=4, 22 ± 2 y; Older: n=4, 73 ± 5 y) performed ~3 s of single‑limb support on a force plate following a crossover step under (1) Normal and (2) Cognitive conditions. Under the Cognitive condition, participants …

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Fat-Free Mass Mediates Sex Differences In Lung Capacity: A Validation And Regression Analysis Of Spirometry Indices In A Hispanic Cohort, Marianna Gamboa, Nicole Cantu, Camila Guadiana, Samantha Martinez, Jose M. Moris Feb 2026

Fat-Free Mass Mediates Sex Differences In Lung Capacity: A Validation And Regression Analysis Of Spirometry Indices In A Hispanic Cohort, Marianna Gamboa, Nicole Cantu, Camila Guadiana, Samantha Martinez, Jose M. Moris

International Journal of Exercise Science: Conference Proceedings

Accurate assessment of pulmonary function is critical for diagnosing respiratory pathology and monitoring chronic disease. PURPOSE: To evaluate the test-retest reliability of a portable spirometry device and to investigate the anthropometric determinants of Forced Vital Capacity (FVC) in a Hispanic adult cohort. METHODS: A cross-sectional analysis was conducted on 94 adults (34 males, 60 females; mean Age = 51.9 ± 7.8 yrs). Subjects underwent sequential spirometry testing during two separate visits within a 10-day period. The primary maneuver assessed was FVC, which consisted of three relaxed tidal breaths followed by a maximal inhalation and a subsequent maximal forced exhalation. Participants …

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Validity Of Hand-To-Foot And Foot-To-Foot Consumer-Grade Bioimpedance Analysis For Body Composition Estimation, Adhirath Malladi, Carina M. Velasquez, Christine M. Florez, Ainsley E. Way, Madison H. Sullivan, Julia Whitson, Reva Ann Rudolph, Grant M. Tinsley, John Alexander Feb 2026

Validity Of Hand-To-Foot And Foot-To-Foot Consumer-Grade Bioimpedance Analysis For Body Composition Estimation, Adhirath Malladi, Carina M. Velasquez, Christine M. Florez, Ainsley E. Way, Madison H. Sullivan, Julia Whitson, Reva Ann Rudolph, Grant M. Tinsley, John Alexander

International Journal of Exercise Science: Conference Proceedings

Consumer-grade bioimpedance analysis (BIA) devices are inexpensive and widely accessible, providing rapid, noninvasive body composition estimates that are frequently used in fitness and clinical settings to monitor changes over time. However, their validity for estimating body fat percentage relative to laboratory methods such as dual-energy X-ray absorptiometry (DXA) remains uncertain. PURPOSE: To evaluate the validity of hand-to-foot and foot-to-foot measurements for two widely used consumer-grade BIA devices when estimating body fat percentage compared with DXA and to determine whether the BIA–DXA difference changes across the range of body fat percentage (i.e., BF%-dependent error/proportional bias). METHODS: Eighty-three healthy adults, including 50 …

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Potential Of Metabolomics As Biomarkers For Cancer Treatment-Induced Cardiac Dysfunction In Adolescents And Young Adults: A Pilot Study, Ethan To, Savannah V. Rauschendorfer, Michael P. Wiggs Feb 2026

Potential Of Metabolomics As Biomarkers For Cancer Treatment-Induced Cardiac Dysfunction In Adolescents And Young Adults: A Pilot Study, Ethan To, Savannah V. Rauschendorfer, Michael P. Wiggs

International Journal of Exercise Science: Conference Proceedings

BACKGROUND: Doxorubicin, an anthracycline chemotherapy, is routinely utilized for cancer treatment in adolescents and young adults (AYAs) and can lead to cardiac dysfunction at high doses. Anthracycline-induced cardiac impairments are associated with fluctuations in lipid and amino acid metabolism. Identification of unique metabolomic signatures may support the use of metabolomic and lipidomic profiling to identify biomarkers of disease risk and development. These signatures may also reveal pathogenetic links between adiposity and cancer treatment-related cardiac dysfunction. PURPOSE: To identify key metabolites associated with cancer treatment-induced cardiac dysfunction in AYAs with cancer. METHODS: 10 AYAs (M = 5, F = 5) treated …

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Effects Of Nasal Breathing Exercise On Systemic And Cellular Inflammatory Biomarkers, Tesleem Imran, Minh Quan Le, Brady Johnson, Jose M. Moris, Yunsuk Koh Feb 2026

Effects Of Nasal Breathing Exercise On Systemic And Cellular Inflammatory Biomarkers, Tesleem Imran, Minh Quan Le, Brady Johnson, Jose M. Moris, Yunsuk Koh

International Journal of Exercise Science: Conference Proceedings

Effective inflammatory control is required to maintain proper immune function and health. While nasal breathing (NB) is recognized for its respiratory and cognitive benefits, its influence on immune regulation remains unclear. PURPOSE: The current study examined the effects of acute and chronic NB exercise on pro- and anti-inflammatory cytokines in serum and peripheral blood mononuclear cells (PBMCs). METHODS: Twenty-two sedentary men (age=21.55±2.58 years, height=180.98±7.89 cm, and weight=86.81±14.33 kg) were randomly assigned to either the NB (N=11) or combined breathing group (CB, N=11). Participants performed aerobic exercise on a recumbent cycle at a moderate intensity (70% VO2max) for 4 …

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