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Cbct Evaluation Of Condylar Changes In Children With Unilateral Posterior Crossbites With A Functional Shift, Lance Pittman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: The unilateral posterior crossbite with a functional shift is one of the most common early adolescent malocclusions. It is caused by a transversely deficient maxilla, relative to the mandible, and results when the mandible shifts to one side to so the teeth can maximally interdigitate. This shift is thought to cause the contralateral condyle to move anteriorly, inferiorly, and medially within the TMJ. Much attention has been given recently to the affects of this functional shift on the condyles. An attempt is being made to determine if pathological position of the condyles can cause condylar signs or symptoms similar …

Blood Pressure And Quality Of Life In Youth Enrolled In A Culinary Skills, Family Mealtime And Physical Activity Program: Pilot Study Icook 4-H, Erin Smith

Graduate Theses, Dissertations, and Problem Reports (ETD)

Objective: The pilot study objective is to determine if blood pressure (BP) and perception of quality of life (QoL) in 9-10 y/o youth changes after a 12 week 6-session program focusing on culinary skills, family mealtime and physical activity. Methods: Pre-post treatment only assessments were collected at 0 and 4 months for child/adult dyads (n=49 dyads). Five states (ME, NE, SD, TN, WV) recruited and delivered 6 sessions every two weeks that focused on increasing cooking skills, family mealtime, and physical activity. During BP assessments, each child had an initial rest of 5 min with 2 min rest between measurements …

Sampling Hay And Haylage, Edward Barrow Rayburn

Faculty & Staff Scholarship

WVU-Extension fact sheet

Forage Species For Northeast, Edward Barrow Rayburn

Faculty & Staff Scholarship

WVU-Extension fact sheet

Sampling Pastures For Nutritive Analysis, Edward Barrow Rayburn

Faculty & Staff Scholarship

WVU-Extension fact sheet

Use Forage Testing To Diagnose Mgmt. Problems, Edward Barrow Rayburn

Faculty & Staff Scholarship

WVU-Extension fact sheet

Making Plastic Wrapped Round Bale Haylage - Baleage, Edward Barrow Rayburn

Faculty & Staff Scholarship

WVU-Extension fact sheet

2014 Symposium Brochure

Programs

No abstract provided.

Prevalence Of Overweight In 2 To 17 Year-Old Children And Adolescents Whose Parents Live Separately: A Nordic Cross-Sectional Study, Lena Hohwu, Mika Gissler, Agneta Sjoberg, Anna M. Biehl, Alfdgeir L. Kristjansson, Carsten Obel

Faculty & Staff Scholarship

Background

Comparative data of parental separation and childhood overweight has not been available before across the Nordic countries. The aim of this study was to examine the within-country prevalence and association between parental cohabitation and overweight in Nordic children.

Methods

A cross-sectional survey of 2-17-year-old children was conducted in 2011, titled: “NordChild”. A random sample of 3,200 parents in each of the Nordic countries (Denmark, Finland, Iceland, Norway, and Sweden were invited to participate in the study with parents of 6,609 children accepting to give answers about their children’s health and welfare including information on height and weight of each …

Nobiletin Suppresses Cell Viability Through Akt Pathways In Pc-3 And Du-145 Prostate Cancer Cells, Jianchu Chen, Ashley Creed, Allen Y. Chen, Haizhi Huang, Zhaoliang Li, Gary O. Rankin, Xingqian Ye, Guihua Xu, Yi C. Chen

Faculty & Staff Scholarship

Background

Nobiletin is a non-toxic dietary flavonoid that possesses anti-cancer properties. Nobiletin has been reported to reduce the risk of prostate cancer, but the mechanism is not well understood. In this study, we investigated the effects of nobiletin in prostate cancer cell lines PC-3 and DU-145.

Methods

Nobiletin was isolated from a polymethoxy flavonoid mixture using HPLC, cell viability was analyzed with MTS-based assays. Protein expression was examined by ELISA and western blotting. Gene expression was examined by luciferase assay. And the pathways were examined by manipulating genetic components with plasmid transfection.

Results

Data showed that nobiletin decreased cell viability …

Genome-Wide Analysis Of The Omega-3 Fatty Acid Desaturase Gene Family In Gossypium, Olga P. Yurchenko, Sunjung Park, Daniel C. Ilut, Jay J. Inmon, Jon C. Millhollon, Zach Liechty, Justin T. Page, Matthew A. Jenks, Kent D. Chapman, Joshua A. Udall, Michael A. Gore, John M. Dyer

Faculty & Staff Scholarship

Background

The majority of commercial cotton varieties planted worldwide are derived from Gossypium hirsutum, which is a naturally occurring allotetraploid produced by interspecific hybridization of A- and D-genome diploid progenitor species. While most cotton species are adapted to warm, semi-arid tropical and subtropical regions, and thus perform well in these geographical areas, cotton seedlings are sensitive to cold temperature, which can significantly reduce crop yields. One of the common biochemical responses of plants to cold temperatures is an increase in omega-3 fatty acids, which protects cellular function by maintaining membrane integrity. The purpose of our study was to identify …

Characterization Of The Rainbow Trout Spleen Transcriptome And Identification Of Immune-Related Genes, Ali Ali, Caird E. Rexroad, Gary H. Thorgaard, Jianbo Yao, Mohamed Salem

Faculty & Staff Scholarship

Resistance against diseases affects profitability of rainbow trout. Limited information is available about functions and mechanisms of teleost immune pathways. Immunogenomics provides powerful tools to determine disease resistance genes/gene pathways and develop genetic markers for genomic selection. RNA-Seq sequencing of the rainbow trout spleen yielded 93,532,200 reads (100 bp). High quality reads were assembled into 43,047 contigs. 26,333 (61.17%) of the contigs had hits to the NR protein database and 7024 (16.32%) had hits to the KEGG database. Gene ontology showed significant percentages of transcripts assigned to binding (51%), signaling (7%), response to stimuli (9%) and receptor activity (4%) suggesting …

Optimizing Data Collection For Public Health Decisions: A Data Mining Approach, Susan N. Partington, Vasil Papakroni, Tim Menzies

Faculty & Staff Scholarship

Background: Collecting data can be cumbersome and expensive. Lack of relevant, accurate and timely data for research to inform policy may negatively impact public health. The aim of this study was to test if the careful removal of items from two community nutrition surveys guided by a data mining technique called feature selection, can (a) identify a reduced dataset, while (b) not damaging the signal inside that data.

Methods: The Nutrition Environment Measures Surveys for stores (NEMS-S) and restaurants (NEMS-R) were completed on 885 retail food outlets in two counties in West Virginia between May and November of 2011. A …

Regulation And Regulatory Role Of Wnt Signaling In Potentiating Fsh Action During Bovine Dominant Follicle Selection, P S P Gupta, Joseph K. Folger, Sandeep K. Rajput, Lihua Lv, Jianbo Yao, James J. Ireland, George W. Smith

Faculty & Staff Scholarship

Follicular development occurs in wave like patterns in monotocous species such as cattle and humans and is regulated by a complex interaction of gonadotropins with local intrafollicular regulatory molecules. To further elucidate potential mechanisms controlling dominant follicle selection, granulosa cell RNA harvested from F1 (largest) and F2 (second largest) follicles isolated at predeviation (PD) and onset of diameter deviation (OD) stages of the first follicular wave was subjected to preliminary RNA transcriptome analysis. Expression of numerous WNT system components was observed. Hence experiments were performed to test the hypothesis that WNT signaling modulates FSH action on granulosa cells during follicular …

Low Sensitivity Of The Metabolic Syndrome To Identify Adolescents With Impaired Glucose Tolerance: An Analysis Of Nhanes 1999–2010, Mark D. Deboer, Matthew J. Gurka

Faculty & Staff Scholarship

Background

The presence of impaired glucose tolerance (IGT) and metabolic syndrome (MetS) are two risk factors for Type 2 diabetes. The inter-relatedness of these factors among adolescents is unclear.

Methods

We evaluated the sensitivity and specificity of MetS for identifying IGT in an unselected group of adolescents undergoing oral glucose tolerance tests (OGTT) in the National Health and Nutrition Evaluation Survey 1999–2010. We characterized IGT as a 2-hour glucose ≥140 mg/dL and MetS using ATP-III-based criteria and a continuous sex- and race/ethnicity-specific MetS Z-score at cut-offs of +1.0 and +0.75 standard deviations (SD) above the mean.

Results

Among 1513 adolescents, …

Feasibility Of Intensity-Modulated And Image-Guided Radiotherapy For Locally Advanced Esophageal Cancer, Nam P. Nguyen, Siyoung Jang, Jacqueline Vock, Vincent Vinh-Hung, Alexander Chi, Paul Vos, Judith Pugh, Richard A. Vo, Misty Ceizyk, Anand Desai, Lexie Smith-Raymond, The International Geriatric Radiotherapy Group

Faculty & Staff Scholarship

Background

In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.

Methods

A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70 Gy (62.4-75 Gy).

Results

At a median follow-up of 14 months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade …

Factors Associated With Non-Utilization Of Child Immunization In Pakistan: Evidence From The Demographic And Health Survey 2006-07, Ayesha S. Bugvi, Rahla Rahat, Rubeena Zakar, Muhammad Z. Zakar, Florian Fischer, Muazzam Nasrullah, Riffat Manawar

Faculty & Staff Scholarship

Background

The proportion of incompletely immunized children in Pakistan varies from 37-58%, and this has recently resulted in outbreaks of measles and polio. The aim of this paper is to determine the factors associated with incomplete immunization among children aged 12-23 months in Pakistan.

Methods

Secondary analysis was conducted on nationally representative cross-sectional survey data from the Pakistan Demographic and Health Survey, 2006-07. The analysis was limited to ever-married mothers who had delivered their last child during the 23 months immediately preceding the survey (n = 2,435). ‘Complete immunization’ was defined as the child having received twelve doses of five …

Inverse Association Of Colorectal Cancer Prevalence To Serum Levels Of Perfluorooctane Sulfonate (Pfos) And Perfluorooctanoate (Pfoa) In A Large Appalachian Population, Kim E. Innes, Jeffrey H. Wimsatt, Stephanie Frisbee, Alan M. Ducatman

Faculty & Staff Scholarship

Background

Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are persistent environmental contaminants that affect metabolic regulation, inflammation, and other factors implicated in the development and progression of colorectal cancer (CRC). However, the link between these compounds and CRC remains unknown. In this cross-sectional study, we investigated the association of CRC diagnosis to PFOA and PFOS blood levels in a large Appalachian population.

Methods

Participants were 47,359 adults ≥ 21 years of age and residing in six PFOA-contaminated water districts in the mid-Ohio Valley (N = 47,151 cancer-free adults, 208 cases of primary CRC). All participants completed a comprehensive health survey between …

Predictors Of Weight Loss Maintenance Following An Insurance-Sponsored Weight Management Program, Christiaan Abildso, Olivier Schmid, Megan Byrd, Sam Zizzi, Alessandro Quartiroli, Sean J. Fitzpatrick

Faculty & Staff Scholarship

Intentional weight loss among overweight and obese adults (body mass index ≥ 25 kg/m²) is associated with numerous health benefits, but weight loss maintenance (WLM) following participation in weight management programming has proven to be elusive. Many individuals attempting to lose weight join formal programs, especially women, but these programs vary widely in focus, as do postprogram weight regain results. We surveyed 2,106 former participants in a community-based, insurance-sponsored weight management program in the United States to identify the pre, during, and post-intervention behavioral and psychosocial factors that lead to successful WLM. Of 835 survey respondents (39.6% response …

Cross-Sectional Association Between The Number Of Missing Teeth And Cardiovascular Disease Among Adults Aged 50 Or Older: Brfss 2010, R Constance Wiener

Faculty & Staff Scholarship

Objective. The relationship between oral health and cardiovascular disease is an emerging area of research. The objective of the current study is to evaluate the association of cardiovascular disease and the number of missing teeth as a risk indicator. Methods. Cross-sectional study design with data on 275,424 respondents aged 50 or older from the 2010 Behavioral Risk Factor Surveillance System survey was used. The dependent variable was self-reported cardiovascular disease. The association between the number of missing teeth and cardiovascular disease was analyzed with multivariable logistic regression. The regression was adjusted for sex, race/ethnicity, age, education, income, dental visits, smoking …

Barriers, Facilitators, And Frequency Of Evidence Based Practice Use In Athletic Training, Michael J. Boehke

Graduate Theses, Dissertations, and Problem Reports (ETD)

Many professions, including medicine, engineering, and design, have embraced the notion of using research to making informed decisions, thus increasing client satisfaction. Called evidence based practice (EBP) in Athletic Training; the concept is viewed as a means to promote the profession, not only through improved patient care, but also through increasing the reputation of athletic trainers as cost-effective health care providers. Over the past two decades, EBP has become a common term and subject of study. However, the extent of research regarding barriers and facilitators to the use of EBP within athletic training lags behind that of other health care …

Regulation Of Satellite Cell Function In Sarcopenia, Stephen E. Alway, Matthew J. Myers, Junaith S. Mohamed

Faculty & Staff Scholarship

The mechanisms contributing to sarcopenia include reduced satellite cell (myogenic stem cell) function that is impacted by the environment (niche) of these cells. Satellite cell function is affected by oxidative stress, which is elevated in aged muscles, and this along with changes in largely unknown systemic factors, likely contribute to the manner in which satellite cells respond to stressors such as exercise, disuse, or rehabilitation in sarcopenic muscles. Nutritional intervention provides one therapeutic strategy to improve the satellite cell niche and systemic factors, with the goal of improving satellite cell function in aging muscles. Although many elderly persons consume various …

Beef Heifer Growth And Reproductive Performance Following Two Levels Of Pasture Allowance During The Fall Grazing Period1, B. L. Bailey, T. C. Griggs, E. B. Rayburn, K. M. Krause

Faculty & Staff Scholarship

No abstract provided.

Inactivation By Uv-Radiation And Internalization Of Coliforms And Escherichia Coli In Aquaponically And Hydroponically Grown Lettuce, Matthew J. Moriarty

Graduate Theses, Dissertations, and Problem Reports (ETD)

Recent studies have shown that coliform bacteria, specifically Escherichia coli O157:H7, can internalize in leafy green produce. Therefore, a risk exists for lettuce being grown in systems using mixed water sources. Additionally, Ultra Violet light radiation has been shown to inactivate coliforms in water. For this reason, an experiment was conducted at West Virginia University's aquaculture facility to determine the effect of UV-radiation in water supplying an aquaponic channel with nutrients, and to assess the risk of coliform and E. coli internalization. In this experiment, the spring fed, flow-through aquaponic system was receiving runoff from cattle pastures as a source …

Effects Of Novel Feed Ingredients And Additives On Feed Quality And Broiler Performance, Ashley Marie Evans

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the poultry industry, feed and feed manufacture account for 60 to 70% of production costs. Because of this, integrators are continually seeking ways to decrease costs while maintaining pellet quality and bird performance. The research presented in this dissertation offer several novel feed ingredients that have the potential to replace costly feed ingredients, increase pellet quality, improve bird growth and performance, and improve nutrient digestibility. In Chapter 2, four experimental phytase enzymes (A -- D) were examined for thermostability during pelleting, as well as efficacy in vivo. Phytase activity post-pelleting demonstrated high variability between phytases, ranging from 120 to …

Evaluating The Inclusion Of Phytase Super-Dose In Various Broiler Diet Formulations And Novel Pellet Binders, John W. Boney

Graduate Theses, Dissertations, and Problem Reports (ETD)

Grains commonly used in poultry diets contain phytic acid, a known anti-nutrient that binds dietary phosphorus rendering it unavailable for absorption also decreasing the digestibility of other nutrients. Phytic acid also increases mucin production and endogenous amino acid secretions causing a gut irritant effect which may decrease performance. An abundance of phytase literatures suggests that phytase enzymes can liberate bound phosphorus enhancing phytate phosphorus utilization and bone mineralization. Recently, the use of super-doses of phytase has been suggested to, not only liberate bound phosphorus, but to alleviate the gut irritant effect associated with phytate phosphorus. Therefore, an experiment was conducted …

Development Of The Dynamic Evaluation Model To Significantly Advance Autism Research, Dana Cihelkova

Graduate Theses, Dissertations, and Problem Reports (ETD)

In my dissertation effort I suggested new directions in order to significantly advance Autism Research. I moved from identification of the problem (Stagnation of Autism Research) to offering one possible explanation for the problem (Conceptualization of Autism as a Complex Phenomenon) to one possible solution for the problem. I developed the Dynamic Evaluation Model which is a five dimensional evaluation system to (a) effectively evaluate Autism interventions, (b) uncover Autism symptoms dynamics, and (c) identify what child with what symptoms characteristics will benefit the most from what currently available treatments. And finally I tested the prototype of the Dynamic Evaluation …

Multimorbidity, Management Of Copd And Health Outcomes Among Medicaid Beneficiaries, Mayank Ajmera

Graduate Theses, Dissertations, and Problem Reports (ETD)

Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent and progressive airflow limitation caused due to chronic inflammation in the lungs. Approximately 15 million adults in the United States (U.S.) are estimated to be diagnosed with COPD and an equal number may have undiagnosed COPD. Challenges to COPD management include high prevalence of inflammation-related multimorbidity among individuals with COPD. The association between multimorbidity, existing COPD management and role of novel therapies with anti-inflammatory properties (e.g. statins) in improving COPD-specific outcomes is not well researched. Therefore, the purpose of this study was to use real-world observational data to provide a comprehensive …

Burden Of Colorectal Cancer Among The Elderly Medicare Beneficiaries In West Virginia A Comparative Analysis With National Data, Pallavi Balwant Rane

Graduate Theses, Dissertations, and Problem Reports (ETD)

West Virginia (WV) which is one of the most rural states in the nation, had the highest colorectal cancer (CRC) mortality rate in United States (US) in 2009. There is a paucity of epidemiologic studies that have decrypt the reasons for this high CRC mortality, or have systematically examined the burden of, and disparities among the population of elderly with CRC from a rural settings such as from WV. This series of retrospective cohort studies was conducted to examine the receipt of CRC treatment and the associated survivorship, comorbidity burden, and healthcare expenditures among Medicare beneficiaries with CRC identified from …

Predicting Opioid Prescribing Behaviors: Influence Of An Expert Opioid-Risk Evaluation, Alison M. Vargovich

Graduate Theses, Dissertations, and Problem Reports (ETD)

Opioid analgesics have been shown to be effective for short-term pain reduction; however, chronic opioid therapy does not improve functioning, and may lead to problems with dependence and abuse. Physicians report having difficulty discerning substance abuse or drug diversion, which can lead to over- or under- prescribing, poor pain management, and may contribute to the growing number of opioid-related overdose deaths. The primary aim of this study was to determine if a psychological opioid risk evaluation influenced opioid prescribing in physicians at the West Virginia University (WVU) Family Medicine Clinic. For this retrospective study, participants were 151 (89 female) adult …