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Sports Arenas, Teams And Property Values: Temporary And Permanent Shocks To Local Amenity Flows, Yulia Chikish, Brad Humphreys, Adam Nowak

Economics Faculty Working Papers Series

Professional sports facilities and teams generate local amenity flows in cities that may affect property values. Previous research shows evidence of important positive and negative local amenity flows based on case studies of changes in residential property values in specific cities. We analyze changes in residential property values in Oklahoma City over a period, 2000 to 2016, where both temporary and permanent exogenous shocks to local sports-related amenities occurred. Results from hedonic price models and repeat sales regression models show that nearby residential property prices increased after the opening of a new arena and the arrival of a new, permanent …

Oxygen-Induced Leakage Of Spin Polarization In Overhauser- Enhanced Magnetic Resonance Imaging: Application For Oximetry In Tumors, Artem A. Gorodetskii, Timothy D. Eubank, Benoit Driesschaert, Martin Poncelet, Emily Ellis, Valery V. Khramtsov, Andrey A. Bobko

Clinical and Translational Science Institute

Overhauser-enhanced Magnetic Resonance Imaging (OMRI) is a double resonance technique applied for oxygen imaging in aqueous samples and biological tissues. In this report, we present an improved OMRI approach of oxygen measurement using the single line “Finland” trityl spin probe. Compared to a traditional approach, we introduced an additional mechanism of leakage of spin polarization due to an interaction of a spin system with oxygen. The experimental comparison of the new approach with an oxygen-dependent leakage factor to a traditional approach performed in phantom samples in vitro, and mouse tumor model in vivo, shows improved accuracy of determination of oxygen …

Populist Placemaking: Grounds For Open Government-Citizen Spatial Regulating Discourse, Michael N. Widener

West Virginia Law Review

No abstract provided.

Geographic Discrimination: Of Place, Space, Hillbillies, And Home, William Rhee, Stephen C. Scott

West Virginia Law Review

This Essay explores the two-sided challenge of geographic discrimination, where U.S. citizens receive disparate treatment from other citizens or the government solely because of where they live or self-identify as home, through the interdisciplinary concepts of space, place, and distance; and an original examination of discrimination against Appalachians. Such disparate treatment is unavoidable and even arguably politically correct. Where we call home matters in a number of legitimate ways to include our access to jobs and services, culture, educational opportunities, and other basic human capabilities. Although technology has increased individual mobility more than ever before, a majority of Americans nevertheless …

Liability For Unintentional Nuisances: How The Restatement Of Torts Almost Negligently Killed The Right To Exclude In Property Law, Jill M. Fraley

West Virginia Law Review

No abstract provided.

Won't You Be My Neighbor: Meza-Rodriguez, The Second Amendment, And The Constitutional Rights Of Noncitizens, Blair E. Wessels

West Virginia Law Review

No abstract provided.

Better Late Than Never: Bringing The Data Security Regulatory Environment Into The Modern Era, Jacob Holden

West Virginia Law Review

No abstract provided.

Building Eden, Roger A. Lohmann

Faculty & Staff Scholarship

Ralph Deigh is the most famous vernacular American architect you've never heard of. After a military career spanning two wars and struggles with homelessness and PTSD, he is invited to design an entirely new rural community for the 21st century. Twin disasters (fire and flood) in Dare County, West Virginia, set up the circumstances for him to join with Rosemary Mueller and the wealthy Ohio-based Mueller Foundation and a mysterious group of local Dare County residents led by Adam Sennett, County Clerk of Dare County. Together, they design and build the new town of Eden, West Virginia.

The whole story …

Conditional Knockout Of Shp2 In Erbb2 Transgenic Mice Or Inhibition In Her2-Amplified Breast Cancer Cell Lines Blocks Oncogene Expression And Tumorigenesis, Hua Zhao, Elisha Martin, Fatimah Matalkah, Neal Shah, Alexey Ivanov, J. Michael Ruppert, Paul R. Lockman, Yehenew M. Agazie

Clinical and Translational Science Institute

Overexpression of the human epidermal growth factor receptor 2 (HER2) is the cause of HER2- positive breast cancer (BC). Although HER2-inactivating therapies have benefited BC patients, development of resistance and disease recurrence have been the major clinical problems, pointing to a need for alternative therapeutic strategies. For that to happen, proteins that play critical roles in the biology of HER2-induced tumorigenesis have to be identified and characterized. Here, we show that the Src homology phosphotyrosyl phosphatase 2 (Shp2) encoded by the Ptpn11 gene is a requisite for ErbB2-induced tumorigenesis. We report that conditional knockout of Shp2 alleles in the ErbB2 …

Human Ancestry Indentification Under Resource Constraints -- What Can One Chromosome Tell Us About Human Biogeographical Ancestry?, Tanjin T. Toma, Jeremy M. Dawson, Donald A. Adjeroh

Clinical and Translational Science Institute

Background: While continental level ancestry is relatively simple using genomic information, distinguishing between individuals from closely associated sub-populations (e.g., from the same continent) is still a difficult challenge. Methods: We study the problem of predicting human biogeographical ancestry from genomic data under resource constraints. In particular, we focus on the case where the analysis is constrained to using single nucleotide polymorphisms (SNPs) from just one chromosome. We propose methods to construct such ancestry informative SNP panels using correlation-based and outlier-based methods. Results: We accessed the performance of the proposed SNP panels derived from just one chromosome, using data from the …

A Novel Method For Training Mice In Visuo-Tactile 3-D Object Discrimination And Recognition, Xian Hu, Ogaga Urhie, Kevin Chang, Rachel Hostetler, Ariel Agmon

Clinical and Translational Science Institute

Perceiving, recognizing and remembering 3-dimensional (3-D) objects encountered in the environment has a very high survival value; unsurprisingly, this ability is shared among many animal species, including humans. The psychological, psychophysical and neural basis for object perception, discrimination, recognition and memory has been extensively studied in humans, monkeys, pigeons and rodents, but is still far from understood. Nearly all 3-D object recognition studies in the rodent used the “novel object recognition” paradigm, which relies on innate rather than learned behavior; however, this procedure has several important limitations. Recently, investigators have begun to recognize the power of behavioral tasks learned through …

In Vivo Extracellular Ph Mapping Of Tumors Using Electron Paramagnetic Resonance, Denis A. Komarov, Yuki Ichikawa, Kumiko Yamamoto, Neil J. Stewart, Shingo Matsumoto, Hironobu Yasui, Igor A. Kirilyuk, Valery V. Khramtsov, Osamu Inanami, Hiroshi Hirata

Clinical and Translational Science Institute

An electron paramagnetic resonance (EPR)- based method for noninvasive three-dimensional extracellular pH mapping was developed using a pH-sensitive nitroxyl radical as an exogenous paramagnetic probe. Fast projection scanning with a constant magnetic field sweep enabled the acquisition of four-dimensional (3D spatial +1D spectral) EPR images within 7.5 min. Three-dimensional maps of pH were reconstructed by processing the pH-dependent spectral information on the images. To demonstrate the proposed method of pH mapping, the progress of extracellular acidosis in tumor-bearing mouse legs was studied. Furthermore, extracellular pH mapping was used to visualize the spatial distribution of acidification in different tumor xenograft mouse …

Psychological Factors Related To Exercise Behaviors Among College Students, Eric D. Jenkins, Phillip J. Dillulio, Fernando Said, Tim Stamper, Samuel Zizzi

Mountaineer Undergraduate Research Review

With the prevalence of obesity steadily increasing throughout the United States, promotion of healthy behavior is as important as ever. Positive exercise and dietary habits promoted during the years an individual is in college can perpetuate a lifestyle change that ideally prolongs an entire lifespan. Researchers gathered data from 108 full time students, 18 years of age or older from the West Virginia University Student Recreation Center. Participants were recruited using convenient sampling and completed a 74-item questionnaire comprised of both qualitative and quantitative questions. The collected data, in collaboration with previous literature, has empowered the research team with suitable …

Relationships Exist Between Chemistry Self-Efficacy In College Students And Academic Outcomes In Chemical Education, Daniel Teoli

Mountaineer Undergraduate Research Review

Introductory and preparatory chemistry courses hold a particular importance to students across a wide range of academic specialties and majors. In addition to serving as a potential primer for students interested in the possibility of majoring in chemistry, introductory and preparatory chemical education has been actively integrated into the curriculum of other fields within the natural science spectrum (such as biology and physics). Additionally, under the umbrella of requisite coursework, it has gained a strong pertinence to applied sciences such as nursing, engineering, and exercise physiology (Tai, Sadler, and Loehr 2005).

Learning From Mistakes: Decriminalizing Prostitution In The United States, Katheryn E. Marcum

Mountaineer Undergraduate Research Review

Prostitution is, according to cliché, the world’s oldest profession. It is also an activity greatly disputed by many, all over the world. Nearly every country has developed some way to address the issue. In the United States of America, prostitution is against the law in forty-nine of fifty states and heavily regulated in the other. The fact of the matter is that prostitution must exist because there is demand for it, and as long as that demand persists, so will the activity. Prostitution occurs across the globe between people of all genders, sexualities, ages and religions, and many other countries …

What Comic Books And Political Cartoons Reveal About Mexican History, Carolyn Brewer

Mountaineer Undergraduate Research Review

History and popular culture have played off one another for centuries. While comic books might certainly seem to be a low-class form of entertainment, lacking the authority of a history textbook, they nonetheless allow the readers to engage in history as they have otherwise never experienced it. Rather than reading descriptions of what happened when the Spanish landed in Mexico, one may read The Cartoon History of the Modern World or Exploring the Americas to see clothing of the time-period as well as how some of the historical characters may have felt. By using comic books and political cartoons, one …

Full Issue

Mountaineer Undergraduate Research Review

No abstract provided.

Giant Pulse Detection In The Andromeda Galaxy For Future Discovery Of Extragalactic Pulsars, Tabitha Smith

Mountaineer Undergraduate Research Review

With the Green Bank Telescope (GBT) in Green Bank, WV, radio data from the Andromeda Galaxy (M31) have been collected by the Naval Research Laboratory (NRL) and brought to West Virginia University (WVU) for processing. A search is being conducted for giant radio bursts from pulsars. Currently, the data are halfway through being analyzed. Several candidates have been sighted, and radio frequency interference is in the process of being continuously mitigated.

Repeat Lactate Level Predicts Mortality Better Than Rate Of Clearance, Zachary D. W. Dezman, Angela C. Comer, Gordon S. Smith, Peter F. Hu, Colin F. Mackenzie, Thomas M. Scalea, Jon Mark Hirshon

Clinical and Translational Science Institute

Background Lactate clearance has been developed into a marker of resuscitation in trauma, but no study has compared the predictive power of the various clearance calculations. Our objective was to determine which method of calculating lactate clearance best predicted 24-hour and in-hospital mortality after injury. Study design Retrospective chart review of patients admitted to a Level-1 trauma center directly from the scene of injury from 2010 to 2013 who survived >15 min, had an elevated lactate at admission (≥3 mmol/L), followed by another measurement within 24 h of admission. Lactate clearance was calculated using five models: actual value of the …

Will Artificial Intelligence Replace The Human Echocardiographer?, Partho P. Sengupta, Donald A. Adjeroh

Clinical and Translational Science Institute

No abstract provided.

Self-Reported Vs. Measured Height, Weight, And Bmi In Young Adults, Melissa D. Olfert, Makenzie L. Barr, Camille M. Charlier, Oluremi A. Famodu, Wenjun Zhou, Anne E. Mathews, Carol Byrd-Bredbenner, Sarah E. Colby

Clinical and Translational Science Institute

Self-reported height and weight, if accurate, provide a simple and economical method to track changes in body weight over time. Literature suggests adults tend to under-report their own weight and that the gap between self-reported weight and actual weight increases with obesity. This study investigates the extent of discrepancy in self-reported height, weight, and subsequent Body Mass Index (BMI) versus actual measurements in young adults. Physically measured and self-reported height and weight were taken from 1562 students. Male students marginally overestimated height, while females were closer to target. Males, on average, closely self-reported weight. Self-reported anthropometrics remained statistically correlated to …

The Stored Communications Act: Property Law Enforcement Tool Or Instrument Of Oppression?, Raymond Boyce

West Virginia Law Review

No abstract provided.

An Effective Approach To Teaching Pharmacogenomics In The First Year Of Pharmacy Curriculum, Marina Gálvez-Peralta, Grazyna D. Szklarz, Werner J. Geldenhuys, Paul R. Lockman

Clinical and Translational Science Institute

Objective. To develop an effective method in teaching pharmacogenomics as a part of a new course, Biopharmaceutics and Pharmacogenomics. Methods. Teaching effectiveness was measured by quizzes, retrospective pre- and post-surveys, team activities, and journal reflections. Four team activities were included in the course: genomic disease, patient case, genetic counselor and a debate about personalized medicine. Outcomes and course impact were evaluated at the end of the course. The evaluation methods included the assessment of knowledge, students’ perceptions regarding the utility of team activities, the impact of the course on students’ confidence to discuss pharmacogenomics with health care providers or patients, …

Executive (Dys)Function After Traumatic Brain Injury: Special Considerations For Behavioral Pharmacology, Jenny E. Ozga, Jessica M. Povroznik, Elizabeth B. Engler-Chiurazzi, Cole Vonder Haar

Clinical and Translational Science Institute

Executive function is an umbrella term that includes cognitive processes such as decision-making, impulse control, attention, behavioral flexibility, and working memory. Each of these processes depends largely upon monoaminergic (dopaminergic, serotonergic, and noradrenergic) neurotransmission in the frontal cortex, striatum, and hippocampus, among other brain areas. Traumatic brain injury (TBI) induces disruptions in monoaminergic signaling along several steps in the neurotransmission process – synthesis, distribution, and breakdown – and in turn, produces long-lasting deficits in several executive function domains. Understanding how TBI alters monoamingeric neurotransmission and executive function will advance basic knowledge of the underlying principles that govern executive function and …

Executive (Dys)Function After Stroke: Special Considerations For Behavioral Pharmacology, Jessica M. Povroznik, Jenny E. Ozga, Cole Vonder Haar, Elizabeth B. Engler-Chiurazzi

Clinical and Translational Science Institute

Stroke is a world-wide leading cause of death and long-term disability with concurrent secondary consequences that are largely comprised of mood dysfunction, as well as sensory, motor, and cognitive deficits. This review focuses on the cognitive deficits associated with stroke specific to executive dysfunction (including decision making, working memory, and cognitive flexibility) in humans, non-human primates, and additional animal models. Further, we review some of the cellular and molecular underpinnings of the individual components of executive dysfunction and their neuroanatomical substrates after stroke, with an emphasis on the changes that occur during biogenic monoamine neurotransmission. We concentrate primarily on changes …

A Comparison Of Pre-College Enrichment Program Participants And Non-Participants: College Academic Performance Measures, Sherron Mckendall, Alan Mckendall, Ann Chester

Faculty & Staff Scholarship

This paper analyzes College Grade Point Averages (CGPAs), American College Testing Composite (ACTC) scores and Scholastic Assessment Test Total (SATT) scores of over 1,300 undergraduates at West Virginia University (WVU) who participated in the Health Sciences and Technology Academy (HSTA) to those students who did not (Non-HSTA). Traditionally, pre-college enrichment programs provide academic enrichment to underrepresented youth with the intent of increasing their chances for post-secondary entry and success. Factorial design determined if HSTA participants were better prepared to pursue postsecondary study. Overall, the results reveal that HSTA students outperformed their Non-HSTA counterparts in that there were significant differences in …

Algebra, Wvu Mathematics Department

M.S. Advanced and Ph.D. Entrance Exams

No abstract provided.

Demonstrating The Efficacy Of The Health Sciences And Technology Academy: Using Archival Standardized Test Scores To Analyze An Ost College-Preparatory Program For Underserved Youth, Feon Smith, Sherron Mckendall, Ann Chester, Bethany Hornbeck, Alan Mckendall

Faculty & Staff Scholarship

To combat educational and health disparities, out-of-school-time (OST) STEM enrichment programs provide services to underserved youth to encourage them to pursue college and health careers. This article describes a study conducted to determine if the Health Sciences and Technology Academy (HSTA) program participants who receive year-round educational interventions to prepare them for STEM and health sciences majors performed better on the West Virginia Educational Standards Test (WESTEST2) than non-participants. This study provides descriptive and inferential statistics, specifically one-way ANOVAs with one-to-one matching based on grade level, gender, race, and GPA at the end of the 8th grade year for 336 …

A Non-Myeloablative Conditioning Approach For Long-Term Engraftment Of Human And Mouse Hematopoietic Stem Cells, Wei Du, Wei Liu, Benjamin Mizukawa, Xun Shang, Jared Sipple, Mark Wunderlich, Hartmut Geiger, Stella Davies, James Mulloy, Qishen Pang, Yi Zheng

Clinical and Translational Science Institute

No abstract provided.

An Examination Of The Perceived Impact Of A Continuing Interprofessional Education Experience On Opiate Prescribing Practices, Roberto Cardarelli, William Elder, Sarah Weatherford, Karen L. Roper, Dana King, Charlotte Workman, Kathryn Stewart, Chong Kim, William Betz

Clinical and Translational Science Institute

Chronic pain is increasingly recognized as a public health problem. We assessed the effectiveness of a multi-modal, interprofessional educational approach aimed at empowering healthcare professionals to make deliberative changes, especially in opiate prescribing practices. Education activities included enduring webcasts, regional interprofessional roundtable events, and state-level conference presentations within targeted Kentucky and West Virginia regions of the United States. Over 1,000 participants accessed the various activities. For the live events, the largest groups reached included nurses (38.1%), nurse practitioners (31.2%), and physicians (22.1%). In addition to our reach, higher levels of educational effectiveness were measured, specifically, learner’s intentions to change practice …