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Articles 1411 - 1440 of 4525
Full-Text Articles in Entire DC Network
A Novel Mechanism Of Non- Feminizing Estrogens In Neuroprotection, Elizabeth B. Engler-Chiurazzi, Douglas F. Covey, James W. Simpkins
A Novel Mechanism Of Non- Feminizing Estrogens In Neuroprotection, Elizabeth B. Engler-Chiurazzi, Douglas F. Covey, James W. Simpkins
Clinical and Translational Science Institute
Estrogens are potent and efficacious neuroprotectants both in vitro and in vivo in a variety of models of neurotoxicity. We determined the structural requirements for neuroprotection in an in vitro assay using a panel of more than 70 novel estratrienes, synthesized to reduce or eliminate estrogen receptor (ER) binding. We observed that neuroprotection could be enhanced by as much as 200-fold through modifications that positioned a large bulky group at the C2 or C4 position of the phenolic A ring of the estratriene. Further, substitutions on the B, C or D rings either reduced or did not markedly change neuroprotection. …
Light Transmission And Interception In Cool-Season Pastures, Edward Barrow Rayburn
Light Transmission And Interception In Cool-Season Pastures, Edward Barrow Rayburn
Faculty & Staff Scholarship
WVU-Extension fact sheet
Co-Option Of A Motor-To-Sensory Histaminergic Circuit Correlates With Insect Flight Biomechanics, Phillip D. Chapman, Samual P. Bradley, Erica J. Haught, Kassandra E. Riggs, Mouaz M. Haffar, Kevin C. Daly, Andrew M. Dacks
Co-Option Of A Motor-To-Sensory Histaminergic Circuit Correlates With Insect Flight Biomechanics, Phillip D. Chapman, Samual P. Bradley, Erica J. Haught, Kassandra E. Riggs, Mouaz M. Haffar, Kevin C. Daly, Andrew M. Dacks
Clinical and Translational Science Institute
Nervous systems must adapt to shifts in behavioural ecology. One form of adaptation is neural exaptation, in which neural circuits are co-opted to perform additional novel functions. Here, we describe the co-option of a motor-to-somatosensory circuit into an olfactory network. Many moths beat their wings during odour-tracking, whether walking or flying, causing strong oscillations of airflow around the antennae, altering odour plume structure. This self-induced sensory stimulation could impose selective pressures that influence neural circuit evolution, specifically fostering the emergence of corollary discharge circuits. In Manduca sexta, a pair of mesothoracic to deutocerebral histaminergic neurons (MDHns), project from the mesothoracic …
From Creativity To Classification: A Logical Approach To Patent Searching, Marian G. Armour-Gemmen
From Creativity To Classification: A Logical Approach To Patent Searching, Marian G. Armour-Gemmen
Faculty & Staff Scholarship
Engineering students and professors need to understand and search intellectual property. In the past, librarians have instructed them on using the United States Patent Classification (USPC). In 2015, after a period of transition, the United States Patent and Trademark Office phased out the USPC and began exclusively classifying in the Cooperative Patent Classification (CPC). This adoption presented librarians a challenge of instructing students and professors in the easiest and most effective patent search. By tying patent searching to an example and presenting classification in an understandable fashion using CPC in conjunction with USPC, this writer presents a logical directed search …
Concurrent Longitudinal Epr Monitoring Of Tissue Oxygenation, Acidosis, And Reducing Capacity In Mouse Xenograft Tumor Models, Andrey A. Bobko, Jason Evans, Nicholas C. Denko, Valery V. Khramtsov
Concurrent Longitudinal Epr Monitoring Of Tissue Oxygenation, Acidosis, And Reducing Capacity In Mouse Xenograft Tumor Models, Andrey A. Bobko, Jason Evans, Nicholas C. Denko, Valery V. Khramtsov
Clinical and Translational Science Institute
Tissue oxygenation, extracellular acidity and tissue reducing capacity are among crucial parameters of tumor microenvironment (TME) of significant importance for tumor pathophysiology. In this paper we demonstrate the complementary application of particulate lithium octa-n-butoxy-naphthalocyanine (LiNc-BuO) and soluble nitroxide (NR) paramagnetic probes for monitoring of these TME parameters using electron paramagnetic resonance (EPR) technique. Two different types of therapeutic interventions were studied: hypothermia and systemic administration of metabolically active drug. In summary, the results demonstrate utility of EPR technique for noninvasive concurrent longitudinal monitoring of physiologically relevant chemical parameters of TME in a mouse xenograft tumor models including that under therapeutic …
Osteoblast Differentiation And Bone Matrix Formation In Vivo And In Vitro, Harry C. Blair, Quitterie C. Larrouture, Yanan Li, Hang Lin, Donna Beer-Stoltz, Li Liu, Rocky S. Tuan, Lisa J. Robinson, Paul H. Schlesinger, Deborah J. Nelson
Osteoblast Differentiation And Bone Matrix Formation In Vivo And In Vitro, Harry C. Blair, Quitterie C. Larrouture, Yanan Li, Hang Lin, Donna Beer-Stoltz, Li Liu, Rocky S. Tuan, Lisa J. Robinson, Paul H. Schlesinger, Deborah J. Nelson
Clinical and Translational Science Institute
We review the characteristics of osteoblast differentiation and bone matrix synthesis. Bone in air breathing vertebrates is a specialized tissue that developmentally replaces simpler solid tissues, usually cartilage. Bone is a living organ bounded by a layer of osteoblasts that, because of transport and compartmentalization requirements, produce bone matrix exclusively as an organized tight epithelium. With matrix growth, osteoblasts are reorganized and incorporated into the matrix as living cells, osteocytes, which communicate with each other and surface epithelium by cell processes within canaliculi in the matrix. The osteoblasts secrete the organic matrix, which are dense collagen layers that alternate parallel …
High-Content Screen Using Zebrafish (Danio Rerio) Embryos Identifies A Novel Kinase Activator And Inhibitor, Werner J. Geldenhuys, Sadie A. Bergeron, Jackie E. Mullins, Rowaa Aljammal, Briah L. Gaasch, Wei-Chi Chen, June Yun, Lori A. Hazlehurst
High-Content Screen Using Zebrafish (Danio Rerio) Embryos Identifies A Novel Kinase Activator And Inhibitor, Werner J. Geldenhuys, Sadie A. Bergeron, Jackie E. Mullins, Rowaa Aljammal, Briah L. Gaasch, Wei-Chi Chen, June Yun, Lori A. Hazlehurst
Clinical and Translational Science Institute
In this report we utilized zebrafish (Danio rerio) embryos in a phenotypical high-content screen (HCS) to identify novel leads in a cancer drug discovery program. We initially validated our HCS model using the flavin adenosine dinucleotide (FAD) containing endoplasmic reticulum (ER) enzyme, endoplasmic reticulum oxidoreductase (ERO1) inhibitor EN460. EN460 showed a dose response effect on the embryos with a dose of 10 μM being significantly lethal during early embryonic development. The HCS campaign which employed a small library identified a promising lead compound, a naphthyl-benzoic acid derivative coined compound 1 which had significant dosage and temporally dependent effects on notochord …
Inhibition Of Vegf And Angiopoietin-2 To Reduce Brain Metastases Of Breast Cancer Burden, Kaci A. Bohn, Chris E. Adkins, Mohamed I. Nounou, Paul R. Lockman
Inhibition Of Vegf And Angiopoietin-2 To Reduce Brain Metastases Of Breast Cancer Burden, Kaci A. Bohn, Chris E. Adkins, Mohamed I. Nounou, Paul R. Lockman
Clinical and Translational Science Institute
For metastases in the central nervous system, angiogenesis enhances metastatic potential and promotes progression. Primary factors which drive vessel growth are vascular endothelial growth factor (VEGF) and angiopoietin-2. Preclinical models show inhibition of either factor reduces metastases spread and inhibits growth. This work sets out to answer two questions in a preclinical mouse model. First, whether the combined inhibition of VEGF and angiopoietin-2, reduces passive permeability and limits drug uptake into brain metastases; and second, whether this inhibition reduces metastases burden in brain. We observed combinatorial inhibition of VEGF and angiopoietin-2, decreased (p < 0.05) angiogenesis and vascular branching in an aortic ring assay and decreased (p < 0.05) endothelial wound closure times. Using a brain metastases of breast cancer model (induced by intracardiac injections of brain seeking MDA-MB-231Br cells or 4T1Br cells), we observed, similar to VEGF, angiopoetin-2 expression correlates to increased angiogenesis (p < 0.05) and increased lesion permeability. To determine efficacy, animals were administered bevacizumab plus L1-10 (angiopoietin inhibitor) twice per week until neurological symptoms developed. Lesion permeability significantly decreased by ∼50% (p < 0.05) compared to untreated lesions, but remained ∼25% greater (p < 0.0%) than brain. In subsequent experiments, animals were administered similar regimens but sacrificed on day 32. The number of metastatic lesions developed was significantly (p < 0.001) reduced in the bevacizumab group (56%) and combination group (86%). Lesions’ size was reduced in bevacizumab treated lesions (∼67%) and bevacizumab and L1-10 treated lesions (∼78%) developing area < 0.5 mm2. In summary, combinatorial inhibition of VEGF and angiopoietin reduces lesion permeability and brain metastatic burden.
Mitochondria Initiate And Regulate Sarcopenia, Stephen E. Alway, Junaith S. Mohamed, Matthew J. Myers
Mitochondria Initiate And Regulate Sarcopenia, Stephen E. Alway, Junaith S. Mohamed, Matthew J. Myers
Clinical and Translational Science Institute
We present the hypothesis that an accumulation of dysfunctional mitochondria initiates a signaling cascade leading to motor neuron and muscle fiber death and culminating in sarcopenia. Interactions between neural and muscle cells that contain dysfunctional mitochondria exacerbate sarcopenia. Preventing sarcopenia will require identifying mitochondrial sources of dysfunction that are reversible.
Arterial Ventricular Uncoupling With Age And Disease And Recoupling With Exercise, Paul D. Chantler
Arterial Ventricular Uncoupling With Age And Disease And Recoupling With Exercise, Paul D. Chantler
Clinical and Translational Science Institute
The deterioration in arterial and cardiac function with aging impairs arterial ventricular coupling, an important determinant of cardiovascular performance. However, exercise training improves arterial ventricular coupling especially during exercise during the age and disease process. This review examines the concept of arterial-ventricular coupling, and how age, and disease uncouples but exercise training recouples the heart and arterial system.
Rethinking The Fourth Amendment In The Age Of Supercomputers, Artificial Intelligence, And Robots, Melanie Reid
Rethinking The Fourth Amendment In The Age Of Supercomputers, Artificial Intelligence, And Robots, Melanie Reid
West Virginia Law Review
In an era of diminishing privacy, the Internet of Things ("loT") has become a consensual and inadvertent tool that undermines privacy protection. The loT, really systems of networks connected to each other by the Internet or other radio-type device, creates consensual mass self-surveillance in such domains as fitness and the Fitbit, health care and heart monitors, "smart" houses and cars, and even "smart" cities. The multiple networks also have created a degree of interconnectivity that has opened up a fire hose of information for companies and governments alike, as well as making it virtually insuperable to live "off the grid" …
Glucagon And Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription By Increasing The Expression Of Activating Transcription Factor 4, Kimberly M. Alonge, Gordon P. Meares, F. Bradley Hillgartner
Glucagon And Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription By Increasing The Expression Of Activating Transcription Factor 4, Kimberly M. Alonge, Gordon P. Meares, F. Bradley Hillgartner
Clinical and Translational Science Institute
Previous studies have shown that glucagon cooperatively interacts with insulin to stimulate hepatic FGF21 gene expression. Here we investigated the mechanism by which glucagon and insulin increased FGF21 gene transcription in primary hepatocyte cultures. Transfection analyses demonstrated that glucagon plus insulin induction of FGF21 transcription was conferred by two activating transcription factor 4 (ATF4) binding sites in the FGF21 gene. Glucagon plus insulin stimulated a 5-fold increase in ATF4 protein abundance, and knockdown of ATF4 expression suppressed the ability of glucagon plus insulin to increase FGF21 expression. In hepatocytes incubated in the presence of insulin, treatment with a PKA-selective agonist …
Imaging Thiol Redox Status In Murine Tumors In Vivo With Rapid-Scan Electron Paramagnetic Resonance, Boris Epel, Subramanian V. Sundramoorthy, Martyna Krzykawska-Serda, Matthew C. Maggio, Mark Tseytlin, Gareth R. Eaton, Sandra S. Eaton, Gerald M. Rosen, Joseph P. Y. Kao, Howard J. Halpern
Imaging Thiol Redox Status In Murine Tumors In Vivo With Rapid-Scan Electron Paramagnetic Resonance, Boris Epel, Subramanian V. Sundramoorthy, Martyna Krzykawska-Serda, Matthew C. Maggio, Mark Tseytlin, Gareth R. Eaton, Sandra S. Eaton, Gerald M. Rosen, Joseph P. Y. Kao, Howard J. Halpern
Clinical and Translational Science Institute
Thiol redox status is an important physiologic parameter that affects the success or failure of cancer treatment. Rapid scan electron paramagnetic resonance (RS EPR) is a novel technique that has shown higher signal-to-noise ratio than conventional continuous-wave EPR in in vitro studies. Here we used RS EPR to acquire rapid three-dimensional images of the thiol redox status of tumors and normal tissues in living mice. This work presents, for the first time, in vivo RS EPR images of the kinetics of the reaction of 2H,15N-substituted disulfide-linked dinitroxide (PxSSPx) spin probe with intracellular glutathione. The cleavage rate is proportional to the …
Transcriptomic Effects Of Adenosine 2a Receptor Deletion In Healthy And Endotoxemic Murine Myocardium, Kevin J. Ashton, Melissa E. Reichelt, S. Jamal Mustafa, Bunyen Teng, Catherine Ledent, Lea M. D. Delbridge, Polly A. Hofmann, R. Ray Morrison, John P. Headrick
Transcriptomic Effects Of Adenosine 2a Receptor Deletion In Healthy And Endotoxemic Murine Myocardium, Kevin J. Ashton, Melissa E. Reichelt, S. Jamal Mustafa, Bunyen Teng, Catherine Ledent, Lea M. D. Delbridge, Polly A. Hofmann, R. Ray Morrison, John P. Headrick
Clinical and Translational Science Institute
Influences of adenosine 2A receptor (A2AR) activity on the cardiac transcriptome and genesis of endotoxemic myocarditis are unclear. We applied transcriptomic profiling (39 K Affymetrix arrays) to identify A2AR-sensitive molecules, revealed by receptor knockout (KO), in healthy and endotoxemic hearts. Baseline cardiac function was unaltered and only 37 A2AR-sensitive genes modified by A2AR KO (≥1.2-fold change, <5 >% FDR); the five most induced are Mtr, Ppbp, Chac1, Ctsk and Cnpy2 and the five most repressed are Hp, Yipf4, Acta1, Cidec and Map3k2. Few canonical paths were impacted, with altered Gnb1, Prkar2b, Pde3b and Map3k2 (among others) implicating modified G protein/cAMP/PKA and …
Emerging Strategies Of Targeting Lipoprotein Lipase For Metabolic And Cardiovascular Diseases, Werner J. Geldenhuys, Li Lin, Altaf S. Darvesh, Prabodh Sadana
Emerging Strategies Of Targeting Lipoprotein Lipase For Metabolic And Cardiovascular Diseases, Werner J. Geldenhuys, Li Lin, Altaf S. Darvesh, Prabodh Sadana
Clinical and Translational Science Institute
Although statins and other pharmacological approaches have improved the management of lipid abnormalities, there exists a need for newer treatment modalities especially for the management of hypertriglyceridemia. Lipoprotein lipase (LPL), by promoting hydrolytic cleavage of the triglyceride core of lipoproteins, is a crucial node in the management of plasma lipid levels. Although LPL expression and activity modulation is observed as a pleiotropic action of some the commonly used lipid lowering drugs, the deliberate development of drugs targeting LPL has not occurred yet. In this review, we present the biology of LPL, highlight the LPL modulation property of currently used drugs …
Interstitial Inorganic Phosphate As A Tumor Microenvironment Marker For Tumor Progression, Andrey A. Bobko, Timothy D. Eubank, Benoit Driesschaert, Ilirian Dhimitruka, Jason Evans, Rahman Mohammad, Elena E. Tchekneva, Mikhail M. Dikov, Valery V. Khramtsov
Interstitial Inorganic Phosphate As A Tumor Microenvironment Marker For Tumor Progression, Andrey A. Bobko, Timothy D. Eubank, Benoit Driesschaert, Ilirian Dhimitruka, Jason Evans, Rahman Mohammad, Elena E. Tchekneva, Mikhail M. Dikov, Valery V. Khramtsov
Clinical and Translational Science Institute
Noninvasive in vivo assessment of chemical tumor microenvironment (TME) parameters such as oxygen (pO2), extracellular acidosis (pHe), and concentration of interstitial inorganic phosphate (Pi) may provide unique insights into biological processes in solid tumors. In this work, we employ a recently developed multifunctional trityl paramagnetic probe and electron paramagnetic resonance (EPR) technique for in vivo concurrent assessment of these TME parameters in various mouse models of cancer. While the data support the existence of hypoxic and acidic regions in TME, the most dramatic differences, about 2-fold higher concentrations in tumors vs. normal tissues, were observed for interstitial Pi - the …
Structure-Activity And In Vivo Evaluation Of A Novel Lipoprotein Lipase (Lpl) Activator, Werner J. Geldenhuys, Joel Caporoso, Thomas C. Leeper, Yoon-Kwang Lee, Li Lin, Altaf S. Darvesh, Prabodh Sadana
Structure-Activity And In Vivo Evaluation Of A Novel Lipoprotein Lipase (Lpl) Activator, Werner J. Geldenhuys, Joel Caporoso, Thomas C. Leeper, Yoon-Kwang Lee, Li Lin, Altaf S. Darvesh, Prabodh Sadana
Clinical and Translational Science Institute
Elevated triglycerides (TG) contribute towards increased risk for cardiovascular disease. Lipoprotein lipase (LPL) is an enzyme that is responsible for the metabolism of core triglycerides of very-low density lipoproteins (VLDL) and chylomicrons in the vasculature. In this study, we explored the structure-activity relationships of our lead compound (C10d) that we have previously identified as an LPL agonist. We found that the cyclopropyl moiety of C10d is not absolutely necessary for LPL activity. Several substitutions were found to result in loss of LPL activity. The compound C10d was also tested in vivo for its lipid lowering activity. Mice were fed a …
Quick Guide Pasture And Grazing Management.Pdf, Edward Barrow Rayburn
Quick Guide Pasture And Grazing Management.Pdf, Edward Barrow Rayburn
Faculty & Staff Scholarship
WVU-Extension fact sheet
Into The Wild: Parallel Transcriptomics Of The Tsetse-Wigglesworthia Mutualism Within Kenyan Populations, Miguel M. Munoz, Adam R. Pollio, Hunter L. White, Rita V M Rio
Into The Wild: Parallel Transcriptomics Of The Tsetse-Wigglesworthia Mutualism Within Kenyan Populations, Miguel M. Munoz, Adam R. Pollio, Hunter L. White, Rita V M Rio
Faculty & Staff Scholarship
Tsetse flies (Diptera: Glossinidae) have medical significance as the obligate vectors of African trypanosomes. In addition, tsetse harbor a simple gut microbiota. A predominant gut microbiota member, the Gammaproteobacterium Wigglesworthia spp., has coevolved with tsetse for a significant portion of Glossina radiation proving critical to tsetse fitness. Although multiple roles have been described for Wigglesworthia within colony flies, little research has been dedicated towards functional characterization within wild tsetse. Here, dual RNA-Seq was performed to characterize the tsetse-Wigglesworthia symbiosis within flies captured in Nguruman, Kenya. A significant correlation in Gene Ontology (GO) distribution between tsetse and Wigglesworthia was observed, with …
Human Retinal Pigment Epithelial Cells Prefer Proline As A Nutrient And Transport Metabolic Intermediates To The Retinal Side, Jennifer R. Chao, Kaitlen Knight, Yekai Wang, Jianhai Du
Human Retinal Pigment Epithelial Cells Prefer Proline As A Nutrient And Transport Metabolic Intermediates To The Retinal Side, Jennifer R. Chao, Kaitlen Knight, Yekai Wang, Jianhai Du
Faculty & Staff Scholarship
No abstract provided.
Targeting Intrinsic And Extrinsic Vulnerabilities For The Treatment Of Multiple Myeloma, Nagaraju Anreddy, Lori A. Hazlehurst
Targeting Intrinsic And Extrinsic Vulnerabilities For The Treatment Of Multiple Myeloma, Nagaraju Anreddy, Lori A. Hazlehurst
Clinical and Translational Science Institute
Multiple myeloma (MM) is a malignant plasma cell disorder, clinically characterized by osteolytic lesions, immunodeficiency, and renal disease. Over the past decade, MM therapy is significantly improved by the introduction of novel therapeutics such as immunomodulatory agents (thalidomide, lenalidomide, and pomalidomide), proteasome inhibitors (bortezomib, carfilzomib, and ixazomib), monoclonal antibodies (daratumumab and elotuzumab), histone deacetylase (HDAC) inhibitors (Panobinostat). The clinical success of these agents has clearly identified vulnerabilities intrinsic to the MM cell- as well as targets that emanate from the tumor microenvironment. Despite these significant improvements, MM remains incurable due to the development of drug resistance. This perspective will discuss …
Fibrous Nanocellulose, Crystalline Nanocellulose, Carbon Nanotubes, And Crocidolite Asbestos Elicit Disparate Immune Responses Upon Pharyngeal Aspiration In Mice, Eun-Jung Park, Timur O. Khaliullin, Michael R. Shurin, Elena R. Kisin, Naveena Yanamala, Bengt Fadeel, Jaerak Chang, Anna A. Shvedova
Fibrous Nanocellulose, Crystalline Nanocellulose, Carbon Nanotubes, And Crocidolite Asbestos Elicit Disparate Immune Responses Upon Pharyngeal Aspiration In Mice, Eun-Jung Park, Timur O. Khaliullin, Michael R. Shurin, Elena R. Kisin, Naveena Yanamala, Bengt Fadeel, Jaerak Chang, Anna A. Shvedova
Faculty & Staff Scholarship
With the rapid development of synthetic alternatives to mineral fibers, their possible effects on the environment and human health have become recognized as important issues worldwide. This study investigated effects of four fibrous materials, i.e. nanofibrillar/nanocrystalline celluloses (NCF and CNC), single-walled carbon nanotubes (CNTs), and crocidolite asbestos (ASB), on pulmonary inflammation and immune responses found in the lungs, as well as the effects on spleen and peripheral blood immune cell subsets. BALB/c mice were given NCF, CNC, CNT, and ASB on Day 1 by oropharyngeal aspiration. At 14 days post-exposure, the animals were evaluated. Total cell number, mononuclear phagocytes, polymorphonuclear …
The Effect Of The 2015 Earthquake On The Bacterial Community Compositions In Water In Nepal, Sital Uprety, Pei-Ying Hong, Nora Sadik, Bipin Dangol, Rameswor Adhikari, Antarpreet Jutla, Joanna L. Shisler, Patrick Degnan, Thanh H. Nguyen
The Effect Of The 2015 Earthquake On The Bacterial Community Compositions In Water In Nepal, Sital Uprety, Pei-Ying Hong, Nora Sadik, Bipin Dangol, Rameswor Adhikari, Antarpreet Jutla, Joanna L. Shisler, Patrick Degnan, Thanh H. Nguyen
Faculty & Staff Scholarship
We conducted a study to examine the effect of seasonal variations and the disruptive effects of the 2015 Nepal earthquake on microbial communities associated with drinking water sources. We first characterized the microbial communities of water samples in two Nepali regions (Kathmandu and Jhapa) to understand the stability of microbial communities in water samples collected in 2014. We analyzed additional water samples from the same sources collected from May to August 2015, allowing the comparison of samples from dry-to-dry season and from dry-to-monsoon seasons. Emphasis was placed on microbes responsible for maintaining the geobiochemical characteristics of water (e.g., ammonia-oxidizing and …
Volatility Spillover And Time-Varying Conditional Correlation Between Ddgs, Corn, And Soybean Meal Markets, Xiaoli L. Etienne, Andres Trujillo-Barrera, Linwood A. Hoffman
Volatility Spillover And Time-Varying Conditional Correlation Between Ddgs, Corn, And Soybean Meal Markets, Xiaoli L. Etienne, Andres Trujillo-Barrera, Linwood A. Hoffman
Faculty & Staff Scholarship
We find distiller's dried grains with solubles (DDGS) prices to be positively correlated with both corn and soybean meal prices in the long run. However, neither corn nor soybean meal prices respond to deviations from this long-run relationship. We also identify strong time-varying dynamic conditional correlations between the markets, with the correlation between DDGS and corn strengthened after the expansion of ethanol production. There also appear to exist significant volatility spillovers from both the corn and soybean meal markets to the DDGS market, with the impact from corn shocks much larger compared to soybean meal shocks.
Perceptions Of Hunting And Hunters By U.S. Respondents, Elizabeth Byrd, John G. Lee, Nicole J. Olynk Widmar
Perceptions Of Hunting And Hunters By U.S. Respondents, Elizabeth Byrd, John G. Lee, Nicole J. Olynk Widmar
Faculty & Staff Scholarship
Public acceptance of hunting and hunting practices is an important human dimension of wildlife management in the United States. Researchers surveyed 825 U.S. residents in an online questionnaire about their views of hunting, hunters, and hunting practices. Eighty-seven percent of respondents from the national survey agreed that it was acceptable to hunt for food whereas 37% agreed that it was acceptable to hunt for a trophy. Over one-quarter of respondents did not know enough about hunting over bait, trapping, and captive hunts to form an opinion about whether the practice reduced animal welfare. Chi-square tests were used to explore relationships …
A Neural Signature Encoding Decisions Under Perceptual Ambiguity, Sai Sun, Rongjun Yu, Shuo Wang
A Neural Signature Encoding Decisions Under Perceptual Ambiguity, Sai Sun, Rongjun Yu, Shuo Wang
Faculty & Staff Scholarship
People often make perceptual decisions with ambiguous information, but it remains unclear whether the brain has a common neural substrate that encodes various forms of perceptual ambiguity. Here, we used three types of perceptually ambiguous stimuli as well as task instructions to examine the neural basis for both stimulus-driven and task-driven perceptual ambiguity. We identified a neural signature, the late positive potential (LPP), that encoded a general form of stimulus-driven perceptual ambiguity. In addition to stimulus-driven ambiguity, the LPP was also modulated by ambiguity in task instructions. To further specify the functional role of the LPP and elucidate the relationship …
Functional Role Of Cyclin-Dependent Kinase 5 In The Regulation Of Melanogenesis And Epidermal Structure, Changsheng Dong, Shanshan Yang, Ruiwen Fan, Kaiyuan Ji, Junzhen Zhang, Xuexian Liu, Shuaipeng Hu, Jianshan Xie, Yu Liu, Wenjun Gao, Haidong Wang, Jianbo Yao, George W. Smith, Muren Herrid
Functional Role Of Cyclin-Dependent Kinase 5 In The Regulation Of Melanogenesis And Epidermal Structure, Changsheng Dong, Shanshan Yang, Ruiwen Fan, Kaiyuan Ji, Junzhen Zhang, Xuexian Liu, Shuaipeng Hu, Jianshan Xie, Yu Liu, Wenjun Gao, Haidong Wang, Jianbo Yao, George W. Smith, Muren Herrid
Faculty & Staff Scholarship
The mammalian integumentary system plays important roles in body homeostasis, and dysfunction of melanogenesis or epidermal development may lead to a variety of skin diseases, including melanoma. Skin pigmentation in humans and coat color in fleece-producing animals are regulated by many genes. Among them, microphthalmia-associated transcription factor (MITF) and paired-box 3 (PAX3) are at the top of the cascade and regulate activities of many important melanogenic enzymes. Here, we report for the first time that cyclin-dependent kinase 5 (Cdk5) is an essential regulator of MITF and PAX3. Cdk5 knockdown in mice causes a lightened coat …
Monocyte-Lymphocyte Cross-Communication Via Soluble Cd163 Directly Links Innate Immune System Activation And Adaptive Immune System Suppression Following Ischemic Stroke, Grant C. O'Connell, Connie S. Tennant, Noelle Lucke-Wold, Yasser Kabbani, Abdul R. Tarabishy, Paul D. Chantler, Taura L. Barr
Monocyte-Lymphocyte Cross-Communication Via Soluble Cd163 Directly Links Innate Immune System Activation And Adaptive Immune System Suppression Following Ischemic Stroke, Grant C. O'Connell, Connie S. Tennant, Noelle Lucke-Wold, Yasser Kabbani, Abdul R. Tarabishy, Paul D. Chantler, Taura L. Barr
Faculty & Staff Scholarship
CD163 is a scavenger receptor expressed on innate immune cell populations which can be shed from the plasma membrane via the metalloprotease ADAM17 to generate a soluble peptide with lympho-inhibitory properties. The purpose of this study was to investigate CD163 as a possible effector of stroke-induced adaptive immune system suppression. Liquid biopsies were collected from ischemic stroke patients (n = 39), neurologically asymptomatic controls (n = 20), and stroke mimics (n = 20) within 24 hours of symptom onset. Peripheral blood ADAM17 activity and soluble CD163 levels were elevated in stroke patients relative to non-stroke control groups, and negatively associated …
Health-Promoting Phytochemicals From 11 Mustard Cultivars At Baby Leaf And Mature Stages, Marissa D. Frazie, Moo J. Kim, Kang-Mo Ku
Health-Promoting Phytochemicals From 11 Mustard Cultivars At Baby Leaf And Mature Stages, Marissa D. Frazie, Moo J. Kim, Kang-Mo Ku
Faculty & Staff Scholarship
Mustard is a Brassica vegetable that provides a number of phytonutrients. However, the phytonutrient profile of mustard has been relatively limited. We analyzed the glucosinolates and their hydrolysis products, carotenoids, total anthocyanin and phenolic contents, and antioxidant capacity of the leaves of 11 mustard cultivars grown in a greenhouse at the baby leaf and mature stages. An aliphatic glucosinolate sinigrin and its hydrolysis products allyl isothiocyanate and 1-cyano-2,3-epithiopropane were the major phytonutrients in the mustard leaves. Carotenoids β-carotene, lutein, violaxanthin, and neoxanthin were detected. We found phytonutrient concentration and their change with plant growth were cultivar-dependent. The %RDA value for …