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Washington University School of Medicine

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The Novel Endosomal Membrane Protein Ema Interacts With The Class C Vps-Hops Complex To Promote Endosomal Maturation, Sungsu Kim, Yogesh P. Wairkar, Richard W. Daniels, Aaron Diantonio Jan 2010

The Novel Endosomal Membrane Protein Ema Interacts With The Class C Vps-Hops Complex To Promote Endosomal Maturation, Sungsu Kim, Yogesh P. Wairkar, Richard W. Daniels, Aaron Diantonio

Open Access Publications

Endosomal maturation is critical for accurate and efficient cargo transport through endosomal compartments. Here we identify a mutation of the novel Drosophila gene, ema (endosomal maturation defective) in a screen for abnormal synaptic overgrowth and defective protein trafficking. Ema is an endosomal membrane protein required for trafficking of fluid-phase and receptor-mediated endocytic cargos. In the ema mutant, enlarged endosomal compartments accumulate as endosomal maturation fails, with early and late endosomes unable to progress into mature degradative late endosomes and lysosomes. Defective endosomal down-regulation of BMP signaling is responsible for the abnormal synaptic overgrowth. Ema binds to and genetically interacts with …


Major Depression And The Metabolic Syndrome, Debra L. Foley, Katherine I. Morley, Pamela A.F. Madden, Andrew C. Heath, John B. Whitfield, Nicholas G. Martin Jan 2010

Major Depression And The Metabolic Syndrome, Debra L. Foley, Katherine I. Morley, Pamela A.F. Madden, Andrew C. Heath, John B. Whitfield, Nicholas G. Martin

Open Access Publications

No abstract provided.


Shrna-Mediated Decreases In C-Met Levels Affect The Differentiation Potential Of Human Mesenchymal Stem Cells And Reduce Their Capacity For Tissue Repair, Ivana Rosová, Daniel Link, Jan A. Nolta Jan 2010

Shrna-Mediated Decreases In C-Met Levels Affect The Differentiation Potential Of Human Mesenchymal Stem Cells And Reduce Their Capacity For Tissue Repair, Ivana Rosová, Daniel Link, Jan A. Nolta

Open Access Publications

No abstract provided.


Classification Of Traumatic Brain Injury For Targeted Therapies, David Brody, Et Al Jan 2010

Classification Of Traumatic Brain Injury For Targeted Therapies, David Brody, Et Al

Open Access Publications

No abstract provided.


Fatty Acid Modulation And Polyamine Block Of Gluk2 Kainate Receptors Analyzed By Scanning Mutagenesis, Timothy J. Wilding, Kevin Chen, James E. Huettner Jan 2010

Fatty Acid Modulation And Polyamine Block Of Gluk2 Kainate Receptors Analyzed By Scanning Mutagenesis, Timothy J. Wilding, Kevin Chen, James E. Huettner

Open Access Publications

No abstract provided.


The Perilipin Homologue, Lipid Storage Droplet 2, Regulates Sleep Homeostasis And Prevents Learning Impairments Following Sleep Loss, Matthew S. Thimgan, Yasuko Suzuki, Laurent Seugnet, Laura Gottschalk, Paul J. Shaw Jan 2010

The Perilipin Homologue, Lipid Storage Droplet 2, Regulates Sleep Homeostasis And Prevents Learning Impairments Following Sleep Loss, Matthew S. Thimgan, Yasuko Suzuki, Laurent Seugnet, Laura Gottschalk, Paul J. Shaw

Open Access Publications

No abstract provided.


The Haemophilus Influenzae Hmw1c Protein Is A Glycosyltransferase That Transfers Hexose Residues To Asparagine Sites In The Hmw1 Adhesin, Susan Grass, Cheryl F. Lichti, R. Reid Townsend, Julia Gross, Joseph W. St. Geme Iii Jan 2010

The Haemophilus Influenzae Hmw1c Protein Is A Glycosyltransferase That Transfers Hexose Residues To Asparagine Sites In The Hmw1 Adhesin, Susan Grass, Cheryl F. Lichti, R. Reid Townsend, Julia Gross, Joseph W. St. Geme Iii

Open Access Publications

No abstract provided.


Detection Of Wuchereria Bancrofti L3 Larvae In Mosquitoes: A Reverse Transcriptase Pcr Assay Evaluating Infection And Infectivity, Sandra J. Laney, Reda M. R. Ramzy, Hanan H. Helmy, Hoda A. Farid, Ameen A. Ashour, Gary J. Weil, Steven A. Williams Jan 2010

Detection Of Wuchereria Bancrofti L3 Larvae In Mosquitoes: A Reverse Transcriptase Pcr Assay Evaluating Infection And Infectivity, Sandra J. Laney, Reda M. R. Ramzy, Hanan H. Helmy, Hoda A. Farid, Ameen A. Ashour, Gary J. Weil, Steven A. Williams

Open Access Publications

No abstract provided.


Surface Properties Of Helicobacter Pylori Urease Complex Are Essential For Persistence, Tobias D. Schoep, Alma Fulurija, Fayth Good, Wei Lu, Robyn P. Himbeck, Carola Schwan, Sung Sook Choi, Douglas E. Berg, Peer R.E. Mittl, Mohammed Benghezal, Barry J. Marshall Jan 2010

Surface Properties Of Helicobacter Pylori Urease Complex Are Essential For Persistence, Tobias D. Schoep, Alma Fulurija, Fayth Good, Wei Lu, Robyn P. Himbeck, Carola Schwan, Sung Sook Choi, Douglas E. Berg, Peer R.E. Mittl, Mohammed Benghezal, Barry J. Marshall

Open Access Publications

No abstract provided.


Phosphorylation Of Mouse Immunity-Related Gtpase (Irg) Resistance Proteins Is An Evasion Strategy For Virulent Toxoplasma Gondii, Tobias Steinfeldt, Stephanie Konen-Waisman, Lan Tong, Nikolaus Pawlowski, Tobias Lamkemeyer, L. David Sibley, Julia P. Hunn, Jonathan C. Howard Jan 2010

Phosphorylation Of Mouse Immunity-Related Gtpase (Irg) Resistance Proteins Is An Evasion Strategy For Virulent Toxoplasma Gondii, Tobias Steinfeldt, Stephanie Konen-Waisman, Lan Tong, Nikolaus Pawlowski, Tobias Lamkemeyer, L. David Sibley, Julia P. Hunn, Jonathan C. Howard

Open Access Publications

No abstract provided.


Gene–Environment Interactions At Nucleotide Resolution, Justin Gerke, Kim Lorenz, Shelina Ramnarine, Barak Cohen Jan 2010

Gene–Environment Interactions At Nucleotide Resolution, Justin Gerke, Kim Lorenz, Shelina Ramnarine, Barak Cohen

Open Access Publications

No abstract provided.


Genome Sequencing Reveals Widespread Virulence Gene Exchange Among Human Neisseria Species, Pradeep Reddy Marri, Mary Paniscus, Nathan J. Weyand, Maria A. Rendon, Christine M. Calton, Diana R. Hernandez, Dustin L. Higashi, Erica Sodergren, George M. Weinstock, Steven D. Rounsley, Magdalene So Jan 2010

Genome Sequencing Reveals Widespread Virulence Gene Exchange Among Human Neisseria Species, Pradeep Reddy Marri, Mary Paniscus, Nathan J. Weyand, Maria A. Rendon, Christine M. Calton, Diana R. Hernandez, Dustin L. Higashi, Erica Sodergren, George M. Weinstock, Steven D. Rounsley, Magdalene So

Open Access Publications

No abstract provided.


Massively Parallel Sequencing And Analysis Of The Necator Americanus Transcriptome, Cinzia Cantacessi, Makedonka Mitreva, Aaron R. Jex, Neil D. Young, Bronwyn E. Campbell, Ross S. Hall, Maria A. Doyle, Stuart A. Ralph, Elida M. Rabelo, Shoba Ranganathan, Paul W. Sternberg, Alex Loukas, Robin B. Gasser Jan 2010

Massively Parallel Sequencing And Analysis Of The Necator Americanus Transcriptome, Cinzia Cantacessi, Makedonka Mitreva, Aaron R. Jex, Neil D. Young, Bronwyn E. Campbell, Ross S. Hall, Maria A. Doyle, Stuart A. Ralph, Elida M. Rabelo, Shoba Ranganathan, Paul W. Sternberg, Alex Loukas, Robin B. Gasser

Open Access Publications

No abstract provided.


Genome-Wide Association Study Of Lp-Pla2 Activity And Mass In The Framingham Heart Study, Sunil Suchindran, David Rivedal, John R. Guyton, Tom Milledge, Xiaoyi Gao, Ashlee Benjamin, Jennifer Rowell, Geoffrey S. Ginsburg, Jeanette J. Mccarthy Jan 2010

Genome-Wide Association Study Of Lp-Pla2 Activity And Mass In The Framingham Heart Study, Sunil Suchindran, David Rivedal, John R. Guyton, Tom Milledge, Xiaoyi Gao, Ashlee Benjamin, Jennifer Rowell, Geoffrey S. Ginsburg, Jeanette J. Mccarthy

Open Access Publications

No abstract provided.


A Functional Metagenomic Approach For Expanding The Synthetic Biology Toolbox For Biomass Conversion, Morten O. A. Sommer, George M. Church, Gautam Dantas Jan 2010

A Functional Metagenomic Approach For Expanding The Synthetic Biology Toolbox For Biomass Conversion, Morten O. A. Sommer, George M. Church, Gautam Dantas

Open Access Publications

No abstract provided.


Valosin-Containing Protein (Vcp) Is Required For Autophagy And Is Disrupted In Vcp Disease, Jeong-Sun Ju, Rodrigo A. Fuentealba, Sara E. Miller, Erin Jackson, David Piwnica-Worms, Robert H. Baloh, Conrad C. Weihl Dec 2009

Valosin-Containing Protein (Vcp) Is Required For Autophagy And Is Disrupted In Vcp Disease, Jeong-Sun Ju, Rodrigo A. Fuentealba, Sara E. Miller, Erin Jackson, David Piwnica-Worms, Robert H. Baloh, Conrad C. Weihl

Open Access Publications

No abstract provided.


Washington University Record, December 10, 2009 Dec 2009

Washington University Record, December 10, 2009

Washington University Record

No abstract provided.


Washington University Record, December 3, 2009 Dec 2009

Washington University Record, December 3, 2009

Washington University Record

No abstract provided.


Washington University Record, November 19, 2009 Nov 2009

Washington University Record, November 19, 2009

Washington University Record

No abstract provided.


Washington University Record, November 12, 2009 Nov 2009

Washington University Record, November 12, 2009

Washington University Record

No abstract provided.


Washington University Record, November 5, 2009 Nov 2009

Washington University Record, November 5, 2009

Washington University Record

No abstract provided.


Washington University Record, October 29, 2009 Oct 2009

Washington University Record, October 29, 2009

Washington University Record

No abstract provided.


Washington University Record, October 22, 2009 Oct 2009

Washington University Record, October 22, 2009

Washington University Record

No abstract provided.


Washington University Record, October 15, 2009 Oct 2009

Washington University Record, October 15, 2009

Washington University Record

No abstract provided.


Washington University Record, October 8, 2009 Oct 2009

Washington University Record, October 8, 2009

Washington University Record

No abstract provided.


Washington University Record, October 1, 2009 Oct 2009

Washington University Record, October 1, 2009

Washington University Record

No abstract provided.


Washington University Record, September 24, 2009 Sep 2009

Washington University Record, September 24, 2009

Washington University Record

No abstract provided.


Washington University Record, September 17, 2009 Sep 2009

Washington University Record, September 17, 2009

Washington University Record

No abstract provided.


Washington University Record, September 10, 2009 Sep 2009

Washington University Record, September 10, 2009

Washington University Record

No abstract provided.


Washington University Record, September 3, 2009 Sep 2009

Washington University Record, September 3, 2009

Washington University Record

No abstract provided.