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Washington University School of Medicine

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Institute Of Clinical And Translational Sciences News, Vol. 3, Issue 1 Jan 2010

Institute Of Clinical And Translational Sciences News, Vol. 3, Issue 1

ICTS Newsletters

No abstract provided.


Prevalence And Correlates Of Trichomonas Vaginalis Infection Among Female Us Federal Prison Inmates, Siobhan Sutcliffe, Sara B. Newman, Andrew Hardick, Charlotte Gaydos Jan 2010

Prevalence And Correlates Of Trichomonas Vaginalis Infection Among Female Us Federal Prison Inmates, Siobhan Sutcliffe, Sara B. Newman, Andrew Hardick, Charlotte Gaydos

Epidemiology Faculty Publications

No abstract provided.


Snps Associated With Cerebrospinal Fluid Phospho-Tau Levels Influence Rate Of Decline In Alzheimer’S Disease, Carlos Cruchaga, John S. K. Kauwe, Kevin Mayo, Noah Spiegel, Sarah Bertelsen, Petra Nowotny, Aarti R. Shah, Richard Abraham, Paul Holligworth, Denise Harold, Michael M. Owen, Julie Williams, Simon Lovestone, Elaine R. Peskind, Ge Li, James B. Leverenz, Douglas Galasko, The Alzheimer's Disease Neuroimaging Initiative, John C. Morris, Anne M. Fagan, David M. Holtzman, Alison M. Goate Jan 2010

Snps Associated With Cerebrospinal Fluid Phospho-Tau Levels Influence Rate Of Decline In Alzheimer’S Disease, Carlos Cruchaga, John S. K. Kauwe, Kevin Mayo, Noah Spiegel, Sarah Bertelsen, Petra Nowotny, Aarti R. Shah, Richard Abraham, Paul Holligworth, Denise Harold, Michael M. Owen, Julie Williams, Simon Lovestone, Elaine R. Peskind, Ge Li, James B. Leverenz, Douglas Galasko, The Alzheimer's Disease Neuroimaging Initiative, John C. Morris, Anne M. Fagan, David M. Holtzman, Alison M. Goate

Open Access Publications

No abstract provided.


Dyskerin Ablation In Mouse Liver Inhibits Rrna Processing And Cell Division, Jingping Ge, David A. Rudnick, Jun He, Dan L. Crimmins, Jack H. Ladenson, Monica Bessler, Philip J. Mason Jan 2010

Dyskerin Ablation In Mouse Liver Inhibits Rrna Processing And Cell Division, Jingping Ge, David A. Rudnick, Jun He, Dan L. Crimmins, Jack H. Ladenson, Monica Bessler, Philip J. Mason

Open Access Publications

No abstract provided.


Leishmania Major Survival In Selective Phlebotomus Papatasi Sand Fly Vector Requires A Specific Scg-Encoded Lipophosphoglycan Galactosylation Pattern, Deborah E. Dobson, Shaden Kamhawi, Phillip Lawyer, Salvatore J. Turco, Stephen M. Beverley, David L. Sacks Jan 2010

Leishmania Major Survival In Selective Phlebotomus Papatasi Sand Fly Vector Requires A Specific Scg-Encoded Lipophosphoglycan Galactosylation Pattern, Deborah E. Dobson, Shaden Kamhawi, Phillip Lawyer, Salvatore J. Turco, Stephen M. Beverley, David L. Sacks

Open Access Publications

No abstract provided.


Human Cytomegalovirus Protein Pul117 Targets The Mini-Chromosome Maintenance Complex And Suppresses Cellular Dna Synthesis, Zhikang Qian, Van Leung-Pineda, Baoqin Xuan, Helen Piwnica-Worms, Dong Yu Jan 2010

Human Cytomegalovirus Protein Pul117 Targets The Mini-Chromosome Maintenance Complex And Suppresses Cellular Dna Synthesis, Zhikang Qian, Van Leung-Pineda, Baoqin Xuan, Helen Piwnica-Worms, Dong Yu

Open Access Publications

No abstract provided.


Enhanced Hepatic Apoa-I Secretion And Peripheral Efflux Of Cholesterol And Phospholipid In Cd36 Null Mice, Pin Yue, Zhouji Chen, Fatiha Nassir, Carlos Bernal-Mizrachi, Brian Finck, Salman Azhar, Nada A. Abumrad Jan 2010

Enhanced Hepatic Apoa-I Secretion And Peripheral Efflux Of Cholesterol And Phospholipid In Cd36 Null Mice, Pin Yue, Zhouji Chen, Fatiha Nassir, Carlos Bernal-Mizrachi, Brian Finck, Salman Azhar, Nada A. Abumrad

Open Access Publications

No abstract provided.


Synthesizing And Salvaging Nad+: Lessons Learned From Chlamydomonas Reinhardtii, Huawen Lin, Alan L. Kwan, Susan K. Dutcher Jan 2010

Synthesizing And Salvaging Nad+: Lessons Learned From Chlamydomonas Reinhardtii, Huawen Lin, Alan L. Kwan, Susan K. Dutcher

Open Access Publications

No abstract provided.


High-Throughput Discovery Of Rare Insertions And Deletions In Large Cohorts, Francesco L.M. Vallania, Todd E. Druley, Enrique Ramos, Jue Wang, Ingrid Borecki, Michael Province, Robi D. Mitra Jan 2010

High-Throughput Discovery Of Rare Insertions And Deletions In Large Cohorts, Francesco L.M. Vallania, Todd E. Druley, Enrique Ramos, Jue Wang, Ingrid Borecki, Michael Province, Robi D. Mitra

Open Access Publications

No abstract provided.


Voltage-Dependent Gating In A ‘‘Voltage Sensor-Less’’ Ion Channel, Harley T. Kurata, Markus Rapedius, Marc J. Kleinman, Thomas Baukrowitz, Colin G. Nichols Jan 2010

Voltage-Dependent Gating In A ‘‘Voltage Sensor-Less’’ Ion Channel, Harley T. Kurata, Markus Rapedius, Marc J. Kleinman, Thomas Baukrowitz, Colin G. Nichols

Open Access Publications

No abstract provided.


Human Cord Blood Progenitors With High Aldehyde Dehydrogenase Activity Improve Vascular Density In A Model Of Acute Myocardial Infarction, Claus S. Sondergaard, David A. Hess, Dustin J. Maxwell, Carla Weinheimer, Ivana Rosová, Michael H. Creer, David Piwnica-Worms, Attila Kovacs, Lene Pedersen, Jan A. Nolta Jan 2010

Human Cord Blood Progenitors With High Aldehyde Dehydrogenase Activity Improve Vascular Density In A Model Of Acute Myocardial Infarction, Claus S. Sondergaard, David A. Hess, Dustin J. Maxwell, Carla Weinheimer, Ivana Rosová, Michael H. Creer, David Piwnica-Worms, Attila Kovacs, Lene Pedersen, Jan A. Nolta

Open Access Publications

No abstract provided.


Mitofusin 2 Is Necessary For Transport Of Axonal Mitochondria And Interacts With The Miro/Milton Complex, Albert Misko, Siriui Jiang, Iga Wegorzewska, Jeffrey Milbrandt, Robert H. Baloh Jan 2010

Mitofusin 2 Is Necessary For Transport Of Axonal Mitochondria And Interacts With The Miro/Milton Complex, Albert Misko, Siriui Jiang, Iga Wegorzewska, Jeffrey Milbrandt, Robert H. Baloh

Open Access Publications

No abstract provided.


Parental Depression And Offspring Psychopathology: A Children Of Twins Study, A. L. Singh, B. M. D'Onofrio, W. S. Slutske, E. Turkheimer, R. E. Emery, K. P. Harden, A. C. Heath, P. A F Madden, D. J. Statham, N. G. Martin Jan 2010

Parental Depression And Offspring Psychopathology: A Children Of Twins Study, A. L. Singh, B. M. D'Onofrio, W. S. Slutske, E. Turkheimer, R. E. Emery, K. P. Harden, A. C. Heath, P. A F Madden, D. J. Statham, N. G. Martin

Open Access Publications

No abstract provided.


Roles Of Membrane Trafficking In Nerve Repair And Regeneration, Elizabeth Tuck, Valeria Cavalli Jan 2010

Roles Of Membrane Trafficking In Nerve Repair And Regeneration, Elizabeth Tuck, Valeria Cavalli

Open Access Publications

No abstract provided.


Histone Modifications During Mammalian Oocyte Maturation: Dynamics, Regulation And Functions, Ling Gu, Qiang Wang, Qing-Yuan Sun Jan 2010

Histone Modifications During Mammalian Oocyte Maturation: Dynamics, Regulation And Functions, Ling Gu, Qiang Wang, Qing-Yuan Sun

Open Access Publications

No abstract provided.


Spot: A Web-Based Tool For Using Biological Databases To Prioritize Snps After A Genome-Wide Association Study, Scott F. Saccone, Raphael Bolze, Prasanth Thomas, Jiaxi Quan, Gaurang Mehta, Ewa Deelman, Jay A. Tischfield, John P. Rice Jan 2010

Spot: A Web-Based Tool For Using Biological Databases To Prioritize Snps After A Genome-Wide Association Study, Scott F. Saccone, Raphael Bolze, Prasanth Thomas, Jiaxi Quan, Gaurang Mehta, Ewa Deelman, Jay A. Tischfield, John P. Rice

Open Access Publications

No abstract provided.


Fibroblast Growth Factor Receptors 1 And 2 In Keratinocytes Control The Epidermal Barrier And Cutaneous Homeostasis, Jingxuan Yang, Michael Meyer, Anna-Katharina Müller, Friederike Böhm, Richard Grose, Tina Dauwalder, Francois Verrey, Manfred Kopf, Juha Partanen, Wilhelm Bloch, David M. Ornitz, Sabine Werner Jan 2010

Fibroblast Growth Factor Receptors 1 And 2 In Keratinocytes Control The Epidermal Barrier And Cutaneous Homeostasis, Jingxuan Yang, Michael Meyer, Anna-Katharina Müller, Friederike Böhm, Richard Grose, Tina Dauwalder, Francois Verrey, Manfred Kopf, Juha Partanen, Wilhelm Bloch, David M. Ornitz, Sabine Werner

Open Access Publications

Fibroblast growth factors (FGFs) are master regulators of organogenesis and tissue homeostasis. In this study, we used different combinations of FGF receptor (FGFR)-deficient mice to unravel their functions in the skin. Loss of the IIIb splice variants of FGFR1 and FGFR2 in keratinocytes caused progressive loss of skin appendages, cutaneous inflammation, keratinocyte hyperproliferation, and acanthosis. We identified loss of FGF-induced expression of tight junction components with subsequent deficits in epidermal barrier function as the mechanism underlying the progressive inflammatory skin disease. The defective barrier causes activation of keratinocytes and epidermal gammadelta T cells, which produce interleukin-1 family member 8 and …


Encode Whole-Genome Data In The Ucsc Genome Browser, Kate R. Rosenbloom, Ting Wang, Et Al Jan 2010

Encode Whole-Genome Data In The Ucsc Genome Browser, Kate R. Rosenbloom, Ting Wang, Et Al

Open Access Publications

No abstract provided.


Identification Of Hookworm Daf-16/Foxo Response Elements And Direct Gene Targets, Xin Gao, Zhengyuan Wang, John Martin, Sahar Abubucker, Xu Zhang, Makedonka Mitreva, John M. Hawdon Jan 2010

Identification Of Hookworm Daf-16/Foxo Response Elements And Direct Gene Targets, Xin Gao, Zhengyuan Wang, John Martin, Sahar Abubucker, Xu Zhang, Makedonka Mitreva, John M. Hawdon

Open Access Publications

No abstract provided.


The Arf Tumor Suppressor Regulates Bone Remodeling And Osteosarcoma Development In Mice, Daniel A. Rauch, Michelle A. Hurchla, John C. Harding, Hongju Deng, Lauren K. Shea, Mark C. Eagleton, Stefan Niewiesk, Michael D. Lairmore, David Piwnica-Worms, Thomas J. Rosol, Jason D. Weber, Lee Ratner, Katherine N. Weilbaecher Jan 2010

The Arf Tumor Suppressor Regulates Bone Remodeling And Osteosarcoma Development In Mice, Daniel A. Rauch, Michelle A. Hurchla, John C. Harding, Hongju Deng, Lauren K. Shea, Mark C. Eagleton, Stefan Niewiesk, Michael D. Lairmore, David Piwnica-Worms, Thomas J. Rosol, Jason D. Weber, Lee Ratner, Katherine N. Weilbaecher

Open Access Publications

No abstract provided.


Low-Density Lipoprotein Receptor-Related Protein 1 (Lrp1) Mediates Neuronal Abeta42 Uptake And Lysosomal Trafficking, Rodrigo A. Fuentealba, Qiang Liu, Juan Zhang, Takahisa Kanekiyo, Xiaoyan Hu, Jin-Moo Lee, Mary Jo Ladu, Guojun Bu Jan 2010

Low-Density Lipoprotein Receptor-Related Protein 1 (Lrp1) Mediates Neuronal Abeta42 Uptake And Lysosomal Trafficking, Rodrigo A. Fuentealba, Qiang Liu, Juan Zhang, Takahisa Kanekiyo, Xiaoyan Hu, Jin-Moo Lee, Mary Jo Ladu, Guojun Bu

Open Access Publications

No abstract provided.


Melanoma Differentiation-Associated Gene 5 (Mda5) Is Involved In The Innate Immune Response To Paramyxoviridae Infection In Vivo, Leonid Gitlin, Loralyn Benoit, Christina Song, Marina Cella, Susan Gilfillan, Michael J. Holtzman, Marco Colonna Jan 2010

Melanoma Differentiation-Associated Gene 5 (Mda5) Is Involved In The Innate Immune Response To Paramyxoviridae Infection In Vivo, Leonid Gitlin, Loralyn Benoit, Christina Song, Marina Cella, Susan Gilfillan, Michael J. Holtzman, Marco Colonna

Open Access Publications

No abstract provided.


Nik Stabilization In Osteoclasts Results In Osteoporosis And Enhanced Inflammatory Osteolysis, Chang Yang, Kathleen Mccoy, Jennifer L. Davis, Marc Schmidt-Supprian, Yoshiteru Sasaki, Roberta Faccio, Deborah Veis Novack Jan 2010

Nik Stabilization In Osteoclasts Results In Osteoporosis And Enhanced Inflammatory Osteolysis, Chang Yang, Kathleen Mccoy, Jennifer L. Davis, Marc Schmidt-Supprian, Yoshiteru Sasaki, Roberta Faccio, Deborah Veis Novack

Open Access Publications

No abstract provided.


In Vitro Transformation Of Primary Human Cd34+ Cells By Aml Fusion Oncogenes: Early Gene Expression Profiling Reveals Possible Drug Target In Aml, Anmaar M. Abdul-Nabi, Enas R. Yassin, Nobish Varghese, Hrishikesh Deshmukh, Nabeel R. Yaseen Jan 2010

In Vitro Transformation Of Primary Human Cd34+ Cells By Aml Fusion Oncogenes: Early Gene Expression Profiling Reveals Possible Drug Target In Aml, Anmaar M. Abdul-Nabi, Enas R. Yassin, Nobish Varghese, Hrishikesh Deshmukh, Nabeel R. Yaseen

Open Access Publications

No abstract provided.


Ips-1 Is Essential For The Control Of West Nile Virus Infection And Immunity, Mehul S. Suthar, Daphne Y. Ma, Sunil Thomas, Jennifer M. Lund, Nu Zhang, Stephane Daffis, Alexander Y. Rudensky, Michael J. Bevan, Edward A. Clark, Murali-Krishna Kaja, Michael S. Diamond, Michael Gale Jr. Jan 2010

Ips-1 Is Essential For The Control Of West Nile Virus Infection And Immunity, Mehul S. Suthar, Daphne Y. Ma, Sunil Thomas, Jennifer M. Lund, Nu Zhang, Stephane Daffis, Alexander Y. Rudensky, Michael J. Bevan, Edward A. Clark, Murali-Krishna Kaja, Michael S. Diamond, Michael Gale Jr.

Open Access Publications

No abstract provided.


Tip-1 Translocation Onto The Cell Plasma Membrane Is A Molecular Biomarker Of Tumor Response To Ionizing Radiation, Hailun Wang, Heping Yan, Allie Fu, Miaojun Han, Dennis Hallahan, Zhaozhong Han Jan 2010

Tip-1 Translocation Onto The Cell Plasma Membrane Is A Molecular Biomarker Of Tumor Response To Ionizing Radiation, Hailun Wang, Heping Yan, Allie Fu, Miaojun Han, Dennis Hallahan, Zhaozhong Han

Open Access Publications

No abstract provided.


Endosymbiont Dna In Endobacteria-Free Filarial Nematodes Indicates Ancient Horizontal Genetic Transfer, Samantha N. Mcnulty, Jeremy M. Foster, Makedonka Mitreva, Julie C. Dunning Hotopp, John Martin, Kerstin Fischer, Bo Wu, Paul J. Davis, Sanjay Kumar, Norbert W. Brattig, Barton E. Slatko, Gary J. Weil, Peter U. Fischer Jan 2010

Endosymbiont Dna In Endobacteria-Free Filarial Nematodes Indicates Ancient Horizontal Genetic Transfer, Samantha N. Mcnulty, Jeremy M. Foster, Makedonka Mitreva, Julie C. Dunning Hotopp, John Martin, Kerstin Fischer, Bo Wu, Paul J. Davis, Sanjay Kumar, Norbert W. Brattig, Barton E. Slatko, Gary J. Weil, Peter U. Fischer

Open Access Publications

No abstract provided.


Mitochondrial Dysfunction And Apoptosis In Cumulus Cells Of Type I Diabetic Mice, Qiang Wang, Antonina I. Frolova, Scott Purcell, Katie Adastra, Erica Schoeller, Maggie M. Chi, Tim Schedl, Kelle H. Moley Jan 2010

Mitochondrial Dysfunction And Apoptosis In Cumulus Cells Of Type I Diabetic Mice, Qiang Wang, Antonina I. Frolova, Scott Purcell, Katie Adastra, Erica Schoeller, Maggie M. Chi, Tim Schedl, Kelle H. Moley

Open Access Publications

No abstract provided.


Retention And Loss Of Rna Interference Pathways In Trypanosomatid Protozoans, Lon-Fye Lye, Katherine Owens, Huafang Shi, Silvane M.F. Murta, Ana Carolina Vieira, Salvatore J. Turco, Christian Tschudi, Elisabetta Ullu, Stephen M. Beverley Jan 2010

Retention And Loss Of Rna Interference Pathways In Trypanosomatid Protozoans, Lon-Fye Lye, Katherine Owens, Huafang Shi, Silvane M.F. Murta, Ana Carolina Vieira, Salvatore J. Turco, Christian Tschudi, Elisabetta Ullu, Stephen M. Beverley

Open Access Publications

No abstract provided.


Coordinated Progression Through Two Subtranscriptomes Underlies The Tachyzoite Cycle Of Toxoplasma Gondii, Michael S. Behnke, John C. Wootton, Margaret M. Lehmann, Josh B. Radke, Olivier Lucas, Julie Nawas, L. David Sibley, Michael W. White Jan 2010

Coordinated Progression Through Two Subtranscriptomes Underlies The Tachyzoite Cycle Of Toxoplasma Gondii, Michael S. Behnke, John C. Wootton, Margaret M. Lehmann, Josh B. Radke, Olivier Lucas, Julie Nawas, L. David Sibley, Michael W. White

Open Access Publications

No abstract provided.