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Washington University School of Medicine

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Characterization Of A Novel, Dominant Negative Kcnj2 Mutation Associated With Andersen-Tawil Syndrome, Scott B. Marrus, Phillip S. Cucilich, Wei Wang, Jeanne M. Nerbonne Jan 2011

Characterization Of A Novel, Dominant Negative Kcnj2 Mutation Associated With Andersen-Tawil Syndrome, Scott B. Marrus, Phillip S. Cucilich, Wei Wang, Jeanne M. Nerbonne

Open Access Publications

No abstract provided.


A Dual Role For A-Type Lamins In Dna Double-Strand Break Repair, Abena B. Redwood, Stephanie M. Perkins, Robert P. Vanderwaal, Zhihui Feng, Kenneth J. Biehl, Ignacio Gonzalez-Suarez, Lucia Morgado-Palacin, Wei Shi, Julien Sage, Joseph L. Roti-Roti, Colin L. Stewart, Junran Zhang, Susana Gonzalo Jan 2011

A Dual Role For A-Type Lamins In Dna Double-Strand Break Repair, Abena B. Redwood, Stephanie M. Perkins, Robert P. Vanderwaal, Zhihui Feng, Kenneth J. Biehl, Ignacio Gonzalez-Suarez, Lucia Morgado-Palacin, Wei Shi, Julien Sage, Joseph L. Roti-Roti, Colin L. Stewart, Junran Zhang, Susana Gonzalo

Open Access Publications

No abstract provided.


Crohn Disease: A Current Perspective On Genetics, Autophagy And Immunity, Thaddeus S. Stappenbeck, John D. Rioux, Atsushi Mizoguchi, Tatsuya Saitoh, Alan Huett, Arlette Darfeuille-Michaud, Tom Wileman, Noboru Mizushima, Simon Carding, Shizuo Akira, Miles Parkes, Ramnik J. Xavier Jan 2011

Crohn Disease: A Current Perspective On Genetics, Autophagy And Immunity, Thaddeus S. Stappenbeck, John D. Rioux, Atsushi Mizoguchi, Tatsuya Saitoh, Alan Huett, Arlette Darfeuille-Michaud, Tom Wileman, Noboru Mizushima, Simon Carding, Shizuo Akira, Miles Parkes, Ramnik J. Xavier

Open Access Publications

No abstract provided.


Cross-Species Comparison Of Orthologous Gene Expression In Human Bladder Cancer And Carcinogen-Induced Rodent Models, Yan Lu, Pengyuan Liu, Weidong Wen, Clinton J. Grubbs, Reid R. Townsend, James P. Malone, Ronald A. Lubet, Ming You Jan 2011

Cross-Species Comparison Of Orthologous Gene Expression In Human Bladder Cancer And Carcinogen-Induced Rodent Models, Yan Lu, Pengyuan Liu, Weidong Wen, Clinton J. Grubbs, Reid R. Townsend, James P. Malone, Ronald A. Lubet, Ming You

Open Access Publications

No abstract provided.


Obscured Phylogeny And Possible Recombinational Dormancy In Escherichia Coli, Shana R. Leopold, Stanley A. Sawyer, Thomas S. Whittam, Phillip I. Tarr Jan 2011

Obscured Phylogeny And Possible Recombinational Dormancy In Escherichia Coli, Shana R. Leopold, Stanley A. Sawyer, Thomas S. Whittam, Phillip I. Tarr

Open Access Publications

No abstract provided.


Catalytic And Non-Catalytic Roles For The Mono-Adp-Ribosyltransferase Arr In The Mycobacterial Dna Damage Response, Christina L. Stallings, Linda Chu, Lucy X. Li, Michael S. Glickman Jan 2011

Catalytic And Non-Catalytic Roles For The Mono-Adp-Ribosyltransferase Arr In The Mycobacterial Dna Damage Response, Christina L. Stallings, Linda Chu, Lucy X. Li, Michael S. Glickman

Open Access Publications

No abstract provided.


A Sensitive High-Throughput Assay For Evaluating Host-Pathogen Interactions In Cryptococcus Neoformans Infection, Deepa Srikanta, Meng Yang, Matthew Williams, Tamara L. Doering Jan 2011

A Sensitive High-Throughput Assay For Evaluating Host-Pathogen Interactions In Cryptococcus Neoformans Infection, Deepa Srikanta, Meng Yang, Matthew Williams, Tamara L. Doering

Open Access Publications

No abstract provided.


The Parkinsonian Mimetic, Mpp+, Specifically Impairs Mitochondrial Transport In Dopamine Axons, Jeong S. Kim-Han, Jo Ann Antenor-Dorsey, Karen L. O'Malley Jan 2011

The Parkinsonian Mimetic, Mpp+, Specifically Impairs Mitochondrial Transport In Dopamine Axons, Jeong S. Kim-Han, Jo Ann Antenor-Dorsey, Karen L. O'Malley

Open Access Publications

No abstract provided.


Critical Role Of Astroglial Apolipoprotein E And Liver X Receptor-Α Expression For Microglial Aβ Phagocytosis, Dick Terwel, Knut R. Steffensen, Philip B. Verghese, Markus P. Kummer, Jan-Åke Gustafsson, David M. Holtzman, Michael T. Heneka Jan 2011

Critical Role Of Astroglial Apolipoprotein E And Liver X Receptor-Α Expression For Microglial Aβ Phagocytosis, Dick Terwel, Knut R. Steffensen, Philip B. Verghese, Markus P. Kummer, Jan-Åke Gustafsson, David M. Holtzman, Michael T. Heneka

Open Access Publications

No abstract provided.


Exenatide Improves Glucose Homeostasis And Prolongs Survival In A Murine Model Of Dilated Cardiomyopathy, Arpita Kalla Vyas, Kai-Chen Yang, Dennis Woo, Anatoly Tzekov, Attila Kovacs, Patrick Y. Jay, Paul W. Hruz Jan 2011

Exenatide Improves Glucose Homeostasis And Prolongs Survival In A Murine Model Of Dilated Cardiomyopathy, Arpita Kalla Vyas, Kai-Chen Yang, Dennis Woo, Anatoly Tzekov, Attila Kovacs, Patrick Y. Jay, Paul W. Hruz

Open Access Publications

No abstract provided.


Common Polymorphisms In Human Lysyl Oxidase Genes Are Not Associated With The Adolescent Idiopathic Scoliosis Phenotype, Tracy L. Mcgregor, Christina A. Gurnett, Matthew B. Dobbs, Carol A. Wise, Jose A. Morcuende, Thomas M. Morgan, Ramkumar Menon, Louis J. Muglia Jan 2011

Common Polymorphisms In Human Lysyl Oxidase Genes Are Not Associated With The Adolescent Idiopathic Scoliosis Phenotype, Tracy L. Mcgregor, Christina A. Gurnett, Matthew B. Dobbs, Carol A. Wise, Jose A. Morcuende, Thomas M. Morgan, Ramkumar Menon, Louis J. Muglia

Open Access Publications

No abstract provided.


Detecting Disease Rare Alleles Using Single Snps In Families And Haplotyping In Unrelated Subjects From The Genetic Analysis Workshop 17 Data, Aldi T. Kraja, Jacek Czajkowski, Mary F. Feitosa, Ingrid B. Borecki, Michael A. Province Jan 2011

Detecting Disease Rare Alleles Using Single Snps In Families And Haplotyping In Unrelated Subjects From The Genetic Analysis Workshop 17 Data, Aldi T. Kraja, Jacek Czajkowski, Mary F. Feitosa, Ingrid B. Borecki, Michael A. Province

Open Access Publications

No abstract provided.


Evolutionarily Divergent, Unstable Filamentous Actin Is Essential For Gliding Motility In Spicomplexan Parasites, Kristen M. Skillman, Karthikeyan Diraviyam, Asis Khan, Keliang Tang, David Sept, L. David Sibley Jan 2011

Evolutionarily Divergent, Unstable Filamentous Actin Is Essential For Gliding Motility In Spicomplexan Parasites, Kristen M. Skillman, Karthikeyan Diraviyam, Asis Khan, Keliang Tang, David Sept, L. David Sibley

Open Access Publications

No abstract provided.


Bioluminescent Imaging Reveals Divergent Viral Pathogenesis In Two Strains Of Stat1-Deficient Mice, And In Αßγ Interferon Receptor-Deficient Mice, Tracy Jo Pasieka, Lynne Collins, Megan A. O'Connor, Yufei Chen, Zachary M. Parker, Brent L. Berwin, David R. Piwnica-Worms, David A. Leib Jan 2011

Bioluminescent Imaging Reveals Divergent Viral Pathogenesis In Two Strains Of Stat1-Deficient Mice, And In Αßγ Interferon Receptor-Deficient Mice, Tracy Jo Pasieka, Lynne Collins, Megan A. O'Connor, Yufei Chen, Zachary M. Parker, Brent L. Berwin, David R. Piwnica-Worms, David A. Leib

Open Access Publications

No abstract provided.


Genetic Variants In Lpl, Oasl And Tomm40/Apoe-C1-C2-C4 Genes Are Associated With Multiple Cardiovascular-Related Traits, Rita Ps Middelberg, Manuel Ar Ferreira, Anjali K. Henders, Andrew C. Heath, Pamela Af Madden, Grant W. Montgomery, Nicholas G. Martin, John B. Whitfield Jan 2011

Genetic Variants In Lpl, Oasl And Tomm40/Apoe-C1-C2-C4 Genes Are Associated With Multiple Cardiovascular-Related Traits, Rita Ps Middelberg, Manuel Ar Ferreira, Anjali K. Henders, Andrew C. Heath, Pamela Af Madden, Grant W. Montgomery, Nicholas G. Martin, John B. Whitfield

Open Access Publications

No abstract provided.


Investigation Of 95 Variants Identified In A Genome-Wide Study For Association With Mortality After Acute Coronary Syndrome, Thomas M. Morgan, John A. House, Sharon Cresci, Philip Jones, Hooman Allayee, Stanley L. Hazen, Yesha Patel, Riyaz S. Patel, Danny J. Eapen, Salina P. Waddy, Arshed A. Quyyumi, Marcus E. Kleber, Winfried Marz, Bernhard R. Winkelmann, Bernhard O. Boehm, Harlan M. Krumholz, John A. Spertus Jan 2011

Investigation Of 95 Variants Identified In A Genome-Wide Study For Association With Mortality After Acute Coronary Syndrome, Thomas M. Morgan, John A. House, Sharon Cresci, Philip Jones, Hooman Allayee, Stanley L. Hazen, Yesha Patel, Riyaz S. Patel, Danny J. Eapen, Salina P. Waddy, Arshed A. Quyyumi, Marcus E. Kleber, Winfried Marz, Bernhard R. Winkelmann, Bernhard O. Boehm, Harlan M. Krumholz, John A. Spertus

Open Access Publications

No abstract provided.


Differential Regional And Subtype-Specific Vulnerability Of Enteric Neurons To Mitochondrial Dysfunction, Andreu Viader, Elizabeth C. Wright-Jin, Bhupinder P.S Vohra, Robert O. Heuckeroth, Jeffrey Milbrandt Jan 2011

Differential Regional And Subtype-Specific Vulnerability Of Enteric Neurons To Mitochondrial Dysfunction, Andreu Viader, Elizabeth C. Wright-Jin, Bhupinder P.S Vohra, Robert O. Heuckeroth, Jeffrey Milbrandt

Open Access Publications

No abstract provided.


Enantioselective Protein-Sterol Interactions Mediate Regulation Of Both Prokaryotic And Eukaryotic Inward Rectifier K+ Channels By Cholesterol, Nazzareno D'Avanzo, Krzysztof Hyrc, Decha Enkvetchakul, Douglas F. Covey, Colin G. Nichols Jan 2011

Enantioselective Protein-Sterol Interactions Mediate Regulation Of Both Prokaryotic And Eukaryotic Inward Rectifier K+ Channels By Cholesterol, Nazzareno D'Avanzo, Krzysztof Hyrc, Decha Enkvetchakul, Douglas F. Covey, Colin G. Nichols

Open Access Publications

No abstract provided.


Application Of Bayesian Network Structure Learning To Identify Causal Variant Snps From Resequencing Data, Christopher E. Schlosberg, Tae-Hwi Schwantes-An, Weimin Duan, Nancy L. Saccone Jan 2011

Application Of Bayesian Network Structure Learning To Identify Causal Variant Snps From Resequencing Data, Christopher E. Schlosberg, Tae-Hwi Schwantes-An, Weimin Duan, Nancy L. Saccone

Open Access Publications

No abstract provided.


Rna Binding Protein Cugbp2/Celf2 Mediates Curcumin- Induced Mitotic Catastrophe Of Pancreatic Cancer Cells, Dharmalingam Subramaniam, Satish Ramalingam, David C. Linehan, Brian K. Dieckgraefe, Russell G. Postier, Courtney W. Houchen, Roy A. Jensen, Shrikant Anant Jan 2011

Rna Binding Protein Cugbp2/Celf2 Mediates Curcumin- Induced Mitotic Catastrophe Of Pancreatic Cancer Cells, Dharmalingam Subramaniam, Satish Ramalingam, David C. Linehan, Brian K. Dieckgraefe, Russell G. Postier, Courtney W. Houchen, Roy A. Jensen, Shrikant Anant

Open Access Publications

No abstract provided.


Role Of Nadph Oxidase Versus Neutrophil Proteases In Antimicrobial Host Defense, R. Robert Vethanayagam, Nikolaos G. Almyroudis, Melissa J. Grimm, David C. Lewandowski, Christine T. N Pham, Timothy S. Blackwell, Ruta Petraitiene, Vidmantas Petraitis, Thomas J. Walsh, Constantin F. Urban, Brahm H. Segal Jan 2011

Role Of Nadph Oxidase Versus Neutrophil Proteases In Antimicrobial Host Defense, R. Robert Vethanayagam, Nikolaos G. Almyroudis, Melissa J. Grimm, David C. Lewandowski, Christine T. N Pham, Timothy S. Blackwell, Ruta Petraitiene, Vidmantas Petraitis, Thomas J. Walsh, Constantin F. Urban, Brahm H. Segal

Open Access Publications

No abstract provided.


Moving Pictures Of The Human Microbiome, J Gregory Caporaso, Christian L. Lauber, Elizabeth K. Costello, Donna Berg-Lyons, Antonio Gonzalez, Jesse Stombaugh, Dan Knights, Pawel Gajer, Jacques Ravel, Noah Fierer, Jeffrey I. Gordon, Rob Knight Jan 2011

Moving Pictures Of The Human Microbiome, J Gregory Caporaso, Christian L. Lauber, Elizabeth K. Costello, Donna Berg-Lyons, Antonio Gonzalez, Jesse Stombaugh, Dan Knights, Pawel Gajer, Jacques Ravel, Noah Fierer, Jeffrey I. Gordon, Rob Knight

Open Access Publications

No abstract provided.


Prediction Error Associated With The Perceptual Segmentation Of Naturalistic Events, Jeffrey M. Zacks, Christopher A. Kurby, Michelle L. Eisenberg, Nayiri Haroutunian Jan 2011

Prediction Error Associated With The Perceptual Segmentation Of Naturalistic Events, Jeffrey M. Zacks, Christopher A. Kurby, Michelle L. Eisenberg, Nayiri Haroutunian

Open Access Publications

No abstract provided.


Phr1 Is Required For Proper Retinocollicular Targeting Of Nasal-Dorsal Retinal Ganglion Cells, Bradley Q. Vo, A J. Bloom, Susan M. Culican Jan 2011

Phr1 Is Required For Proper Retinocollicular Targeting Of Nasal-Dorsal Retinal Ganglion Cells, Bradley Q. Vo, A J. Bloom, Susan M. Culican

Open Access Publications

No abstract provided.


Early Toxicity Predicts Long-Term Survival In High-Grade Glioma, Yaacov R. Lawrence, Meihua Wang, Adam Paul Dicker, David W. Andrews, Walter John Curran, Jeff Michael Michalski, Luis Souhami, Alfred K. Yung, Minesh Mehta Jan 2011

Early Toxicity Predicts Long-Term Survival In High-Grade Glioma, Yaacov R. Lawrence, Meihua Wang, Adam Paul Dicker, David W. Andrews, Walter John Curran, Jeff Michael Michalski, Luis Souhami, Alfred K. Yung, Minesh Mehta

Open Access Publications

No abstract provided.


Genomic And Metabolic Profiling Of Nonulosonic Acids In Vibrionaceae Reveal Biochemical Phenotypes Of Allelic Divergence In Vibrio Vulnificus, Amanda L. Lewis, Jean-Bernard Lubin, Shilpa Argade, Natasha Naidu, Biswa Choudhury, E. Fidelma Boyd Jan 2011

Genomic And Metabolic Profiling Of Nonulosonic Acids In Vibrionaceae Reveal Biochemical Phenotypes Of Allelic Divergence In Vibrio Vulnificus, Amanda L. Lewis, Jean-Bernard Lubin, Shilpa Argade, Natasha Naidu, Biswa Choudhury, E. Fidelma Boyd

Open Access Publications

No abstract provided.


Calling Cards Enable Multiplexed Identification Of The Genomic Targets Of Dna-Binding Proteins, Haoyi Wang, David Mayhew, Xuhua Chen, Mark Johnston, Robi David Mitra Jan 2011

Calling Cards Enable Multiplexed Identification Of The Genomic Targets Of Dna-Binding Proteins, Haoyi Wang, David Mayhew, Xuhua Chen, Mark Johnston, Robi David Mitra

Open Access Publications

No abstract provided.


Plasticity In Patterns Of Histone Modifications And Chromosomal Proteins In Drosophila Heterochromatin, Nicole C. Riddle, Sarah C.R. Elgin, Et Al Jan 2011

Plasticity In Patterns Of Histone Modifications And Chromosomal Proteins In Drosophila Heterochromatin, Nicole C. Riddle, Sarah C.R. Elgin, Et Al

Open Access Publications

No abstract provided.


Cd103+ Pulmonary Dendritic Cells Preferentially Acquire And Present Apoptotic Cell-Associated Antigen, A Nicole Desch, Gwendalyn J. Randolph, Kenneth Murphy, Emmanuel L. Gautier, Ross M. Kedl, Mireille H. Lahoud, Irina Caminschi, Ken Shortman, Peter M. Henson, Claudia V. Jakubzick Jan 2011

Cd103+ Pulmonary Dendritic Cells Preferentially Acquire And Present Apoptotic Cell-Associated Antigen, A Nicole Desch, Gwendalyn J. Randolph, Kenneth Murphy, Emmanuel L. Gautier, Ross M. Kedl, Mireille H. Lahoud, Irina Caminschi, Ken Shortman, Peter M. Henson, Claudia V. Jakubzick

Open Access Publications

Cells undergoing programmed cell death (apoptosis) are removed in situ by macrophages and dendritic cells (DCs) through a specialized form of phagocytosis (efferocytosis). In the lung, there are two primary DC subsets with the potential to migrate to the local lymph nodes (LNs) and initiate adaptive immune responses. In this study, we show that only CD103(+) DCs were able to acquire and transport apoptotic cells to the draining LNs and cross present apoptotic cell-associated antigen to CD8 T cells. In contrast, both the CD11b(hi) and the CD103(+) DCs were able to ingest and traffic latex beads or soluble antigen. CD103(+) …


Bop5 Mutations Reveal New Roles For The Ic138 Phosphoprotein In The Regulation Of Flagellar Motility And Asymmetric Waveforms, Kristyn E. Vanderwaal, Ryosuke Yamamoto, Ken-Ichi Wakabayashi, Laura Fox, Ritsu Kamiya, Susan K. Dutcher, Phillip V. Bayly, Winfield S. Sale, Mary E. Porter Jan 2011

Bop5 Mutations Reveal New Roles For The Ic138 Phosphoprotein In The Regulation Of Flagellar Motility And Asymmetric Waveforms, Kristyn E. Vanderwaal, Ryosuke Yamamoto, Ken-Ichi Wakabayashi, Laura Fox, Ritsu Kamiya, Susan K. Dutcher, Phillip V. Bayly, Winfield S. Sale, Mary E. Porter

Open Access Publications

No abstract provided.