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Washington University School of Medicine

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Fine-Tuning P53 Activity Through C-Terminal Modification Significantly Contributes To Hsc Homeostasis And Mouse Radiosensitivity, Yunyuan V. Wang, Mathias Leblanc, Norma Fox, Jian-Hua Mao, Kelsey L. Tinkum, Kurt Krummel, Dannielle Engle, David Piwnica-Worms, Helen Piwnica-Worms, Allan Balmain, Kenneth Kaushanszy, Geoffrey M. Wahl Jan 2011

Fine-Tuning P53 Activity Through C-Terminal Modification Significantly Contributes To Hsc Homeostasis And Mouse Radiosensitivity, Yunyuan V. Wang, Mathias Leblanc, Norma Fox, Jian-Hua Mao, Kelsey L. Tinkum, Kurt Krummel, Dannielle Engle, David Piwnica-Worms, Helen Piwnica-Worms, Allan Balmain, Kenneth Kaushanszy, Geoffrey M. Wahl

Open Access Publications

No abstract provided.


Eisosome Proteins Assemble Into A Membrane Scaffold, Lena Karotki, Juha T. Huiskonen, Christopher J. Stefan, Natasza E. Ziółkowska, Robyn Roth, Michal A. Surma, Nevan J. Krogan, Scott D. Emr, John Heuser, Kay Grünewald, Tobias C. Walther Jan 2011

Eisosome Proteins Assemble Into A Membrane Scaffold, Lena Karotki, Juha T. Huiskonen, Christopher J. Stefan, Natasza E. Ziółkowska, Robyn Roth, Michal A. Surma, Nevan J. Krogan, Scott D. Emr, John Heuser, Kay Grünewald, Tobias C. Walther

Open Access Publications

Spatial organization of membranes into domains of distinct protein and lipid composition is a fundamental feature of biological systems. The plasma membrane is organized in such domains to efficiently orchestrate the many reactions occurring there simultaneously. Despite the almost universal presence of membrane domains, mechanisms of their formation are often unclear. Yeast cells feature prominent plasma membrane domain organization, which is at least partially mediated by eisosomes. Eisosomes are large protein complexes that are primarily composed of many subunits of two Bin-Amphiphysin-Rvs domain-containing proteins, Pil1 and Lsp1. In this paper, we show that these proteins self-assemble into higher-order structures and …


A Genomic Storm In Critically Injured Humans, Wenzhong Xiao, Bernard H. Brownstein, Et Al Jan 2011

A Genomic Storm In Critically Injured Humans, Wenzhong Xiao, Bernard H. Brownstein, Et Al

Open Access Publications

No abstract provided.


Statistical Analysis And Interpretation Of Prenatal Diagnostic Imaging Studies, Part 2: Descriptive And Inferential Statistical Methods, Methodius G. Tuuli, Anthony O. Odibo Jan 2011

Statistical Analysis And Interpretation Of Prenatal Diagnostic Imaging Studies, Part 2: Descriptive And Inferential Statistical Methods, Methodius G. Tuuli, Anthony O. Odibo

Open Access Publications

No abstract provided.


Digital Gene Expression For Non-Model Organisms, Lewis Z. Hong, Jun Li, Anne Schmidt-Küntzel, Wesley C. Warren, Gregory S. Barsh Jan 2011

Digital Gene Expression For Non-Model Organisms, Lewis Z. Hong, Jun Li, Anne Schmidt-Küntzel, Wesley C. Warren, Gregory S. Barsh

Open Access Publications

No abstract provided.


Fig1 Facilitates Calcium Influx And Localizes To Membranes Destined To Undergo Fusion During Mating In Candida Albicans, Meng Yang, Alexandra Brand, Thyagarajan Srikantha, Karla J. Daniels, David R. Soll, Neil A.R. Gow Jan 2011

Fig1 Facilitates Calcium Influx And Localizes To Membranes Destined To Undergo Fusion During Mating In Candida Albicans, Meng Yang, Alexandra Brand, Thyagarajan Srikantha, Karla J. Daniels, David R. Soll, Neil A.R. Gow

Open Access Publications

No abstract provided.


The Transcriptional Diversity Of 25 Drosophila Cell Lines, Marijke J. Van Baren, Laura Langton, Aaron E. Tenney, Michael R. Brent Jan 2011

The Transcriptional Diversity Of 25 Drosophila Cell Lines, Marijke J. Van Baren, Laura Langton, Aaron E. Tenney, Michael R. Brent

Open Access Publications

No abstract provided.


Chimeric 16s Rrna Sequence Formation And Detection In Sanger And 454-Pyrosequenced Pcr Amplicons, Erica Sodergren, Et Al Jan 2011

Chimeric 16s Rrna Sequence Formation And Detection In Sanger And 454-Pyrosequenced Pcr Amplicons, Erica Sodergren, Et Al

Open Access Publications

No abstract provided.


Distinct Time-Resolved Roles For Two Catabolite-Sensing Pathways During Streptococcus Pyogenes Infection, Colin C. Kietzman, Michael G. Caparon Jan 2011

Distinct Time-Resolved Roles For Two Catabolite-Sensing Pathways During Streptococcus Pyogenes Infection, Colin C. Kietzman, Michael G. Caparon

Open Access Publications

No abstract provided.


Role Of Fatty Acid Transporters In Epidermis: Implications For Health And Disease, Denis Khnykin, Jeffrey H. Miner, Frode Jahnsen Jan 2011

Role Of Fatty Acid Transporters In Epidermis: Implications For Health And Disease, Denis Khnykin, Jeffrey H. Miner, Frode Jahnsen

Open Access Publications

No abstract provided.


The Diverse Functions Of Short-Term Plasticity Components In Synaptic Computations, Pan-Yue Deng, Vitaly A. Klyachko Jan 2011

The Diverse Functions Of Short-Term Plasticity Components In Synaptic Computations, Pan-Yue Deng, Vitaly A. Klyachko

Open Access Publications

No abstract provided.


Inhibition Of Indoleamine 2,3-Dioxygenase Activity By Levo-1-Methyl Tryptophan Blocks Gamma Interferon-Induced Chlamydia Trachomatis Persistence In Human Epithelial Cells, Joyce A. Ibana, Robert J. Belland, Arnold H. Zea, Danny J. Schust, Takeshi Nagamatsu, Yasser M. Abdelrahman, David J. Tate, Wandy L. Beatty, Ashok A. Aiyar, Alison J. Quayle Jan 2011

Inhibition Of Indoleamine 2,3-Dioxygenase Activity By Levo-1-Methyl Tryptophan Blocks Gamma Interferon-Induced Chlamydia Trachomatis Persistence In Human Epithelial Cells, Joyce A. Ibana, Robert J. Belland, Arnold H. Zea, Danny J. Schust, Takeshi Nagamatsu, Yasser M. Abdelrahman, David J. Tate, Wandy L. Beatty, Ashok A. Aiyar, Alison J. Quayle

Open Access Publications

No abstract provided.


Structural And Functional Interactions Between The Cholera Toxin A1 Subunit And Erdj3/Hedj, A Chaperone Of The Endoplasmic Reticulum, Shane Massey, Helen Burress, Michael Taylor, Kathleen N. Nemec, Supriyo Ray, David B. Haslam, Ken Teter Jan 2011

Structural And Functional Interactions Between The Cholera Toxin A1 Subunit And Erdj3/Hedj, A Chaperone Of The Endoplasmic Reticulum, Shane Massey, Helen Burress, Michael Taylor, Kathleen N. Nemec, Supriyo Ray, David B. Haslam, Ken Teter

Open Access Publications

No abstract provided.


Immune Activation And Suppression By Group B Streptococcus In A Murine Model Of Urinary Tract Infection, Kimberly A. Kline, Drew J. Schwartz, Warren G. Lewis, Scott J. Hultgren, Amanda L. Lewis Jan 2011

Immune Activation And Suppression By Group B Streptococcus In A Murine Model Of Urinary Tract Infection, Kimberly A. Kline, Drew J. Schwartz, Warren G. Lewis, Scott J. Hultgren, Amanda L. Lewis

Open Access Publications

No abstract provided.


Differential Microbicidal Effects Of Human Histone Proteins H2a And H2b On Leishmania Promastigotes And Amastigotes, Yingwei Wang, Yang Chen, Lijun Xin, Stephen M. Beverley, Eric D. Carlsen, Vsevolod Popov, Kwang-Poo Chang, Ming Wang, Lynn Soong Jan 2011

Differential Microbicidal Effects Of Human Histone Proteins H2a And H2b On Leishmania Promastigotes And Amastigotes, Yingwei Wang, Yang Chen, Lijun Xin, Stephen M. Beverley, Eric D. Carlsen, Vsevolod Popov, Kwang-Poo Chang, Ming Wang, Lynn Soong

Open Access Publications

No abstract provided.


Implications Of The Prion-Related Q/N Domains In Tdp-43 And Fus, Maria Udan, Robert H. Baloh Jan 2011

Implications Of The Prion-Related Q/N Domains In Tdp-43 And Fus, Maria Udan, Robert H. Baloh

Open Access Publications

No abstract provided.


Register Shifting Of An Insulin Peptide-Mhc Complex Allows Diabetogenic T Cells To Escape Thymic Deletion, James F. Mohan, Shirley J. Petzold, Emil R. Unanue Jan 2011

Register Shifting Of An Insulin Peptide-Mhc Complex Allows Diabetogenic T Cells To Escape Thymic Deletion, James F. Mohan, Shirley J. Petzold, Emil R. Unanue

Open Access Publications

In nonobese diabetic (NOD) mice, two sets of autoreactive CD4(+) T cells recognize the B:9-23 segment of the insulin B chain. One set, type A, recognizes insulin presented by antigen-presenting cells (APCs). These T cells are highly deleted in the thymus. The second set, type B, does not recognize insulin protein but reacts with soluble B chain peptide. This set is not deleted in the thymus but is activated in the islets of Langerhans. In this study, we examine the specificity of these two types of T cells. The protein-reactive set recognizes the stretch of residues 13-21 of the insulin …


Washington University School Of Medicine Bulletin, 2011 Jan 2011

Washington University School Of Medicine Bulletin, 2011

Washington University School of Medicine Bulletins

No abstract provided.


Outlook Magazine, Winter 2011 Jan 2011

Outlook Magazine, Winter 2011

Outlook Magazine

No abstract provided.


Outlook Magazine, Autumn 2011 Jan 2011

Outlook Magazine, Autumn 2011

Outlook Magazine

No abstract provided.


The Importance Of Addressing Stress In Parents Of Hearing Impaired Children, Sara Renee Nolte Jan 2011

The Importance Of Addressing Stress In Parents Of Hearing Impaired Children, Sara Renee Nolte

Independent Studies and Capstones

The focus of this study was to provide a summary of the existing literature concerning parental stress. The goal of highlighting factors that contribute to increased stress levels and the effects of stress on parents and children was to provide deaf educators with an understanding of parental stress and insight into the need for programs that minimize stress.


Efficacy Of A Combined Drug Therapy For Ameliorating Noise-Induced Hearing Loss, Randi Lynn Luxmore Jan 2011

Efficacy Of A Combined Drug Therapy For Ameliorating Noise-Induced Hearing Loss, Randi Lynn Luxmore

Independent Studies and Capstones

Experiments investigated the median effective dose of antiepileptic drugs and synthetic glucocorticoids for the prevention and treatment of noise-induced hearing loss for C57BL/6J mice. We also tested the possible synergistic effects of combining drugs from the two drug families.


Interactions Of Alpha And Beta Synuclein Proteins In Auditory Functioning, Sarah Jane Carls Jan 2011

Interactions Of Alpha And Beta Synuclein Proteins In Auditory Functioning, Sarah Jane Carls

Independent Studies and Capstones

Alpha-synuclein is found in synaptic terminals at the base of both inner and outer hair cells, while the beta isoform is prominently localized to spiral ganglion neuron cell bodies. The present study assessed the role of beta-synuclein in auditory function, and potential interactions between isoforms.


A New Role For The Library: Measuring Research Productivity And Impact, Cathy C. Sarli, Kristi L. Holmes Jan 2011

A New Role For The Library: Measuring Research Productivity And Impact, Cathy C. Sarli, Kristi L. Holmes

Becker Library Publications and Presentations

No abstract provided.


Identifying And Assessing Research Impact, Cathy C. Sarli, Kristi L. Holmes Jan 2011

Identifying And Assessing Research Impact, Cathy C. Sarli, Kristi L. Holmes

Becker Library Publications and Presentations

No abstract provided.


Assessing The Impact Of Biomedical Research, Mae O. Gordon, Cathy C. Sarli, Kristi L. Holmes Jan 2011

Assessing The Impact Of Biomedical Research, Mae O. Gordon, Cathy C. Sarli, Kristi L. Holmes

Becker Library Publications and Presentations

No abstract provided.


Billing And Compliance Issues With Devices, Yi Zhang, Carlos Brown Jan 2011

Billing And Compliance Issues With Devices, Yi Zhang, Carlos Brown

2011 Device Advice from the FDA

No abstract provided.


2011 Device Advice From The Fda: Agenda, Human Research Protection Office, Washington University School Of Medicine In St. Louis Jan 2011

2011 Device Advice From The Fda: Agenda, Human Research Protection Office, Washington University School Of Medicine In St. Louis

2011 Device Advice from the FDA

No abstract provided.


Cxcr7 Antagonism Prevents Axonal Injury During Experimental Autoimmune Encephalomyelitis As Revealed By In Vivo Axial Diffusivity, Lillian Cruz-Orengo, Ying-Jr Chen, Joong Hee Kim, Denise Dorsey, Sheng-Kwei Song, Robyn S. Klein Jan 2011

Cxcr7 Antagonism Prevents Axonal Injury During Experimental Autoimmune Encephalomyelitis As Revealed By In Vivo Axial Diffusivity, Lillian Cruz-Orengo, Ying-Jr Chen, Joong Hee Kim, Denise Dorsey, Sheng-Kwei Song, Robyn S. Klein

Open Access Publications

No abstract provided.


Engraftment Of Insulin-Producing Cells From Porcine Islets In Non-Immune-Suppressed Rats Or Nonhuman Primates Transplanted Previously With Embryonic Pig Pancreas, Marc R. Hammerman Jan 2011

Engraftment Of Insulin-Producing Cells From Porcine Islets In Non-Immune-Suppressed Rats Or Nonhuman Primates Transplanted Previously With Embryonic Pig Pancreas, Marc R. Hammerman

Open Access Publications

No abstract provided.