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Articles 7621 - 7650 of 11111
Full-Text Articles in Entire DC Network
A Systematic Study Of Gene Expression Variation At Single-Nucleotide Resolution Reveals Widespread Regulatory Roles For Uaugs, Yue Yun, T.M. Ayodele Adesanya, Robi D. Mitra
A Systematic Study Of Gene Expression Variation At Single-Nucleotide Resolution Reveals Widespread Regulatory Roles For Uaugs, Yue Yun, T.M. Ayodele Adesanya, Robi D. Mitra
Open Access Publications
No abstract provided.
Dna2 And Exo1 In Replication-Coupled, Homology-Directed Repair And In The Interplay Between Hdr And The Fa/Brca Network, Kenneth K. Karanja, Stephanie W. Cox, Julien P. Duxin, Sheila A. Stewart, Judith L. Campbell
Dna2 And Exo1 In Replication-Coupled, Homology-Directed Repair And In The Interplay Between Hdr And The Fa/Brca Network, Kenneth K. Karanja, Stephanie W. Cox, Julien P. Duxin, Sheila A. Stewart, Judith L. Campbell
Open Access Publications
No abstract provided.
Conserved Motifs And Prediction Of Regulatory Modules In Caenorhabditis Elegans, Guoyan Zhao, Nnamdi Ihuegbu, Mo Lee, Larry Schriefer, Ting Wang, Gary D. Stormo
Conserved Motifs And Prediction Of Regulatory Modules In Caenorhabditis Elegans, Guoyan Zhao, Nnamdi Ihuegbu, Mo Lee, Larry Schriefer, Ting Wang, Gary D. Stormo
Open Access Publications
No abstract provided.
Offspring Adhd As A Risk Factor For Parental Marital Problems: Controls For Genetic And Environmental Confounds, Alice C. Schermerhorn, Brian M. D'Onofrio, Wendy S. Slutske, Robert E. Emery, Eric Turkheimer, K. Paige Harden, Andrew C. Heath, Nicholas G. Martin
Offspring Adhd As A Risk Factor For Parental Marital Problems: Controls For Genetic And Environmental Confounds, Alice C. Schermerhorn, Brian M. D'Onofrio, Wendy S. Slutske, Robert E. Emery, Eric Turkheimer, K. Paige Harden, Andrew C. Heath, Nicholas G. Martin
Open Access Publications
No abstract provided.
Ajuba Is Required For Rac Activation And Maintenance Of E-Cadherin Adhesion, Sébastien Nola, Reiko Daigaku, Kasia Smolarczyk, Maryke Carstens, Belen Martin-Martin, Gregory Longmore, Maryse Bailly, Vania M.M. Braga
Ajuba Is Required For Rac Activation And Maintenance Of E-Cadherin Adhesion, Sébastien Nola, Reiko Daigaku, Kasia Smolarczyk, Maryke Carstens, Belen Martin-Martin, Gregory Longmore, Maryse Bailly, Vania M.M. Braga
Open Access Publications
No abstract provided.
Focal Spot, Fall/Winter 2010/2011
What's New In Orthopaedic Trauma, William M. Ricci, Christopher Mcandrew, David Merriman, Michael J. Gardner
What's New In Orthopaedic Trauma, William M. Ricci, Christopher Mcandrew, David Merriman, Michael J. Gardner
Open Access Publications
No abstract provided.
In Vivo Microdialysis Reveals Age-Dependent Decrease Of Brain Interstitial Fluid Tau Levels In P301s Human Tau Transgenic Mice, Kaoru Yamada, John R. Cirrito, Floy R. Stewart, Hong Jiang, Mary Beth Finn, Brandon B. Holmes, Lester I. Binder, Eva-Maria Mandelkow, Marc I. Diamond, Virginia M.-Y. Lee, David M. Holtzman
In Vivo Microdialysis Reveals Age-Dependent Decrease Of Brain Interstitial Fluid Tau Levels In P301s Human Tau Transgenic Mice, Kaoru Yamada, John R. Cirrito, Floy R. Stewart, Hong Jiang, Mary Beth Finn, Brandon B. Holmes, Lester I. Binder, Eva-Maria Mandelkow, Marc I. Diamond, Virginia M.-Y. Lee, David M. Holtzman
Open Access Publications
Although tau is a cytoplasmic protein, it is also found in brain extracellular fluids, e.g., CSF. Recent findings suggest that aggregated tau can be transferred between cells and extracellular tau aggregates might mediate spread of tau pathology. Despite these data, details of whether tau is normally released into the brain interstitial fluid (ISF), its concentration in ISF in relation to CSF, and whether ISF tau is influenced by its aggregation are unknown. To address these issues, we developed a microdialysis technique to analyze monomeric ISF tau levels within the hippocampus of awake, freely moving mice. We detected tau in ISF …
Spinal Reconstruction With Pedicle Screw-Based Instrumentation And Rhbmp-2 In Patients With Neurofibromatosis And Severe Dural Ectasia And Spinal Deformity: Report Of Two Cases And A Review Of The Literature, Samuel K. Cho, Geoffrey E. Stoker, Keith H. Bridwell
Spinal Reconstruction With Pedicle Screw-Based Instrumentation And Rhbmp-2 In Patients With Neurofibromatosis And Severe Dural Ectasia And Spinal Deformity: Report Of Two Cases And A Review Of The Literature, Samuel K. Cho, Geoffrey E. Stoker, Keith H. Bridwell
Open Access Publications
No abstract provided.
Controlled Cortical Impact Traumatic Brain Injury In 3xtg-Ad Mice Causes Acute Intra-Axonal Amyloid-Β Accumulation And Independently Accelerates The Development Of Tau Abnormalities, Hien T. Tran, Frank M. Laferla, David M. Holtzman, David L. Brody
Controlled Cortical Impact Traumatic Brain Injury In 3xtg-Ad Mice Causes Acute Intra-Axonal Amyloid-Β Accumulation And Independently Accelerates The Development Of Tau Abnormalities, Hien T. Tran, Frank M. Laferla, David M. Holtzman, David L. Brody
Open Access Publications
Alzheimer's disease (AD) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β (Aβ) peptides, and neurofibrillary tangles composed of hyperphosphorylated tau proteins. Aβ is thought to act upstream of tau, affecting its phosphorylation and therefore aggregation state. One of the major risk factors for AD is traumatic brain injury (TBI). Acute intra-axonal Aβ and diffuse extracellular plaques occur in ∼30% of human subjects after severe TBI. Intra-axonal accumulations of tau but not tangle-like pathologies have also been found in these patients. Whether and how these acute accumulations contribute to subsequent AD development is not …
Informatics And Data Mining Tools And Strategies For The Human Connectome Project, Daniel S. Marcus, John Harwell, Timothy Olsen, Michael Hodge, Matthew F. Glasser, Fred Prior, Mark Jenkinson, Timothy Laumann, Sandra W. Curtiss, David C. Van Essen
Informatics And Data Mining Tools And Strategies For The Human Connectome Project, Daniel S. Marcus, John Harwell, Timothy Olsen, Michael Hodge, Matthew F. Glasser, Fred Prior, Mark Jenkinson, Timothy Laumann, Sandra W. Curtiss, David C. Van Essen
Open Access Publications
No abstract provided.
Evaluation Of The Toxicity Of Triamcinolone Acetonide And Dexamethasone Sodium Phosphate On Human Lens Epithelial Cells (Hle B-3), Ashish Sharma, Ashkan Pirouzmanesh, Jayaprakash Patil, M. F. Estrago-Franco, Leandro Cabral Zacharias, Usha P. Andley, M. Cristina Kenney, Baruch D. Kuppermann
Evaluation Of The Toxicity Of Triamcinolone Acetonide And Dexamethasone Sodium Phosphate On Human Lens Epithelial Cells (Hle B-3), Ashish Sharma, Ashkan Pirouzmanesh, Jayaprakash Patil, M. F. Estrago-Franco, Leandro Cabral Zacharias, Usha P. Andley, M. Cristina Kenney, Baruch D. Kuppermann
Open Access Publications
No abstract provided.
Congenital Bone Marrow Failure In Dna-Pkcs Mutant Mice Associated With Deficiencies In Dna Repair, Shichuan Zhang, Hirohiko Yajima, Hoangdinh Huynh, Junke Zheng, Elsa Callen, Hua-Tang Chen, Nancy Wong, Samuel Bunting, Yu-Fen Lin, Mengxia Li, Kyung-Jone Lee, Michael Story, Eric Gapud, Barry P. Sleckman, André Nussenzweig, Cheng Cheng Zhang, David J. Chen, Benjamin P.C. Chen
Congenital Bone Marrow Failure In Dna-Pkcs Mutant Mice Associated With Deficiencies In Dna Repair, Shichuan Zhang, Hirohiko Yajima, Hoangdinh Huynh, Junke Zheng, Elsa Callen, Hua-Tang Chen, Nancy Wong, Samuel Bunting, Yu-Fen Lin, Mengxia Li, Kyung-Jone Lee, Michael Story, Eric Gapud, Barry P. Sleckman, André Nussenzweig, Cheng Cheng Zhang, David J. Chen, Benjamin P.C. Chen
Open Access Publications
No abstract provided.
Long-Term Calorie Restriction, But Not Endurance Exercise, Lowers Core Body Temperature In Humans, Andreea Soare, Roberto Cangemi, Daniela Omodei, John O. Holloszy, Luigi Fontana
Long-Term Calorie Restriction, But Not Endurance Exercise, Lowers Core Body Temperature In Humans, Andreea Soare, Roberto Cangemi, Daniela Omodei, John O. Holloszy, Luigi Fontana
Open Access Publications
Reduction of body temperature has been proposed to contribute to the increased lifespan in calorie restricted animals and mice overexpressing the uncoupling protein-2 in hypocretin neurons. However, nothing is known regarding the long-term effects of calorie restriction (CR) with adequate nutrition on body temperature in humans. In this study, 24-hour core body temperature was measured every minute by using ingested telemetric capsules in 24 men and women (mean age 53.7 ± 9.4 yrs) consuming a CR diet for an average of 6 years, 24 age- and sex-matched sedentary (WD) and 24 body fat-matched exercise-trained (EX) volunteers, who were eating Western …
The Cytoplasmic Adaptor Protein Caskin Mediates Lar Signal Transduction During Drosophila Motor Axon Guidance, Yi-Lan Weng, Nan Liu, Aaron Diantonio, Heather T. Broihier
The Cytoplasmic Adaptor Protein Caskin Mediates Lar Signal Transduction During Drosophila Motor Axon Guidance, Yi-Lan Weng, Nan Liu, Aaron Diantonio, Heather T. Broihier
Open Access Publications
The multiprotein complexes that receive and transmit axon pathfinding cues during development are essential to circuit generation. Here, we identify and characterize the Drosophila sterile α-motif (SAM) domain-containing protein Caskin, which shares homology with vertebrate Caskin, a CASK [calcium/calmodulin-(CaM)-activated serine-threonine kinase]-interacting protein. Drosophila caskin (ckn) is necessary for embryonic motor axon pathfinding and interacts genetically and physically with the leukocyte common antigen-related (Lar) receptor protein tyrosine phosphatase. In vivo and in vitro analyses of a panel of ckn loss-of-function alleles indicate that the N-terminal SAM domain of Ckn mediates its interaction with Lar. Like Caskin, Liprin-α is a neuronal adaptor …
Functional Analysis Of Novel Analogues Of E3330 That Block The Redox Signaling Activity Of The Multifunctional Ap Endonuclease/Redox Signaling Enzyme Ape1/Ref-1, Mark R. Kelley, Meihua Luo, April Reed, Dian Su, Sarah Delaplane, Richard F. Borch, Rodney L. Nyland Ii, Michael L. Gross, Millie M. Georgiadis
Functional Analysis Of Novel Analogues Of E3330 That Block The Redox Signaling Activity Of The Multifunctional Ap Endonuclease/Redox Signaling Enzyme Ape1/Ref-1, Mark R. Kelley, Meihua Luo, April Reed, Dian Su, Sarah Delaplane, Richard F. Borch, Rodney L. Nyland Ii, Michael L. Gross, Millie M. Georgiadis
Open Access Publications
No abstract provided.
Igh Gene Rearrangements As Plasma Biomarkers In Non- Hodgkin's Lymphoma Patients, Jian He, Jian Wu, Yuchen Jiao, Nina Wagner-Johnston, Richard F. Ambinder, Luis A. Diaz, Kenneth W. Kinzler, Bert Vogelstein, Nickolas Papadopoulos
Igh Gene Rearrangements As Plasma Biomarkers In Non- Hodgkin's Lymphoma Patients, Jian He, Jian Wu, Yuchen Jiao, Nina Wagner-Johnston, Richard F. Ambinder, Luis A. Diaz, Kenneth W. Kinzler, Bert Vogelstein, Nickolas Papadopoulos
Open Access Publications
New biomarkers with improved accuracy could be helpful for monitoring disease in patients with Non-Hodgkin's lymphomas (NHL). Towards this end, we have explored the feasibility of identifying the sequence of rearranged IgH genes using next-generation sequencing, then using PCR to detect specific rearranged DNA fragments in patients' plasma. By capturing and sequencing the IgH genomic regions (IgCap), we were able to detect and precisely determine the sequence of rearranged IgH loci in the tumors of three NHL patients. Moreover, circulating rearranged DNA fragments could be identified in the plasma of all three patients. Even in cases wherein tumor biopsies were …
Effect Of Short-Duration Low-Magnitude Cyclic Loading Versus Immobilization On Tendon-Bone Healing After Acl Reconstruction In A Rat Model, Robert H. Brophy, David Kovacevic, Carl W. Imhauser, Mark Stasiak, Asheesh Bedi, Alice J.S. Fox, Xiang-Hua Deng, Scott A. Rodeo
Effect Of Short-Duration Low-Magnitude Cyclic Loading Versus Immobilization On Tendon-Bone Healing After Acl Reconstruction In A Rat Model, Robert H. Brophy, David Kovacevic, Carl W. Imhauser, Mark Stasiak, Asheesh Bedi, Alice J.S. Fox, Xiang-Hua Deng, Scott A. Rodeo
Open Access Publications
No abstract provided.
Podokinetic Stimulation Causes Shifts In Perception Of Straight Ahead, John T. Scott, Corey A. Lohnes, Fay B. Horak, Gammon M. Earhart
Podokinetic Stimulation Causes Shifts In Perception Of Straight Ahead, John T. Scott, Corey A. Lohnes, Fay B. Horak, Gammon M. Earhart
Physical Therapy Faculty Publications
No abstract provided.
Calcium-Independent Inhibitory G-Protein Signaling Induces Persistent Presynaptic Muting Of Hippocampal Synapses, Devon C. Crawford, Chun Yun Chang, Krzysztof L. Hyrc, Steven Mennerick
Calcium-Independent Inhibitory G-Protein Signaling Induces Persistent Presynaptic Muting Of Hippocampal Synapses, Devon C. Crawford, Chun Yun Chang, Krzysztof L. Hyrc, Steven Mennerick
Open Access Publications
Adaptive forms of synaptic plasticity that reduce excitatory synaptic transmission in response to prolonged increases in neuronal activity may prevent runaway positive feedback in neuronal circuits. In hippocampal neurons, for example, glutamatergic presynaptic terminals are selectively silenced, creating "mute" synapses, after periods of increased neuronal activity or sustained depolarization. Previous work suggests that cAMP-dependent and proteasome-dependent mechanisms participate in silencing induction by depolarization, but upstream activators are unknown. We, therefore, tested the role of calcium and G-protein signaling in silencing induction in cultured hippocampal neurons. We found that silencing induction by depolarization was not dependent on rises in intracellular calcium, …
In Vitro And In Vivo Evaluation Of 64cu-Radiolabeled Kccysl Peptides For Targeting Epidermal Growth Factor Receptor-2 In Breast Carcinomas, Senthil R. Kumar, Fabio A. Gallazzi, Riccardo Ferdani, Carolyn J. Anderson, Thomas P. Quinn, Susan L. Deutscher
In Vitro And In Vivo Evaluation Of 64cu-Radiolabeled Kccysl Peptides For Targeting Epidermal Growth Factor Receptor-2 In Breast Carcinomas, Senthil R. Kumar, Fabio A. Gallazzi, Riccardo Ferdani, Carolyn J. Anderson, Thomas P. Quinn, Susan L. Deutscher
Open Access Publications
No abstract provided.
Pacs Bulletin 2011-2012, Program In Audiology And Communication Sciences
Pacs Bulletin 2011-2012, Program In Audiology And Communication Sciences
PACS News
No abstract provided.
Institute Of Clinical And Translational Sciences News, Vol. 3, Issue 4
Institute Of Clinical And Translational Sciences News, Vol. 3, Issue 4
ICTS Newsletters
No abstract provided.
Changes In Events Alter How People Remember Recent Information, Khena M. Swallow, Deanna M. Barch, Denise Head, Corey J. Maley, Derek Holder, Jeffrey M. Zacks
Changes In Events Alter How People Remember Recent Information, Khena M. Swallow, Deanna M. Barch, Denise Head, Corey J. Maley, Derek Holder, Jeffrey M. Zacks
Open Access Publications
No abstract provided.
Reading Comprehension And Oral Reading Fluency Of Deaf Children With Cochlear Implants, Kasie Gueringer
Reading Comprehension And Oral Reading Fluency Of Deaf Children With Cochlear Implants, Kasie Gueringer
Independent Studies and Capstones
This study investigates whether deaf children with cochlear implants have oral reading fluency scores comparable to reading-age matched hearing peers. It also examines the reading comprehension skills of deaf children with cochlear implants.
Cellular Signals Of Cisplatin Ototoxicity, Lindsey M. Yarnell
Cellular Signals Of Cisplatin Ototoxicity, Lindsey M. Yarnell
Independent Studies and Capstones
Three separate theories of inhibiting cisplatin-induced apoptosis were investigated utilizing different cellular mechanisms. Specifically, the copper transport cycle, TRPV1, and the JNK pathway were inhibited and immunohistochemistry was performed to determine levels of apoptosis. All three resulted in statistically significant effects; increasing CuSO4 levels resulted in increased apoptosis, and inhibiting TRPV1
Multiplexed Immunoassay Panel Identifies Novel Csf Biomarkers For Alzheimer's Disease Diagnosis And Prognosis, Rebecca Craig-Shapiro, Max Kuhn, Chengjie Xiong, Eve H. Pickering, Jingxia Liu, Thomas P. Misko, Richard J. Perrin, Kelly R. Bales, Holly Soares, Anne M. Fagan, David H. Holtzman
Multiplexed Immunoassay Panel Identifies Novel Csf Biomarkers For Alzheimer's Disease Diagnosis And Prognosis, Rebecca Craig-Shapiro, Max Kuhn, Chengjie Xiong, Eve H. Pickering, Jingxia Liu, Thomas P. Misko, Richard J. Perrin, Kelly R. Bales, Holly Soares, Anne M. Fagan, David H. Holtzman
ICTS Faculty Publications
No abstract provided.
Identification And Validation Of Novel Cerebrospinal Fluid Biomarkers For Staging Early Alzheimer's Disease, Richard J. Perrin, Rebecca Craig-Shapiro, James P. Malone, Aarti R. Shah, Petra Gilmore, Alan E. Davis, Catherine M. Roe, Elaine R. Peskind, Ge Li, Douglas R. Galasko, Christopher M. Clark, Joseph F. Quinn, Jeffrey A. Kaye, John C. Morris, David H. Holtzman, Anne M. Fagan
Identification And Validation Of Novel Cerebrospinal Fluid Biomarkers For Staging Early Alzheimer's Disease, Richard J. Perrin, Rebecca Craig-Shapiro, James P. Malone, Aarti R. Shah, Petra Gilmore, Alan E. Davis, Catherine M. Roe, Elaine R. Peskind, Ge Li, Douglas R. Galasko, Christopher M. Clark, Joseph F. Quinn, Jeffrey A. Kaye, John C. Morris, David H. Holtzman, Anne M. Fagan
ICTS Faculty Publications
No abstract provided.
Vacuolization Of Mucolipidosis Type Ii Mouse Exocrine Gland Cells Represents Accumulation Of Autolysosomes, Marielle Boonen, Eline Van Meel, Viola Oorschot, Judith Klumperman, Stuart Kornfeld
Vacuolization Of Mucolipidosis Type Ii Mouse Exocrine Gland Cells Represents Accumulation Of Autolysosomes, Marielle Boonen, Eline Van Meel, Viola Oorschot, Judith Klumperman, Stuart Kornfeld
Open Access Publications
No abstract provided.