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Articles 1471 - 1500 of 3014
Full-Text Articles in Entire DC Network
N-3 Pufas Induce Inflammatory Tolerance By Formation Of Keap1-Containing Sqstm1/P62-Bodies And Activation Of Nfe2l2, Jennifer Mildenberger, Ida Johansson, Ismail Sergin, Eli Kjøbli, Jan Kristian Damås, Babak Razani, Trude Helen Flo, Geir Bjørkøy
N-3 Pufas Induce Inflammatory Tolerance By Formation Of Keap1-Containing Sqstm1/P62-Bodies And Activation Of Nfe2l2, Jennifer Mildenberger, Ida Johansson, Ismail Sergin, Eli Kjøbli, Jan Kristian Damås, Babak Razani, Trude Helen Flo, Geir Bjørkøy
Open Access Publications
Inflammation is crucial in the defense against infections but must be tightly controlled to limit detrimental hyperactivation. Our diet influences inflammatory processes and omega-3 polyunsaturated fatty acids (n-3 PUFAs) have known anti-inflammatory effects. The balance of pro- and anti-inflammatory processes is coordinated by macrophages and macroautophagy/autophagy has recently emerged as a cellular process that dampens inflammation. Here we report that the n-3 PUFA docosahexaenoic acid (DHA) transiently induces cytosolic speckles of the autophagic receptor SQSTM1/p62 (sequestosome 1) (described as SQSTM1/p62-bodies) in macrophages. We suggest that the formation of SQSTM1/p62-bodies represents a fast mechanism of NFE2L2/Nrf2 (nuclear factor, erythroid 2 like …
Insights Into Onchocerca Volvulus Population Biology Through Multilocus Immunophenotyping, Carmelle T Norice-Tra, José Ribeiro, Sasisekhar Bennuru, Michael P Fay, Rahul Tyagi, Makedonka Mitreva, Thomas B Nutman
Insights Into Onchocerca Volvulus Population Biology Through Multilocus Immunophenotyping, Carmelle T Norice-Tra, José Ribeiro, Sasisekhar Bennuru, Michael P Fay, Rahul Tyagi, Makedonka Mitreva, Thomas B Nutman
2010-2019 OA Pubs
We have developed a serologically based immunophenotyping approach to study Onchocerca volvulus (Ov) population diversity. Using genomic sequence data and polymerase chain reaction-based genotyping, we identified nonsynonymous single-nucleotide polymorphisms (SNPs) in the genes of 16 major immunogenic Ov proteins: Ov-CHI-1/Ov-CHI-2, Ov16, Ov-FAR-1, Ov-CPI-1, Ov-B20, Ov-ASP-1, Ov-TMY-1, OvSOD1, OvGST1, Ov-CAL-1, M3/M4, Ov-RAL-1, Ov-RAL-2, Ov-ALT-1, Ov-FBA-1, and Ov-B8. We assessed the immunoreactivity of onchocerciasis patient sera (n = 152) from the Americas, West Africa, Central Africa, and East Africa against peptides derived from 10 of these proteins containing SNPs. Statistically significant variation in immunoreactivity among the regions was seen in SNP-containing peptides …
Recommendations For The Clinical Management Of Patients Receiving Macitentan For Pulmonary Arterial Hypertension (Pah): A Delphi Consensus Document, Franck F Rahaghi, Murali M Chakinala, Et Al
Recommendations For The Clinical Management Of Patients Receiving Macitentan For Pulmonary Arterial Hypertension (Pah): A Delphi Consensus Document, Franck F Rahaghi, Murali M Chakinala, Et Al
2010-2019 OA Pubs
In patients treated with macitentan (Opsumit®, Actelion Pharmaceuticals Ltd., Basel, Switzerland) for pulmonary arterial hypertension (PAH), prevention and/or effective management of treatment-related adverse events may improve adherence. However, management of these adverse events can be challenging and the base of evidence and clinical experience for macitentan is limited. In the absence of evidence, consensus recommendations from physicians experienced in using macitentan to treat PAH may benefit patients and physicians who are using macitentan. Consensus recommendations were developed by a panel of physicians experienced with macitentan and PAH using a modified Delphi process. Over three iterations, panelists developed and refined a …
Effective Antibiotic Conservation By Emergency Antimicrobial Stewardship During A Drug Shortage, Kevin Hsueh, Maria Reyes, Tamara Krekel, Ed Casabar, David J. Ritchie, S. Reza Jafarzadeh, Amanda J. Hays, Michael A. Lane, Michael J. Durkin
Effective Antibiotic Conservation By Emergency Antimicrobial Stewardship During A Drug Shortage, Kevin Hsueh, Maria Reyes, Tamara Krekel, Ed Casabar, David J. Ritchie, S. Reza Jafarzadeh, Amanda J. Hays, Michael A. Lane, Michael J. Durkin
Open Access Publications
No abstract provided.
Current State Of Antimicrobial Stewardship In Children’S Hospital Emergency Departments, Rakesh D. Mistry, Jason G. Newland, Jeffrey S. Gerber, Adam L. Hersh, Larissa May, Sarah M. Perman, Nathan Kuppermann, Peter S. Dayan
Current State Of Antimicrobial Stewardship In Children’S Hospital Emergency Departments, Rakesh D. Mistry, Jason G. Newland, Jeffrey S. Gerber, Adam L. Hersh, Larissa May, Sarah M. Perman, Nathan Kuppermann, Peter S. Dayan
Open Access Publications
No abstract provided.
An Efficient Platform For Astrocyte Differentiation From Human Induced Pluripotent Stem Cells, Julia Tcw, Minghui Wang, Anna A. Pimenova, Kathryn R. Bowles, Brigham J. Hartley, Emre Lacin, Saima I. Machlovi, Rawan Abdelaal, Celeste M. Karch, Hemali Phatnani, Paul A. Slesinger, Bin Zhang, Alison M. Goate, Kristen J. Brennand
An Efficient Platform For Astrocyte Differentiation From Human Induced Pluripotent Stem Cells, Julia Tcw, Minghui Wang, Anna A. Pimenova, Kathryn R. Bowles, Brigham J. Hartley, Emre Lacin, Saima I. Machlovi, Rawan Abdelaal, Celeste M. Karch, Hemali Phatnani, Paul A. Slesinger, Bin Zhang, Alison M. Goate, Kristen J. Brennand
Open Access Publications
No abstract provided.
Icd-9-Cm Coding For Multidrug Resistant Infection Correlates Poorly With Microbiologically Confirmed Multidrug Resistant Infection, Jason P. Burnham, Jennie H. Kwon, Hilary M. Babcock, Margaret A. Olsen, Marin H. Kollef
Icd-9-Cm Coding For Multidrug Resistant Infection Correlates Poorly With Microbiologically Confirmed Multidrug Resistant Infection, Jason P. Burnham, Jennie H. Kwon, Hilary M. Babcock, Margaret A. Olsen, Marin H. Kollef
Open Access Publications
No abstract provided.
Perinatal Mortality Associated With Positive Postmortem Cultures For Common Oral Flora, Mai He, Alison R. Migliori, Patricia Lauro, C. James Sung, Halit Pinar
Perinatal Mortality Associated With Positive Postmortem Cultures For Common Oral Flora, Mai He, Alison R. Migliori, Patricia Lauro, C. James Sung, Halit Pinar
Open Access Publications
No abstract provided.
Randomised Controlled Trial Of Lactobacillus Rhamnosus (Lgg) Versus Placebo In Children Presenting To The Emergency Department With Acute Gastroenteritis: The Pecarn Probiotic Study Protocol, David Schnadower, Phillip I. Tarr, Feng Gao, Et Al
Randomised Controlled Trial Of Lactobacillus Rhamnosus (Lgg) Versus Placebo In Children Presenting To The Emergency Department With Acute Gastroenteritis: The Pecarn Probiotic Study Protocol, David Schnadower, Phillip I. Tarr, Feng Gao, Et Al
Open Access Publications
No abstract provided.
17Β-Estradiol Dysregulates Innate Immune Responses To Pseudomonas Aeruginosa Respiratory Infection And Is Modulated By Estrogen Receptor Antagonism, Shadaan Abid, Shangkui Xie, Moumita Bose, Philip W. Shaul, Lance S. Terada, Steven L. Brody, Philip J. Thomas, John A. Katzenellenbogen, Sung Hoon Kim, David E. Greenberg, Raksha Jain
17Β-Estradiol Dysregulates Innate Immune Responses To Pseudomonas Aeruginosa Respiratory Infection And Is Modulated By Estrogen Receptor Antagonism, Shadaan Abid, Shangkui Xie, Moumita Bose, Philip W. Shaul, Lance S. Terada, Steven L. Brody, Philip J. Thomas, John A. Katzenellenbogen, Sung Hoon Kim, David E. Greenberg, Raksha Jain
Open Access Publications
No abstract provided.
Exploitation Of A Newly-Identified Entry Pathway Into The Malaria Parasite-Infected Erythrocyte To Inhibit Parasite Egress, Svetlana Glushakova, Brad L. Busse, Matthias Garten, Josh R. Beck, Rick M. Fairhurst, Daniel E. Goldberg, Joshua Zimmerberg
Exploitation Of A Newly-Identified Entry Pathway Into The Malaria Parasite-Infected Erythrocyte To Inhibit Parasite Egress, Svetlana Glushakova, Brad L. Busse, Matthias Garten, Josh R. Beck, Rick M. Fairhurst, Daniel E. Goldberg, Joshua Zimmerberg
Open Access Publications
No abstract provided.
Renal Scar Formation And Kidney Function Following Antibiotic-Treated Murine Pyelonephritis, Patrick D. Olson, Lisa K. Mclellan, Alice Liu, Kelleigh L. Briden, Kristin M. Tiemann, Allyssa L. Daugherty, Keith A. Hruska, David A. Hunstad
Renal Scar Formation And Kidney Function Following Antibiotic-Treated Murine Pyelonephritis, Patrick D. Olson, Lisa K. Mclellan, Alice Liu, Kelleigh L. Briden, Kristin M. Tiemann, Allyssa L. Daugherty, Keith A. Hruska, David A. Hunstad
Open Access Publications
No abstract provided.
Lineage A Betacoronavirus Ns2 Proteins And The Homologous Torovirus Berne Pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation Of Rnase L, Stephen A. Goldstein, Joshua M. Thornbrough, Rong Zhang, Babal K. Jha, Yize Li, Ruth Elliott, Katherine Quiroz-Figueroa, Annie I. Chen, Robert H. Silverman, Susan R. Weiss
Lineage A Betacoronavirus Ns2 Proteins And The Homologous Torovirus Berne Pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation Of Rnase L, Stephen A. Goldstein, Joshua M. Thornbrough, Rong Zhang, Babal K. Jha, Yize Li, Ruth Elliott, Katherine Quiroz-Figueroa, Annie I. Chen, Robert H. Silverman, Susan R. Weiss
Open Access Publications
No abstract provided.
Use Of Low-Dose Computed Tomography To Assess Pulmonary Tuberculosis Among Healthcare Workers In A Tuberculosis Hospital, Wei He, Bu-Dong Chen, Yan Lv, Zhen Zhou, Jin-Ping Xu, Ping-Xin Lv, Xin-Hua Zhou, Feng-Gang Ning, Cheng-Hai Li, Dong-Po Wang, Jie Zheng
Use Of Low-Dose Computed Tomography To Assess Pulmonary Tuberculosis Among Healthcare Workers In A Tuberculosis Hospital, Wei He, Bu-Dong Chen, Yan Lv, Zhen Zhou, Jin-Ping Xu, Ping-Xin Lv, Xin-Hua Zhou, Feng-Gang Ning, Cheng-Hai Li, Dong-Po Wang, Jie Zheng
Open Access Publications
No abstract provided.
Nnktt120, An Anti-Inkt Cell Monoclonal Antibody, Produces Rapid And Sustained Inkt Cell Depletion In Adults With Sickle Cell Disease, Joshua J. Field, Elaine Majerus, Kenneth I. Ataga, Elliot P. Vichinsky, Robert Schaub, Robert Mashal, David G. Nathan
Nnktt120, An Anti-Inkt Cell Monoclonal Antibody, Produces Rapid And Sustained Inkt Cell Depletion In Adults With Sickle Cell Disease, Joshua J. Field, Elaine Majerus, Kenneth I. Ataga, Elliot P. Vichinsky, Robert Schaub, Robert Mashal, David G. Nathan
Open Access Publications
No abstract provided.
Insights Into Enterotoxigenic Escherichia Coli Diversity In Bangladesh Utilizing Genomic Epidemiology, Jason W. Sahl, Jeticia R. Sistrunk, Nabilah Ibnat Baby, Yasmin Begum, Qingwei Luo, Alaullah Sheikh, Firdausi Qadri, James M. Fleckenstein, David A. Rasko
Insights Into Enterotoxigenic Escherichia Coli Diversity In Bangladesh Utilizing Genomic Epidemiology, Jason W. Sahl, Jeticia R. Sistrunk, Nabilah Ibnat Baby, Yasmin Begum, Qingwei Luo, Alaullah Sheikh, Firdausi Qadri, James M. Fleckenstein, David A. Rasko
Open Access Publications
No abstract provided.
Genome-Wide Physical Activity Interactions In Adiposity ― A Meta-Analysis Of 200,452 Adults, Mary F. Feitosa, Llilda Barata, Ingrid B. Borecki, Et Al.
Genome-Wide Physical Activity Interactions In Adiposity ― A Meta-Analysis Of 200,452 Adults, Mary F. Feitosa, Llilda Barata, Ingrid B. Borecki, Et Al.
Open Access Publications
No abstract provided.
Thirty-Day Readmissions In Hospitalized Patients Who Received Bezlotoxumab With Antibacterial Drug Treatment For Clostridium Difficile Infection, Vimalanand S. Prabhu, Oliver A. Cornely, Yoav Golan, Erik R. Dubberke, Sebastian M. Heimann, Mary E. Hansen, Jane Liao, Alison Pedley, Mary Beth Dorr, Stephen Marcella
Thirty-Day Readmissions In Hospitalized Patients Who Received Bezlotoxumab With Antibacterial Drug Treatment For Clostridium Difficile Infection, Vimalanand S. Prabhu, Oliver A. Cornely, Yoav Golan, Erik R. Dubberke, Sebastian M. Heimann, Mary E. Hansen, Jane Liao, Alison Pedley, Mary Beth Dorr, Stephen Marcella
Open Access Publications
No abstract provided.
The Surgical Infection Society Revised Guidelines On The Management Of Intra-Abdominal Infection, John E. Mazuski, Jeffrey M. Tessier, Addison K. May, Robert G. Sawyer, Evan P. Nadler, Matthew R. Rosengart, Phillip K. Chang, Patrick J. O'Neill, Kevin P. Mollen, Jared M. Huston, Jose J. Diaz Jr, Jose M. Prince
The Surgical Infection Society Revised Guidelines On The Management Of Intra-Abdominal Infection, John E. Mazuski, Jeffrey M. Tessier, Addison K. May, Robert G. Sawyer, Evan P. Nadler, Matthew R. Rosengart, Phillip K. Chang, Patrick J. O'Neill, Kevin P. Mollen, Jared M. Huston, Jose J. Diaz Jr, Jose M. Prince
Open Access Publications
No abstract provided.
Evaluation Of Correlation Between Pretest Probability For Clostridium Difficile Infection And Clostridium Difficile Enzyme Immunoassay Results, Jennie H. Kwon, Kimberly A. Reske, Tiffany Hink, Carey-Ann D. Burnham, Erik R. Dubberke
Evaluation Of Correlation Between Pretest Probability For Clostridium Difficile Infection And Clostridium Difficile Enzyme Immunoassay Results, Jennie H. Kwon, Kimberly A. Reske, Tiffany Hink, Carey-Ann D. Burnham, Erik R. Dubberke
Open Access Publications
No abstract provided.
Improved Survival After Acute Graft-Versus-Host Disease Diagnosis In The Modern Era, Robert J. Hayashi, Ravi Vig, Et Al.
Improved Survival After Acute Graft-Versus-Host Disease Diagnosis In The Modern Era, Robert J. Hayashi, Ravi Vig, Et Al.
Open Access Publications
No abstract provided.
Becker Medical Library Annual Report 2017
Becker Medical Library Annual Report 2017
Library Annual Reports
No abstract provided.
Esterase Mutation Is A Mechanism Of Resistance To Antimalarial Compounds, Eva S. Istvan, Jeremy P. Mallari, Victoria C. Corey, Neekesh V. Dharia, Garland R. Marshall, Elizabeth A. Winzeler, Daniel E. Goldberg
Esterase Mutation Is A Mechanism Of Resistance To Antimalarial Compounds, Eva S. Istvan, Jeremy P. Mallari, Victoria C. Corey, Neekesh V. Dharia, Garland R. Marshall, Elizabeth A. Winzeler, Daniel E. Goldberg
Open Access Publications
No abstract provided.
Exacerbated Leishmaniasis Caused By A Viral Endosymbiont Can Be Prevented By Immunization With Its Viral Capsid, Patrick Castiglioni, Mary-Anne Hartley, Matteo Rossi, Florence Prevel, Chantal Desponds, Daniel T. Utzxchneider, Remzi-Onur Eren, Haroun Zangger, Livia Brunner, Nicolas Collin, Dietmar Zehn, F. Matthew Kuhlmann, Stephen M. Beverley, Nicolas Fasel, Catherine Ronet
Exacerbated Leishmaniasis Caused By A Viral Endosymbiont Can Be Prevented By Immunization With Its Viral Capsid, Patrick Castiglioni, Mary-Anne Hartley, Matteo Rossi, Florence Prevel, Chantal Desponds, Daniel T. Utzxchneider, Remzi-Onur Eren, Haroun Zangger, Livia Brunner, Nicolas Collin, Dietmar Zehn, F. Matthew Kuhlmann, Stephen M. Beverley, Nicolas Fasel, Catherine Ronet
Open Access Publications
No abstract provided.
Targeting Dendritic Cells To Accelerate T-Cell Activation Overcomes A Bottleneck In Tuberculosis Vaccine Efficacy, Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell, Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno, Shabaana A. Khader
Targeting Dendritic Cells To Accelerate T-Cell Activation Overcomes A Bottleneck In Tuberculosis Vaccine Efficacy, Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell, Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno, Shabaana A. Khader
Open Access Publications
No abstract provided.
A Murine Herpesvirus Closely Related To Ubiquitous Human Herpesviruses Causes T-Cell Depletion, Swapneel J. Patel, Guoyan Zhao, Vinay R. Penna, Eugene Park, Elvin J. Lauron, Ian B. Harvey, Wandy L. Beatty, Beatrice Plougastel-Douglas, Jennifer Poursine-Laurent, Daved H. Fremont, Wayne M. Yokoyama
A Murine Herpesvirus Closely Related To Ubiquitous Human Herpesviruses Causes T-Cell Depletion, Swapneel J. Patel, Guoyan Zhao, Vinay R. Penna, Eugene Park, Elvin J. Lauron, Ian B. Harvey, Wandy L. Beatty, Beatrice Plougastel-Douglas, Jennifer Poursine-Laurent, Daved H. Fremont, Wayne M. Yokoyama
Open Access Publications
No abstract provided.
The Norovirus Ns3 Protein Is A Dynamic Lipid- And Microtubule-Associated Protein Involved In Viral Rna Replication, Ben T. Cotton, Jennifer L. Hyde, Soroush T. Sarvestani, Stanislav V. Sosnovtsev, Kim Y. Green, Peter A. White, Jason M. Mackenzie
The Norovirus Ns3 Protein Is A Dynamic Lipid- And Microtubule-Associated Protein Involved In Viral Rna Replication, Ben T. Cotton, Jennifer L. Hyde, Soroush T. Sarvestani, Stanislav V. Sosnovtsev, Kim Y. Green, Peter A. White, Jason M. Mackenzie
Open Access Publications
No abstract provided.
Potential Value Of Triple Drug Therapy With Ivermectin, Diethylcarbamazine, And Albendazole (Ida) To Accelerate Elimination Of Lymphatic Filariasis And Onchocerciasis In Africa, Peter U. Fischer, Christopher L. King, Julie A. Jacobson, Gary J. Weil
Potential Value Of Triple Drug Therapy With Ivermectin, Diethylcarbamazine, And Albendazole (Ida) To Accelerate Elimination Of Lymphatic Filariasis And Onchocerciasis In Africa, Peter U. Fischer, Christopher L. King, Julie A. Jacobson, Gary J. Weil
Open Access Publications
No abstract provided.