Digital Commons Network^™

Scopolamine-Induced Modulation Of Serotonin And Dopamine Transporters Activity: Behavioral And Molecular Insights Into Rapid Antidepressant Action, Deepak Karunakaran

Theses and Dissertations

Major depressive disorder (MDD) affects over 350 million individuals worldwide and is characterized by profound dysregulation of serotonin (5-HT) and dopamine (DA) systems that govern mood, reward processing, and motivation. The serotonin transporter (SERT) and dopamine transporter (DAT), both dynamically regulated through phosphorylation, serve as critical determinants of synaptic monoamine signaling. Despite decades of therapeutic development, current antidepressants require 4-6 weeks to achieve efficacy, and approximately one-third to half of patients develop treatment-resistant depression. The emergence of rapid-acting antidepressants like ketamine represents a paradigmatic shift, demonstrating symptom relief within hours; however, ketamine's therapeutic potential remains constrained by abuse liability, dissociative …

We Are Worthy Of Investment: Exploring Forms Of Cultural Capital Among Black American Families, Joyice Robinson Myers

Theses and Dissertations

This three-paper dissertation investigates how the cultural wealth of Black American families functions as a foundation for educational, developmental, and economic outcomes, especially for Black males, across childhood, adolescence, and the transition into adulthood. Grounded in frameworks of the Revised Cultural Wealth Model, African American Male Theory, and the Racial Stratification Model, the research repositions Black families as producers of capital rather than subjects of deficit. In Paper Paper 1, I synthesized scholarship on family structure, educational attainment, and economic standing, framing racial "achievement gaps” as long-standing education debts owed to Black males. In Paper 2, I used longitudinal data …

Knowing By Heart: Philosophical Dimensions Of Humanistic Mathematics Education, Catherine Henney

Theses and Dissertations

This project seeks to revive interest in late twentieth century humanistic mathematics education (HME) so that its principles might cross the boundary of higher education and settle in corners of the K-12 math education space. In particular, HME’s theme of teaching math humanistically directs attention to features and phenomena that bear strongly on students’ daily classroom experiences. Personhood, agency, inquiry, meaning, environment, feelings, relationships: these elements invite a more thorough meditation and philosophical analysis. Though it is a largely philosophical endeavor, this project is enlivened by classroom vignettes and case studies that bring practical relevance to HME’s core principles. Chapters …

Why People Stay: Factors Contributing To Staff Retention In Community Mental Health Clinics, Brianna D. Boggs

Theses and Dissertations

The current behavioral health crisis is exacerbated by a crisis in the behavioral health workforce. Recruiting and retaining workers in behavioral health has become a challenge, making access to services for those needing them even more difficult. This study aimed to examine which factors have the strongest influence on an employee’s work engagement and decision to remain employed at their current organization. This study used Aarons et al.’s multilevel, multiphase implementation model (2011), with a focus on inner contextual factors as a means to help inform potential interventions to address the factors and improve retention. This study also applied the …

Effectiveness Of Immersive Virtual Reality Combined With Task-Specific Training On Hemiplegic Arm Function Following Stroke: A Single Case Series Study, Rahsaan J. Holley

Theses and Dissertations

Motor recovery of the arm following a neurological injury is a common goal of the rehabilitation process for individuals impacted by the condition . Due to the long-term functional implications of impaired arm movement, individuals are often trained to use compensatory strategies to complete functional tasks without incorporating the weakened limb. While compensatory strategies offer stroke survivors the opportunity to regain a level of independence, such approaches fail to directly address the underlying causes of the disability (i.e., limited range of motion, decreased strength, poor coordination, motor planning difficulties) which can unfortunately result in long-term impairment and functional disability.

Motor …

The Influence Of The Covid-19 Pandemic On Student Engagement At A Historically Black University, John C. Travis

Theses and Dissertations

This study examined student engagement across three NSSE administrations at an HBCU—pre-COVID (2018), during COVID (2019), and post-COVID (2022). Engagement was analyzed across four themes: Academic Challenge, Learning with Peers, Experiences with Faculty, and Campus Environment. Results showed that Learning with Peers declined significantly over time, with the largest drop between 2018 and 2022, reflecting pandemic-related disruptions to peer interaction. No significant year effects emerged for the other themes. Two-way MANOVAs indicated that gender, first-generation status, and major did not significantly predict engagement, nor did they interact with year. In contrast, classification emerged as the most consistent predictor, with upper-division …

Exploring Western Clinicians’ Treatment Of Cultural Concepts Of Distress, Lisa Y. Chung

Theses and Dissertations

As the rates of diverse ethnic populations and therefore cultural concepts of distress continue to grow in the United States, it becomes critical to learn and understand how western-trained mental health professionals are selecting treatments and implementing them. However, there is a paucity of research on cultural concepts of distress as a whole and much less on the psychotherapy of cultural concepts of distress in the United States. This exploratory study aimed to explore the treatment plan of mental health clinicians in the United States when encountering the Korean cultural concept of distress, hwabyung. Ninety-eight clinicians were recruited from Arkansas, …

Maternal Postpartum Depression And Affect Incongruence: Exploring Early Developmental Pathways To Emotion Dysregulation, Laura E. Boylan

Theses and Dissertations

Emotion dysregulation, or responses to emotions that do not meet the needs of the situational demands or social standards, has been noted as an early risk factor for later psychopathology. Maternal postpartum depression (PPD) has been shown to increase children’s risk of developing maladaptive emotion regulation (ER) strategies. One potential mechanism linking PPD to these outcomes is affect incongruence, or a mismatch between biological and emotional responses to stress. While such incongruence may be adaptive in older individuals who consciously mask their internal stress (e.g., suppressing biological arousal while appearing calms), it may be maladaptive in infants and young children …

In Praise Of Dust, Hasler Gomez-Perez

Theses and Dissertations

A desire path is a physical manifestation of where a system has failed, but also where it has been refused, where a new path has been made. The wake exists in the post, it is not a singular, untethered event, but a subtle double entendre that lives in the post-death, but also in the pre-life—not a liminal limbo, but a superposition of dying and waking.

This collection was assembled and composed over the course of two years as I navigated my practice, myself, and others. Present here are my thoughts, my experiences, and in many ways my beliefs. IN PRAISE …

Building A Culture Of Preparedness: Using Community Emergency Response Teams To Promote Preparedness Behavior, Joseph Faulk

Theses and Dissertations

Communities throughout the nation use the Community Emergency Response Team (CERT) program to supplement the disaster response after hazard events as well as help build a culture of preparedness. Currently, practitioners and academics have limited knowledge about how CERTs promote enhanced preparedness postures. To address that knowledge gap, 20 CERT program managers were interviewed in this study to improve the general understanding of how CERTs contribute to developing a preparedness culture. The results identify program activities, objectives, and measures. In addition, this study introduces the Preparedness Behavior Change Model and collects feedback on its usefulness, which suggests it has a …

Theatre As Sanctuary: Queer Identity, Religious Trauma, And The Path To Healing, Casey Worley

Theses and Dissertations

Growing up as a queer individual in a deeply religious Southern Baptist community, I learned early that faith and identity could feel like irreconcilable forces. I sat in the pews, surrounded by voices that preached love but often excluded people like me. For years, I struggled with the question: Can I be both queer and faithful? This tension—between belief and belonging, between the church I was raised in and the identity I could no longer deny—became the foundation of my journey, my artistic practice, and this thesis.

Through this research, I explore the intersections of queer identity, religious trauma, and …

From Ink To Code, From Binary To Boundless Reality—Until All Returns To Emptiness, Weitong Sun

Theses and Dissertations

This thesis explores the entangled relationship between language, memory, and technology through the lens of immigrant experience. Moving from programming to visual storytelling, I investigate how dyslexia, bilingualism, and cultural displacement have shaped my ways of reading, writing, and coding.

Beginning with personal reflections on switching from computer science to art, I trace how code offered a form of clarity and expression where written language had once failed me. Yet as I ventured into real-time simulation and XR storytelling, I encountered new forms of mistranslation—where narratives dissolved, mutated, or resisted coherence altogether.

Through a series of experiments in code-driven art, …

A Parting Repast, Debra D. Dowden-Crockett

Theses and Dissertations

Both the thesis document and exhibition comprise the story of my journey through grief, examination of loss, contemplation of death, and transformation through acceptance and relinquishment. I conflate art and emotion to put form to the complex human experience of watching a loved one die, having to say a last goodbye, and the mourning that ultimately follows.

I examine the rituals surrounding death, the role of memory, and the symbolic presence of food as a shared experience of both mourning and nourishment, the intimate moments of mourning, and the gradual process of finding peace and closure.

Featuring works from a …

Love Letter, Amy S. Duval Ms

Theses and Dissertations

I applied to graduate school to reconnect with and better understand my studio practice, acquire language, and to disrupt my known ways of making. Generally speaking, I see my practice as being about being seen, and unseen, and the pain and pleasure of being perceived. I’ve learned about my ways of being in the studio. I’ve come closer to speaking honestly about my relationship with my materials, processes, tools, how I value my own labor, and how this informs my work. I am grateful for the cascade of small epiphanies that came and left me while I worked in my …

The Paradox Of Value, David Enrique Guarnizo

Theses and Dissertations

The present thesis project examines how, in the United States, and especially in the state of Virginia, archetypes of "wealth," "value," and "identity" have been constructed in relation to land and territory. This analysis explores the tension between the inherent value of life on the land and the economic value that can be derived from it. This tension is exemplified by a theory known as the "paradox of value", also referred to as the "paradox of water and diamonds", which was developed by the renowned Scottish economist and philosopher, Adam Smith. This theoretical framework serves as a fundamental axis for …

Feeling Foreign / Foreign Feeling: Affect In Southeast Asian Diasporic Short Story Collections, Francys Aerin Fortes

Theses and Dissertations

Affect studies have long been saturated with scholarship investigating the fluidity of emotions, though a larger turn in the field now prioritizes the felt experiences of marginalized peoples. Sianne Ngai’s work is one part of this turn that seeks to unpack the effects of oppressive systemic forces on Black, Brown, and queer bodies. Sianne Ngai reexamined the nature of emotions in her seminal text Ugly Feelings (2005), particularly concerned with how negative feelings are disproportionately felt by marginalized bodies as a result of conditions of obstructed agency, systems of power, and wage labor capitalism. Drawing from Ngai’s writing, this thesis …

Development Of A Mediation Model Of Pain Cognition In Adult Patients With Sickle Cell Disease, Daniel M. Sop

Theses and Dissertations

Pain is a hallmark of Sickle Cell Disease (SCD), a genetic hemoglobinopathy characterized by chronic hemolytic anemia, vaso-occlusion, and organ damage. While acute vaso-occlusive crises (VOC) have been extensively studied, the mechanisms underlying chronic pain and its interplay with brain function remain unclear. This dissertation investigates the relationships between cerebral blood flow (CBF), fluid cognition, and pain sensitivity in adults with SCD, utilizing advanced imaging techniques and validated assessment tools.

Arterial spin labeling (ASL) and functional magnetic resonance imaging (fMRI) were employed to measure CBF and brain activity, respectively. Pain sensitivity was assessed using the Pain Sensitivity Questionnaire (PSQ), and …

Teaching Under Political Influence: A Multiple Case-Study Examining The Impact Of Curricular Restriction Policy On Community-Connected Instruction (Cci) In Full-Service Community Schools (Fscs), Isaiah Moore

Theses and Dissertations

Scholars describe the political landscape as polarized, where partisanship —loyalty to a particular political party— dictates one’s beliefs. In education, this partisanship is best exhibited through conservative policy restricting curricula regarding race, racism's pervasiveness, gender identity, and how history is taught in public schools. Conversely, Community-Connected Instruction (CCI) affirms students’ culture and builds critical thinking skills in an authentic environment. While studies suggest its benefits to students, the current curricular restriction policy challenges its usage. This form of teaching is closely associated with Full-Service Community Schools (FSCS), which primarily serve underserved student populations. This study examines how FSCS educators in …

Cannabis Use Among Cancer Survivors And The Impact On Cancer-Related Pain, Tiffanie A. Vargas

Theses and Dissertations

With a growing population of older adult cancer survivors—many of whom experience cancer-related pain—interest in medical cannabis as a pain management strategy has increased. This secondary analysis used data from the 2022 U.S. Behavioral Risk Factor Surveillance System (BRFSS) to examine cannabis use behaviors among cancer survivors and assess associations with cancer-related pain. The study had three aims: (1) to describe 30-day cannabis use (prevalence, intensity, and administration routes) by chronic health condition and cancer diagnosis, focusing on non-melanoma skin cancer, melanoma, and other cancers; (2) to compare demographics, health characteristics, and tobacco use by cannabis use status among cancer …

Existing In The Context: A Conjunctural Analysis Of Kamala Harris Memes, Amaya Mcneal

Theses and Dissertations

Political memes have become a common way for people to express their political views online, helping politics reach young adults who weren’t previously interested. Consequently, politicians have begun sharing and creating memes themselves. The memeification of American politics has diminished debate about ideas, ideals, issues, and people’s vital interests, debasing voters by treating them not as citizens but as passive “consumers” and “spectators” of mediated politics. This paper helps make sense of this crisis, focusing on the example of former Vice President Kamala Harris. Vice President Kamala Harris' memeified presidential campaign during the 2024 U.S. election targeted voters through a …

Civic Conservation Workshop: A User Manual For Creating A Makerspace Dedicated To Historic Preservation, Building Repair, And Civic Engagement, Madeleine Bean

Theses and Dissertations

Research Abstract:

Democracy depends on citizens’ participation at all levels, from local to national; moreover, engagement in one’s community is directly correlated with greater reported feelings of happiness and trust (Cox et al., 2021). This research examines how makerspaces can act as civic hubs that promote inclusive community interaction, facilitate the exchange of cultural and skills-based knowledge, encourage civic discourse, and serve as sites for political engagement through the provision of tools and resources that focus on historic home repair/preservation and craft-based trades. Specifically, this study proposes the development and design of a preservation-focused makerspace in Jackson Ward, a historically …

Orb Weaver, Quinn Standley

Theses and Dissertations

Orb Weaver is a 24-minute experimental video/lm. This essay does not explain its meaning, as viewers should feel the power to trust their own interpretations. Instead, it reflects on the process of making the lm interwoven with autobiographical thoughts.

Trauma-Informed Beliefs And Our Child Welfare System, Gabriela Ana Aisenberg

Theses and Dissertations

The integration of trauma-informed care (TIC) into behavioral health and child welfare systems has garnered increasing attention, reflecting a growing acknowledgment of the pervasive and multifaceted impacts of trauma on individuals, families, and service delivery structures (Barnett et al., 2019; Bartlett et al., 2018; Bassuk et al., 2017; Substance Abuse and Mental Health Services Administration [SAMHSA], 2014). Legislation such as the Family First Prevention Services Act (FFPSA) has led to increased adoption of trauma-informed practices through increased funding for training and services (Bowen & Murshid, 2016; Brown et al., 2023). Research shows that providers’ understanding and implementation of TIC is …

Rehabilitation In Stroke-Related Flexor Synergy, Shawn J. Dirocco

Theses and Dissertations

Upper extremity abnormal flexor synergy caused by stroke can impair individuals by coupling upper extremity muscles with deltoid activation. Previous studies have shown that reduction in deltoid loading can decrease flexor synergy. Robotic rehabilitation has the ability to allow for reduced deltoid loading while assisting or constraining joints along the arm to increase rehabilitation outcomes. The effects of higher degree of freedom low impedance robotics needs to be tested to learn how various parameters affect flexor synergy in comparison to end point robotics. During the first experiment, we tested 16 chronic stroke patients with flexor synergy problems in 3 tasks. …

Using A Dimension Reduction Approach To Parse Heterogeneity In Dietary Restriction, Amanda Makara

Theses and Dissertations

Dietary restriction, the problematic reduction of caloric or macronutrient intake, is a critical eating behavior occurring transdiagnostically across eating disorders and subclinical disordered eating. The definition of dietary restriction is highly heterogeneous, and restriction is often conflated with other distinct constructs, such as dietary restraint. The current practices related to the definition and measurement of dietary restriction have notable flaws, negatively impacting the ability to identify and establish risk, diagnosis, and treatment of eating disorders. There is also limited evidence that commonly-used dietary restriction measures can validly predict food choice and objective intake. These issues raise questions about whether dietary …

Beliefs Related To Diagnosing Bpd And Complex Ptsd, Bailey Pascuzzi

Theses and Dissertations

There has been speculation that Borderline personality disorder (BPD) and Complex post-traumatic stress disorder (Complex PTSD) are the same disorder or represent separate disorders on a broader trauma spectrum (Frost et al., 2020; Lewis & Grenyer, 2009). BPD and Complex PTSD share several symptoms but differ in their presentation (Ford & Courtis, 2021). Because the two disorders present so similarly, it could be that clinicians have difficulty differentiating them, leading to misdiagnosis (Miller, 2014). This study examined clinicians’ diagnostic decision-making and stigma toward BPD and Complex PTSD. Participants (N = 426) completed an online survey where they diagnosed a written …

“Some Vague Utopia”: Searching For Urania, Moira L. Neve

Theses and Dissertations

Despite the global pendulum swing of gender trouble marked by the United States’ President’s declaration that there are only two sexes, activists have been rejecting assimilation (ie. defining equality as gay marriage or queer people in the military) within queer studies long before 2025. In the first half of the 20th century, a journal by the name of Urania (1916-1940), privately published and circulated to their home base in the United Kingdom and beyond, five editors (Esther Roper, Eva Gore-Booth, Jessey Wade, Dorothy Cornish, and Irene Clyde/Thomas Baty), challenged the gender binary and the resulting assumptions of heterosexual marriage. This …

“You’Re Only As Good As Your Resources”: Exploring Virginia Police Chiefs’ And Sheriffs’ Decisions As Public Administrators To Engage In Community Collaborations With Domestic And Sexual Violence Agencies, Christine E. Wengloski

Theses and Dissertations

The collaborations between domestic and sexual violence victim-serving agencies (DSVAs) and law enforcement agencies help connect victims of crime to needed services. To maximize the benefits of these victim-serving initiatives in Virginia, it is imperative that victim-serving agencies understand the perceptions and factors that influence the decision-making of law enforcement administrators. In this study, I first present a theoretical framework of Herbert Simon’s Decision-Making Theory as a guide to understanding police chiefs and sheriffs as public administrators. A review of the literature demonstrates gaps in existing scholarship around chiefs’ and sheriffs’ decision-making about domestic and sexual violence victim-serving initiatives. Next, …

Social Support, Tobacco Attitudes/Perceptions Of Harm, And Asthma Status As Moderators In The Association Between Tobacco Exposure And Cotinine Levels, Rachel L. Pitts

Theses and Dissertations

Tobacco use and exposure are linked to adverse health outcomes (e.g., respiratory conditions) and increased healthcare utilization (e.g., emergency room visits). This study examined the moderating role of social support, tobacco attitudes/perceptions of harm, and asthma status on associations between tobacco use (e.g., combustible product use) and exposure (e.g., secondhand smoke) and cotinine levels among individuals in Richmond, Virginia. We also explored differences in tobacco-related variables by asthma status and associations among tobacco use, secondhand smoke exposure, cotinine levels, and asthma control. Youth (n = 201) and adults (n = 209) (95.7% Black/African American; 60.6% female; 65.8% non-tobacco users; 21% …

Improving Telehealth Education And Training: A Needs Assessment Of Healthcare Providers And Trainees, Conor Duffy

Theses and Dissertations

Telehealth utilization has increased dramatically since the start of the COVID-19 pandemic. There are many positive impacts of this shift to telehealth, including increasing access to care and reducing patient burden. However, healthcare providers report several consistent challenges that limit their ability to deliver telehealth, such as effective communication, technological difficulties, and difficulty performing physical examinations. To address these concerns, it is necessary to integrate telehealth education and training into healthcare professional training programs and healthcare systems. While many institutions have implemented telehealth education and training since the start of the pandemic, there is little consistency in the content, duration, …