Associations Among Acculturative Stress, Body Ideal Internalization, Body Dissatisfaction And Disordered Eating Behaviors Among Cisgender Heterosexual And Lgbt People Of Color, Taryn Henning

Theses and Dissertations

Research supports the relation between acculturative stress and disordered eating behaviors (DEBs) across racially and ethnically diverse groups of men and women. However, there is minimal research examining factors that further explain the relation between acculturative stress and DEBs. Also, this relation has not been evaluated in racially and ethnically diverse LGBT individuals. The current study aimed to address these gaps by examining the role of thin-, muscular-, and hourglass-ideal internalization and body dissatisfaction as mediators of the relation between acculturative stress and disordered eating behaviors among cisgender heterosexual Black, Latine, Asian American, Multiracial men and women and LGBT men …

Reflection: Cultivating Creativity And Healing Through Art Therapy, Caroline Ciccone

Theses and Dissertations

I was first introduced to the healing powers of art after working in an orphanage in Jamaica with children who had a wide range of disabilities. Some children were mute or unable to communicate, but art was a form of communication that brought us all together. Within the City of Richmond public school system, 31.7% of students are economically challenged and 13.1% of students are disabled (Education, 2022). Giving more resources in the arts and mental health support to students outside of their school environments is the goal. Art therapy helps reduce the dropout rate and improve mental health (10 …

The Merit Of Adaptation: An Exploration Of Adaptation In Regard To Sophocles’ Theban Plays And The Role Of Antigone Within The Story, Hogan T. Holt

Theses and Dissertations

The creation of an adaptation is extremely challenging and time-consuming, but with the right tools and inspiration, that task of creation can be eased. By looking at three different adaptations of the Theban plays, the goal of creating a new adaptation of this series of plays can be achieved. At the same time, this adaptation can achieve a goal of highlighting an important character from the original set of plays, Antigone, and give her a role that elevates her to the main protagonist across all three plays, thus allowing the Theban plays to become a more feminine piece that works …

Particl Plant Medicine, Tommye Dean

Theses and Dissertations

In an era marked by a growing recognition of mental health as a critical component of overall well-being, unconventional approaches to therapeutic interventions have gained prominence. One such intervention coincides with the importance of setting the intersection of psychedelic therapy and interior design, creating a synergistic environment for emotional healing and self-discovery. This thesis ventures to delve into the uncharted territory where the realms of altered states of consciousness and thoughtful spatial design converge, seeking to discover the profound impact this collaboration may have on the therapeutic and design landscape.

Evaluating The Role Of Interoceptive Awareness In Insomnia And Across The Sleep Health Spectrum, Lara Lobrutto

Theses and Dissertations

Interoceptive awareness, characterized by a non-judgmental and trusting attitude towards body sensations, is an understudied construct that is implicated in sleep and health outcomes. Interoceptive awareness is cultivated via contemplative and mindfulness-based practices. Given that it may be utilized to reduce pre-sleep arousal, which is a key mechanism in insomnia, interoceptive awareness is posited to be a protective factor for sleep health. A cross-sectional study was conducted among undergraduate university students (N = 420) in the Mid-Atlantic region of the United States to assess the association between interoceptive awareness and sleep outcomes. Participants received a survey link and completed …

Side Effects, Shannon R. Kurzyniec

Theses and Dissertations

Through the exploration of the personal and social impacts of prescription medications on the human condition, I have discovered that the side effects of prescription medications on myself and others are much greater than I had ever anticipated. The deeper I dig into my subconscious, the further back I find that the impact was created. Most of us are taught at a young age to take medicine when we don’t feel well. Stomach ache, headache, sore throat, fever, even the imaginary boo boo is given a pill to cure. As we age we begin to reach for pills due to …

Notes Toward A Personal Afrofuturism, Jalen T. Adams

Theses and Dissertations

This paper is penned by a young adult who is generally confused about a lot of things regarding life, but has one singular focus that is perhaps larger than life—trying to find the bridge between a future already lived, and a past yet to happen. These are his findings so far.

Large Language Models, Prompting, And Synthetic Data Generation For Continual Named Entity Recognition, Charles I. Cutler

Theses and Dissertations

With the ever-growing amount of textual data, the task of Named Entity Recognition (NER) is vital to Natural Language Processing (NLP), a field which focuses on enabling computers to understand and manipulate human language. NER enables the extraction of information from unstructured text. Accurate information extraction is crucial for applications ranging from information retrieval to systems for question-answering. To ensure that NER models are robust to changes in data distributions and capable of recognizing new entity types, one may consider expanding the capabilities of an existing model. Continual learning is a paradigm within machine learning. It studies the objective of …

Analyzing The Role Of Slc25a32 In Hepatocellular Carcinoma, Mimansha Shah

Theses and Dissertations

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related deaths worldwide. Despite advances in understanding its molecular pathogenesis, treatment options for HCC remain limited, highlighting the need for identifying novel therapeutic targets. This study investigates the role of SLC25A32, a mitochondrial transporter gene located on chromosome 8q22.3, in HCC progression. SLC25A32 is involved in the transport of tetrahydrofolate (THF) and flavin adenine dinucleotide (FAD) into mitochondria, playing a crucial role in one-carbon metabolism and redox balance. Using CRISPR/Cas9 technology, we generated potential SLC25A32 knockout clones in the HCC cell line Huh-7. Quantitative PCR …

Supervisor-Subordinate Communication In The Contemporary Audit Environment, Devon P. Jefferson

Theses and Dissertations

Just five years ago I was working as an Audit Manager in person (in the office or at the client site), amongst each of my subordinates, which made common work practices like knowledge sharing, responding to questions, and building team morale easy. Since then, remote work has become the new norm, which has significantly changed the communication dynamics between supervisors and subordinates. This dissertation is my personal pursuit to understanding how supervisor and subordinate auditors are currently interacting to achieve desired work outcomes, and identifying specific areas where challenges may exist. I accomplish this objective through four papers, including a …

The Effect Of 17Β Estradiol On Local Production Of Active Vitamin D3 Metabolites In Laryngeal Squamous Cell Carcinoma, Tillat Batool

Theses and Dissertations

Laryngeal squamous cell carcinoma (LSCC) has garnered attention as a sex-hormone-dependent cancer with notable responsiveness to 17β-estradiol (E₂), in which it’s tumorigenesis can be mediated through estrogen receptors (ER). The ESR1 gene encodes for the classical full-length ERα66, as well as splice variants ERα36 and ERα46. Previous studies have shown that an active vitamin D₃metabolite, 24R,25(OH)₂D_3. has pro-tumorigenic or anti-tumorigenic responses in LSCC cells with different ER profiles, and that the tumor cells have the capability of localized production of vitamin D metabolites at the cellular level when treated with 25(OH)D₃-d6 …

Capiz Reborn: Preserving And Enhancing Traditional Philippine Shellcraft, Destarte A. Prieto

Theses and Dissertations

The capiz shell is a thin, translucent exoskeleton of a mollusk found in the Philippine Sea. Traditionally, capiz shells were made into window panes and home decor, used so widely they became an iconic part of Philippine identity. Today, the influx of cheap, mass-produced merchandise threatens the capiz shell industry. To encourage renewed interest and sustainable revival of this long-standing industry, my research demonstrates new possibilities for the capiz shell.

In reconstituting cast-off bits and shell trimmings to form a new capiz biomaterial, my work is informed by the three traditional techniques used by Philippine capiz artisans—sewing, welding and bonding. …

Spin Wave Devices For Embedded Applications And Information Processing, Raisa Fabiha

Theses and Dissertations

Device miniaturization is a prerequisite for modern day electronics. Spintronics offers immense potential in energy efficient data storage, solid states devices, ultrafast computing and other electronic applications because of their low power consumption, non-volatile nature and unique activation mechanism. The conventional nano-antennas used for wireless communication, biomedical and wearable devices and IoT applications are limited by the traditional Harrington limit. As we attempt to miniaturize the antenna size beyond its emitted wavelength (also called “subwavelength” antenna), its gain and efficiency plummet. To overcome this challenge, the researchers have proposed magnetoelectric antennas. The ultra-thin film based magnetoelastic antennas suffer from eddy …

How Ebony Transcends In The Ivory Tower: Unveiling Transformational Black Women Forging Leadership Paths In Historically White Institutions, Lauren N. Jackson

Theses and Dissertations

Considerable literature has amplified the perceived challenges and deficits of Black women as they advance in their careers within historically white institutions (HWI). As a result, there is a notable absence of anti-deficit explorations of the inherent abilities and strengths that contribute to Black women’s professional mobility. Grounded in anti-deficit achievement framework and Black feminist leadership, this study aimed to illuminate the assets and factors that influence the professional ascension of seven, current/former senior-level Black women in a HWI within the Southeastern region of the U.S. By adopting a qualitative, phenomenological framework, this study provides in-depth insights into the participants’ …

Sphingosine Kinase 2 Depletion Dysregulates Hepatic Redox Metabolism And Enhances Inflammation In Early Metabolic Dysfunction-Associated Steatohepatitis (Mash), Kaitlyn Georgene Jackson

Theses and Dissertations

Metabolic dysfunction-associated steatotic liver disease (MASLD) currently affects one in three people worldwide; its prevalence is growing alongside other cardiometabolic disorders. Aberrations to redox and sphingolipid metabolism contribute to MASLD pathologic progression. Sphingosine-1-phosphate (S1P) is an active lipid, meaning that S1P participates in biochemical processes within the cell. S1P is generated by two distinct isoenzymes, sphingosine kinase (SphK)1 and SphK2. The localization of the SphK enzyme dictates S1P function. While cytosolic SphK1-generated S1P is well-characterized, nuclear and mitochondrial SphK2-generated S1P is less known. Moreover, SphK2 depletion effects on cellular redox processes and inflammation are not well-defined.

This study defines the …

Cardiometabolic Genomics And Pharmacogenomics In Filipino Americans: A Cross-Sectional Study, Khalifa Y. Alrajeh

Theses and Dissertations

Background: Heart disease remains a leading cause of death in the country, with significant ethnic disparities. Filipino Americans (FAs), the third-largest Asian subgroup in U.S., face an elevated burden of dyslipidemia, a primary modifiable risk factor for heart disease. Objectives: This community-based study addresses critical knowledge gaps by characterizing the cardiometabolic and genetic factors contributing to dyslipidemia among FAs and implications for personalized cardiovascular drug therapies, particularly statin pharmacogenomics (PGx). Methods: We characterized dyslipidemia prevalence in FAs and major ethnic subgroups using nationally representative NHANES data. We examined associations between uric acid (UA) levels and lipid profiles, …

Longitudinal Analysis Of Maternal Depression, Physical Work Demand, And Working Hours Before, During, And After Pregnancy On Offspring Blood Pressure Trajectories, Medhin Tsegaye Haile

Theses and Dissertations

Overall Abstract

Background: Pediatric high blood pressure (BP) is a growing global concern, with 1 in 7 adolescents in the U.S. experiencing elevated BP or hypertension. Maternal lifestyle factors, including depressive symptoms, physically demanding work, and work hours during pregnancy, may influence offspring BP trajectories. However, prior studies often focus on single time points or specific age groups, limiting understanding of long-term effects. This study investigates the associations between maternal depressive symptoms, physically demanding work-related factors, and work hours before, during, and after pregnancy with offspring systolic blood pressure (SBP) trajectories from early childhood to adolescence.

Methods: We utilized …

Observed Parent And Child Differences In Black Mothers Of Children With And Without Attention-Deficit/Hyperactivity Disorder, Sydney E. Padgett

Theses and Dissertations

Attention-Deficit/Hyperactivity Disorder (ADHD) is childhood's most common neuro- developmental disorder, mainly distinguished by a pattern of inattention, hyperactivity and/or impulsivity. Compared to the plethora of research on White children with ADHD, the research on Black children with ADHD is limited. Looking more closely at the functions related to parenting children with ADHD, there is even less information known on the interactions between Black children and their parents compared to White children and their parents. The primary aim of the thesis study was to compare observed parenting and child behaviors between Black mother/child dyads of children with and without ADHD. This …

A Multilevel, Mixed Methods Examination Of Food Insecurity, Housing Instability, And Cardiovascular Health, Sarah Collins

Theses and Dissertations

BACKGROUND

Housing instability and food access are both robust risk factors for cardiovascular disease (CVD), which claims more lives annually in the U.S. than cancer and chronic lung disease combined. We hypothesized that experiencing both housing instability and food insecurity would have an additive effect on CVD risk, resulting in elevated blood pressure (BP) and perceived stress among young adults (YA).

METHODS

This research examined the relationships between food insecurity, housing instability, stress, and cardiovascular disease risk through three aims. First, multivariate linear regression was used to assess associations among YA, focusing on eviction, food insecurity, and blood pressure. Second, …

The Role Of Hdac6 In Periodontal Inflammation, Hannah S. Lohner

Theses and Dissertations

Periodontal disease is a polymicrobial infection-induced chronic inflammatory disease and results in irreversible tissue damage and bone loss. While bacteria play a large role in the initiation of this disease, excessive and prolonged inflammatory immune responses are fundamental for its progression, making host directed therapy (HDT) a possible and potentially valuable treatment. Histone Deacetylase 6 (HDAC6) is an enzyme that removes acetyl groups from both histone and non-histone proteins, giving it a potential role in regulating inflammation initiated by pathogenic oral bacteria. Previous studies indicated that HDACs act as a bivalent regulator in inflammatory responses; however, the role that HDAC6 …

Correlates Of Coffee And Energy Drink Use Among Individuals With Severe Alcohol Use Disorder, Enkelejda Ngjelina

Theses and Dissertations

Research on caffeine consumption among college students and young adults has primarily focused on caffeinated energy drinks (EDs) and their combination with alcohol, demonstrating a strong association with heavy and problematic alcohol use. However, little attention has been directed toward older adults. Furthermore, studies have shown that regular ED consumers are more likely to meet the criteria for alcohol dependence compared to their peers. Despite this association, little is known about ED consumption among individuals with Alcohol Use Disorder (AUD), particularly those undergoing treatment, and even less is understood about other caffeine sources such as coffee. This study aimed to …

Roleplaying Builds Character: Avatar Performance In Dungeons & Dragons As An Art-Form For Self-Development., Maria F. Pagola Garcia

Theses and Dissertations

This paper examines the impact of the performance and embodiment of Dungeons & Dragons characters on their player’s self-development and self-confidence. Focusing on the game’s 5th edition, this narrative inquiry study is concerned with the applications of D&D as an artistic tool to build both community in formal and informal spaces of art education and individual players’ self-development through the avatars being portrayed during game time.

Ten adult participants ranging from age 23-28 were selected using a mix of direct recruitment and voluntary response. They filled out a digital survey introducing themselves and their main D&D characters, then a 45-minute …

Acute Effects Of An Oral Nicotine Pouch In People Who Use Smokeless Tobacco, Alisha Eversole

Theses and Dissertations

People who use smokeless tobacco (SLT) are exposed to a variety of carcinogenic toxicants, yet, despite health risks, nearly 6 million people in the US use SLT. SLT contains and delivers nicotine, a psychostimulant that causes dependence and hinders cessation efforts. An orally-administered nicotine pouch marketed as “tobacco-free” recently has become available for purchase in the US. However, there are very few non-industry-sponsored studies regarding the effects of these oral nicotine pouches.

The current study used clinical laboratory methods to determine the acute effects of an oral nicotine pouch in people who use SLT. Participants completed four sessions (within subjects, …

Towards Effective Developer Communication In Open Source Software Via Emotional Awareness, Mia Mohammad Imran

Theses and Dissertations

Emotions play an integral yet understudied role in open-source software development, profoundly shaping critical collaborative processes such as knowledge sharing, decision-making, and team dynamics. However, accurately detecting and analyzing emotions in developer communications poses significant challenges due to the lack of visual and auditory cues in text-based interactions. This dissertation investigates techniques to enhance the understanding and modeling of emotions within the textual artifacts of open-source projects. We conduct an extensive evaluation of existing emotion classification tools using a novel dataset of annotated GitHub comments. An error analysis reveals deficiencies in handling implicit emotional expressions and figurative language. We demonstrate …

Problems In Graph Theory With Applications To Topology And Modeling Rna, Rayan K. Ibrahim

Theses and Dissertations

In this thesis, we explore four projects. In the first project, we explore $r$-neighbor bootstrap percolation on a graph $G$. We establish upper bounds for the number of vertices required to percolate in the case that $r=2$ for particular classes of graphs. In the second project, we study the structure of graphs with independence number two. We prove a lower bound on the number of edges of such graphs, related to an upper bound on the number of edges in a triangle-saturated graph, and give a sufficient forbidden induced subgraph condition for independence number two graphs. In the third project, …

Latent Profiles Of Child Coping And Perception Of Experience Processes To Predict Long-Term Symptoms Of Depression, Intrusive Grief, And Suicidality Outcomes In Parentally Bereaved Children, Rebecca Hoppe

Theses and Dissertations

Childhood bereavement is a significant public health issue and the most distressing form of childhood trauma. The death of a parent can disrupt the course of a children's development and potentially predispose them to enduring adverse mental health outcomes, such as depression, intrusive grief, and suicidality. Recognizing grief as a dynamic process, theories have suggested that children’s unique coping and perceptions of experience can contribute to variations in individual adaptations to the death and the onset of mental health problems. The goals of this study were to (a) use latent profile analysis to empirically group recently bereaved children into distinct …

Exploring The Role Of Senescence In Disuse-Induced Bone Loss And Therapeutic Strategies For Prevention, Steven J. Meas

Theses and Dissertations

Both age-related and disuse-related bone loss result in decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. Disuse induces physiological changes in bone similar to those seen with aging. This study compared age- and disuse-related bone loss using C57BL/6J mice of various ages that were hind-limb unloaded (HLU). In male and female mice, HLU induced a bone phenotype between those of 6-month-old and 22-month-old control mice. Gene analysis suggested that HLU leads to mitochondrial dysfunction, while aging primarily downregulates cell cycle processes. Although, the specific response to HLU appeared to be dependent on age. The study identified …

A Qualitative Analysis Of Section 1983 Filings By Incarcerated Plaintiffs, Hollie Macdonald

Theses and Dissertations

The onset of the COVID-19 pandemic was a “watershed moment" in human history, transcending its role as a mere health crisis to reveal deeper fissures within societies. The present retrospective longitudinal study examined COVID-19 as an “era” of complexity utilizing it as an intermediate construct that delineates “pre-COVID” and “post-COVID.” In order to understand the impact of the COVID-19 era, the design of the study and hypotheses stem from an assumption of the interconnectedness of issues related to health, social justice, racial justice, politics, and information dissemination.

This study utilized both manifest and latent content analysis to explore the most …

The Relationship Between Outcomes Associated With Patient Blood Management Programs And Transfusion Safety Officers, Gary Morral

Theses and Dissertations

BACKGROUND: Patient Blood Management (PBM) has become the standard of care for transfusion services in hospitals. Transfusion Safety Officers (TSOs) have been identified by some as being a crucial part of a successful PBM program; however, no studies have been done to show their effectiveness, or if there is even a relationship between having a TSO and outcomes associated with PBM programs. The purpose of this study was to describe and test the relationship between having a TSO and six outcomes associated with PBM programs including blood product wastage (red blood cells, plasma, and platelets), hospital lengths of stay, rates …

Effect Of Social Anxiety On Trial-By-Trial Changes In Attentional Biases To Emotional Faces, Nina Plotnikov

Theses and Dissertations

Cognitive research suggests that many anxiety disorders, including social anxiety disorder, are associated with an increased attentional bias toward potentially threat-related stimuli. However, inconsistent findings suggest the effect of anxiety on attentional bias to threat is not direct and that other factors, including emotion, perceptual load, and time on-task, impact the relationship between social anxiety and attentional biases to facial stimuli. In the present study, 157 undergraduate students completed a computerized letter search task identifying one of two target letters (N or X) from a circular arrangement of different letters (high load) or dots (low load). In 20% of trials, …