Digital Commons Network^™

To, From: Of Time, Of Distance, Of Body And Mind, Fanxi Sun

Theses and Dissertations

This paper introduces the concepts, theories, and techniques associated with my thesis project “To, From.” The paper consists of three parts: Time as Structure, Distance as Premise, and Body and Mind. Each chapter is written in a mixture of personal narration and a general introduction to materials that are directly or implicatively relevant and important to the creation of my project. In this experimental narrative comprises film screening and live performance with multi-channel sound, I tell a story of non-story. Words and the exchange of words, movements and non- movements, objects that are being handled and subjects that are handling... …

Development Of A Qa Plan For A 3.0t Cannon Galan Mr-Sim, Nathaniel D. Teague

Theses and Dissertations

Purpose: To develop and incorporate a QA (quality assurance) program for a Canon Galan 3 tesla MR Simulator for applications in radiation therapy.

Methods and materials: The QA program was centered around tests performed with three separate levels of frequency. The daily QA procedure consisted of scanning a vendor provided daily QA cube phantom that measures basic performance parameters. Additionally, a series of basic safety check were performed. The monthly QA procedure consisted of several tests, including scanning the ACR MRI large accreditation phantom and manually performing its corresponding image quality tests. Scanning the MagPhan RT for its detailed geometric …

Through The Lens Of Glass, Paul J. Van Den Bijgaart

Theses and Dissertations

Glass is a key component of the development of the modern world and within this China has become the leading producer and consumer of the material. Through the dedication to my skilled craft as a glassblower I use my material understanding to explore eastern and western philosophical associations and artistic concepts through painting. As well as investigate the relevance of how craft contributes to the development of culture through consumables. An intuitive expressionist painting style is explored in relation to landscape painting with glass as a practice towards mindful engagement within an age of digitized globalization.

“Trans Broken Arm Syndrome”: Examining Causal Antecedents Of Gender-Related Medical Misattribution And Invasive Questioning In An Analogous Healthcare Setting Through The Lens Of Person Perception, Catherine Wall

Theses and Dissertations

Transgender individuals face particular challenges when interacting with a cisgender focused medical system. Gender-related medical misattribution and invasive questioning (GRMMIQ), colloquially known by the tongue-in-cheek named “trans broken arm syndrome,” is a form of medical discrimination wherein a healthcare provider assumes that a transgender patient’s medical complaints, regardless of origin, result from their gender identity or medical transition. Previous research has suggested that this, and other forms of identity-related discrimination both in and outside of healthcare, might be understood either using a top-down approach focused on stereotypes founded in schema, or a bottom-up approach examining perceived typicality. One additional theory, …

Attitudes And Beliefs Of Cannabis Use During Pregnancy: Hashing Out The Impact Of Location And Legality, Anna Wiese

Theses and Dissertations

As more states authorize the use of cannabis for medical and recreational purposes, rates of prenatal cannabis use are on the rise. Yet research on perceptions of prenatal cannabis use has been limited, and the existing research lacks reliable, quantitative measures. In response, researchers in Denver developed the Perceptions of Prenatal Cannabis Use (PPCU) survey, a 16-item measure designed to assess perceived risks and benefits of prenatal cannabis use. The present study analyzed PPCU survey data administered at three different recruitment sites (Denver, CO; Pittsburgh, PA; and Richmond, VA). The present study examined women’s perceptions of the risks and benefits …

Prospective Investigation Of Insomnia Symptoms And Sleep Duration As Risk Factors For Stroke Incidence And All-Cause Mortality In U.S Adult, Wendemi Sawadogo

Theses and Dissertations

Background and Objectives: Stroke is the second leading cause of death in the world. In the United States, on average, someone has a stroke every 40 seconds and someone dies as a result of stroke every 3.5 minutes. Identifying modifiable risk factors of stroke is therefore a public health priority. The purpose of this study was to investigate the extent to which insomnia symptoms and sleep duration contribute to stroke incidence, all-cause mortality, and explore potential causal pathways.

Methods: The Health and Retirement Study (HRS) and the REasons for Geographic And Racial Differences in Stroke (REGARDS) study were …

Random Acts Of Stem: A Systematic Review Of Local K-12 School Division Stem Experiences In Virginia, Caro H. Medawar

Theses and Dissertations

The initial purpose of the study was to determine whether the school divisions in Virginia have definitions of STEM education. For the divisions that have described STEM education, the following valuation was based on the precise STEM education definition each has implemented. The population for the study included all 132 school divisions in This mixed-methods study investigated the implementation of STEM programs in Virginia K-12 schools. Data were collected through two avenues: publicly available online resources from school divisions and interviews with STEM leaders in the Virginia educational system. Data analysis on these two sources yielded five themes: (a) existence …

Examining Psychosocial Factors Of Chronic Disease Control To Improve Outcomes For Patients With Multiple Chronic Conditions, Kristen O'Loughlin

Theses and Dissertations

Psychosocial needs are associated with worse health outcomes for patients with multiple chronic conditions (MCC). The Biopsychosocial Model provides a framework for conceptualizing the influence that psychosocial factors have on the management of disease. To date, research has primarily focused on examining the relation between psychosocial factors and chronic disease onset. Therefore, the temporal relation between psychosocial factors and disease management remains poorly understood. The current study aimed to 1) describe patients’ psychosocial needs and their prioritization, 2) examine reciprocal relations between anxious symptoms, depressive symptoms, social needs, and MCC management, and 3) qualitatively explore patient definitions of health in …

Using Superatomic Clusters And Charge Transfer Ligands To Control Electronic Characteristics Of Phosphorene Nanoribbons And Phosphorene Monolayer, Ryan Lambert

Theses and Dissertations

Phosphorene is a two-dimensional electron poor p-type semiconductor with high carrier mobility and great promise for applications in electronics and optoelectronics. As the main theme in this dissertation, the following work represents different investigations of various electronic properties associated with phosphorene. Most notable are the findings on charge transfer doping with metal-chalcogenide superatoms which displays novel control of the two most important properties of a semiconductor – the band gap energy and the nature of carriers. By tuning the width of the gap and p-/n-type character of conduction, we gain control over a material’s capacity to play a certain role …

Early Termination In Phase Ii Clinical Trials: Admissible Designs Using Decreasingly Informative Priors, Chen Wang

Theses and Dissertations

In Phase II clinical trials, Thall and Simon’s Bayesian posterior probability design is commonly implemented to allow for an early termination to determine whether a new treatment warrants further investigation in a larger-scale Phase III trial; this in turn requires a pre-selected prior distribution based on known clinical opinion or historical information. Moreover, this Bayesian approach can result in an issue of inflating type I error rate by monitoring interim data to inform early termination decisions. Alternatively, a Bayesian approach with the decreasingly informative prior (DIP), which is an informative yet skeptical prior, can be implemented to overcome the contentious …

Evaluating The Acute Effect Of Vaping On Food Intake, Gabrielle Maldonado

Theses and Dissertations

Background: Weight control is a common motive for continued cigarette smoking, and weight concerns pose a barrier to quitting. These effects are driven in part by nicotine’s ability to reduce overall appetite and ultimately body weight. Electronic nicotine delivery systems (ENDS) have been marketed and used for weight control, suggesting that the use of these products potentially may share similar effects as well as barriers to quitting as observed for cigarette smoking. However, little to no controlled clinical lab evidence exists supporting ENDS use for weight control. The present study tested the influence of an ENDS on acute eating behavior …

A Learning Health System For Radiation Oncology, Rishabh Kapoor

Theses and Dissertations

The proposed research aims to address the challenges faced by clinical data science researchers in radiation oncology accessing, integrating, and analyzing heterogeneous data from various sources. The research presents a scalable intelligent infrastructure, called the Health Information Gateway and Exchange (HINGE), which captures and structures data from multiple sources into a knowledge base with semantically interlinked entities. This infrastructure enables researchers to mine novel associations and gather relevant knowledge for personalized clinical outcomes.

The dissertation discusses the design framework and implementation of HINGE, which abstracts structured data from treatment planning systems, treatment management systems, and electronic health records. It utilizes …

Exploring Polyamorous Relationship Experiences Of Lesbian, Gay, Bisexual, And Pansexual Individuals, Jiale Man

Theses and Dissertations

Polyamory is a type of relationship under the consensual non-monogamy relationship umbrella that assumes the possibility, validity, and worthwhileness of maintaining romantic, sexual, and intimate relationships with multiple people simultaneously. In Western society, the prevalence and domination of mononormativity have led to the marginalization of relationships alternative to monogamy (i.e., polyamory). As a result, individuals in polyamorous relationships continue to experience bias, stigma, and discrimination at varying levels. With a rise in public interest in CNM in the past two decades, scientists and researchers have slowly started to examine various topics related to CNM, including its prevalence, public attitudes toward …

The Effect Of Mild Traumatic Brain Injury On Perineuronal Nets Surrounding Neocortical Parvalbumin Interneurons, Olivia Lowman

Theses and Dissertations

Mild traumatic brain injury (mTBI) is an extremely common affliction with an estimated 42 million people being affected by it worldwide each year. It can lead to a range of long-term chronic issues and the underlying pathology is not well understood. Several previous studies have shown that parvalbumin inhibitory interneurons (PV+) are injured during TBI, therefore altering the excitatory to inhibitory ratio in neural networks which can lead to several neurodegenerative disorders such as epilepsy. Perineuronal nets (PNNs) are an extracellular matrix element that preferentially surround PV+ neurons in the neocortex and are recently thought to have important roles in …

How Do Early Interventionists Adapt Instruction When Delivering Services In Natural Environments?, Brian C. Wysong

Theses and Dissertations

Early Interventionists (EIs) play a pivotal role in supporting development for young children with disabilities. It is vital that they are able to support child and family outcomes through building strong partnerships with families, utilizing best practices, and individualizing services to children and families. The purpose of this study was to explore early interventionists’ perceptions regarding how they adapted instruction when delivering services in natural environments. Specifically, this study aimed to understand how changes in the child’s skill level, interests, and level of engagement affected early interventionists’ decision-making process during service delivery. A qualitative research design was employed, utilizing semi-structured …

Machine Learning Models To Automate Radiotherapy Structure Name Standardization, Priyankar Bose

Theses and Dissertations

Structure name standardization is a critical problem in Radiotherapy planning systems to correctly identify the various Organs-at-Risk, Planning Target Volumes and `Other' organs for monitoring present and future medications. Physicians often label anatomical structure sets in Digital Imaging and Communications in Medicine (DICOM) images with nonstandard random names. Hence, the standardization of these names for the Organs at Risk (OARs), Planning Target Volumes (PTVs), and `Other' organs is a vital problem. Prior works considered traditional machine learning approaches on structure sets with moderate success. We compare both traditional methods and deep neural network-based approaches on the multimodal vision-language prostate cancer …

Model-Based Imputation Of Below Detection Limit Missing Data And Group Selection In Bayesian Group Index Regression, Matthew Carli

Theses and Dissertations

Investigations into the association between chemical exposure and health outcomes are increasingly focused on the role of chemical mixtures, as opposed to individual chemicals. The analysis of chemical mixture data required the development of novel statistical methods, one of these being Bayesian group index regression. A statistical challenge common to all chemical mixture analyses is the ubiquitous presence of below detection limit (BDL) data. We propose an extension of Bayesian group index regression that treats both regression effects and missing BDL observations as parameters in a model estimated through a Markov Chain Monte Carlo algorithm that we refer to as …

Selected Problems In Graph Coloring, Hudson Lafayette

Theses and Dissertations

The Borodin–Kostochka Conjecture states that for a graph G, if ∆(G) ≥ 9 and ω(G) ≤ ∆(G) − 1, then χ(G) ≤ ∆(G) − 1. We prove the Borodin–Kostochka Conjecture for (P5, gem)-free graphs, i.e., graphs with no induced P5 and no induced K1 ∨P4.

For a graph G and t, k ∈ Z+ at-tone k-coloring of G is a function f : V (G) → [k] such that |f(v) ∩f (w)| < d(v,w) for all distinct v, w ∈ V(G). The t-tone chromatic number of G, denoted τt(G), is the minimum k such that G is t-tone k-colorable. For small values of t, we prove sharp or nearly sharp upper bounds on the t-tone chromatic number of various classes of sparse graphs. In particular, we determine τ2(G) exactly when mad(G) < 12/5 and also determine τ2(G), up to a small additive constant, when G is outerplanar. Finally, we determine τt(Cn) exactly when t ∈ {3, 4, 5}.

The Living Legends Of Sholoukh – شلوخ الأساطير Facial Scarification In Sudan, Ayah S. Elnour

Theses and Dissertations

Sholoukh — ritual face scarring—is a dying art form in Sudan.

Used to distinguish members of one tribe from another,

Sholoukh reflects the tribal pride of an individual. In the past,

sholoukh was seen as important as having a passport for a tribe

member, however, it was not always applied by choice. Using

just a razor blade, the wisest, most senior tribal elder would scar

the face of a child, initiating them into the tribe for life.

As this tribal art form fades away, the dwindling Sholoukh-bearers

have become living legends in Sudan. To honor them, I create

a collage …

Kpt-330 Synergizes With Everolimus To Reduce Mtorc1-Overactive Basal-Like Triple-Negative Breast Cancer Brain Metastasis Burden, Aaron D. Valentine

Theses and Dissertations

Triple-negative breast cancer (TNBC), a highly metastatic breast cancer subtype, accounts for approximately 20% of all breast cancer diagnoses. Basal-like TNBC is notably difficult to treat due to the lack of actionable drug targets such as estrogen and progesterone receptors, as well as HER2. Due to the deficiency in TNBC-targeting drugs that are able to cross the blood-brain barrier (BBB) for breast-to-brain metastasis, there is a need to develop novel BBB-permeable treatments. After preliminary testing, KPT-330 (XPO1 inhibitor) and everolimus (FKBP1A/mTOR inhibitor) were selected as drug candidates for this study. Patient-derived xenograft (PDX) models for in vitro and in vivo …

Community On Campus: Examining The Impact Of Campus Climate, Belonging, And Flourishing On Bystander Behavior Among Diverse University Students, Amelia Liadis

Theses and Dissertations

This exploratory, nonexperimental study aimed to investigate the relationships among diverse undergraduate and graduate students’ perceived campus climate, flourishing, and university belonging on bystander intentions and bystander behaviors during the COVID-19 pandemic. The study’s theoretical framework combined the Theory of Planned Behavior and feminist theory, and examined intersectionality through an Identity Risk Index. Data used in the current study were originally collected as part of an institutional Healthy Minds Survey, on health behaviors of college students; responses from n = 171 of the randomly selected participants were used in the current study’s analyses. The majority of participants indicated at least …

Effects Of Slip On Highly Viscous Thin-Film Flows Inside Vertical Tubes (Constant Radius, Constricted And Flexible), Mark S. Schwitzerlett

Theses and Dissertations

Viscous liquid film flows in a tube arise in numerous industrial and biological applications, including the transport of mucus in human airways. Previous modeling studies have typically used no-slip boundary conditions, but in some applications the effects of slip at the boundary may not be negligible. We derive a long-wave model based on lubrication theory which allows for slippage along the boundary. Linear stability analysis verifies the impact of slip-length on the speed, growth rate, and wavelength of the most unstable mode. Nonlinear simulations demonstrate the impact of slip-length on plug formation and wave dynamics. These simulations are conducted for …

“It's Just Not Enough”: Examining The Experiences Of School-Based Sexual Health Education And Conversation Engagement With Trusted Adults Among Black Boys In Richmond, Va, Sharyn A. Dougherty

Theses and Dissertations

The Centers for Disease Control and Prevention estimate that youth make up a quarter of the sexually active population, yet account for half of the 20 million new sexually transmitted infections in the United States.In 2021, youth age 15-19 living in Virginia’s central region, which includes the Richmond Metropolitan area, had the second highest number of chlamydia cases and fourth highest number of gonorrhea cases among all age groups, with the highest rates among Black youth. The aim of this study is to explore the experiences of Black youth in Richmond, VA with school-based sexual health education (SHE) and their …

Rainbow Turan Methods For Trees, Victoria Bednar

Theses and Dissertations

The rainbow Turan number, a natural extension of the well-studied traditional
Turan number, was introduced in 2007 by Keevash, Mubayi, Sudakov and Verstraete. The rainbow Tur ́an number of a graph F , ex*(n, F ), is the largest number of edges for an n vertex graph G that can be properly edge colored with no rainbow F subgraph. Chapter 1 of this dissertation gives relevant definitions and a brief history of extremal graph theory. Chapter 2 defines k-unique colorings and the related k-unique Turan number and provides preliminary results on this new variant. In Chapter 3, we explore the …

Coming Out To Treatment: Identifying Facilitators & Characterizing Experiences Of Sexual And Gender Minoritized Individuals In Opioid Use Disorder Treatment Before And During The Covid-19 Pandemic, Jaclyn S. Sadicario

Theses and Dissertations

Sexual and Gender Minority (SGM) individuals are disproportionately impacted by substance use disorders vs. their non-SGM counterparts. Additionally, SGM folks face more barriers to access for treatment than others due to minority stressors including discrimination, internalized stigma, and marginalization related to their sex and gender minority statuses. It is important for researchers and treating providers alike to understand how these different factors are impacting the treatment of substance use disorders in SGM populations. With this in mind, this two phase study employed a mixed-methods approach to (1) describe the population of SGM folks enrolled in a MOUD treatment program with …

The Influence Of The Covid-19 Pandemic On Rural Virginia Secondary Teachers’ Self-Efficacy, Sherol L. Southerland

Theses and Dissertations

The COVID-19 pandemic has presented unique challenges for PK-12 education and exposed educators’ skill deficits. Teachers had to learn new approaches to doing their jobs while navigating the mental, emotional, spiritual, and financial impact of the pandemic on their personal lives. This undertaking was even more demanding for rural school divisions, which tend to lack the resources (e.g., personnel, technology, financial) that suburban and urban school divisions have. Schools reopened in fall 2020 offering fully remote, fully in-person, and hybrid modalities, however, there was no going back to teaching as it was before the pandemic. The present study sought to …

Grounded In Teachers’ Reality: A Collective Case Study On Middle School Teachers’ Self-Efficacy For Equity-Centered Trauma-Informed Educational Practices, Margaret Wallace

Theses and Dissertations

The current body of literature clearly demonstrates the high prevalence of student trauma and the significant impact of trauma on adolescents' well-being and academic outcomes. Middle school teachers are uniquely positioned to support adolescents experiencing trauma using trauma-informed educational practices (TIEP), however, more work is needed to understand their self-efficacy beliefs for using TIEP. Thus, the purpose of this qualitative collective case study is to explore middle-school teachers' self-efficacy (TSE) beliefs for trauma-informed educational practices particularly as they relate to centering equity, and what factors impact those beliefs. Specifically, my study asks the following research questions, (1) How do middle …

Examining The Home Interventionist Model Of Care In Pediatric Asthma, Katherine D. Lohr

Theses and Dissertations

Pediatric asthma disproportionately affects children living in urban areas and within families reporting an income below the poverty threshold. Home interventionist models of care, utilizing interventionists from the communities they serve, have been found to improve pediatric asthma symptoms and reduce Medicaid costs. Home interventionists, such as community health workers (CHWs) and Healthy Homes assessors (HHAs), focus on connecting care among schools, providers, and homes, and empowering families in accessing resources to overcome barriers to care. However, research is just beginning to understand how home interventionists create positive change among families within low-income, urban communities. This dissertation study used a …

Evaluation Of Spliceai For Improved Genetic Variant Classification In Inherited Ophthalmic Disease Genes, Melissa Reeves

Theses and Dissertations

ABSTRACT

EVALUATION OF SPLICEAI FOR IMPROVED GENETIC VARIANT CLASSIFICATION IN INHERITED OPHTHALMIC DISEASE GENES

By Melissa Jean Reeves, Ph.D.

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University.

Virginia Commonwealth University, 2023

Major Director: Melissa Jamerson, PhD, MLS(ASCP)

Associate Professor, Department of Medical Laboratory Sciences

Inherited ophthalmic diseases impact individuals around the globe. Inherited retinal diseases (IRDs) are the leading cause of blindness in individuals aged 15 to 45. The personal, social, and economic impact of vision loss is profound. Due to individual differences, symptoms can be variable, and …

Improving The Use Of Diffusing Wave Spectroscopy As A Multiphase Process Analytical Technology, Robert Emerson Mcmillin Iii

Theses and Dissertations

The study of multiphase formulations is a difficult task due to inhomogene- ity. Typical methods of study, such as microscopy, suffer from sampling drawbacks and are ill-equipped at probing the system in its native state. Additionally, more concentrated sys- tems, including optically-dense emulsions and suspensions, render common light-scattering techniques, such as dynamic light scattering (DLS), useless. Lastly, macroscopic phase track- ing or transmission intensity techniques can only obtain partial information about a system. Herein, the use of diffusing wave spectroscopy (DWS), a multiple scattering adjunct to DLS, to study optically dense multiphase systems is explored. Three different systems are exam- …