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Review Of The Effects Of Asphalt Fume Emission (Vocs And Pahs) In Vitro, In Vivo And Human Studies, Omran Taqi, Nastassja Lewinski, Elham Fini, Eran Rozewski, Judith Klein-Seetharaman

Undergraduate Research Posters

Review of the effects of Asphalt fume emission (VOCs and PAHs) in vitro, in vivo and human studies

Omran Taqi, Nastassja Lewinski¹

1) Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA

Background

Asphalt is abundantly available around human operations including road paving and roofing sites. However, their emissions and fumes (specifically volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs)) have been found to have adverse effects on health. Asphalt fumes are a class 2A carcinogen and exposure can increase the risk of lung cancer, asthma, headache, fatigue, and other cardiovascular diseases.

Methods

We used …

Astrocyte Elevated Gene-1 (Aeg-1) Deletion Selectively Enhances The Antinociceptive Effects Of Morphine, Apurva Puli, Shivani Patel, Bryan Mckiver, Eda Köseli, Devanand Sarkar Ph.D., M. Imad Damaj Ph.D.

Undergraduate Research Posters

Background: Opioids are a class of drugs that are utilized in clinical settings to alleviate acute and chronic pain, but can often lead to development of tolerance, addiction and overdose following prolonged usage. Opioids such as morphine function by activating endogenous µ opioid receptors, which are located in various tissues throughout the body. Astrocyte Elevated Gene-1 (AEG-1) is a multifunctional protein that regulates inflammation, myeloid cell activity and lipid metabolism. Studies have shown interactions and overlaps in cellular signaling between the inflammatory/immune responses and the endogenous opioid system which could suggest a role for AEG-1 in opioids effects. Our goal …

A Participatory Group Process To Collect And Disseminate Covid-19 Needs Assessment Data, Areebah Ahmed

Undergraduate Research Posters

The Richmond, VA COVID-19 Needs Assessment Survey (RVA CoNA) was created in March 2020 to identify behaviors and needs related to COVID-19 in Richmond area adults ages 18 and over. Results are being used to inform support, strategic efforts, and educational outreach of local community organizations. The purpose of this study is to (1) summarize the process used to develop the RVA CoNA, (2) summarize preliminary survey results from a second phase of data collection as well as initial feedback from community partners, and (3) summarize initial conclusions and results dissemination strategies.Community partners and researchers at Virginia Commonwealth University jointly …

Determining Effective Treatment Regimens For Breast Cancer Using Combined Immunotherapy And Chemotherapy In Vivo, Akhila R. Kunuthuru, Laura Graham, Harry D. Bear Md, Phd

Undergraduate Research Posters

Breast cancer has the highest incidence rate of all cancers globally in women, and those of African descent, especially West African females, face higher rates of triple-negative breast cancer (TNBC), a more aggressive form of breast cancer. Immunotherapy for breast cancer is a relatively new treatment option, and research is ongoing to identify the best combination treatments for increasing survival of those diagnosed with TNBC. Eganelisib (IPI-549: a PI3K-gamma inhibitor that works to shift M2 macrophages to M1 to augment T cell function) with other combinatory treatments has shown promising results in reducing tumor growth and increasing survival in mice. …

Modified Ysk12-Mend-Sirna In Dendritic Cells For Cancer Immunotherapy, Syed S. Alam

Undergraduate Research Posters

Tumors may induce tolerogenesis through signaling dendritic cells to produce tolerogenic molecules, such as indoleamine 2, 3-dioxygenase 1 (IDO1). Tumor-associated immunosuppression is associated with higher mortality in patients. Small interfering RNA (siRNA) has been shown to silence specific target genes in the target cell. The siRNA associated with these genes could support a gene knockdown of these immunosuppressors and reduce mortality. Delivery of these therapeutic nucleic acids is difficult in vivo because siRNA is easily broken down inside the cell and the bloodstream through present nucleases. Use of liposome polymers has been reviewed extensively in literature. YSK12-C4, a lipid nanoparticle …

A Personal History Of The Department Of Biology, Margaret L. May

VCU University History Books

Former faculty member Margaret May recounts the history and development of the Department of Biology at Virginia Commonwealth University.

Mechanisms And Treatment Of Pain-Depressed Behavior In Male And Female Mice, Clare M. Diester

Theses and Dissertations

One of the largest discrepancies between preclinical and clinical assessment of pain and analgesia is the type of behavioral endpoint used. Although most preclinical research has historically focused on drug effectiveness to block reflexive withdrawal behaviors stimulated by a noxious stimulus, increasing evidence shows that drug-induced restoration of pain-depressed behaviors provides increased clinical translation with decreased susceptibility to false-positives. Accordingly, the first portion of this dissertation designed a behavioral battery that featured pain-depressed behaviors as well as more conventional pain-stimulated behaviors for testing candidate analgesics in male and female mice. The main findings are as follows. (1) Intraperitoneal injection of …

The Experiences Of Religiously And Spiritually Diverse Counselors And Psychotherapists Who Work With Survivors Of Sexual Violence, John M. Waters

Theses and Dissertations

The purpose of this qualitative study was to examine the lived experiences of religiously and spiritually diverse counselors and psychotherapists who work with survivors of sexual violence. The researcher used a transcendental phenomenological approach to understand how the participants engaged their religious and/or spiritual identity to cope with the traumatic stress that accompanies continuous exposure to their clients’ trauma narratives over time. As the only study that has examined these phenomena qualitatively, the present study aimed to enhance counselors and counselor educators’ understanding of the ways that religiously and spiritually diverse counselors make meaning of their experiences. The researcher collected …

Impact Of The Covid-19 Pandemic On Child Anxiety Symptoms: The Influence Of The Caregiver-Child Relationship, Rebecca Hoppe

Theses and Dissertations

Research suggests that youth are dealing with a myriad of worries during the COVID-19 pandemic (Ellis et al., 2020), which highlights the need for investigations focused on child anxiety. However, to date little research has examined children’s anxiety in the COVID-19 pandemic nor the potential protective effects of the caregiver-child relationship. Therefore, this research aimed to contribute to the literature by investigating the influence of COVID-19 related stressors in younger children and leveraging children’s report of their own attachment security within their relationship with their caregiver and mental health. The current study used a national, quantitative survey of young children …

Generation 1.5 Students’ Academic Success: The Interrelationship Between Capital Used And Identity Formation, Susan D. Dudley

Theses and Dissertations

As the number of people immigrating to the United States increases, so does the number of generation 1.5 students in K-12 education (Kanno & Cromley, 2013). With more generation 1.5 students graduating from U.S. high schools, more are also matriculating into higher education institutions (Harklau & Siegal, 2009; Kanno & Cromley, 2013; Kanno & Harklau, 2012; Roberge, 2009). While some generation 1.5 students are successful in U.S. higher education, others are not, and the percentage of generation 1.5 students who are successful is disproportionately less than the percentage of those students who have a U.S. heritage culture (Kanno & Harklau, …

Effect Of Clear Aligner Attachment Design On Extrusion Of Maxillary Lateral Incisors: A Randomized Clinical Trial, Justin Groody

Theses and Dissertations

Introduction: The aims of this randomized clinical trial were to compare the efficacy of extrusion of maxillary lateral incisors among “optimized”, rectangular “horizontal”, rectangular horizontal “incisally beveled”, rectangular horizontal “gingivally beveled” attachments, and to provide a clinically relevant recommendation for attachment planning for extrusion of maxillary lateral incisors during aligner treatment.

Methods: 30 16-to-58 year old Invisalign patients and 56 maxillary lateral incisors requiring extrusion were randomly allocated to one of four attachment groups (optimized, horizontal, incisally beveled, and gingivally beveled). Participants were recruited from two private practice offices and the Virginia Commonwealth University School of Dentistry. The outcome assessor …

Roots And Webs And Nets And Branches And Bulletin Boards And Banners And Newsletters And Mutual Aid Text Threads And Kin And Caretakers And Porches And Poems Of Today And Spaces Of Survival, Lukaza Branfman-Verissimo

Theses and Dissertations

As I welcome Richmond, VA into my family, I find myself needing to make roots and webs and nets and branches that ground me, that place myself as a Black, queer, mixed race, artist, activist, educator, storyteller, and cultural worker in this city. I am called to the streets before I am called to my studio. I question what it means to be a part of an institution that is slowly eating this city up. I become a story collector. I need to know where I am and whose land I now call home.

Improving Feature Learning Capability And Interpretability Of Unsupervised Neural Networks, Chathurika S. Wickramasinghe Brahmana

Theses and Dissertations

The motivation for this dissertation is two-prong. Firstly, the current state of machine learning imposes the need for unsupervised Machine Learning (ML). Secondly, once such models are developed, a deeper understanding of ML models is necessary for humans to adapt and use such models.

Real-world systems generate massive amounts of unlabeled data at rapid speed, limiting the usability of state-of-the-art supervised machine learning approaches. Further, the manual labeling process is expensive, time-consuming, and requires the expertise of the data. Therefore, the existing supervised learning algorithms are unable to take advantage of the abundance of real-world unlabeled data. Thus, relying on …

Temporal Disambiguation Of Relative Temporal Expressions In Clinical Texts Using Temporally Fine-Tuned Contextual Word Embeddings., Amy L. Olex

Theses and Dissertations

Temporal reasoning is the ability to extract and assimilate temporal information to reconstruct a series of events such that they can be reasoned over to answer questions involving time. Temporal reasoning in the clinical domain is challenging due to specialized medical terms and nomenclature, shorthand notation, fragmented text, a variety of writing styles used by different medical units, redundancy of information that has to be reconciled, and an increased number of temporal references as compared to general domain texts. Work in the area of clinical temporal reasoning has progressed, but the current state-of-the-art still has a ways to go before …

Advancing Forest Structure-Function Relationships: Linking Above- And Belowground Structure To Soil Respiration, Laura J. Hickey

Theses and Dissertations

Variation in the soil-to-atmosphere C flux, or soil respiration (Rs), is influenced by a suite of biotic and abiotic factors, including soil temperature, soil moisture, and root biomass. However, whether canopy structure is tied to soil respiration through its simultaneous influence over these drivers is not known. We assessed relationships between measures of above- and belowground vegetation density and complexity, and evaluated whether Rs is linked to remotely sensed canopy structure through pathways mediated by established biotic and abiotic mechanisms. Our results revealed that, at stand-scale, canopy rugosity–a measure of complexity–and vegetation area index were coupled to soil respiration through …

Peri-Implantitis Incidence And Effect Of Supportive Periodontal Therapy On Outcomes: Retrospective Cohort Study, Michael Ha

Theses and Dissertations

Purpose: Management of peri-implantitis is becoming an increasing component of dental practice. Dental implants can develop peri-implantitis lesions which occur in a non‐linear and accelerating pattern compared to a gradual periodontitis lesion. It is crucial to diagnose and treat this disease early, or ideally prevent it. Contemporary implants have a rough surface texture which is difficult to properly decontaminate as a crucial component for treatment prognosis. Evidence on the long-term effects of Periodontal implant maintenance therapy (PIMT) on implants is limited. This study aims to investigate the effect of periodontal maintenance on peri-implant tissue health.

Methods: A retrospective chart review …

Detailing The Genetic And Environmental Influences Shared Between Conventional And Electronic Cigarette Use Across Measures Of Initiation And Past 12-Month Use, James Clifford

Theses and Dissertations

Introduction. Tobacco use is a public health crisis with nearly 500,000 Americans suffering premature mortality attributable to tobacco use in 2014. New development efforts have created new nicotine delivery systems whose health consequences are not yet fully understood such as electronic cigarettes (ECIG). It is possible there are shared genetic and environmental factors that influence an individual’s liability to initiate cigarette (CIG) or ECIG use, as both systems are designed to deliver nicotine.

Methods. Four study designs were used to resolve the genetic and environmental influences that underlie CIG and ECIG initiation. A twin study, scoping review, genome-wide association study …

Mathematical Models Of Infection Prevention Programs In Hospital Settings, Kelly A. Reagan

Theses and Dissertations

Hospitals play a vital role in providing for the healthcare needs of a community. Patients can develop hospital-acquired infections (HAIs) during their hospitalization due to exposure to foreign bacteria, viruses, and fungi. Infection prevention programs target and reduce HAIs, but implementing the infection prevention programs often comes with a cost. The goal of my research is to use mathematical models to quantify the impact of infection prevention programs on cases of HAIs and total healthcare costs. First, I use a Markov chain model to quantify how one infection prevention program reduces general HAIs in the hospital. Then, I calculate the …

Synthesis And Modeling Of Manganese Ferrite Nanoparticles For Magnetic Hyperthermia Applications, Margaret E. Thornton

Theses and Dissertations

Biologically targeted magnetic hyperthermia (MH) is a promising cancer therapeutic that is both non-invasive and has the potential to serve as a single-modality cancer treatment. MH operates through the elevation of temperatures between 40-43 °C to induce apoptosis in malignant tumor cells, while the small size of the magnetic nanoparticles preserves the healthy surrounding tissue. At present, MH is limited by low heating efficiency and heterogenous outcomes, and treatment requires direct-injection of the nanoparticles, excluding deep-tissue and metastatic tumors from the therapy. The most popular candidates for MH are the spinel ferrites iron oxide and manganese iron oxide (MFO). These …

Analysis Of Microdroplets And Microorganisms By Single Entity Electrochemistry, Junaid U. Ahmed

Theses and Dissertations

Single Entity Electrochemistry (SEE) is an emerging electrochemical technique that has been used to characterize discrete entities by measuring the change in current or potential during individual stochastic events (collision or adsorption) of an entity with an ultramicroelectrode (UME) of similar dimensions. The shape and magnitude of the SEE signal depend on the underlying mechanism of interaction with the UME surface. There is a critical need for quantitative models that correlate the SEE signal with properties of the entity-UME system, including effects of acquisition instrumentation, to prevent misinterpretation of data.

This research focused on integrated experiments and simulations to quantify …

Antiviral Effects Of Metalloshielding: Differential Antiviral Activity Of Polynuclear Platinum And Cobalt Compounds, Mary Zoepfl

Theses and Dissertations

The majority of antiviral drug development has focused on virus-specific discovery targeting discrete steps in the individual life cycles. Although great strides have been made for a number of clinically relevant diseases such as human immunodeficiency virus, influenza virus, and hepatitis B, broad spectrum antivirals do not exist. Broad spectrum antivirals would offer (1) treatment for viruses without specifically-targeted antivirals, (2) treatment for viruses which have developed resistance to their available treatments, and (3) a rapidly deployable treatment option in viral epidemics. Many viruses including human cytomegalovirus (HCMV), HIV, and SARS-CoV-2. rely on heparan sulfate (HS), a highly sulfated glycosaminoglycan …

Metamosque – Envisioning The Mosque As A Virtual Public Space, Alaa Albarazy

Theses and Dissertations

Historically, the mosque was not only a space for a communal prayer but also a place for building a community. Today, however, with conflicts and diseases fragmenting society, people are less able to gather physically in large spaces. Out of necessity, people rely on technology to get together and interact virtually. In this context, my research challenges the notion of the mosque as a physical space, proposing, instead, its extension into virtual space. Recent global events pose the question: Can the metaverse offer an opportunity for the mosque to reassert itself as a public space. I propose that a MetaMosque …

Detection And Reporting Of Child Abuse And Neglect: A Survey Amongst Pediatric Dental Care Providers In The United States, Daniel J. Lander

Theses and Dissertations

Purpose: The purpose of this study is to survey pediatric dental care providers in the United States to evaluate their knowledge in the detection and reporting of child abuse and neglect (CAN). Methods: This study has been modeled as a cross sectional- survey based research study. Email invitations were sent to pediatric dentists, orthodontists, and others who work in pediatric dental practices in the United States through email lists of the American Association of Pediatric Dentists (AAPD) and the American Association of Orthodontists (AAO). The survey completion page included sample text and the public survey link for providers to use …

How Is Biophilic Urbanism Being Used In Planning To Rejuvenate Post-Industrial Cities?, Andrea A. Kerley

Theses and Dissertations

ARE POST-INDUSTRIAL CITIES USING BIOPHILIC URBANISM TO MERGE NATURE AND THE BUILT ENVIRONMENT? A PLAN EVALUATION OF FOUR U.S. LEGACY CITIES

By Andrea (Andi) Ames Kerley, Master in Urban and Regional Planning

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Urban and Regional Planning, at Virginia Commonwealth University.

Virginia Commonwealth University, 2020.

Major Director: Megan Z. Gough, Associate Professor, L. Douglas Wilder School of Government and Public Affairs,

Urban and Regional Studies and Planning

The re-imaging of U.S. post-industrial cities from desolate, impoverished, and polluted areas to unique, equitable, and environmentally aware cities …

Wet, Flowering, Dry, Caroline A. Minchew

Theses and Dissertations

Wet, flowering, dry is a series of photographic works that explore how vernal pools are a macrocosm for holding memory and a site of omnipresent solitude and decay. This installation distills an embodied and ephemeral experience of how we are grounded in a network of invisible connections with our surroundings. This network becomes evident through biological, historical, and field research conducted at the vernal pools for over a year. Through slow observation and consideration of how multiple stories of place can weave together into a larger parable, Wet, flowering, dry reveals how the life cycle of a vernal pool is …

Traumatic Brain Injury-Induced Changes Of Immune/Inflammatory Response In The Context Of Predisposition Of Alzheimer’S Disease, Alexandra Pedin

Theses and Dissertations

Alzheimer’s Disease (AD) is a progressive neurogenerative disease that affects millions globally. At this time there are no effective treatment options as the primary cause for AD is not fully understood. In addition to old age, genetic predisposition, and certain health conditions, traumatic brain injury (TBI) has been identified as a risk factor for AD. While the pathway that links TBI to AD is still largely unknown, the neuroinflammatory response to both conditions has been connected to the NLRP3 inflammasome. Due to its role in the innate immune system and proinflammatory cytokine mediation, the NLRP3 inflammasome could be a potential …

Defiantly Childlike: Using Aesthetic Resistance To Heal, Sarah K. Reagan

Theses and Dissertations

This thesis examines an alternative processing mechanism surrounding the act of healing after traumatic experiences in life. Using a methodology of iterative patterning and tool-pathing, a collection of inflatable garments and wooden mannequins analyzes defense mechanisms learned in early childhood development. This work highlights an essential body of recent scholarship that takes cuteification seriously to restore a childlike approach to mastering fear. This paper will review the definitions of cuteness and childlike humor and then describe how visual culture has implemented these components to subvert established power.

Periodic Trends In The Infrared And Optical Absorption Spectra Of Metal Chalcogenide Clusters, Alain Ward

Theses and Dissertations

We have investigated the Optical absorption, Infrared spectra, Binding Energies, and various other cluster properties to determine the existence of periodic trend for Transition Metal Chalcogenide Clusters ligated with CO ligands. We were motivated to answer the question of whether periodic behavior can be observed in properties of octahedral metal-chalcogenide clusters. We have used the Amsterdam Density Functional code to calculate the electronic structure of Transition Metal Chalcogenide Clusters using gradient-corrected density functional theory. We determined the existence of several periodic trends in properties of octahedral Transition Metal Chalcogenide Clusters TM₆Se₈(CO)₆. To investigate these …

Connections Exposed | A Library For The People, Stephanie Wilburn

Theses and Dissertations

MOTIVATION

The U.S. economy, democracy, and the health and happiness of citizens depends on maintaining social capital, the networks of bonds between community members. Social capital creates the trust that facilitates action and cooperation for mutual benefit. Since the 1960s, there has been a decline in-person socialization and social bonds both within and between demographic groups in the US resulting in reduced social capital (Putnam, 2000).

One measure to combat declining social capital is to create third places where incidental and repeated social interactions build and reinforce bonds between community members (Oldenburg, 1997).

With the reduction of accessible and inclusive …

Towards New Antimalarial Drug: Depolarization Of Liposomal Membranes By Aminooxoethylcarbamothioate In The Presence Of Fe3+ Ions, Aaron Wilson

Theses and Dissertations

Despite the efforts of scientists around the world 409,000 people died of malaria in 2019 alone. According to the WHO 90% of those deaths occurred in Africa. Despite the high number of available treatments, malaria continues to plague many parts of the world. This is due in part to drug resistance developed among mosquito populations as well as limited access to medicines that do work. Furthermore, when traveling to malaria prone areas, pretreatment with a chemoprophylaxis is common practice. However, often the side effects to malaria pretreatment are severe. A new approach to the treatment of malaria is a compound …