Digital Commons Network^™

Small Leucine-Rich Proteoglycans In Cancer: Three Decades Of Discovery, Gabriel J. Pascal, Sadie Kim, Christopher Xie, Maria Danial, Iris Barone, Renato V. Iozzo

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Small leucine-rich proteoglycans (SLRPs) are a well-known family of extracellular matrix (ECM) molecules. They consist of five classes with 18 different protein cores originally recognized as having a physically supportive component to the extracellular structure and tissue integrity. There has been a significant conceptual shift from the original paradigm as mere contributors to ECM structure to the current concept of bioactive signaling molecules. Over the past three decades, SLRPs have evolved into critical modulators of signaling events in cells by contributing to the regulation of receptor activity and intercellular communication. They also affect key biological processes such as tissue remodeling, …

A Water-Soluble Pro-Drug Of Acetaminophen Has Increased Intracellular Delivery Of Active Drug And Anti-Cancer Activity In Triple-Negative Breast Cancer And Pancreatic Ductal Adenocarcinoma., Allyn Bryan, Rudra Pangeni, Jephte Y Akakpo, Alex Wendling, Madison Isbell, Rebecca K Martin, George Weistroffer, Hartmut Jaeschke, Diane Ingabire, Won S Lee, Anthony C Faber, Stacey M Bagby, Todd M Pitts, Joseph Landry, Bhaumik Patel, Qingguo Xu, Alexander Neuwelt

PCOM Scholarly Works

Background/Objectives. Triple-negative breast cancer (TNBC) and pancreatic ductal adenocarcinoma (PDAC) are two of the deadliest adult cancers. High-dose acetaminophen (AAP) has anti-cancer activity when given in conjunction with CYP2E1 inhibitors to block liver toxicity. However, the administration of high doses of AAP presents practical challenges stemming from limited water solubility, making it difficult to create a concentrated treatment solution in limited volume. Propacetamol (PROP) is a water-soluble AAP pro-drug that has been used clinically as an IV AAP formulation for analgesia. Methods. We sought to investigate the pharmacokinetics, safety and anti-cancer activity of PROP in comparison to AAP …

Magnesium Intake, Sociodemographic Determinants, And Memory Performance In Older Adults: A Sex-Stratified Analysis In Nhanes 2011–2014, Huma Shahzad, Mohammed Razzaque, Juan Lopez-Alvarenga

School of Medicine Publications

Simple Summary: Magnesium is an essential nutrient found in foods such as leafy green vegetables, nuts, seeds, and whole grains, and is also commonly taken in dietary supplements. We studied whether total magnesium intake from food and supplements was related to memory in 2397 U.S. adults aged 60 years and older who participated in a national health and nutrition survey. Magnesium intake showed a small positive relationship with memory before considering total energy intake, particularly among women, but the relationship was not statistically significant. People who consumed more magnesium also tended to consume more calories overall. After taking energy intake …

Transgender Individuals’ Experiences Within The Lgbtq+ Community: A Qualitative Study, Anita Bruno

Walden Dissertations and Doctoral Studies

Transgender and gender-diverse individuals experience disproportionate mental health challenges, such as chronic stress, due to social exclusion. Research indicates that transgender individuals disproportionately experience poorer mental health outcomes compared to the broader LGBTQ+ community. This study expands research on how proximal and distal stressors impact transgender individuals' perceptions of inclusion within the LGBTQ+ community. Minority stress theory posits that increased discrimination causes transgender people to experience greater psychological distress than their cisgender LGBTQ+ peers. The present qualitative study employed semistructured interviews with 12 transgender participants to examine their perceptions of inclusion within the LGBTQ+ community. Braun and Clarke's 6-step, thematic …

Perceptions Of Police And Mental Health In Black American Men And Women Who Have Experienced Vicarious Police Violence, Kiera L. Posey

Walden Dissertations and Doctoral Studies

Incidents of publicized police violence against Black Americans have increased significantly, expanding the exposure and vicarious experiences involving these events, resulting in poor mental health and mistrust of law enforcement among Black Americans. Due to much of the literature focusing on Black men, the purpose of this study is to compare the perceptions of police and the mental health of Black men and Black women who have experienced vicarious police violence. Understanding this relationship would aid in better understanding how Black women's experiences are essential and need to be considered when discussing the effects of police violence in the Black …

Relationship Between African American Women’S Health Literacy, Appetitive Traits, And Body Mass Index, Esther Souffrant

Walden Dissertations and Doctoral Studies

Obesity remains a public health concern among African American (AA) women in the southern United States. Despite separate research on health literacy, eating habits, and obesity, few studies investigate their combined relationship with BMI among AA women in Georgia. Guided by the health belief model, this cross-sectional quantitative study examined whether health literacy and appetitive traits independently and jointly predicted BMI. AA women aged 18 or older living in Georgia were recruited through social media using purposive homogeneous sampling to complete an anonymous Google Forms survey. Health literacy was measured using the Newest Vital Sign, appetitive traits were assessed using …

"Two Different Histories": Lgbtq Educator Identity In An Era Of Policy Precarity In Further Education, Liberty Heath-Tavener

Journal of Queer and Trans Studies in Education

In Zadie Smith’s debut novel White Teeth (2000) she writes: ‘every moment happens twice: inside and outside, and they are two different histories.’ (p. 532) Although this notion related to the struggles of global majority people in Britain after decolonisation, I liken it to the concept of identity for Lesbian, Gay, Bisexual, Trans and Queer (LGBTQ) educators within further education, where their internal thoughts, feelings and reality are often in conflict with external norms, ideals and policies, all of which are geared towards heteronormativity and cisnormativity. Lakoff and Johnson (1980) argue that metaphors transcend rhetorical devices and are an essential …

Veterinary Vaccine Registration: Global Regulatory Standards, Harmonization, And Approval Challenges, Dhithya Venkateswaran, Trong Tung Nguyen, Quynh Anh Nguyen, Hongyao Lin, Roypim Suntisukwattana, Waranya Atthaapa, Angkana Tantituvanont, Dachrit Nilubol

The Thai Journal of Veterinary Medicine

The global demand for veterinary vaccines is growing due to the rising incidence of transboundary animal diseases and the increasing recognition of animal health as a cornerstone of public and environmental well-being. Central to this effort is a robust and well-defined vaccine registration process, which ensures that products entering the market meet established standards of safety, quality, and efficacy. Despite progress, the veterinary regulatory landscape remains fragmented, with varying protocols, timelines, and expectations across countries and regions. This review critically examines global regulatory frameworks and key data requirements involved in veterinary vaccine development and approval, including the roles of key …

Where’D You Go, Ohio: Progressive Ohio Ballot Initiative Passage In A Republican Aligned State, Colin D. Swearingen, Elizabeth Stiles, Barrett Scheatzle

The Journal of Economics and Politics

We investigate the effects of cosmopolitan and traditional county features on the opposition to three successful liberal state-wide initiatives on abortion and recreational marijuana using county-level data. Cosmopolitan/traditional variables include urban/rural living patterns, college graduates, average income and religiosity while control variables include turnout, poverty, race, region, and union support. We observe the results of these three elections to see the relationship between vote shares and factors such as income, education, rural/urban, and religiosity, controlling for other factors. Utilizing OLS and GAM regression models, our results provide support for our hypothesis that there is a relationship between cosmopolitanism and votes …

The Methodology Of Multiple Regressions For Gdp Per Capita For Nations In The World Between 0 Ce And 1940, Robert Rogers

The Journal of Economics and Politics

A reduced-form model of GDP per capita is estimated using the classical econometric method and two Bayesian techniques, Extreme Bounds Analysis (EBA) and Bayesian Analysis of Classical Estimation (BACE) for the two millenniums. For several variables, such as the impact of colonialism, the Goldstone hypothesis of efflorescence increasing economic growth, and the impact of technology, this paper lends support, especially when the Bayesian methods are applied. Other results are mixed. Generally, the results support use of Bayesian methods by eliminating hypotheses that are not consistently supported over all models.

Ohio's Current Agricultural Use Program: Eligibility, Recoupment, And Current Issues, Allen Prindle

The Journal of Economics and Politics

No abstract provided.

The Poor Laws: A Comparison Of Three Original Reform Proposals, Rachel Wilson

The Journal of Economics and Politics

No abstract provided.

Can A Dependent Region Be An Optimum Currency Area? : The Case Of West Africa, Godwin Chukwu Duru

The Journal of Economics and Politics

No abstract provided.

Religion And Democracy In Contemporary Iran And The United States, Jeneen Hobby

The Journal of Economics and Politics

No abstract provided.

Entrepreneurship And Classical Economics: Adam Smith And His Undertaker, Henry G. Rennie

The Journal of Economics and Politics

No abstract provided.

Public Affairs And Policy Studies Organizations And Public Policy (The Nigerian Experience), Ufot B. Inamete

The Journal of Economics and Politics

No abstract provided.

Urasawa’S Monster And The Aesthetics Of Uncertainty, Simon Lindblom

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

This essay examines the anime Monster (Urasawa, 2001) through the lens of Aesthetic action (Klinger, 2024) and ethical praxis. Set in a nostalgically rendered pre-accelerationist Europe, the anime cultivates an atmosphere of uncertainty that prompts viewers to engage in complex moral issues. By exploring the anime's aesthetic strategies, this analysis reveals how Monster functions as a political device, exposing the dark undercurrents of historical trauma and the systemic exclusion of marginalised groups. The essay argues that Monster's deliberate cultivation of indeterminacy, particularly through its morally ambiguous characters and unresolved dilemmas, embodies a Determinate Performance of Indeterminacy (Klinger, 2024). This …

Spec-242-Core: Lie Algebraic Coherence Mapping And Non-Von Neumann Runtime Ingestion Interfaces --- Systematic Deployment Of Su(3) Manifold Invariants Across Hydrodynamic Eckesonium™ Core Grids For Thermal And Reconstructive Data Verification, Christopher L. Eckes

Defensive Publications Series

This disclosure establishes a deterministic, non-von Neumann hardware ingestion and mapping interface that converts high-dimensional, non-factorizing state trajectories into low-entropy, coherent resonance signatures. By formalizing a physical bridge between topological SU(3) Lie group geometry and the co-harmonic standing wave storage cavities of interstitial Eckesonium(TM) core grids, this system provides an open-source technical architecture to bypass traditional institutional gatekeeping and corporate enclosure of multi-variable data validation. The primary utility of this specification lies in its capacity to ingest raw, multi-channel time-series data vectors, execute an on-the-fly SVD matrix flatten combined with a Cartan-Root decomposition, and isolate structural coherence fields from chaotic …

Exploring The Role Of Generative Ai In Enhancing Perceptions Of Support And Clarity In Online Asynchronous Classes, Todd H. West, Jessica L. Clark, George O. Hanshaw

The Interdisciplinary Journal for Research on Pedagogy and Learning Design, Vol. 1, Issue 1., Fall 2026

This study examines the relationship between the use of Spark, a Socratic generative AI assistant, and students’ perceptions of Spark as a potential Vygotskian More Knowledgeable Other (MKO) in asynchronous online courses. Analysis of 4,587 end-of-course surveys compared Spark users with non-users across two constructs: Student Experience (encouragement, engagement, and support) and Sense of Clarity (instructional clarity, structure, and feedback). Spark users reported significantly higher perceptions on both constructs, with differences remaining statistically significant after adjusting for course and instructor variation. Sentiment analysis showed no significant group differences. Spark use was associated with modestly more favorable perceptions of clarity and …

Forks Of Cypress Correspondence From Waring Sherwood With Article From The Nov. 14, 1978, Memphis Press-Scimitar, Pg. 5, Waring Sherwood

Correspondence

Correspondence from Waring Sherwood to William Lindsey McDonald about Sherwood's book on local history The Story of James Jackson at the Forks. The book discusses the history of the Forks of Cypress in Lauderdale County, Alabama and the James Jackson family that inhabited it.

Waring also included an article from page five of the November 14, 1978, Memphis Press-Scimitar, which references his career and offers a summary of the publication.

From Your Green Lawn To What’S Lurking Beyond Your Property Line, Jackson D. Southern, Aleia Castro

Nontechnically Speaking Substack

This third issue of the Nontechnically Speaking Substack features an article written by Ursinus College students Jackson Southern and Aleia Castro entitled “Is Your Yard a Killer? How to Improve Your Lawn's Environmental Impact.” It also highlights student-created Instagram reels and announces other upcoming events.

Hagfish Intermediate Filament Proteins: From A Natural Protein System To Functional Biomaterials, Oran Wasserman, Kristin K. Durrant, Katee Stromberg, Brianne E. Bell, Paula E. Oliveira, Justin A. Jones

Biology Student Research

Sourcing protein-based biomaterials directly from nature presents persistent challenges in scalability, processing, and batch-to-batch variability. Recombinant engineering has focused largely on spider silks, and hagfish intermediate filament (HIF) proteins remain a comparatively unexplored alternative, with small non-repetitive subunits that have been produced full-length at high yield. This review examines the biology of naturally produced HIF protein threads from the Pacific hagfish, Eptatretus stoutii, advances in recombinant expression and purification, and their translation into functional biomaterials. We first describe the tripartite domain architecture and biochemical classification of the threonine-rich α- and γ-keratin-like subunits, and then the defensive biomechanics of HIF …

Wilson's Phalarope, A Migratory Bird, Depends On The Declining Great Salt Lake, William Christenson, Kendall Becker, Spencer J. Good, T.J. Clark-Wolf, Scott Hotaling

All Current Publications

This fact sheet describes how declining water levels and increasing salinity degrade habitat for brine flies and other prey Wilson’s phalaropes rely on. Because human use drives low water levels, changes to water management could reverse the lake’s decline and improve habitat quality for Wilson’s phalaropes and other species that depend on the Great Salt Lake.

Towards Transparency In Sampling For Plant Xylem Water Isotope Studies: Current Practices And New Perspectives, Magali F. Nehemy, Hannes P.T. De Deurwaerder, Ginevra Fabiani, Gregory R. Goldsmith, W. Jesse Hahm, Danielle Hudson, Suzanne Jacobs, Huai Jianjun, James Knighton, Marco M. Lehmann, Pedro A. M. Leite, Kevin Li, Min Li, Xiuqiang Liu, Aline Meyer Oliveira, Yunpeng Nie, Natalie Orlowski, Daniele Penna, María Poca, Ricardo Sánchez-Murillo, Hongxiu Wang, Mingyi Wen, Lixin Wang, Seth E. Younger, Giulia Zuecco, Scott T. Allen

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Xylem water isotope values are widely used to trace plant water sources. However, the sampling decisions that precede extraction are rarely fully reported in isotope studies, limiting reproducibility and cross comparisons. A survey of 42 researchers across five continents, complemented by a virtual community workshop, revealed substantial methodological diversity: only 51% maintain standard operating procedures, with variation in organ selection among respondents (branches 73.8%, stems 64.3%, roots 35.7%), sapwood-heartwood separation (63.2% separate), bark removal (59% always) and transport conditions (56% ice packs vs. 39% ambient). From the surveyed researchers, 77.5% adapt sampling strategies to their extraction system, but these adaptations …

Calibrated Simulations For Dynamic Focusing Of Ultrasound Through The Temporal Window, Ehsan Dadgar-Kiani, Vibha Hebbale, Malachy W. Newman, Grace Attalla, John L. Alvarez, Suraya Dunsford, Kevin A. Caulfield, Cameron H. Good, Andrew D. Krystal, Leo P. Sugrue, Joline M. Fan, Elsa Fouragnan, Charles F. Caskey, Samuel Pichardo, Kim Butts Pauly, Keith R. Murphy

School of Psychology

Focused ultrasound can be delivered through the temporal window to modulate heterogeneously located brain areas. Acoustic simulations allow for safety assessments when dynamically targeting brain structures, but the mismatch between simulation and measured focal pressure can vary across the steerable range due to mechanically inaccurate assumptions made about the skull and transducer. Here, we describe efficient methods for simulation-measurement calibration using axisymmetric projections and sparse sampling across a 3D steerable subspace encompassing deep brain targets across 157 subjects. To address the simulation-reality mismatch in skull transmission, we used the measured and predicted pressure values through eight human temporal window fragments …

The Rider (2026-10-19), Daniela Chapa-Reyes

The Rider Archives

Vol. 12, No. 9

The Impact Of Environmental Exposures On Cystic Acne: A Narrative Review, Angela Vaysman, Morgan Ulczak, Carly Achterberg, Lucas Goetz, Luke Atwood, Reed Hildenbrant, Erin Hallman, Caitlyn Shaughnessy, Karen Vo

Student Publications

Cystic acne is a severe inflammatory dermatological condition traditionally associated with genetic, hormonal, and microbial factors. Although environmental exposures may contribute to acne pathogenesis, the role of airborne agricultural irritants remains underexplored. Agricultural environments contain a complex mixture of organic dusts, pesticides, fertilizers, volatile compounds, and animal-derived particulates that may influence skin barrier integrity and inflammatory responses. This narrative review examines the potential relationship between airborne agricultural exposures and cystic acne by integrating evidence from dermatology, environmental health, and immunology. Particular attention is given to mechanisms through which agricultural irritants may disrupt epidermal barrier proteins, including filaggrin and claudins; promote …

From Shallow Semantic Analysis To Knowledge Intelligence:Paradigm Shifts In Full-Text Bibliometrics Driven By Large Language Models:A Review Of The 2025 Academic Salon On Full-Text Bibliometric Analysis, Haicheng Zhou, Shuo Xu, Jin Mao, Liang Chen, Guoxiu He

Journal of Scientific Information Research

[Purpose/significance] In September 2025, the 8th Chengdu Conference on Scientometrics & Evaluation, hosted by the National Science Library (Chengdu), Chinese Academy of Sciences, and undertaken by the Scientometrics & Evaluation Research Center (SERC), was held in Chengdu. This article reviews the Academic Salon on Full-Text Bibliometric Analysis at the forum, summarizing methodological advances, application expansion, and paradigm shifts in full-text bibliometrics in the era of large language models (LLMs), and providing references for future research. [Method/process] Based on invited talks and on-site discussions, this article synthesizes the research paradigms and application directions of LLM enabled full-text bibliometrics. It highlights key …

Research On Interdisciplinary Scientific Research Behavior Of Nobel Prize Laureates In The Field Of Natural Sciences, Gao Zhi, Gang Sun

Journal of Scientific Information Research

[Purpose/significance] This study explores the evolutionary patterns of interdisciplinary research behavior among Nobel Prize laureates in natural sciences over their careers and its impact on academic performance, aiming to provide theoretical foundations and policy implications for the cultivation of high-level scientific talents and the management of interdisciplinary research. [Method/process] The study focuses on Nobel Prize laureates in natural sciences who began publishing papers since 1960. Using panel data models, it analyzes the authorship patterns, volume, interdisciplinarity, and academic impact of interdisciplinary publications from a career perspective. [Result/conclusion] The interdisciplinary behavior of Nobel Prize laureates in natural sciences exhibits significant stage-based …

The Student Movement Volume 111 Issue 3: Colorful Trees, Cultures, And Clubs, Holli Kirschbaum, Joel Pelletier, Anna Rybachek, Isa Demoraes, Megan Constantine, Matthew Henderson, Melanie Webb, Jj Nixon

The Student Movement v. 111 (2026-2027)

NEWS

Clubs of All Shapes and Sizes, Holli Kirschbaum

Counseling & Testing Center Introduces Walking Consultations, Joel Pelletier

AULA Brings Food, Music, and Fun at Their Annual Noche Latina, Joel Pelletier

ARTS & ENTERTAINMENT

BTS and the Grammy Boycott, Anna Rybachek

David Phelps Delivers Memorable Performances at the HPAC, Isa DeMoraes

Howard Presents: An Evening of Romantic-Era Masterpieces, Megan Constantine

IDEAS

The Paramount-Warner Merger: Who Are Monopolies For?, Matthew Henderson

In Defense of Underperforming Programs and Useless Degrees, Melanie Webb

PULSE

Why Do More Than School?, Holli Kirschbaum

Was 'Spider-Man: Brand New Day' Worth the Hype?, Anna Rybachek

LAST WORD …