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Articles 4831 - 4860 of 7363
Full-Text Articles in Entire DC Network
Immunohistochemical Study Of Phenotypes Of Dendritic Cells In Dental Pulps From Non-Carious And Carious Teeth, Melissa A. Harmon
Immunohistochemical Study Of Phenotypes Of Dendritic Cells In Dental Pulps From Non-Carious And Carious Teeth, Melissa A. Harmon
Theses and Dissertations
Mature dendritic cells (DCs) in inflamed tissues may promote inflammation but the status of DCs in pulpitis is not known. We hypothesized that DC maturation would correlate with carious lesion depth and that CD4+ cells would be found in association with mature DCs. Pulps were collected from teeth exhibiting: (I) no caries (n=9), (II) shallow dentinal caries (n=5), and (III) deep caries (n=9). Pulpal tissues were cryo-sectioned and positive cells were examined with immunohistochemistry, Mature DCs (CD83+) were almost exclusively restricted to pulps from deep caries. Furthermore, CD209+ DCs in deep caries were elevated over other groups and CD209+ cells …
Pedagogical Fusion, David Maurice White
Pedagogical Fusion, David Maurice White
Theses and Dissertations
During the five semesters that I have been at VCU I have learned a great deal from the courses that I have been enrolled in but I have learned the most through my experiences as a Teaching Assistant. These experiences have been so valuable because of the wide range of subject areas in which I have been involved and the diverse instructors that I have assisted. Although I hesitate to use the word "problem" I feel that there is a tendency in teacher training for a student to latch onto one professor and model their teaching practices after that one …
An Exploration Of The Influence Of Race And Gender On Sexual Beliefs And Attitudes Of Adolescents, Kristine Marie Vandenberg
An Exploration Of The Influence Of Race And Gender On Sexual Beliefs And Attitudes Of Adolescents, Kristine Marie Vandenberg
Theses and Dissertations
This study explores factors that influence the sexual attitudes and behaviors of adolescents specifically through an examination of social constructs that measure sexual beliefs and attitudes of adolescents and the relationships between race and gender and sexual beliefs and attitudes. As the U.S. has maintained one of the highest rates of unplanned teen pregnancy and births among industrialized nations, schools and community groups have struggled to combat teen pregnancy and worked toward designing effective prevention programs. Through an emphasis either on abstinence or safe sex practices, these programs strive to influence adolescents' sexual behavior. However, studies and reports reveal a …
Structures And Reactivities Of Ionized And Metal Cation-Containing Acetylene Clusters, Paul O. Momoh
Structures And Reactivities Of Ionized And Metal Cation-Containing Acetylene Clusters, Paul O. Momoh
Theses and Dissertations
In this dissertation, the ion mobility technique is used to determine the structures of small acetylene cluster ions, (C2H2)1-3+, mass-selected from the largest ever reported ionized acetylene clusters. The technique is also used to characterize the reaction of acetylene clusters with water in an effort to elucidate thermochemistry and kinetics of some interesting ion-molecule reactions suspected to occur in interstellar clouds and other interplanetary bodies.A combination of ion mobility measurements, collision induced dissociation (CID), and theoretical calculations are used to provide the most conclusive evidence for the frequently hypothesized trimerization of ionized acetylene to form the benzene ion. The results …
Induction Of Heme Oxygenase By A Carbon Monoxide-Releasing Molecule, Robert Andrew Kulina
Induction Of Heme Oxygenase By A Carbon Monoxide-Releasing Molecule, Robert Andrew Kulina
Theses and Dissertations
We have recently demonstrated that heme oxygenase is expressed in both healing wounds and in pressure ulcers. Heme oxygenase has been shown to have important cytoprotective functions in myocardial ischemia-reperfusion injury and organ allograft survival. The cytoprotective effects of heme oxygenase are multifactorial. Besides reducing levels of pro-oxidant heme, heme oxygenase products (bilirubin, carbon monoxide, and iron) have been demonstrated to possess anti-oxidant, anti-inflammatory, anti-apoptotic, and anti-proliferative properties. These properties make heme oxygenase an attractive therapeutic target for the prevention and treatment of chronic wounds. The purpose of this study was two-fold: evaluate the effects of carbon monoxide (CO) on …
Divergent Roles Of Pi3k And Akt In Rapamycin-Induced Cardioprotection Against Ischemia-Reperfusion Injury, Shivani Kirit Desai
Divergent Roles Of Pi3k And Akt In Rapamycin-Induced Cardioprotection Against Ischemia-Reperfusion Injury, Shivani Kirit Desai
Theses and Dissertations
Coronary heart disease (CHD) is one of the leading causes of death every year with nearly three-fourths of all deaths caused by the disease. The challenge scientists are facing today is discovering new drugs to protect the heart against cellular damage caused by ischemia-reperfusion injury (I-R injury). Rapamycin is one such drug that has been shown to protect the heart against ischemia-induced cellular injury. Rapamycin(sirolimus) inhibits protein synthesis through inhibition of the mammalian target ofrapamycin (mTOR). This property of rapamycin has led to its current clinical applications in drug-eluting stents and in immunosuppresive treatment to organ transplant patients. The mechanism …
Children With Special Needs Oral Health Quality Of Life Survey, Kristin Elizabeth Nelson
Children With Special Needs Oral Health Quality Of Life Survey, Kristin Elizabeth Nelson
Theses and Dissertations
Purpose: The purpose of this study was to asses the oral health quality of life of children with special health care needs. This study examined the effects of oral health conditions on general well-being and family life of these children. A secondary aim of the study was to investigate correlations between specific health care conditions, gender, and age of these children and their global ratings of oral health and well-being.Methods: This study was a cross-sectional design with subjects who are members of the Virginia Care Connection for Children program, based at Virginia Commonwealth University. The oral health quality of life …
The Role Of Inhibitory Interneurons In A Model Od Developmental Epilepsy, Patrick James Wolfgang
The Role Of Inhibitory Interneurons In A Model Od Developmental Epilepsy, Patrick James Wolfgang
Theses and Dissertations
Epilepsy, defined by recurrent seizures, is the one of the most prevalent neurological disorders worldwide (World Health Organization 2007). While many forms of epilepsy are well-controlled by anti-epileptogenic medications, a significant portion of patients have intractable, i.e. untreatable, seizures. The etiology of these seizures is varied, but a significant cause, particularly for patients with intractable epilepsy is developmental malformation. In these cases, an error or interruption during the development of the neocortex produces a structural alteration. Such patients may have other neurological problems, but seizures are the most common symptom. The neuronal mechanisms that link malformation and cortical hyperexcitability are …
Initial Studies On A Novel Target-Promoted Dna Alkylation System, Ting Xu
Initial Studies On A Novel Target-Promoted Dna Alkylation System, Ting Xu
Theses and Dissertations
A novel target-promoted DNA alkylation system was designed, which consists of a DNA intercalating/alkylating quinone methide (QM) precursor, a removable amine linker, and a sequence-specific delivery. The QM in this system was regenerated by eliminating the amino linker promoted by the hydrophobic interaction between the target DNA and the intercalating QM precursor. Three alkylation model systems (methoxyl polycyclic system, intramolecular hydrogen bonding system and biaryl system) were proposed and synthesized. The potential DNA QM alkylation was investigated by deoxyadenosine (dA) and deoxyguanosine (dG) alkylation with the biaryl system. Only one deoxynucleoside adduct was observed when dA or dG reacted with …
Design Of An Electrospun Type Ii Collagen Scaffold For Articular Cartilage Tissue Engineering, Catherine Pemble Barnes
Design Of An Electrospun Type Ii Collagen Scaffold For Articular Cartilage Tissue Engineering, Catherine Pemble Barnes
Theses and Dissertations
Traumatic defects in articular cartilage can lead to joint disease and disability including osteoarthritis. Because cartilage is unable to regenerate when injured, the field of tissue engineering holds promise in restoring functional tissue. In this research, type II collagen was electrospun, cross-linked, and tested as scaffolds for supporting chondrocyte growth. The mechanical, biochemical, and histological characteristics of the engineered tissue were assessed as a function of the electrospinning solution concentration (i.e. scaffold fiber diameter and pore properties) and as a function of the time in culture (evaluated at 2, 4, and 6 weeks). Fiber diameter had a linear relationship with …
Constraints On Breastfeeding Choices For Low Income Mothers, Carol Grace Hurst
Constraints On Breastfeeding Choices For Low Income Mothers, Carol Grace Hurst
Theses and Dissertations
The choice to breastfeed a baby is a woman's concern with impact reaching beyond each individual mother and child to longer term health and mental health outcomes for society. The U.S. government has made increasing breastfeeding rates one of its major public health goals for 2010. Breastfeeding is a health disparity issue with mothers who are poor, young, less educated or Black less likely to breastfeed. This project examined impacts of sexual perceptions of breastfeeding, social support, and work on breastfeeding choices made by a sample of low income mothers. A cross-sectional survey design was employed to examine potential barriers …
Oral Health Services In A Medical Setting, Robert William Mansman Ii
Oral Health Services In A Medical Setting, Robert William Mansman Ii
Theses and Dissertations
Purpose: The purpose of this study is to examine the baseline oral health status of infants and the level of their caregiver's oral health knowledge for families who received preventive oral health services in a medical setting. Methods: Using a prospective cohort study, children 0-3 years of age received an oral health screening, risk assessment, caregiver education, and a fluoride varnish treatment in an ambulatory pediatric medical clinic. A 16-item oral health knowledge and socio-demographic questionnaire was delivered to the caregiver of child. This questionnaire included knowledge, behavior and opinion items on risk factors for dental diseases, care of child's …
In Search Of The Ooey Gooey Good, Lauren Ashley Clay
In Search Of The Ooey Gooey Good, Lauren Ashley Clay
Theses and Dissertations
This thesis explores ideas of everydayness, the mundane, and the repetitive emptiness of consumer culture. It looks at the malaise that plagues everyday life and examines several attempts throughout history to break from its grips which revolve around a search for a more ideal state. This research includes utopias of modernism, the transcendental, the communal living of Shakers and Early Christians, ascetic monks and The Desert Fathers. These ideas have shaped my studio practice as I construct installations based on worlds which allude to the eternal, the otherworldly, and the fragility of our physical world when compared to more eternal …
Study Of Covalent And Non-Covalent Interactions In Ternary Systems Involving: Metal/Dna-Rna/Protein, Where Metal = Platinum(Ii), Palladium(Ii), Anzellotti I. Atilio
Study Of Covalent And Non-Covalent Interactions In Ternary Systems Involving: Metal/Dna-Rna/Protein, Where Metal = Platinum(Ii), Palladium(Ii), Anzellotti I. Atilio
Theses and Dissertations
Ternary systems comprising DNA/RNA, proteins and one (or more) metal ion are generating increased interest due to its biological relevance. The knowledge gained from the study of these systems could provide important clues regarding the precise mechanism for transcription factors, repair proteins and metal complexes with anti-tumoral/anti-viral activities.The interactions occurring among the components of these ternary systems can be broadly grouped into covalent and non-covalent. The first kind of interactions can lead to the irreversible transformation of the components in the system, while the second is thought to be reversible leading to transient states and fluxionality. Both kinds of interaction …
Observational Intelligence: An Overview Of Computational Actual Entities And Their Use As Agents Of Artificial Intelligence, Brandon Scot Saunders
Observational Intelligence: An Overview Of Computational Actual Entities And Their Use As Agents Of Artificial Intelligence, Brandon Scot Saunders
Theses and Dissertations
This thesis' focus is on the use of Alfred North Whitehead's concept of Actual Entities as a computational tool for computer science and the introduction of a novel usage of Actual Entities as learning agents. Actual Entities are vector based agents that interact within their environment through a process called prehension. It is the combined effect of multiple Actual Entities working within a Colony of Prehending Entities that produces emergent, intelligent behavior. It is not always the case that prehension functions for desired behavior are known beforehand and frequently the functions are too complex to construct by hand. Through the …
The Role Of Sphingosine Kinase 2 In Cell Growth And Apoptosis, Heidi M. Sankala
The Role Of Sphingosine Kinase 2 In Cell Growth And Apoptosis, Heidi M. Sankala
Theses and Dissertations
Two isoforms of sphingosine kinase (SphK) catalyze the formation of sphingosine-1-phosphate (SIP). Whereas, SphKl stimulates cell growth and survival, it was found that when overexpressed in mouse NIH 3T3 fibroblasts SphK2 enhances caspase-dependent apoptosis in response to serum deprivation, independently of S1P receptors. Sequence analysis revealed that SphK2 contains a 9 amino acid motif similar to that present in BH3-only proteins. Studies showed that the BH3-only domain, catalytic activity, endoplasmic reticulum (ER) stress, and uptake of calcium by the mitochondria may all contribute to the apoptotic effects of overexpressed SphK2 in NIH 3T3 cells. Further studies in human carcinoma cells …
Mechanisms Of Accumulation And Biological Consequences Of Polynuclear Platinum Compounds, Peyman Kabolizadeh
Mechanisms Of Accumulation And Biological Consequences Of Polynuclear Platinum Compounds, Peyman Kabolizadeh
Theses and Dissertations
The novel trinuclear complex, BBR3464 has undergone Phase II clinical trials and been shown to have greater cytotoxicity and cellular uptake than clinical anticancer platinum drugs such as cisplatin, oxaliplatin and carboplatin. The clinical efficacy of cisplatin, oxaliplatin and carboplatin is limited due to acquired resistance and dose limiting side effects. The three major pharmacological factors contributing to the intrinsic cytotoxicity of, and cellular resistance to, platinum drugs are (i) cellular uptake and efflux of platinum; (ii) the frequency and nature of Pt-DNA adducts; and (iii) deactivating metabolic reactions with sulfur-containing nucleophiles. Since decreased cellular uptake of platinum drugs is …
A Comparison Of The Pectoral Spines In Virginia Catfishes, Amanda Dawn Duvall
A Comparison Of The Pectoral Spines In Virginia Catfishes, Amanda Dawn Duvall
Theses and Dissertations
Catfish pectoral spines are an anti-predator defense mechanism. They can be bound or locked, making the fish harder to swallow, or used to produce distress calls by rubbing ridges on the dorsal process against a channel in the wall of the pectoral girdle. Growth of the pectoral spine and girdle were examined in relation to fish size within and across species that occur throughout central and eastern Virginia. These included blue catfish (Ictalurus furcatus), channel catfish (Ictalurus punctatus), white catfish (Ameiurus catus), brown bullheads (Ameiurus nebulosus), yellow bullheads (Ameiurus natalis), flathead catfish (Pylodictis olivaris), margined madtom (Noturus insignis), and tadpole …
The Influence Of Adenoviral Infection And The Group Via Calcium-Independent Phospholipase A2 On Hepatic Lipid Metabolism, William Palmer Wilkins Iii
The Influence Of Adenoviral Infection And The Group Via Calcium-Independent Phospholipase A2 On Hepatic Lipid Metabolism, William Palmer Wilkins Iii
Theses and Dissertations
Sterol regulatory element-binding proteins (SREBP) are transcription factors that regulate genes involved in lipid metabolism especially in the liver. Therefore, hepatic SREBP is significant regulator of systemic lipid metabolism. Evidence demonstrates that insulin and dietary unsaturated fatty acid (UFA) regulate SREBP1 expression and subsequent SREBP1-mediated gene transcription, events that in many instances result in modulation of systemic fatty acid and triglyceride (TG) homeostasis. A series of investigations was designed to uncover novel regulators of SREBP1. Dietary and exogenous addition of UFA has been shown to regulate SREBP function yet, an endogenous source of UFA capable of modulating SREBP remains elusive. …
Interleukin-10 Suppresses Mast Cell Ige Receptor Expression And Signaling In Vitro And In Vivo, Sarah B. Kennedy
Interleukin-10 Suppresses Mast Cell Ige Receptor Expression And Signaling In Vitro And In Vivo, Sarah B. Kennedy
Theses and Dissertations
Background: Mast cells are known for their role in allergy, asthma, and systemic anaphylaxis, and have been shown to play a role in inflammatory disease. Interleukin-10 can regulate inflammatory responses both in vitro and in vivo, and may be a natural regulator of mast cell activation.Objective: To examine Interleukin-10 mediated regulation of FcεRI expression and related downstream signaling molecules, and to determine how this affects mast cell function in vitro and in vivo.Methods: Mast cell FcεRI expression was evaluated with and without IL-10 treatment in human lung and skin mast cells, and on peritoneal mast cells from mice overexpressing IL-10 …
Seeing It Straight, Heather Harvey
Seeing It Straight, Heather Harvey
Theses and Dissertations
This Master of Fine Arts thesis is divided into four main sections:FAITH and DISBELIEF: In which I reckon with the implications of faith versus rationality as a secular nontheistic artist. IDEAS: The central locus of my work is a place of indeterminacy between what is known/familiar and what is just one step outside of that. This has nothing to do with mysticism, science fiction, or anything else unmoored from established fact. Section also touches on the particular vantage of a female artist with working class roots.THE WORK: Selection of work made during graduate school, and the the guiding thoughts behind …
Concurrent Whitening And Orthodontic Treatment, Jason Thomas Gladwell
Concurrent Whitening And Orthodontic Treatment, Jason Thomas Gladwell
Theses and Dissertations
The aim was to evaluate whether a whitening system, when used during the final stages of orthodontics, would yield results comparable to whitening alone. Patients were assigned to either the control (n=20) or experimental (n=26) groups. At T1, patients were given a ten day supply of Trèswhite⢠by Opalescence®, instructions on use, and initial shade determination was made and photographs were taken. At T2 and T3, shade determination was accomplished and updated photographs were taken. Whitening of the teeth occurred in both groups on average, but significantly more whitening was experienced in the experimental group (p < 0.004). An average of 87% of teeth whitened during orthodontic treatment compared to 97% of control teeth (p < 0.01) were judged to be uniform in appearance. In conclusion, the data do not contraindicate the concurrent accomplishment of teeth whitening during orthodontic treatment.
The Vine (2006-12)
The Vine, 1994-2008
The Vine was a successor to Reflections in Ink, published from 1994 to 2008. It transitioned from a mostly African American student perspective to a multi-cultural one.
[2006-11-16] Minutes Of A Regular Meeting Of The Board Of Visitors Of Virginia Commonwealth University November 16, 2006., Virginia Commonwealth University. Board Of Visitors
[2006-11-16] Minutes Of A Regular Meeting Of The Board Of Visitors Of Virginia Commonwealth University November 16, 2006., Virginia Commonwealth University. Board Of Visitors
VCU Board of Visitors Minutes
Official minutes of the VCU Board of Visitors and its Executive Committee.
The Vine (2006-10)
The Vine, 1994-2008
The Vine was a successor to Reflections in Ink, published from 1994 to 2008. It transitioned from a mostly African American student perspective to a multi-cultural one.