Digital Commons Network^™

The Impact Of Mental Challenge On Indicators Of Endothelial Function In Obese Individuals, Chun-Jung Huang

Theses and Dissertations

A number of investigators have examined psychological stress-induced endothelial dysfunction, however, the underlying mechanisms for these responses have not been clearly elucidated. The purpose of this study was to compare the effects of mental challenge on forearm blood flow, total antioxidant capacity (a measure of oxidative stress), the release of norepinephrine (NE; stress induced neurotransmitter), and pro-inflammatory cytokine responses [both lipopolysaccharide (LPS)-stimulated TNF-α and IL-6 cytokine and mRNA] in lean and obese individuals. Twelve subjects who had a BMI above 30 kg/m2 and were above 30% body fat were categorized as obese and twelve subjects with a BMI below 25 …

Kingdom Compossible, Ryan Lauterio

Theses and Dissertations

Does God exist? Can we know for sure? What might it mean to know this? Furthermore what might it look like to make works of art while also seeking to find answers to these questions? This thesis details my personal experiences growing up in a world steeped in postmodernism and my move to answer such questions while looking to develop a meaningful, clear worldview and body of work. I have turned my focus on specific episodes in my life, which significantly illuminate a progression of thinking and experience. Together these thoughts and experiences have become the impetus for both questions …

Virginia Dental Journal (Vol. 86, No. 4, 2009)

Virginia Dental Journal

No abstract provided.

The Impact Of Early Positive Results On A Mathematics And Science Partnership: The Experience Of The Institute For Chemistry Literacy Through Computational Science, K. S. Murray, M. A. Henry, M. C. Hogrebe

Journal of Mathematics and Science: Collaborative Explorations

After one year of implementation, the Institute for Chemistry Literacy through Computational Science, an NSF Mathematics and Science Partnership Institute Project led by the University of Illinois at Urbana-Champaign’s Department of Chemistry, College of Medicine, and National Center for Supercomputing Applications, experienced statistically significant gains in chemistry content knowledge among students of the rural high school teachers participating in its intensive, year-round professional development course, compared to a control group. The project utilizes a two-cohort, delayed-treatment, random control trial, quasi-experimental research design with the second cohort entering treatment one year following the first. The three-year treatment includes intensive two-week summer …

Invertebrate Colonization And Plant Architecture: The Influence Of Two Non-Native Milfoil Species, Elizabeth W. Rielly

Theses and Dissertations

The purpose of this study was to determine if the complexity and surface area of a macrophyte’s

structure has an influence on invertebrate colonization, and to determine the influence of two non-native species on invertebrate colonization. Three plant architectures were compared. Floating leaved plants were represented by the following species: Nuphar lutea, Nymphaea odorata, and Brasenia schreberi. Moderately dissected leaved plants were represented by Potamogeton natans, and highly dissected leaved plants were represented by two non-native species, Myriophyllum spicatum and Myriophyllum heterophyllum. The number of invertebrates/g dry biomass and the number of individuals/m², diversity, evenness, and richness were calculated for …

Surgical Smoke Evacuation Guidelines: Compliance Among Perioperative Nurses, Kay A. Ball

Theses and Dissertations

Smoke (plume) is produced when tissue is cut or coagulated with lasers or electrosurgery devices during surgery. Research has documented that surgical smoke creates a serious workplace hazard for over 500,000 healthcare workers. Toxic gases create an offensive odor, small particulate matter causes respiratory complications, and pathogens may be transmitted within the surgical smoke to the surgical team. Previous research notes that smoke evacuation recommendations are not being consistently followed by perioperative nurses.

The purpose of this study is to determine key indicators that are associated with compliance with smoke evacuation recommendations by perioperative nurses. The Diffusion of Innovation theory …

Identification And Characterization Of Prevotella Intermedia 17 Toll-Like Receptor 2 Ligands, Jamie Feng-Hsia Yuan

Theses and Dissertations

Periodontal disease is one of the most prevalent human diseases affecting millions of individuals. Bacteria are the trigger of the host response that then results in initiation and progression of periodontal disease. The interactions between the host and the bacteria, although very complex and intricate, are not well understood. Species of gram-negative anaerobic bacteria implicated in the development of periodontal disease include Porphyromonas gingivalis and Prevotella intermedia. The goal of our study was to identify P. intermedia surface proteins interacting with TLR2 receptor. Using Cy5-labeled surface proteins we identified multiple proteins using our capture assay. The interaction of three …

Pulmonary Delivery Of Anorectic Gut Secreted Peptides For Appetite Suppression In Rats, Priya Nadkarni

Theses and Dissertations

This dissertation project aimed to demonstrate that pulmonary delivery of two anorectic gut secreted peptides, peptide YY (PYY) and oxyntomodulin (OXM) enabled food intake suppression and reduced body weight gain in rats via their systemic absorption from the lung and interaction with the brain. After PYY and OXM were administered to the lungs at varying doses, food intake and body weight gain were monitored in freely feeding rats. Significant 30-35 % food intake suppression was achieved for 4-6 h following pulmonary administration of endogenously active PYY3-36 and OXM1-37 at 0.80 and 0.50 mg/kg, respectively. Moreover, when administered daily for 7 …

Spatial And Temporal Variability Of Macroinvertyebrate Communities In Vernal Pools On The Coastal Plain Of Virginia, Shrijeeta Ganguly

Theses and Dissertations

Vernal pools are often defined as seasonal pools that typically are inundated beginning in the winter and then drying out completely in summer. Though evidence of spatial and temporal variability in the macroinvertebrate communities of vernal pools has been found in previous studies, it has not been studied extensively. The primary objective of this study was to determine the extent of variability in the macroinvertebrate communities within vernal pools closely situated in a forested landscape. An effort was made to explain this variability with respect to certain physiochemical environmental variables of the pools. Significant variability was observed in the macroinvertebrate …

Identification Of Camk-Ii Protein Targets In Tissue Culture And Zebrafish Embryos Using Tandem Mass Spectrometry, Alexandra Myers

Theses and Dissertations

Calcium (Ca2+)/calmodulin-dependent kinase 2 (CaMK-II) is one member of a family of Ca2+/calmodulin-dependent protein kinases that responds to intracellular Ca2+ signals (Hudmon, A. and H. Schulman (2002)). CaMK-II is a multifunctional regulator of transcription, cell cycle progression, cell motility and neuronal development. (Wang, C., et al. (2008), Easley, C. A. IV, et al. (2008), Osterhoff, M., et al. (2003), Faison, M. O., et al. (2002)). Recently, CaMK-II has been shown to be important in the early development of vertebrates. In developing zebrafish, disruption of CaMK-II expression has been shown to induce phenotypes similar to those documented in several human diseases. …

Tailoring Local Conductivity By The Formation Of Ag Nanoclusters In Sio2 Xerogel Films, Ricky Caperton

Theses and Dissertations

Porous silicon dioxide thin films were produced via dip-coating and doped with Ag+ by adding AgNO3 to the dipping solution. Nanoparticles were formed within the pores of these films by UV exposure. Nanoparticle formation was confirmed by UV-visible spectroscopy and Transmission Electron Microscopy (TEM). Conductive Atomic Force Microscopy (CAFM) showed that the conductivity of the films decreased upon exposure to UV. This decrease in the conductivity is most likely due to the clustering of charge carriers. Initially, Ag+ ions are attached to negatively charged pore walls in a dense packing network. Upon UV exposure (125 mW @ 266 nm), the …

Molecular Modeling Studies Of Heparin And Heparin Mimetics Binding To Coagulation Proteins, Chandravel Krishnasamy

Theses and Dissertations

Heparin, a glycosaminoglycan (GAG), is a complex biopolymer of varying chain length and consisting of uronic acid and glucosamine residues, which are sulfated at various positions. The interaction of heparin with antithrombin is the basis for anticoagulation therapy. Heparin accelerates the antithrombin mediated inhibition of factor Xa and thrombin by a conformational activation mechansism and bridging mechanism, respectively. The sequence specific pentasaccharide DEFGH in full length heparin is the most important fragment for high affinity and activation of antithrombin, without which the heparin is incapable of binding to antithrombin. Although heparin is a commonly used anticoagulant, it suffers from serious …

Noncovalent Interaction Of Platinum Planar Amine Compounds With Tryptophan: A Strategy To Interfere With P53-Mdm2 Interactions And Targeting Retroviral Zn Finger-Dna Interaction (Hiv Ncp7), Aaron Bate

Theses and Dissertations

Non-covalent interactions involving π-π stacking play an essential role in self-assembly and molecular recognition processes such as protein folding and DNA/RNA-protein selective recognition. The knowledge gained from these studies could provide insight into possible site recognition complexes, inhibiting or mimicking protein-protein or protein-DNA interactions. Based on molecular modeling as well as HOMO and LUMO energies, several chromophores were selected with a variety of ∆ε values (∆ε= |εHOMO,NAcTrp – εLUMO,chromophores|), high and low, to establish a correlating trend with the modeling and experimental data. The corresponding Pt(dien) compounds were synthesized and their ability to stack to N-acetyl tryptophan was evaluated by …

Physiological Correlates Of Aggression In Adolescent Females, Ashley Dibble

Theses and Dissertations

Recently, with the development of new technology, researchers have focused on physiological predictors of aggressive behavior, specifically cortisol and alpha amylase. Gordis, Granger, Susman, and Trickett (2006) found the interaction between cortisol and alpha-amylase significantly predicted parent reports of aggression indicating that low levels of physiological reactivity was associated with higher levels of problem behavior. While this research has provided valuable information about aggressive behavior, a major limitation is the majority of research focuses on males, or has not examined gender differences explicitly. This study expanded on work by Gordis et al. (2006) and other researchers on the HPA axis …

Development Of An Inexpensive, Haptic Graphical Display Device, David Burch

Theses and Dissertations

A finger-worn haptic device capable of rendering 2-D graphics through vibrotactile feedback is presented. The device development is presented from its initial stages of being a stylus design using a photo-interrupter optical sensor and pager-motor actuator to a small case worn on the finger using a RGB color sensor and a piezoelectric actuator. Testing of the latest prototype design shows that it has a spatial sensitivity (<2mm) comparable to natural touch (~1mm) and can be used to output a variety of vibrotactile textures. The design can be expanded for a multiple finger, independent device, while remaining affordable (<$100) and highly portable (<500g).

Effects Of Metal Protoporphyrins On Burn Wound Conversion, Katie Braun

Theses and Dissertations

A murine model was utilized to test the influence of heavy metal protoporphyrins on burn conversion, heme oxygenase – 1 (HO-1) expression, and inflammation. Heavy metal protoporphyrins, such as cobalt protoporphyrin (Co PP) and tin protoporphyrin (Sn PP), were used to influence the heme oxygenase activity. The effects of these heavy metal protoporphyrins on burn wound conversion were examined using a burn comb model in rats. In addition to assessing the extent of conversion, HO-1 expression and parameters of inflammation were also examined in the area of injury (interspace region) subject to conversion. These studies demonstrate proof in principal that …

Season Of Birth And Risk For Schizophrenia, Seth Roberts

Theses and Dissertations

Background: Schizophrenia is a chronic, debilitating mental disorder characterized by positive (e.g., hallucinations, delusions) and negative (e.g., catatonia, flat affect) signs and symptoms. Many studies suggest that individuals born in winter or spring months are at increased risk for schizophrenia. Study Objectives: 1) To determine whether season of birth affects risk for schizophrenia in the Irish Study of High Density Schizophrenia Families (ISHDSF). 2) To examine, by computer simulation, power to detect genetic associations with schizophrenia under a variety of conditions and using different analytic strategies. 3) To test whether specific genes are associated with schizophrenia in the Irish Case …

Asian American Social Workers: Exploring Relationships Among Factors Influencing Career Choices, Soon Min Lee

Theses and Dissertations

Asian Americans are one of the fastest growing minority groups in the United States. One of the stereotypes associated with Asians is that they are more likely to choose careers in science, medicine, and engineering rather than social science, inclusive of social work, mass communication, or humanities (Leong & Serafica, 1995; Tang et al., 1999). This occupational stereotyping of Asians is not just a myth in that descriptive studies have shown that only a few Asians choose social work as a career (Lennon, 2005; NASW, 2006). Few studies exist on Asian Americans who do not choose Asian stereotypical career choices, …

Molecular Mechanisms Involved In Oligodendrocyte Development, Rochelle Coelho

Theses and Dissertations

Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) characterized by demyelination and loss of oligodendrocytes (OLGs), the CNS myelin-producing cells. Thus, understanding the mechanisms that control OLG development can provide valuable knowledge regarding remyelination therapies for MS. This disease is thought to result from an autoimmune attack towards myelin. FTY720, an immunomodulator under evaluation for MS treatment is a sphingosine-1-phosphate (S1P) analog. We found before that S1P plays a crucial role in the NT-3-mediated survival of OLGs, an observation that led us to investigate whether FTY720 could have any effect on these cells. Our studies …

Energy Efficient Embedded System Design For Medical Care System Using Wireless Sensor Network, Qi Li

Theses and Dissertations

Recent surveys on medical service systems show that the cost of patient monitoring has grown significantly. The widespread use of portable digital medical device makes it possible to provide a more comprehensive tracking of patient conditions. However, the development of a full scale, distributed health monitoring system is much delayed due to the lack of efficient wireless communication in a large distributed network. This becomes a challenging research topic which is to find a way to provide accurate and real time patient information to medical experts in a fast, efficient and cost effective fashion. This paper proposes a novel solution …

Regulation Of Mdm2 Mediated Nfκb2 Pathway In Human Lung Cancer, Lathika Mohanraj

Theses and Dissertations

Overexpression of oncoprotein MDM2 and mutations of tumor suppressor p53 are frequently observed in human cancers. The NFκB pathway is one of the deregulated pathways in oncogenesis. The overall goal of the project was to study the regulation of NFκB pathway by MDM2 in lung cancer. Our first effort was to determine the frequency of MDM2 overexpression in human lung tumor samples and to identify co-occurring abnormal gene expression by studying the levels of MDM2 and members of NFκB pathway with respect to p53 status. Higher than normal levels of MDM2 were found in approximately 30% of the cancer samples …

Pathways To Drug Use Among Rural And Urban African American Adolescents: The Mediating And Moderating Effects Of Parent And Peer Influences, Trenette Clark

Theses and Dissertations

African American adolescents have traditionally engaged in drug use at disproportionately lower rates than youth of other ethnic groups. Nonetheless, African American youth and adults suffer disproportionately higher rates of drug-related consequences. This paradox is a health and social disparity that has been given fair attention but needs additional culturally intelligent theoretical and empirical explanations. Research that targets African American adolescent drug use has emerged but has failed to fully or moderately explain this paradox. The purpose of this study was to fill a gap in the literature by helping to explain the first part of the paradox, African American …

Crosstalk Between Mdm2 And Akt Signaling Pathway In Oncogenesis., Mahesh Ramamoorthy

Theses and Dissertations

MDM2, the human homologue of the Mouse Double Minute 2 gene product, has been shown to be over-expressed in many cancers and to induce tumorigenesis. The role of MDM2 in oncogenesis was thought to be p53 dependent. However recent years have shown MDM2 to be a key player in a complex network of interactions that affect cell cycle, apoptosis, and tumorigenesis in a p53 independent manner. Here we report a novel p53 independent role for the multidimensional protein MDM2; its ability to induce phosphorylation of Akt at serine 473 residue. Transient and stable over-expression of MDM2 in cultured cell lines …

Does Light Control Algal Abundance In Large River Systems?, Amy Macdonald

Theses and Dissertations

A limited amount of research has been done to investigate the factors influencing algal abundance in large river systems. This study examines light as the primary factor that controls algal abundance in the Upper Mississippi, Missouri and Ohio Rivers. Data were collected for 2004 in conjunction with the Environmental Monitoring Assessment Program- Great River Ecosystems EMAP-GRE project using EPA approved methods. Chlorophyll a concentrations were 34.6 µg•L-1 in the Upper Mississippi, 19.8 µg•L-1 in Missouri River and 9 µg•L-1 in the Ohio River for 2004. Chlorophyll a concentrations were significantly different among the three rivers (p<0.0001) but not between years. Inter-river variation could be loosely correlated with light availability: mean Average Irradiance Dosages, which consider factors that affect light climate (depth, transparency, velocity, surface irradiance), by river corresponded with mean chlorophyll a levels by river. Intra-river variation seemed to be due to both the influence of light and nutrients.

Commonwealth Times 2008-12-01

Commonwealth Times, 1969-

No abstract provided.

Ink (2008-12)

Ink, 2008-

The student-run features magazine covering the fashion, art, music and culture worlds at VCU and in Richmond. Published annually in print and updated regularly online.

Agenda-Setting And The Media: A Look At Child Welfare Legislation, 1995-2005, Tamara Temoney

Theses and Dissertations

This project used a content analysis methodology to determine the agenda-setting capacity of the media to influence child welfare legislation in a state legislature. With a foundation in agenda-setting theory, this study identifies how the coverage of child abuse and neglect in the print media impacts decision-makers to introduce legislation related to child abuse and neglect. Through a comparison of the issues covered in the newspaper with the issues receiving legislative attention, this study showed that media influence varies by topic, with some topics being more open to media affects than others. A second component of this study analyzed how …

Creation Of A Mouse With A Humanized Fpgs Gene Compatible With Normal Development, Linying Xie

Theses and Dissertations

Abstract: Folylpoly-γ-glutamate synthetase (FPGS) catalyzes the formation of polyglutamate forms of the reduced folates and antifolates such as methotrexate (MTX) and pemetrexed; this allows the retention of folates and antifolate cancer drugs inside the cell. The enzyme activity of FPGS is essential for cell proliferation and survival. The mouse fpgs gene contains two promoters spaced 10 kb apart which are activated in a tissue-specific manner. The upstream promoter (P1) and exons A1a and A1b are used in some differentiated tissues, mainly liver and kidney, whereas the downstream promoter (P2) and exon 1 are used in rapidly dividing cells. In contrast, …

Synthesis And Characterization Of Novel Temperature-Responsive Dendritic Peg-Pdlla Star Polymers For Drug Delivery, Arunvel Kailasan

Theses and Dissertations

This study describes a novel thermoresponsive dendritic polyethylene glycol-poly(D, L-lactide) (PEG-PDLLA) core-shell nanoparticle with potential for drug delivery and controlled release. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG to Starburst™ polyamidoamine (PAMAM) dendrimer G3.0 and subsequent ring-opening polymerization of DLLA, in which PEG chain length (i.e., MW=1500, 6000 or 12000 Dalton) was varied; however, the feeding molar ratio of DLLA monomers to the overall PEG repeat units on the dendrimer surface was kept at 1:1. Linear PEG-PDLLA copolymers were also syntheiszed under the same condition and used as control. According to our results, dendritic PEG-PDLLA …

The Expression And Function Of Phosphacan/Rptpβ In Adaptive Synaptogenesis After Traumatic Brain Injury, Janna Harris

Theses and Dissertations

Traumatic brain injury (TBI) affects 1.5 million Americans annually and is a major health concern. Increasing evidence suggests that the brain extracellular environment regulates plasticity and synaptic recovery following TBI. Here we have focused on phosphacan/RPTPβ, an alternatively spliced group of chondroitin sulfate proteoglycans which are prominent within the mature brain extracellular matrix (ECM). Previous studies show that phosphacan/RPTPβ influences neuronal migration, adhesion, neurite outgrowth, and morphogenesis. However, our understanding of how these important ECM components are involved in recovery from brain trauma remains unclear. In the present study, we used unilateral entorhinal cortex lesion (UEC), a model which induces …