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In Vivo Immunotoxicological Evaluation Of Electrospun Polycaprolactone (Epcl) And Investigation Of Epcl As A Drug Delivery System For Immunomodulatory Compounds, Colleen Mcloughlin May 2012

In Vivo Immunotoxicological Evaluation Of Electrospun Polycaprolactone (Epcl) And Investigation Of Epcl As A Drug Delivery System For Immunomodulatory Compounds, Colleen Mcloughlin

Theses and Dissertations

Electrospun materials have potential use in many biomedical applications such as soft tissue replacements or as scaffolds to target drug delivery to local sites. Electrospinning is a polymer processing technique that can be used to create materials composed of fibers with diameters ranging from the micron to the nanoscale. We investigated the effects of microfibrous and nanofibrous electrospun polycaprolactone (EPCL) on innate, cell-mediated, and humoral components of the immune system. Results demonstrated that in both young (12 week) and old (6 month) mice, EPCL had no effect on various immune parameters. With its lack of immunotoxicity, EPCL presents an excellent …

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The Reciprocal Relation Between Maternal Depressive Symptomatology And Adolescents’ Aggression: The Role Of Parenting Practices And Family Functioning, Kelly Pugh May 2012

The Reciprocal Relation Between Maternal Depressive Symptomatology And Adolescents’ Aggression: The Role Of Parenting Practices And Family Functioning, Kelly Pugh

Theses and Dissertations

Research on family influences on adolescents’ aggression has revealed a relation between maternal depressive symptoms and adolescents’ frequency of aggression. A recent cross-sectional study of these relations (Pugh & Farrell, 2011) indicated that maternal depressive symptoms had a significant relation with teachers,’ students,’ and mothers’ reports of adolescents’ aggression. This effect was mediated by parenting practices and family functioning. The cross-sectional designs used in previous studies examining relations between maternal depressive symptoms and adolescents’ aggression make it difficult to draw clear inferences regarding the causal nature of this association. The present study used longitudinal data across five waves of data …

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Functional And Biochemical Consequences Of Single Nucleotide Polymorphisms In The Human Vesicular Monoamine Transporter 1 Gene (Slc18a1) By Sally Gamal Shukry, B.S., Sally Gamal Shukry May 2012

Functional And Biochemical Consequences Of Single Nucleotide Polymorphisms In The Human Vesicular Monoamine Transporter 1 Gene (Slc18a1) By Sally Gamal Shukry, B.S., Sally Gamal Shukry

Theses and Dissertations

Abstract FUNCTIONAL AND BIOCHEMICAL CONSEQUENCES OF SINGLE NUCLEOTIDE POLYMORPHISMS IN THE HUMAN VESICULAR MONOAMINE TRANSPORTER 1 GENE (SLC18A1) By Sally Gamal Shukry, B.S. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Biology at Virginia Commonwealth University. Virginia Commonwealth University, 2012 Major Advisor: Jennifer K. Stewart Associate Professor and Graduate Director, Department of Biology Single nucleotide polymorphisms (SNP) in the human VMAT1 gene (SLC18A1) have been associated with schizophrenia in three different populations: Han Chinese, Western European and Japanese. Effects of these mutations on transport function of the hVMAT1 protein have not …

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Engineering Of Polyamidoamine (Pamam) Dendrimers For Gene And Drug Delivery, Quan Yuan Apr 2012

Engineering Of Polyamidoamine (Pamam) Dendrimers For Gene And Drug Delivery, Quan Yuan

Theses and Dissertations

Dendrimers are a class of polymers with a highly branched, three-dimensional architecture composed of an initiator core, several interior layers of repeating units and multiple surface groups. They have been recognized as the most versatile compositionally and structurally controlled nanoscale building blocks throughout the fields of engineering, materials science, chemistry, and biology, and they have been widely investigated for drug and gene delivery. Polyamidoamine (PAMAM) dendrimers have inherent properties for gene delivery because of their high buffering capacity, polycationic surface and numerous surface groups for biofunctionlization. This dissertation is organized into four independent sections. The first section investigates a series …

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Fast Neural Network Algorithm For Solving Classification Tasks, Noor Albarakati Apr 2012

Fast Neural Network Algorithm For Solving Classification Tasks, Noor Albarakati

Theses and Dissertations

Classification is one-out-of several applications in the neural network (NN) world. Multilayer perceptron (MLP) is the common neural network architecture which is used for classification tasks. It is famous for its error back propagation (EBP) algorithm, which opened the new way for solving classification problems given a set of empirical data. In the thesis, we performed experiments by using three different NN structures in order to find the best MLP neural network structure for performing the nonlinear classification of multiclass data sets. A developed learning algorithm used here is the batch EBP algorithm which uses all the data as a …

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A Multifaceted Approach Identifies Erbb2 And Erbb3 Proteins And Microrna-125b As Key Contributors To Prostate Cancer Progression, Danielle Weaver Apr 2012

A Multifaceted Approach Identifies Erbb2 And Erbb3 Proteins And Microrna-125b As Key Contributors To Prostate Cancer Progression, Danielle Weaver

Theses and Dissertations

Prostate cancer is the most common cancer affecting men today. Therefore, there is a strong need for accurate biomarkers and successful therapeutic treatments. A novel approach combining a computationally built protein-protein interaction network of proven microRNA protein targets with high throughput proteomics identified ErbB2 and ErbB3 as key proteins in prostate cancer. These results coupled with microRNA array screening of an androgen-independent prostate cancer progression model, substantiated by single microRNA analysis, suggested miR125b as a key tumor suppressor contributing to prostate cancer progression. miR125b expression was shown to be substantially increased in the non-tumorigenic P69 cell line compared to its …

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Therapeutic Drug Monitoring Of Factor Viii Prophylaxis Using Its Plasma Coagulant Activity And Global Hemostasis Biomarkers: A Pharmacokinetic/Pharmacodynamic Pilot Study, Hawaj Maitham Al Apr 2012

Therapeutic Drug Monitoring Of Factor Viii Prophylaxis Using Its Plasma Coagulant Activity And Global Hemostasis Biomarkers: A Pharmacokinetic/Pharmacodynamic Pilot Study, Hawaj Maitham Al

Theses and Dissertations

Background: The current clinical practice of factor VIII (FVIII) prophylaxis revolves around converting patients with severe hemophilia A, hereafter simply referred to as hemophilia, phenotype (defined as plasma factor VIII coagulant activity [FVIII:C] <1 IU dL-1) to moderate hemophilia phenotype (defined as plasma FVIII:C from 1–5 IU dL-1). However, a wide inter-individual variation in bleeding tendency is observed despite changes in plasma FVIII:C (pharmacokinetic [PK] changes). Therefore, monitoring FVIII prophylaxis by global hemostasis biomarkers (pharmacodynamic [PD] response) can potentially be beneficial. Objective: To conduct appropriate PK/PD modeling using plasma FVIII:C and global hemostasis (platelet function and blood viscoelastic) biomarkers in severe hemophilia. Methods: Nine non-bleeding severe hemophiliacs (plasma FVIII:C <1 IU dL-1) with variant bleeding tendency (5 frequent bleeders and 4 infrequent bleeders) were infused with a recombinant factor FVIII (rFVIII) prophylactic dose (mean = 32.1 international units per kilogram [IU kg-1]). Blood was collected at baseline and 0.5-, 1-, 2-, 4-, 8-, 12-, 24- and 48-hours (h) post-dose for plasma FVIII:C, platelet function (platelet contractile force [PCF], clot elastic modulus [CEM] and force onset time [FOT]) and blood viscoelastic (reaction-time [R], kinetics-time [K] and maximum amplitude [MA]) biomarkers and activated partial thromboplastin time (aPTT). Non-compartmental analysis (NCA) was performed using standard methods. Compartmental analysis (CA) and PK/PD modeling were performed by non-linear regression. Correlation and analysis of variance (ANOVA) were used to explore the role of clinically relevant modifiers of bleeding tendency, as appropriate. ANOVA was used to assess inter-group differences in pertinent PK and PD parameters. P value <0.05 significance level was pre-specified for all statistical tests. Results: Mean (±SD) volume of distribution at steady state (Vss), total clearance (CLtot) and terminal half-life (t1/2) from NCA were 40.5 (±11.2) milliliter per kilogram (mL kg-1), 2.9 (±1.2) milliliter per hour per kilogram (mL h-1 kg-1) and 11.6 (±6.2) h, respectively. Mean (±SD) Vss and CLtot from the one-compartment body model (CA) were 39.6 (±8.9) mL kg-1 and 3.1 (±1.3) mL h-1 kg-1, respectively. The mean (±SD) baseline effect (E0) and slope from the PK/PD linear modeling were: for aPTT, 48.9 (±4.4) seconds (sec) and -0.025 (±0.009) second deciliter per international unit (sec dL IU-1), respectively; for PCF, 0.3 (±0.3) kilodynes (kdynes) and 0.008 (±0.004) kilodynes deciliter per international unit (kdynes dL IU-1), respectively; and for CEM, 0.0 (±0.0) kilodynes per square centimeter (kdynes cm-2) and 0.032 (±0.016) kilodynes deciliter per international unit per square centimeter (kdynes dL IU-1 cm-2), respectively. The mean (±SD) maximum effect (Emax) and half the maximum effective concentration (EC50) from the PK/PD sigmoidal Emax model were: for FOT, 70.1 (±16.9) % reduction and 87.8 (±31.4) IU dL-1 for FOT, respectively; for R, 74.9 (±26.0) % reduction and 68.5 (±28.4) IU dL-1, respectively; and for K, 73.2 (±36.4) % reduction and 67.2 (±29.0) IU dL-1, respectively. MA was not PK/PD modeled due to its low sensitivity. Conclusions: Plasma FVIII:C remained ≥1 IU dL-1 over the prophylactic interval. FOT and R were the most sensitive biomarkers at lower plasma FVIII:C. PCF and CEM were more sensitive than K and aPTT at lower plasma FVIII:C. MA was the least sensitive biomarker. Correlation and inter-group differences did not reach statistical significance (small sample size). These results may be used to assess risk of bleeding and dose-optimize FVIII prophylaxis in severe hemophilia.

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The Effect Of The Advanced Placement Training And Incentive Program On Increasing Enrollment And Performance On Advanced Placement Science Exams, Susan Ramsey Apr 2012

The Effect Of The Advanced Placement Training And Incentive Program On Increasing Enrollment And Performance On Advanced Placement Science Exams, Susan Ramsey

Theses and Dissertations

The purpose of this study is to examine the effectiveness of the National Math and Science Initiative’s Advanced Placement Training and Incentive Program (APTIP) on the number of students taking AP science courses and their performance. The study evaluated 39 schools over a six-year period in six states that participate in the APTIP. The National Math and Science Initiative provided data for cohort I. A general linear model for repeated measures was used to evaluate the data. Data was evaluated three years prior to the intervention and three years during the intervention, which will actually continue for two more years …

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Inhibition Of Injury-Induced Cell Proliferation In The Dentate Gyrus Impairs Cognitive Recovery Following Traumatic Brain Injury, Teresa Daniels Apr 2012

Inhibition Of Injury-Induced Cell Proliferation In The Dentate Gyrus Impairs Cognitive Recovery Following Traumatic Brain Injury, Teresa Daniels

Theses and Dissertations

Traumatic brain injury (TBI) induces a robust cellular proliferative response among neural stem/progenitor cells (NS/NPCs) in the dentate gyrus of the hippocampus. This proliferative effect is thought to contribute to the innate cognitive recovery observed following TBI. Inhibition of hippocampal neurogenesis impairs cognitive function. Furthermore, enhancement of injury-induced hippocampal neurogenesis via intraventricular administration of basic fibroblast growth factor (bFGF) improves cognitive function in animals following TBI. In this experiment, we investigated the direct association between injury-induced hippocampal neurogenesis and cognitive recovery utilizing an antimitotic agent, arabinofuranosyl cytidine (Ara-C). In this study, adult rats received a moderate lateral fluid percussion injury …

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Quantitative Analysis Of Multiple Charged Large Molecules In Human Or Rat Plasma Using Liquid Chromatography Tandem Mass Spectrometry, Matthew Halquist Apr 2012

Quantitative Analysis Of Multiple Charged Large Molecules In Human Or Rat Plasma Using Liquid Chromatography Tandem Mass Spectrometry, Matthew Halquist

Theses and Dissertations

Immunoassays have traditionally been employed for the determination of plasma concentration-time profiles for pharmacokinetic studies of therapeutic proteins and peptides. These ligand binding assays have high sensitivity but require significant time for antibody generation (1 to 2 years) for assay development. Despite high sensitivity, these assays suffer from cross-reactivity that can lead to inaccurate results. As an alternative to immunoassays, this dissertation was focused on the development and validation of assays that can be used for quantitative analysis of peptides or proteins in plasma using liquid chromatography tandem mass spectrometry (LC-MS/MS). Two approaches were considered for measurement of proteins and …

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Synthesis And Characterization Of Doxorubicin Carrying Cetuximab-Pamam Dendrimer Bioconjugates, Gunjan Saxena Apr 2012

Synthesis And Characterization Of Doxorubicin Carrying Cetuximab-Pamam Dendrimer Bioconjugates, Gunjan Saxena

Theses and Dissertations

A tumor targeted dendrimer based drug delivery system was designed and synthesized to carry chemotherapy drug doxorubicin. Polyamidoamine (PAMAM) dendrimer G4.5 was chosen as the underlying carrier. Anionic G4.5 is a good option for drug delivery as it consists of 128 surface groups, is less cytotoxic and favorably biodistributed. The delivery system was synthesized using a layer-by layer arrangement of three functional entities: chemotherapy drug doxorubicin, monoclonal antibody Cetuximab against EGF receptor, and polyethylene glycol (PEG). Doxorubicin was attached via an acid-sensitive hydrazon linkage to the dendrimer. Macromolecules are taken in by cells through endocytosis. pH inside the early endosomes …

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Associations Between Binge Eating And Executive Functioning Among Young Women, Nichole Kelly Apr 2012

Associations Between Binge Eating And Executive Functioning Among Young Women, Nichole Kelly

Theses and Dissertations

Binge eating is a pervasive disordered eating behavior associated with numerous psychological and physical comorbidities. Preliminary research indicates that emotion regulation difficulties, behavioral impulsivity, and executive dysfunction may contribute to the onset and/or maintenance of these behaviors. However, few studies have utilized neuropsychological measures to examine this link, and the assessment of behavioral and cognitive emotion regulation strategies are limited in scope. The purpose of the current study was to gain a deeper understanding of the emotional, behavioral and cognitive processes associated with binge eating behavior. Greater clarity regarding how these factors relate to binge eating is critical to the …

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Compliance-Free Class Ii Correction And Its Relationship To Vertical Facial Characteristics, Michael Shoff Apr 2012

Compliance-Free Class Ii Correction And Its Relationship To Vertical Facial Characteristics, Michael Shoff

Theses and Dissertations

Background: While efficacy of the Forsus appliance has been shown, there are disagreements on its mechanism for Class II correction. Class II studies have been criticized for ignoring potential differences in results based on differing vertical facial phenotypes. The purpose of this study was to better understand the effects of Class II correction using the Forsus appliance and relate changes during and at the completion of treatment to initial MP-SN angles. Materials and Methods: Records of 59 patients obtained at 4 different time points were examined retrospectively. ANOVA was used to describe the cephalometric changes and Pearson’s correlation tested for …

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Assessing The Genotoxicity Of Triclosan In Tadpoles Of The American Bullfrog, Lithobates Catesbeianus., David Emery Apr 2012

Assessing The Genotoxicity Of Triclosan In Tadpoles Of The American Bullfrog, Lithobates Catesbeianus., David Emery

Theses and Dissertations

Amphibians are particularly sensitive to environmental degradation and, therefore, serve as effective environmental quality indicators. Research has suggested that amphibian declines are exacerbated by manmade environmental toxicants, especially those found in high concentrations in urban areas. The NIH has pinpointed genotoxicity as a major route of cancer causation, and has since developed stringent testing procedures for potentially hazardous chemicals. One such method, recognized for its simplicity and economy, is the micronucleus assay. A study was conducted assessing the genotoxicity of the widely used antimicrobial agent Triclosan to American Bullfrog tadpoles. Lithobates catesbeianus tadpoles were reared in glass aquaria containing ultra-high …

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Mandibular Symphyseal Distraction Osteogenesis (Msdo): Association With Temporomandibular Dysfunction (Tmd) Symptoms, Sheldon Bates Apr 2012

Mandibular Symphyseal Distraction Osteogenesis (Msdo): Association With Temporomandibular Dysfunction (Tmd) Symptoms, Sheldon Bates

Theses and Dissertations

Background: Transverse mandibular discrepancies are often overlooked during orthodontic treatment. MSDO is a treatment to address this issue, but much debate exists over the long-term implications on the temporomandibular joint (TMJ). Few studies have sample sizes sufficient to draw clear conclusions about the impact of MSDO on TMJ health. Materials and Methods: This study evaluated private practice records including 49 MSDO patients and 57 traditionally-treated controls. The subjects were assessed by TMD exams that evaluated jaw pain and discomfort using visual analog scales, range of motion for opening, right and left lateral, and protrusive movements, and the presence of clenching, …

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The Impact Of Maternal Influences On Early Childhood Dental Caries, Rana Graham-Montaque Apr 2012

The Impact Of Maternal Influences On Early Childhood Dental Caries, Rana Graham-Montaque

Theses and Dissertations

Purpose: The purpose of this study was to examine the maternal influences on the development of infant oral biofilm and early childhood dental caries. Methods: The study utilized a cross-sectional design to evaluate factors influencing biofilm colonization and the identification of bacterial strains present in mother and child by utilizing oral health literacy surveys, clinical examinations, and plaque samples. Participants were enrolled in the Children’s Health Involving Parents of Greater Richmond (CHIP). Plaque samples and dental disease levels were collected from mother and children ages six months to thirty-six months. Oral Health Literacy was compared to both mother and child’s …

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Commonwealth Times 2012-04-23 Apr 2012

Commonwealth Times 2012-04-23

Commonwealth Times, 1969-

No abstract provided.

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The Effect Of Esthetic Crown Lengthening On Perceptions Of A Patient’S Attractiveness, Friendliness, Trustworthiness, Intelligence, And Self-Confidence, Samuel Lyon Malkinson Apr 2012

The Effect Of Esthetic Crown Lengthening On Perceptions Of A Patient’S Attractiveness, Friendliness, Trustworthiness, Intelligence, And Self-Confidence, Samuel Lyon Malkinson

Theses and Dissertations

BACKGROUND: Smile esthetics play a major role in the perception of a person’s attractiveness, as well as other social parameters. The study aim was to see if altering the gingival display of patients would affect perceptions of the aforementioned social parameters. METHODS: Smiling photographs were taken and then digitally altered so as to lengthen the teeth and reduce the amount of gingiva. These photographs were shown to a group of senior dental students, and a group of evaluators with no formal dental training. Groups were asked to rate each picture’s attractiveness, friendliness, trustworthiness, intelligence, and self-confidence. RESULTS: The digitally altered …

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Thin Time, Jonathan Benjamin Apr 2012

Thin Time, Jonathan Benjamin

Theses and Dissertations

THIN TIME by Jonathan Benjamin, MFA in Sculpture + Extended Media A thesis submitted in partial fulfillment of the requirements for the degree of Master of Fine Arts in Sculpture + Extended Media at Virginia Commonwealth University. Virginia Commonwealth University, 2012. Major Director: Corin Hewitt, Assistant Professor, Department of Sculpture + Extended Media This thesis is an honest attempt to put language to a non-lingual practice. It describes my studio process, my thoughts on materials and surface, and outlines some of the images and things out in the world that inform my work.

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Blues Trope As A Cultural Intersection In Alice Walker's The Temple Of My Familiar And Sherman Alexie's Reservation Blues, Julia Leuthardt Apr 2012

Blues Trope As A Cultural Intersection In Alice Walker's The Temple Of My Familiar And Sherman Alexie's Reservation Blues, Julia Leuthardt

Theses and Dissertations

Though bound historically through hundreds of years, the African-Native American relation has not received much attention by scholars of literature; hence, the emphasis of this thesis is to investigate the literary portrayal of the interethnic relation between African Americans and Native Americans through the blues trope. The blues trope provides an intriguing literary platform for the psychological and physical struggles in finding an identity within such a diverse multiethnic society like the United States. For African American writer Alice Walker and Native American author Sherman Alexie the blues trope is a successful literary device in expressing long lost and rediscovered …

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Examining Racial Differences In Sympathetic Activity Assessed During Recovery From Exercise In Obese Adolescent Females, Stacey Hall Apr 2012

Examining Racial Differences In Sympathetic Activity Assessed During Recovery From Exercise In Obese Adolescent Females, Stacey Hall

Theses and Dissertations

Sympathetic overactivity (SO) is associated with obesity and cardiovascular disease (CVD) mortality. Black adolescents have an increased risk of obesity and CVD later in life, particularly females. PURPOSE: To evaluate differences in SO between black (BOA) and white obese female adolescents (WOA). METHODS: Sixty-one BOA (n=49, 13.7±1.6 yrs, 38.1±6.1 kg/m2) and WOA (n=12, 13.3±2.2 yrs, 34.3±4.9 kg/m2) completed a maximal graded treadmill test after which an exercise recovery index (ERI; heart rate/VO2 plateau) was calculated. RESULTS: The ERI was significantly greater in BOA compared to WOA (29.8 ± 6.4 vs. 24.1 ± 3.1, P = 0.004). Multiple linear regression modeling …

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Dispositional Mindfulness And Cardiovascular Functioning Under Stress: Predictions Of Social Evaluative Stress Reactivity And Recovery, Melissa P. Holt Apr 2012

Dispositional Mindfulness And Cardiovascular Functioning Under Stress: Predictions Of Social Evaluative Stress Reactivity And Recovery, Melissa P. Holt

Theses and Dissertations

Mindfulness – a receptive attentiveness to present experience – has been shown to promote more adaptive emotion regulation (Brown et al. 2008). Additionally, dispositional mindfulness has been shown to predict reduced cortisol response to social stressors (Brown et al, in press) and mindfulness training has been shown to promote more adaptive cardiac functioning at rest (Ditto et al., 2006; Tang et al., 2009; Telles et al., 2005; Zeidan et al., 2010) and in response to social stressors (Kemeny et al., 2012). To better understand the regulatory potential of a mindful disposition on cardiovascular functioning in healthy adult participants (N = …

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Tgf-Beta Receptors And Alcohol Sensitivity In Drosophila, Kristyn Sennett Apr 2012

Tgf-Beta Receptors And Alcohol Sensitivity In Drosophila, Kristyn Sennett

Theses and Dissertations

Clic proteins influence ethanol-related behavior in flies and other species and also mediate TGF-β signaling. These findings suggest that Clics and the TGF-β signaling pathway might work together to modulate behavioral responses to ethanol. I used the Drosophila model to address the hypothesis that TGF-β signaling is important for ethanol sensitivity. Ethanol sensitivity was blunted by multiple transposon insertions in the TGF-β receptor gene thickveins. Collectively, however, I found no consistent correlation between expression of thickveins and altered ethanol sensitivity in flies harboring transposons. I therefore also assessed ethanol sensitivity in flies with loss of function point mutations in thickveins. …

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The Role Of Sulfatide In The Development And Maintenance Of The Nodal And Paranodal Domains In The Peripheral Nervous System, Heather Herman Apr 2012

The Role Of Sulfatide In The Development And Maintenance Of The Nodal And Paranodal Domains In The Peripheral Nervous System, Heather Herman

Theses and Dissertations

Sulfatide is a galactolipid and a major lipid component of the myelin sheath. Its production is catalyzed by the enzyme cerebroside sulfotransferase (CST). To determine the functions of sulfatide, the gene encoding CST was genetically disrupted resulting in mice incapable of sulfatide synthesis. Using these mice, it has been shown in the central nervous system (CNS) that sulfatide is essential for normal myelin synthesis and stability even though the onset of myelination is not impaired. Additionally, proper initial clustering of paranodal proteins and cluster maintenance of nodal proteins is impaired suggesting that paranodal domains are important for long-term node stability. …

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Grandparents Raising Grandchildren: Implications For School Systems And School Personnel, Carmen Y. Ward Apr 2012

Grandparents Raising Grandchildren: Implications For School Systems And School Personnel, Carmen Y. Ward

Theses and Dissertations

ABSTRACT A crucial issue facing our educational system is the changing family structure, particularly the increase in the number of children being raised by their grandparents. Many of these children live in a situation that places them at risk academically. Thus, it is vital that the educational system consider identifying the special needs of these children to provide supports. This study aimed to identify support services that middle school and high school grandparents perceived they needed from school systems and school personnel to ensure the educational success of their grandchildren. I developed a survey based on concerns and issues that …

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Fullerene C70 Derivatives Dampen Anaphylaxis And Allergic Asthma Pathogenesis In Mice, Sarah Norton Apr 2012

Fullerene C70 Derivatives Dampen Anaphylaxis And Allergic Asthma Pathogenesis In Mice, Sarah Norton

Theses and Dissertations

Fullerenes are carbon nanospheres that can be solublized by the addition of polar chemical groups to the carbon cage, forming fullerene derivatives. One specifically derivatized fullerene compound, termed C70-Tetragylocolate (C70-TGA), has been shown to stabilize mast cell responses in vitro thus we hypothesized it may have an effect on mast cell-driven diseases such as asthma and systemic anaphylaxis. To observe the effects of C70-TGA on systemic anaphylaxis, mice were subjected to a model of passive systemic anaphylaxis. In this model, mice were injected with DNP-specific IgE 16 hours prior to challenge, then treated with C70-TGA. Immediately prior to DNP challenge, …

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Attitudinal Responses To Mixed Evidence: The Role Of Attitude Extremity And Political Ideology In Effecting Change Versus Resistance, Jessica Barber Apr 2012

Attitudinal Responses To Mixed Evidence: The Role Of Attitude Extremity And Political Ideology In Effecting Change Versus Resistance, Jessica Barber

Theses and Dissertations

Four studies investigated the effects of attitude extremity and political ideology on the degree and direction of changes in issue attitudes following the presentation of mixed evidence. Based upon previous work, it was predicted that those holding relatively more extreme attitudes would resist changing those views when presented with a mixture of supporting and opposing statements and would potentially adopt more extreme evaluative positions – a phenomenon known as attitude polarization (Lord, Ross, & Lepper, 1979). Evaluative entrenchment or intensification was also expected among more politically conservative participants, based upon prior work describing cognitive rigidity and resistance to change as …

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Segmentation And Fracture Detection In Ct Images For Traumatic Pelvic Injuries, Jie Wu Apr 2012

Segmentation And Fracture Detection In Ct Images For Traumatic Pelvic Injuries, Jie Wu

Theses and Dissertations

In recent decades, more types and quantities of medical data have been collected due to advanced technology. A large number of significant and critical information is contained in these medical data. High efficient and automated computational methods are urgently needed to process and analyze all available medical data in order to provide the physicians with recommendations and predictions on diagnostic decisions and treatment planning. Traumatic pelvic injury is a severe yet common injury in the United States, often caused by motor vehicle accidents or fall. Information contained in the pelvic Computed Tomography (CT) images is very important for assessing the …

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Commonwealth Times 2012-04-19 Apr 2012

Commonwealth Times 2012-04-19

Commonwealth Times, 1969-

No abstract provided.

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The Play's The Thing: An Examination Of Play's Role In The Cognitive Development Of Adolescents, Ian Scheu Apr 2012

The Play's The Thing: An Examination Of Play's Role In The Cognitive Development Of Adolescents, Ian Scheu

Theses and Dissertations

The study explored the relationship of play and development in adolescents. It was developed to determine if play in adolescents has a cognitive developmental purpose. The research design was a quantitative study with qualitative elements. The design of the study consisted two groups of participants who engaged in either a computer program to test cognitive skills or a computer game which contains the same tests. The participants (N = 216) were adolescent males and females (ages 12-19) from urban mid-Atlantic Catholic high schools. After vetting the data, the total was N = 167 and only included males (ages 14-19). The …

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