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Commonwealth Times 2013-11-18 Nov 2013

Commonwealth Times 2013-11-18

Commonwealth Times, 1969-

No abstract provided.

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“The Flow Of Blood In Nature” Franz Marc’S Animal Theory, Morgan Rinehart Nov 2013

“The Flow Of Blood In Nature” Franz Marc’S Animal Theory, Morgan Rinehart

Theses and Dissertations

This thesis argues for a coherent theory of the animal in the written and visual works of the German Expressionist painter, Franz Marc. By contextualizing Marc’s animal theory within the history of animal studies, this thesis will analyze how Marc’s animal theory corresponds with several central concepts within this field. One of these concepts—a theory of animal death—is central to the artist’s greater theory of the animal and to the analysis this thesis provides. In examining Marc’s theory of animal death, the following work will propose that the artist’s theory of animal spirituality is his greatest legacy within the field …

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Alcohol And Medication Use In Community-Dwelling Older Adults: Understanding The Effect Of Alcohol And Central Nervous System-Acting Medications On The Risk For Falls, Maitreyee Mohanty Nov 2013

Alcohol And Medication Use In Community-Dwelling Older Adults: Understanding The Effect Of Alcohol And Central Nervous System-Acting Medications On The Risk For Falls, Maitreyee Mohanty

Theses and Dissertations

Introduction: Aging, comorbid conditions, and use of medications render older adults more susceptible to alcohol-disease or alcohol-drug interactions that may lead to harmful outcomes. In this dissertation project the risk profile of alcohol and medications use among older adults was investigated. Considering the rise in CNS-acting medication use and the adverse effect profile linked to CNS-acting medications, it was also of interest to find if older adults were at risk of falling due to interactions between alcohol and CNS-acting medication. Objectives: The objectives were as follows: 1) to determine the prevalence, pattern and factors associated with at-risk drinking, 2) to …

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Accidental Octopus, Elizabeth Patterson Nov 2013

Accidental Octopus, Elizabeth Patterson

Theses and Dissertations

I head to the ocean for inspiration. Diving deep, the diverse organic shapes and fluidity of the flora and fauna inspire me to create modular pieces that incorporate intricate line work. This repetitive line and patterning gives me peace and helps me meditate. This self-exploration has opened up a stimulating world that pushes me to produce prints and silver jewelry that are individual and introspective. I have learned that the journey has become the aspiration and the production, a gift.

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High Throughput Data Framework Based Characterization And Evaluations Of Thermobifida Fusca For Industrial Applications, Niti Vanee Nov 2013

High Throughput Data Framework Based Characterization And Evaluations Of Thermobifida Fusca For Industrial Applications, Niti Vanee

Theses and Dissertations

Cellulolytic organisms are being heavily studied for the production of biofuels, given that lignocellulosic biomass would be a cheap, abundant, and renewable starting material for chemical production. A challenge with cellulolytic microorganisms is that they are typically poorly characterized and often difficult to genetically manipulate. Our group focuses characterization and engineering of a thermophilic aerobic, cellulolytic actinobacterium, Thermobifida fusca. The wider range of optimal temperature and pH for the growth condition, besides the secretion of several group of cellulases, have made this microbe a potentially efficient host system for industrially application. After the development of first ever successful genetic manipulation …

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Commonwealth Times 2013-11-11 Nov 2013

Commonwealth Times 2013-11-11

Commonwealth Times, 1969-

No abstract provided.

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Behavioral And Genomic Characterization Of Scheduled Ethanol Deprivation, Jonathan Warner Nov 2013

Behavioral And Genomic Characterization Of Scheduled Ethanol Deprivation, Jonathan Warner

Theses and Dissertations

Alcoholism is a persistent substance abuse disorder that is associated with negative health, social, and economic outcomes. Treatment strategies for alcohol use disorders are limited, and only three drugs have been approved by the FDA for treatment. Although behavioral therapy and drug combination strategies improve abstinence outcomes, the majority of those in treatment will not achieve long-term abstinence. Therefore, better treatment strategies are needed. While much progress has been made toward understanding the neurobiology of alcoholism, this knowledge has not been effectively translated into treatment strategies. Animal models of alcohol drinking have been crucial to this research effort, but until …

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Analyzing The Functions Of Human Polynucleotide Phosphorylase (Hpnpaseold-35), Upneet K. Sokhi Nov 2013

Analyzing The Functions Of Human Polynucleotide Phosphorylase (Hpnpaseold-35), Upneet K. Sokhi

Theses and Dissertations

RNA degradation plays a fundamental role in maintaining cellular homeostasis, along with being a part of normal regulatory mechanisms, whether it occurs as a surveillance mechanism eliminating aberrant mRNAs or during RNA processing to generate mature transcripts. 3’-5’ exoribonucleases are essential mediators of RNA decay pathways, and one such evolutionarily conserved enzyme is polynucleotide phosphorylase (PNPase). The human homologue of this fascinating enzymatic protein (hPNPaseold-35) was cloned a decade ago in the context of terminal differentiation and senescence through a novel ‘overlapping pathway screening’ approach. Since then, significant insights have been garnered about this exoribonuclease and its repertoire of expanding …

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Laser Vaporization Methods For The Synthesis Of Metal And Semiconductor Nanoparticles; Graphene, Doped Graphene And Nanoparticles Supported On Graphene, Parichehr Afshani Oct 2013

Laser Vaporization Methods For The Synthesis Of Metal And Semiconductor Nanoparticles; Graphene, Doped Graphene And Nanoparticles Supported On Graphene, Parichehr Afshani

Theses and Dissertations

The major objective of the research described in this dissertation is the development of new laser vaporization methods for the synthesis of metal and semiconductor nanoparticles, graphene, B- and N-doped graphene, and metal and semiconductor nanoparticles supported on graphene. These methods include the Laser Vaporization Controlled Condensation (LVCC) approach, which has been used in this work for the synthesis of: (1) gold nanoparticles supported on ceria and zirconia nanoparticles for the low temperature oxidation of carbon monoxide, and (2) graphene, boron- and nitrogen-doped graphene, hydrogen-terminated graphene (HTG), metal nanoparticles supported on graphene, and graphene quantum dots. The gold nanoparticles supported …

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A Molecular Mechanism Regulating The Timing Of Corticogeniculate Innervation, Justin Brooks Oct 2013

A Molecular Mechanism Regulating The Timing Of Corticogeniculate Innervation, Justin Brooks

Theses and Dissertations

Visual system development requires the formation of precise circuitry in the dorsal lateral geniculate nucleus (dLGN) of the thalamus. Although much work has examined the molecular mechanisms by which retinal axons target and form synapses in dLGN, much less is known about the mechanisms that coordinate the formation of non-retinal inputs in dLGN. These non-retinal inputs represent ~90% of the terminals that form in dLGN. Interestingly, recently reports show that the targeting and formation of retinal and non-retinal inputs are temporally orchestrated. dLGN relay neurons are first innervated by retinal axons, and it is only after retinogeniculate synapses form that …

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Mangrove Forest Age As A Predictor Of Overwintering Habitat Quality For Migratory Songbirds, Ryan Weaver Oct 2013

Mangrove Forest Age As A Predictor Of Overwintering Habitat Quality For Migratory Songbirds, Ryan Weaver

UROP Posters

Wetland ecosystems are critical habitats for a host of organisms including resident and migratory birds. Forested wetlands (i.e., mangroves) surrounding Panama City, Panama are currently being drained and cleared to allow for commercial development. Restoration or replacement of mangroves (i.e. younger stands) may not be a sufficient surrogate for existing mature stands. Our main objective was to determine if mature mangrove forests provided higher quality habitat to (wintering) birds compared with younger mangroves. To assess this, we compared the following in mature and young mangroves in Panama (1) Prothonotary warbler and Northern waterthrush body condition, our most abundant species, and …

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The Development Of A Discipline: Examination Of The Profession Of Gerontology And Gerontological Professionals, Tracey Gendron Oct 2013

The Development Of A Discipline: Examination Of The Profession Of Gerontology And Gerontological Professionals, Tracey Gendron

Theses and Dissertations

The growth of the aging population has warranted increased training and education to prepare professionals with the specific knowledge needed to best serve older adults. Gerontology, as an academic discipline, provides professionals with the conceptual knowledge and the skills necessary to address the complexities of working with a diverse aging population. Little research has been done of the characteristics of professionals both with and without formal education in gerontology that are working with the aging population. The aim of this study was to investigate the roles of career motivation, job satisfaction, attitudes about aging, career commitment, and professional identity among …

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Commonwealth Times 2013-10-07 Oct 2013

Commonwealth Times 2013-10-07

Commonwealth Times, 1969-

No abstract provided.

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Effects Of Nitrite And Oxygen On Angiogenesis In Vascular Networks Of The Chicken Embryo, Michael Connery Oct 2013

Effects Of Nitrite And Oxygen On Angiogenesis In Vascular Networks Of The Chicken Embryo, Michael Connery

Theses and Dissertations

Nitric oxide (NO) is an important mediator of angiogenesis and is primarily produced endogenously through the action of nitric oxide synthase (NOS). An alternate pathway for NO production is the conversion of nitrite to NO, which depends on the presence of hemoglobin (Hb) and hypoxic conditions. The angiogenic effects of topically applied sodium nitrite on two vascular beds in the ex ovo chicken embryonic model of angiogenesis were assessed. Gas barrier films were used to modulate local oxygen levels in the chorioallantoic membrane (CAM), a respiratory vascular network, and the area vasculosa (AV) on the yolk sac, a typical peripheral …

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Heart Rate Variability As A Moderator Of Trauma Writing Outcomes, Alison Eonta Sep 2013

Heart Rate Variability As A Moderator Of Trauma Writing Outcomes, Alison Eonta

Theses and Dissertations

Writing about personal traumatic experiences is associated with beneficial effects on physical and psychological symptoms compared with writing about emotionally neutral events. However, not everyone benefits from trauma writing to the same extent. The present study hypothesized that the effectiveness of trauma writing may be moderated by emotion regulation, as indexed by respiratory sinus arrhythmia (RSA). Research also shows that greater physiological reactivity is predictive of better trauma writing outcomes. Given the importance of physiological output in emotional processing, response training was developed and found to increase appropriate physiological reactivity. Because higher RSA is thought to indicate a more flexible …

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Protein Kinase C Dependent Inhibition Of Kir3.2 (Girk2) Channel Activity And Its Molecular Determinants, Scott Adney Sep 2013

Protein Kinase C Dependent Inhibition Of Kir3.2 (Girk2) Channel Activity And Its Molecular Determinants, Scott Adney

Theses and Dissertations

Inwardly rectifying potassium (Kir) channels are critically important for regulating resting membrane potential in excitable cells, a job underscored by the severe pathophysiology associated with channel dysfunction. While all Kir channels require the activating lipid PIP2, many of these channels have diverse modulatory factors that couple to PIP2-dependent gating. Channels in the Kir3 (GIRK) family, in particular, have several co-activating elements, including G-protein betagamma subunits, ethanol, and sodium. During stimulation of Gq-coupled receptors, downstream activation of Protein Kinase C can phosphorylate and inhibit Kir3 channels, yet the mechanism of inhibition and phosphorylation sites are incompletely understood. We took a combined …

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The Effects Of Neurotensin On The Rat Distal Colon, Rick Chainani Sep 2013

The Effects Of Neurotensin On The Rat Distal Colon, Rick Chainani

Theses and Dissertations

The enteric nervous system controls the gut through the release of specific neurotransmitter and neuromodulators at specific sites such as mucosal secretory cell or smooth muscle cell. In the present study, we have examined the response to one of these neurohumoral agents, Neurotensin, in the rat distal colon. Neurotensin is a paracrine and endocrine modulator of the digestive tract. Even though these effects have been seen in colonic preparations, there are very few functional studies of the effects of Neurotensin in the rat colon, especially the distal colon. In the current study we propose the following hypothesis that Neurotensin will …

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The Role Of Outer Membrane Protein A In Anaplasma Marginale Cellular Invasion And Its Potential As A Cross-Protective Antigen, Sarvani Emani Sep 2013

The Role Of Outer Membrane Protein A In Anaplasma Marginale Cellular Invasion And Its Potential As A Cross-Protective Antigen, Sarvani Emani

Theses and Dissertations

Anaplasma phagocytophilum and A. marginale are the etiologic agents of human granulocytic anaplasmosis and bovine anaplasmosis, respectively. Both diseases can be severe, even fatal, and protective vaccines for each are lacking. We recently identified A. phagocytophilum outer membrane protein A (ApOmpA) as being critical for cellular invasion and is expressed during infection of mammalian but not tick cells. Disrupting ApOmpA-host cell interactions significantly inhibits A. phagocytophilum entry into host cells. ApOmpA and its A. marginale ortholog, AM854 (A. marginale OmpA; AmOmpA) exhibit 44% amino acid identity. The ApOmpA invasin domain is highly conserved between both proteins. In this study, we …

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The Role Of Nitric Oxide Dysregulation In Tumor Maintenance, Christopher Rabender Sep 2013

The Role Of Nitric Oxide Dysregulation In Tumor Maintenance, Christopher Rabender

Theses and Dissertations

The inflammatory nature of the tumor microenvironment provides a cytokine and chemokine rich proliferative environment. Much of the responsibility of this environment is due to the production of Reactive Oxygen Species (ROS). These studies examined the proliferative rich tumor environment from a new perspective of Nitric Oxide Synthase (NOS) dysregulation. NOS’s have the ability to become uncoupled and generate superoxide in lieu of nitric oxide (NO). A requirement of NOS for the production of NO is the cofactor tetrahydrobiopterin (BH4) and when it is missing NOS becomes uncoupled and turns into a peroxynitrite synthase. Here I demonstrate that NOS is …

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Patient Perceptions Of Shared Decision Making: What Does It Mean And How Does It Affect Patient Outcomes?, Laura Aubree Shay Sep 2013

Patient Perceptions Of Shared Decision Making: What Does It Mean And How Does It Affect Patient Outcomes?, Laura Aubree Shay

Theses and Dissertations

Introduction: Shared decision making (SDM) has been advocated as an optimal approach to medical decision-making. Yet, little is known about how patients perceive SDM and whether patient-defined SDM is associated with patient outcomes. Methods: This three-manuscript dissertation used a mixed-methods approach including a systematic literature review and both qualitative and quantitative research methods. The aims were to: (1) systematically review the patient outcomes studied in relation to SDM and identify under what measurement contexts SDM is associated with which types of patient outcomes; (2) use in-depth, qualitative interviews to develop a conceptual model of patient-defined SDM and compare this to …

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Functional Characterization Of Crip1a Knockout Mice, Joanna Jacob Aug 2013

Functional Characterization Of Crip1a Knockout Mice, Joanna Jacob

Theses and Dissertations

CB1 cannabinoid receptors are G-protein-coupled receptors that mediate the central nervous system (CNS) effects of marijuana and endocannabinoids. Recently, cannabinoid receptor interacting protein 1a (CRIP1a) was discovered as a novel protein that binds to the CB1 receptor C-terminus and inhibits CB1 receptor activity without affecting CB1 expression. This thesis investigated the functions of CRIP1a by characterizing the first CRIP1a knockout (KO) mouse line. The absence of CRIP1a was confirmed in KO mice using quantitative PCR and immunoblotting. I hypothesized that CRIP1a KO mice would exhibit enhanced CB1 receptor-mediated G-protein activity in the CNS, as well as cannabimemetic phenotypes and enhanced …

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Commonwealth Times 2013-08-26 Aug 2013

Commonwealth Times 2013-08-26

Commonwealth Times, 1969-

No abstract provided.

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Spit For Science: The Relationship Between Deviant High School Behavior And College Substance Use, Preetha Palasuberniam Aug 2013

Spit For Science: The Relationship Between Deviant High School Behavior And College Substance Use, Preetha Palasuberniam

UROP Posters

This study examined the relationship between deviant high school behavior, as defined by symptoms of conduct disorder, and frequency of alcohol and cigarette use in the past 30 days in college freshman at VCU. Deviant high school behaviors included skipping school, running away, stealing, starting a fire, destroying property, hurting animals or people, using weapons, fighting, and lying. The sample included first year freshmen at VCU who participated in the Spit for Science study. The software SPSS was used to calculate the significance of the correlations between deviant high school behavior and frequency of alcohol and cigarette use. A sum …

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Positron Emission Tomography For Pre-Clinical Sub-Volume Dose Escalation, Christopher Bass Aug 2013

Positron Emission Tomography For Pre-Clinical Sub-Volume Dose Escalation, Christopher Bass

Theses and Dissertations

Purpose: This dissertation focuses on establishment of pre-clinical methods facilitating the use of PET imaging for selective sub-volume dose escalation. Specifically the problems addressed are 1.) The difficulties associated with comparing multiple PET images, 2.) The need for further validation of novel PET tracers before their implementation in dose escalation schema and 3.) The lack of concrete pre-clinical data supporting the use of PET images for guidance of selective sub-volume dose escalations. Methods and materials: In order to compare multiple PET images the confounding effects of mispositioning and anatomical change between imaging sessions needed to be alleviated. To mitigate the …

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Intra And Extracellular Functions Of Sphingosine-1-Phosphate In Sterile Inflammation., Jessie Yester Aug 2013

Intra And Extracellular Functions Of Sphingosine-1-Phosphate In Sterile Inflammation., Jessie Yester

Theses and Dissertations

Sterile inflammation is a key component of a variety of diseases including, gout, arthritis, type 1 diabetes, Alzheimer’s disease and multiple sclerosis (MS). Sterile inflammation induces the recruitment of immune cells via chemokines, such as CCL5 and CXCL10. Expression of these chemokines is dependent on IRF-1. Recently the FDA has approved the use of a pro-drug, FTY720 that after phosphorylation becomes a S1P mimetic for the treatment of MS. This report describes two novel and opposing mechanisms of S1P action in sterile inflammation. First, intracellular S1P acts as a cofactor of cIAP2 that inducesIL-1-dependent K63-polyubiquitination of IRF-1, which leads to …

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The Role Of Pain-Related Catastrophizing In Outcomes And Recovery From Minimally Invasive And Surgical Procedures For Treating Temporomandibular Disorders, Aaron Martin Aug 2013

The Role Of Pain-Related Catastrophizing In Outcomes And Recovery From Minimally Invasive And Surgical Procedures For Treating Temporomandibular Disorders, Aaron Martin

Theses and Dissertations

The current study examined the ability of pain-related catastrophizing to predict outcomes following non-surgical and surgical intervention for temporomandibular disorders (TMDs). The interpersonal context of pain-related catastrophizing, referred to as the communal coping model, was also examined to determine if patient perceptions of punishing and solicitous responses from significant others would moderate or mediate relations between pain catastrophizing and outcomes. The role of pain duration as a moderator of the relation between pain-related catastrophizing and perceived significant other responding was also examined. A total of 94 patients were identified for which 65 had follow-up outcomes that could be examined. Patient …

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Osteopontin Expression During The Acute Immune Response Mediates Reactive Synaptogenesis And Adaptive Outcome, Julie Chan Aug 2013

Osteopontin Expression During The Acute Immune Response Mediates Reactive Synaptogenesis And Adaptive Outcome, Julie Chan

Theses and Dissertations

Traumatic brain injury (TBI) is a worldwide epidemic as the number of victims living with the resulting cognitive and physical impairment continues to rise, principally due to limited treatment options which fail to address its multifaceted sequelae. By approaching TBI therapy from a molecular standpoint, we have the opportunity to develop a better understanding of the mechanisms which prevent effective recovery. With this information, we can move toward the identification of novel therapeutic treatments which target specific molecules to improve patient outcome following TBI. Here, we have focused on the therapeutic potential of osteopontin (OPN), an extracellular matrix (ECM) protein …

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Factor H Cleavage By The Treponema Denticola Protease Dentilisin: Understanding The Pathogenesis Of Periodontal Disease, Sahil Aggarwal Aug 2013

Factor H Cleavage By The Treponema Denticola Protease Dentilisin: Understanding The Pathogenesis Of Periodontal Disease, Sahil Aggarwal

UROP Posters

Periodontal disease is an infectious condition that results in the inflammation and gradual degradation of gum tissue and alveolar bone. Caused by plaque deposits on teeth that harden into tartar to inflame gum tissue, the condition is highly pervasive, with 15 percent of US adults over 30 years of age exhibiting destructive periodontal disease. The abundance of Treponema denticola, a spirochete, in the oral flora is strongly correlated with disease severity. T. denticola binds to Factor H (FH), a negative regulator of the complement system, through its Factor H binding protein (FhbB) to evade complement-mediated killing. The protease dentilisin, produced …

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Confocal Microscopy Study Of The Embryonic Development Of The Viviparous Nemertean Prosorhochmus Americanus Reveals Larval Features Supporting Indirect Development In Hoplonemerteans, S Tyler Spindle Aug 2013

Confocal Microscopy Study Of The Embryonic Development Of The Viviparous Nemertean Prosorhochmus Americanus Reveals Larval Features Supporting Indirect Development In Hoplonemerteans, S Tyler Spindle

Theses and Dissertations

Recent studies of hoplonenemertean planuliform larvae have clarified their development and provided insight into larval evolution within the phylum. However, an assessment of viviparous development using modern techniques is lacking. To help facilitate a comprehensive comparative evaluation of developmental diversity within hoplonemerteans, we have conducted a confocal laser scanning microscopy investigation of the development in Prosorhochmus americanus, one of the few viviparous hoplonemertean species. Phalloidin staining provides evidence of a modified transitory larval epidermis, and reveals that the foregut, midgut, proboscis, central nervous system, and body wall musculature form early in development, consistent with observations for planktonic and encapsulated hoplonemertean …

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Overuse Of Fluoride In Public Water Systems: Stimulating Fluorosis Rather Than Preventing Dental Caries, Kaixin Chen Aug 2013

Overuse Of Fluoride In Public Water Systems: Stimulating Fluorosis Rather Than Preventing Dental Caries, Kaixin Chen

UROP Posters

In the early 1940’s, researchers sponsored by the Centers for Disease Control and Prevention (CDC) discovered an inverse correlation between the prevalence of dental caries and the quantity of fluoride consumption and exposure. As a result of this finding, the Environmental Protection Agency under the advisement of the CDC instructed municipalities in the United States to fluoridate their public water systems in order to increase fluoride exposure. More recently though, other researchers have concluded that there is a positive correlation between another dental condition, dental fluorosis, and fluoride consumption and have made recommendations to decrease fluoride consumption due to the …

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