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Roles Of Seed Dispersal And Environmental Filters In Establishment Of The Dominant Shrubs: Morella Cerifera And M. Pensylvanica, On An Atlantic Barrier Island, Benjamin Dows May 2014

Roles Of Seed Dispersal And Environmental Filters In Establishment Of The Dominant Shrubs: Morella Cerifera And M. Pensylvanica, On An Atlantic Barrier Island, Benjamin Dows

Theses and Dissertations

Patterns of the expansion of woody cover into grasslands on barrier islands of the Virginia coast were investigated. Seed dispersal of the dominant shrub Morella spp., was sampled deploying seed traps (n = 82) throughout a landscape under shrub encroachment pressure on Hog Island, VA. Traps were placed underneath: fruiting Morella, non-fruiting Morella, co-occurring species (Iva frutescens and Baccharis halimifolia) and in grass land, (no shrub cover). Environmental filters that act upon dispersed seeds and subsequently determine establishment patterns were also investigated. Dispersal distribution throughout the encroachment zone was leptokurtic and dispersal among cover types suggest co-occurring shrub species facilitate …

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High Speed Atomic Force Microscope Design Using Dvd Optics, Thomas Carlson May 2014

High Speed Atomic Force Microscope Design Using Dvd Optics, Thomas Carlson

Theses and Dissertations

We examine the design of a high speed atomic force microscope using an optical pickup from a commercially available compact disc/digital versatile disc drive. An investigation of the commercial optical pickup is done with the goal of determining how it can be used for dimensional measurements on nanometer scale. An evaluation of noise sources, imaging capabilities, and functionality is performed.

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Approaches To Reduce Selection Of Genomic Variants In Human Pluripotent Stem Cell Culture, Marion Riggs May 2014

Approaches To Reduce Selection Of Genomic Variants In Human Pluripotent Stem Cell Culture, Marion Riggs

Theses and Dissertations

Optimizing culture conditions that reduce genomic instability in human pluripotent stem cells (hPSCs) is an unmet challenge in the field. Results from our lab and numerous research groups demonstrate that hPSCs are prone to genomic aberrations and single-cell passaging increases the rate of genomic alterations. However, single-cell based passaging maintains advantages for scale-up and standardizing differentiation protocols. In this study, we investigated the problem of genomic instability in hPSC cultures with the goal towards identifying and characterizing candidate genes that could contribute to generation and survival of abnormal hPSCs. Based on microarray analysis, we identify ARHGDIA, located on 17q25, as …

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Potential Energy And The Three Odalisques, Yamins Roxanne May 2014

Potential Energy And The Three Odalisques, Yamins Roxanne

Theses and Dissertations

The goal of this paper is to examine some ways in which BEHAVIOR, POTENTIAL ENERGY, and EMPATHY are critical components in my thinking and work. The impetus for my work is an investigation of how these three components can be manifested in visually expressive and powerful states. My masters thesis, The Three Odalisques, is an attempt at making a space and world which privileges these components and the potential for art to express these ideas. This paper is divided into two parts. The first section is a formal analysis of the pieces in my work from my MFA thesis show. …

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Mandibular Incisor Proclination Variability During Class Ii Correction, James Redford May 2014

Mandibular Incisor Proclination Variability During Class Ii Correction, James Redford

Theses and Dissertations

Background: Lower incisor proclination has been shown to increase during Class II correction with appliances such as the Forsus. This lower incisor flaring shows great variability among patients. The purpose of this study was to evaluate the effects of Class II severity, mandibular growth, and occlusal plane rotation on lower incisor flaring in patients treated with the Forsus appliance. Materials and Methods: 121 records of Class II patients treated with the Forsus appliance were analyzed retrospectively. Cephalograms were traced at three time points. ANOVA was used to compare changes in cephalometric measurements over time. Pearson’s correlation was used to test …

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Artificial Dissemination, Brian Fleetwood May 2014

Artificial Dissemination, Brian Fleetwood

Theses and Dissertations

This writing is an experiment in combining the two most important frameworks through which I understand the world, the storytelling traditions of my people, the Mvskoke(Creek), and the rational tradition that began with European Enlightenment era thinking. By weaving allegorical narrative (much of it personal) into theoretical speculation, I draw connections between recollection, truth, and the act of making. This examination of the gaps and connections between seemingly disparate worldviews, runs in parallel to the purpose of my work, wherein I construct fictive symbiotic and parasitic relationships between jewelry and wearer. This work takes advantage of the wearer as environment, …

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Thinking Bodies And Sensational Minds: Affect And Embodiment In Contemporary Art, Sandra Burke May 2014

Thinking Bodies And Sensational Minds: Affect And Embodiment In Contemporary Art, Sandra Burke

Theses and Dissertations

The human subject is profoundly interdependent, in relation to other people and to the surrounding environment, both “natural” and technological. Western dualistic thinking creates bounded and oppositional categories and generates a conception of human subjects as autonomous, self-sufficient beings that are transparent to themselves and in control of self, other, and world. This contributes to the ongoing inequalities in society and supports normative hegemony. This dissertation argues that it is imperative to insist on the intersubjective, permeable, and contingent qualities of existence. While this project is preceded by a great deal of theoretical criticism of Western metaphysical dualism, we must …

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A Passive Acoustic And Experimental Study Of Juvenile Blue Catfish, Ictalurus Furcatus, Sound Production And Agnostic Behavior In The Tidal Freshwater James River, Laura Morgan May 2014

A Passive Acoustic And Experimental Study Of Juvenile Blue Catfish, Ictalurus Furcatus, Sound Production And Agnostic Behavior In The Tidal Freshwater James River, Laura Morgan

Theses and Dissertations

Blue catfish, Ictalurus furcatus, are an invasive species in the James River, VA. They produce stridulation sounds and passive acoustic monitoring may prove useful in locating and monitoring their populations. Little is known about their behavior, therefore my goal was to examine agonistic behavior and the use of sound in defending a territory. This thesis consists of two manuscripts: 1) A passive acoustic study of the tidal freshwater James River, 2) An experimental study of agonistic behavior in juvenile Blue catfish, Ictalurus furcatus. The first study showed that three sounds (click, run croak) occurred more often in warmer months than …

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Planar Cell Polarity And Neurodevelopment, Simon Sun May 2014

Planar Cell Polarity And Neurodevelopment, Simon Sun

Theses and Dissertations

Planar cell polarity (PCP) is a developmental signaling mechanism that establishes a polarity within the plane of an epithelium. PCP has been shown to play a role in guiding numerous neurodevelopmental processes such as convergent extension, neuron migration, and axon pathfinding. Certain commissural neurons in the dorsal spinal cord make a series of guidance decisions en route to the brain: first, a ventral projection along the D-V axis, followed by a midline crossing, and after exiting the floorplate, a dorso-anterior turn along the A-P axis. Here, we provide in vivo evidence that the axons of the Commissural Primary Ascending (CoPAs) …

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Understanding The Role Of Stylochus Ellipticus As A Predator Of Crassostrea Virginica In Chesapeake Bay Tributaries, Marion Kensey Barker May 2014

Understanding The Role Of Stylochus Ellipticus As A Predator Of Crassostrea Virginica In Chesapeake Bay Tributaries, Marion Kensey Barker

Theses and Dissertations

Predation may be a key component of the unsuccessful restoration of the Eastern Oyster (Crassostrea virginica), a former keystone species in Chesapeake Bay. Here, I examine the polyclad flatworm Stylochus ellipticus and its potential role as an important predator of C. virginica. Using small-fragment size C. virginica specific DNA primers, oyster DNA was successfully detected in whole organisms homogenates of wild-caught S. ellipticus individuals. Of the 1,575 individuals tested, 68.1% tested positive, thus predation occurred. Predation did not appear to be affected by salinity or temperature; however, season did appear to have an effect on both predation and S. ellipticus …

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Parental Perceptions And Experiences Of Physical And Emotional Violence Between Siblings: A Mixed-Methods, Comparative Case Study, Nathan Perkins May 2014

Parental Perceptions And Experiences Of Physical And Emotional Violence Between Siblings: A Mixed-Methods, Comparative Case Study, Nathan Perkins

Theses and Dissertations

Sibling violence is a common occurrence for many children yet this form of family violence has received minimal attention in research compared to other forms of child maltreatment. With parents as an integral component in the lives of many children, parental perceptions and experiences of violence between siblings are important to understand. Furthermore, with the increased variation in family structures within society, inclusion of multiple types of families in research is necessary to encompass a broad understanding of sibling violence. This case study included seven parents from four different family structures to examine their perceptions and experiences of physical and …

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The Role Of Cytoprotective And Non-Protective Autophagy In Radiation Sensitivity In Breast Tumor Cells, Jade Le May 2014

The Role Of Cytoprotective And Non-Protective Autophagy In Radiation Sensitivity In Breast Tumor Cells, Jade Le

Theses and Dissertations

In general, ionizing radiation promotes cytoprotective autophagy in a majority of breast tumor cells. Previous studies from our laboratory indicated that radiation (5x2 Gy) induces cytoprotective autophagy in MCF-7 cells. In the current work, inhibition of autophagy by silencing of Beclin-1 in MCF-7 cells resulted in an increase in sensitivity to radiation based both on cell number and clonogenic survival; however, there was no increase in apoptosis and the basis for this sensitization is currently under investigation. Unexpectedly, enhancement of autophagy by silencing of Bcl-2 also led to an increase in sensitivity to radiation, possibly through the conversion of cytoprotective …

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Relationship Of Mitochondrial Enzymes To Fatigue Intensity And Health-Related Quality Of Life In Men With Prostate Cancer Receiving External Beam Radiation Therapy, Kristin Filler May 2014

Relationship Of Mitochondrial Enzymes To Fatigue Intensity And Health-Related Quality Of Life In Men With Prostate Cancer Receiving External Beam Radiation Therapy, Kristin Filler

Theses and Dissertations

Introduction: Cancer-related fatigue is often described by patients as a lack of energy, mental or physical tiredness, diminished endurance, and prolonged recovery after activity. Etiologic mechanisms underlying CRF are not well understood. Methods: A literature review was conducted to examine studies that had investigated the association of mitochondrial dysfunction with fatigue. The major conclusion from this review was that alterations in energy metabolism may contribute to fatigue. Therefore, the dissertation study focused on laboratory techniques for measuring mitochondrial oxidative phosphorylation enzymes (complexes I-V) and a mitochondrial-specific oxidative stress marker (superoxide dismutase 2 [SOD2]). The primary aim of the dissertation research …

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Conspecific Attraction In A Low-Density Population Of A Threatened Songbird, Daniel James Albrecht-Mallinger May 2014

Conspecific Attraction In A Low-Density Population Of A Threatened Songbird, Daniel James Albrecht-Mallinger

Theses and Dissertations

Many organisms use both vegetation structure and social cues in selecting habitats. Many species of songbirds use the presence of breeding conspecifics as a social cue and sign of habitat quality, and can be induced to settle in unoccupied habitats by artificially broadcasting breeding song, a process referred to as “conspecific attraction”. In our study, we tested response to conspecific attraction a low-density population of the threatened Golden-winged Warbler (Vermivora chrysoptera) in Highland County, VA. Response to broadcast song was observed, with a modest increase in mean male abundance at survey points within 250 meters of treatments, and mean abundance …

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Unification, Agency, Systemization, Intuition: My Art Making Process And Ideas, Zachary Duer May 2014

Unification, Agency, Systemization, Intuition: My Art Making Process And Ideas, Zachary Duer

Theses and Dissertations

This essay is an attempt to describe my ideas about my work, my process, and my philosophy of art by examining five of the major pieces I created during the pursuit of a Master of Fine Arts degree at Virginia Commonwealth University. I will discuss the pieces in chronological order, first providing a description of the works’ salient characteristics, then delving into both my specific thoughts about the work as well as the background ideas that were pertinent to me during my process of creation.

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Role Of Membrane Fusion Protein Ykt6 In Regulating Epithelial Cell-Cell And Cell-Matrix Adhesions., Supriya Joshi May 2014

Role Of Membrane Fusion Protein Ykt6 In Regulating Epithelial Cell-Cell And Cell-Matrix Adhesions., Supriya Joshi

Theses and Dissertations

Intercellular junctions and cell-matrix adhesions play important roles in the maintenance of epithelial integrity. Assembly and remodeling of the plasma membrane complexes are regulated by membrane trafficking and fusion. This thesis is aimed to elucidate the roles of an important membrane fusion protein, Ykt6, in the regulation of epithelial cell adhesion and migration. For the first time, we show that Ykt6 is essential for assembly of adherens junctions and tight junctions in human prostate epithelial cells. We also observed that Ykt6 negatively regulates both collective epithelial cell migration and cell invasion into Matrigel. The effects of YKT6 on epithelial junctions …

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Benthic Macroinvertebrate Subsampling Effort And Taxonomic Resolution For Bioassessments Of Streams In The James River Watershed Of Virginia, Laurel Williams May 2014

Benthic Macroinvertebrate Subsampling Effort And Taxonomic Resolution For Bioassessments Of Streams In The James River Watershed Of Virginia, Laurel Williams

Theses and Dissertations

Benthic macroinvertebrate diversity influences stream food web dynamics, nutrient cycling and material exchange between the benthos and the water column. Stream bioassessment has moved to the forefront of water quality monitoring in terms of benthic macroinvertebrate diversity in the recent past. The objectives of this study were to determine optimum subsample size and level of taxonomic resolution necessary to accurately and precisely describe macroinvertebrate diversity in streams flowing in the Piedmont province of the James River watershed in Virginia. Forty-nine sampling sites were selected from streams within the Piedmont Physiographic Province of the James River watershed. Ten sites were randomly …

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Inferring Gene Regulatory Networks From Expression Data Using Ensemble Methods, Janusz Slawek May 2014

Inferring Gene Regulatory Networks From Expression Data Using Ensemble Methods, Janusz Slawek

Theses and Dissertations

High-throughput technologies for measuring gene expression made inferring of the genome-wide Gene Regulatory Networks an active field of research. Reverse-engineering of systems of transcriptional regulations became an important challenge in molecular and computational biology. Because such systems model dependencies between genes, they are important in understanding of cell behavior, and can potentially turn observed expression data into the new biological knowledge and practical applications. In this dissertation we introduce a set of algorithms, which infer networks of transcriptional regulations from variety of expression profiles with superior accuracy compared to the state-of-the-art techniques. The proposed methods make use of ensembles of …

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Crossing Boundaries: Building A Model To Effectively Address Difference In Community Practice, Jason Sawyer May 2014

Crossing Boundaries: Building A Model To Effectively Address Difference In Community Practice, Jason Sawyer

Theses and Dissertations

Community organizing has a rich tradition within the field of social work. Prevailing community practice models, approaches, and frameworks remain primarily based on practice wisdom, experience, and intuition. Difference, pervasive in various contemporary contexts of practice, largely mediates interactions at the community level. Although difference is addressed at various levels of the practice continuum and within the IFSW and NASW codes of ethics, few methodologically driven tools exist within the literature to guide practitioners. This grounded theory study initiates early development of a community practice model based on forging alliances across boundaries of difference. The Critical Difference Engagement model is …

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Hospital: A Creature Of Duality, Gordon Mccormick May 2014

Hospital: A Creature Of Duality, Gordon Mccormick

Theses and Dissertations

Hospitals can no longer be thought of as simply healing machines--they are healing organisms. It is Nature that permits every miracle of medicine, and it is Science that permits our understanding of medicine. By combining the two into a single idea, we aim to strike a balance between the duality of Nature and Technology, in order to design a space that relies more on the healing powers of Nature and less on the intrusiveness of Technology.

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Investigations Of Novel Mechanisms Of Action For Anti-Bacterial And Anti-Cancer Agent Development, Jenson Verghese May 2014

Investigations Of Novel Mechanisms Of Action For Anti-Bacterial And Anti-Cancer Agent Development, Jenson Verghese

Theses and Dissertations

The development of drugs and therapeutic agents for combating infections and human malignancies continues to be a forefront area in both academic and industrial research. This is driven by the rapid emergence of multi-drug resistant bacterial strains and accumulating mutations in cancer targets that is quickly rendering our current arsenal of drugs ineffective for these therapies. Unless new drugs with novel mechanisms of action are identified and developed at a faster pace, we face a losing battle in managing these diseases. The first part of this work concerns with the natural product Simocyclinone D8 (SD8). Simocyclinone D8 is an angucyclinone …

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Bakhtin’S Carnivalesque: A Gauge Of Dialogism In Soviet And Post-Soviet Cinema, Randy Davis Apr 2014

Bakhtin’S Carnivalesque: A Gauge Of Dialogism In Soviet And Post-Soviet Cinema, Randy Davis

Theses and Dissertations

This dissertation examines fifteen films produced in seven political eras from 1926 thru 2008 in Soviet / Post-Soviet Russia. Its aim is to determine if the cinematic presence of Bakhtin’s ten signifiers of the carnivalesque (parody, death, grotesque display, satirical humor, billingsgate, metaphor, fearlessness, madness, the mask, and the interior infinite) increase in their significance with the historical progression from a totalitarian State (e.g., USSR under Stalin) to a federal semi-residential constitutional republic (e.g., The Russian Federation under Yeltsin - Putin). In this study, the carnivalesque signifiers act as a gauge of dialogism, the presence of which is indicative of …

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Queeranimal Imaginary: An Intra-Active Investigation Of Ecology, Performance, And Sound, Caryn Brissey Apr 2014

Queeranimal Imaginary: An Intra-Active Investigation Of Ecology, Performance, And Sound, Caryn Brissey

Theses and Dissertations

Through interrelated experiments in writing, video, sound, and movement, this research investigates the intersections of intimacy, ecology, and performance. Integrating an autoethnographic approach to gender and sexuality with creative practice and theoretical inquiry, this layered investigation offers implications that are both deeply personal and widely accessible. I am using my own experiences growing up as a queer child to generative corporeal and experience-based material, while also incorporating the ideas of current queer and gender theorists to frame my own research within the larger context of feminist studies. This research culminated into an evening length performance at Dogtown Dance Theatre on …

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Indirect Effects Between Deer, Mice, And The Gypsy Moth In A Forest Community, John Wojcikiewicz Apr 2014

Indirect Effects Between Deer, Mice, And The Gypsy Moth In A Forest Community, John Wojcikiewicz

Theses and Dissertations

White-tailed deer are ecosystem engineers that dramatically alter forest understory vegetation. Consequently, deer can impact many species in a forest through both direct and indirect effects. One species that deer may indirectly affect is the gypsy moth, whose pupae are preyed upon by the white-footed mouse. Through alterations to understory habitat of mice, deer may reduce mouse predation on gypsy moth pupae. In this study, I tested for indirect effects of deer on the gypsy moth by comparing mouse abundance, vegetation properties, and predation on pupae inside, and outside, of long-term deer exclosures. Overall, I did not find evidence for …

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Forest Net Primary Production Resistance Across A Gradient Of Moderate Disturbance, Ellen Goodrich-Stuart Apr 2014

Forest Net Primary Production Resistance Across A Gradient Of Moderate Disturbance, Ellen Goodrich-Stuart

Theses and Dissertations

The global carbon (C) balance is vulnerable to disturbances that alter terrestrial C uptake and loss. Moderate disturbances that kill or defoliate only a subset of canopy trees such as insect defoliation, drought, and age-related senescence are increasing in extent and frequency; yet, little is known about the effect of moderate disturbance on forest production and the mechanisms sustaining or supporting the recovery of the C cycle across a range of moderate disturbance severities. We used a broad plot-scale gradient of upper canopy tree mortality within a large manipulation of forest disturbance to: 1) quantify how aboveground wood net primary …

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Necessary Movements, Janelle Proulx Apr 2014

Necessary Movements, Janelle Proulx

Theses and Dissertations

This thesis follows the trajectory of my artistic practice over the past two years which has led me to the creation of the installation REVERB. While incorporating performance, installation, and video into my modes of creation, I’ve likewise expanded my conceptual research regarding the influential capabilities of touch, gesture, and environment. By focusing on the relationship of REVERB to a broader discussion regarding these themes, I hope to situate the work among its art, cultural, and scientific referents.

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Untitled, Adriane Connerton Apr 2014

Untitled, Adriane Connerton

Theses and Dissertations

This text is an exploration of the ideas and work that I made in 2014.

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Commonwealth Times 2014-04-28 Apr 2014

Commonwealth Times 2014-04-28

Commonwealth Times, 1969-

No abstract provided.

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Academically Resilient English Language Learners: A Focus Group Study Exploring Risk Factors And Protective Factors, Michelle Abrams-Terry Apr 2014

Academically Resilient English Language Learners: A Focus Group Study Exploring Risk Factors And Protective Factors, Michelle Abrams-Terry

Theses and Dissertations

In this study, the researcher explored high school English language learners’ perceptions of risk factors and protective factors present in their academic and social lives. The researcher also explored how these students negotiated risk factors and used protective factors to be academically resilient. Therefore, the study was designed to examine academic resilience from the students’ perspectives, allowing them to share their story about their success in high school. The following research questions guided this study: (1) What risk factors are present in high school English language learners’ academic and social lives? and (2) Which protective factors do high school English …

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Prevalence And Distribution Of Periapical Lesions Submitted For Histopathologic Analysis By Endodontists, Gerhard Claire Siegel Apr 2014

Prevalence And Distribution Of Periapical Lesions Submitted For Histopathologic Analysis By Endodontists, Gerhard Claire Siegel

Theses and Dissertations

The current understanding of the distribution and frequency of periapical pathoses include biopsies submitted by all specialists and general dentists. As a result, they do not accurately reflect the distribution seen by endodontists. This retrospective chart review aims to determine the prevalence of periapical pathoses and associated demographics from biopsies submitted by endodontists over 30 years. All biopsy reports submitted to the Virginia Commonwealth University Oral Pathology Diagnostic Service from January 1, 1983 to December 31, 2012 were reviewed. Only reports submitted by verified endodontists and those with a periapical location were included. The following data was recorded from each …

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