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Identification Of Active Compounds And Antidiabetic Activity Of Red Shoot (Syzygium Myrtifolium) Leaves Extract With In Vitro And In Silico Methods, Muhamad Iqbal Prakoso, Siti Warnasih

Pharmaceutical Sciences and Research

Diabetes mellitus (DM) is a chronic metabolic disease that affects approximately 537 million people worldwide (1 in 10 individuals), and its prevalence is projected to reach 783 million by 2045. One of the plants that has the potential to be an antidiabetic is red shoots (Syzygium myrtifolium) since it contains various secondary metabolite compounds such as flavonoids, triterpenoids, steroids, saponins, phenolics, and anthocyanins. This study aimed to evaluate the antidiabetic properties of red shoot leaves extract and to identify and predict interactions between its active compounds and the α-glucosidase receptor. Ethanol, ethyl acetate, and n-hexane extracts of red …

Defining Life: A Conversation, K. Kofman, C. Adami, F. Baluška, J. Bongard, D. Brash, P. Calvo, G. Dodig-Crnkovic, P. Das, C. Fields, T. Froese, P. L. Gentili, G. Y. Georgiev, Scott F. Gilbert, T. N. W. Jackson, S. Kauffman, N. Lane, P. Marshall, D. Mcshea, W. Miller, S. Newman, A. Nunn, T. P. Pavlic, M. Picard, W. Ratcliff, A. Reber, J. Shapiro, A. Sloman, R. Solé, C. Sonnenschein, S. Stepney, R. Watson, O. Witkowski, M. Levin

Biology Faculty Works

Life is one of the most fascinating features of the physical world. Despite centuries of scientific study, experts still disagree about the definition, and even the possibility or utility of a definition, of this field. In a recent paper, we used AI to analyze the conceptual space formed by definitions of life given by a select set of modern workers in the life sciences and related fields. However, some of the most interesting material emerged as real-time conversations among those polled. In order to ensure that these ideas are not lost to the peer-reviewed scientific record, we here provide a …

Online Decoding Of Rat Self-Paced Locomotion Speed From Eeg Using Recurrent Neural Networks, Alejandro De Miguel, Nelson Totah, Uri Maoz

Psychology Faculty Articles and Research

Objective. Accurate and reliable neural decoding of locomotion holds promise for advancing clinical applications such as rehabilitation and prosthetic control, as well as for understanding neural correlates of action. Recent studies have demonstrated successful decoding of locomotion kinematics across species in motorized treadmill settings. However, efforts to decode locomotion speed directly and continuously in more natural contexts—where pace is self-selected rather than externally imposed—are scarce, and those that exist generally achieve only modest accuracy and require intracranial implants. Here, we aim to decode self-paced locomotion speed non-invasively and continuously using cortex-wide electroencephalography (EEG) recordings from rats. Approach. We introduce an …

Integrating Nutrition And Stress Into Life History Stages Of Wild Free-Ranging Female Pronghorn, Cole A. Bleke, Eric M. Gese, Juan J. Villalba, Shane B. Roberts, Susannah S. French

Wildland Resources Student Research

Studies addressing seasonal changes in diet quality and hormones are important for understanding the interactions between ecology and physiology. We collected fecal samples from free-ranging adult female pronghorn (Antilocapra americana) to examine the relationships between indicators of nutrition and glucocorticoid activity. This occurred during three population-level, life-history-correlated sampling periods across five subpopulations. We evaluated nutrition via fecal nitrogen, fecal 2,6-diaminopimelic acid (DAPA), and assessed glucocorticoid activity using fecal glucocorticoid metabolites (FGM). We found positive relationships between fecal nitrogen and DAPA, whereas DAPA and fecal nitrogen with FGM varied in influence and strength, depending upon life history stage. Generally, …

How To Engage With, And Have Impact On, Marine Governance: A Practical Guide For Early-Career Researchers, Denis B. Karcher, Christopher Cvitanovic, Melanie C. Austen, Aislinn F. Dunne, Louisa Evans, Rebecca Gruby, Nicole Malinconico, Shannon Mclaughlin, E. J. Milner-Gulland, Nathalie A. Steins

School of Biological and Marine Sciences

Early-career researchers (ECRs) are at the forefront of producing the knowledge and solutions needed to address contemporary ocean challenges. Their work is often highly inter- and transdisciplinary, generating insights that are critical for informed decision-making, and effective and equitable marine governance. Yet, despite this potential for impact, many ECRs lack access to the tools, training, and institutional support necessary to engage meaningfully with governance processes. Such structural complexities are further compounded by practical constraints that ECRs experience such as short project timelines and limited networks, making engagement with governance particularly intimidating and/or difficult for ECRs. This commentary seeks to empower …

Um–Protoshare: Unet-Guided, Multi-Scale Shared Prototypes For Interpretable Brain Tumour Classification Using Multi-Sequence 3d Mri, Ali Golbaf, Vivek Singh, Swen Gaudl, Emmanuel Ifeachor

School of Engineering, Computing and Mathematics

Deep learning shows strong promise in brain tumour classification using Magnetic Resonance Imaging (MRI), although limited interpretability constrains clinical translation. Most interpretability methods are post-hoc and yield visual attribution maps that are only weakly connected to the decision process. Clinicians prefer decisions built from evidence they can recognise and verify on MRI, rather than post-hoc explanations. Case-based models embed reasoning by comparing image evidence with learned prototypes, yielding “this looks like that” rationales at decision time and mirroring clinical reasoning. Building on this paradigm, we introduce UM–ProtoShare, which compares the input multi-sequence 3D brain MRI with a bank of shared, …

Evaluating Cardiotoxicity And Factors Associated With In-Hospital Mortality Among Emergency Department Patients With Substance Use Disorder: An 11-Year Retrospective Study, Darpanarayan Hazra, Nadia Ahmed Said Alqusaimi, Alyaqeen Ahmed Abdullah Al Breiki, Raghad Saleh Mohammed Al Akhzami, Aya Hasan Hadi Aalhamad, Suad Abdullah Al Abri

Sultan Qaboos University Medical Journal

Objective: Substance use disorder (SUD)-related emergencies are increasing globally, with cardiotoxicity contributing substantially to morbidity and mortality. This study evaluated cardiotoxicity patterns and factors associated with in-hospital mortality among adults with SUD presenting to the emergency department (ED).Methods: This retrospective observational study was conducted from January 2014 to December 2024 at Sultan Qaboos University Hospital, University Medical City, Muscat, Oman. Adults aged ≥18 years with SUD and positive urine drug screening (UDS) were included if they had elevated troponin (>14 ng/L), electrocardiographic abnormalities or echocardiographic structural dysfunction. Clinical, laboratory, imaging, management and outcome data were analysed. Results …

Tgf-Β Drives The Conversion Of Conventional Nk Cells Into Uterine Tissue-Resident Nk Cells To Support Murine Pregnancy, Josselyn D Barahona, Liping Yang, D Michael Nelson, Wayne M Yokoyama

2020-Current year OA Pubs

Tissue microenvironments shape lymphocyte differentiation to align immune function with local physiological demands. Uterine natural killer (NK) cells are critical for reproductive success, yet the molecular cues in the uterus that instruct their specialized identities remain incompletely understood. Here, we identify a TGF-β-dependent differentiation pathway by which circulating conventional NK cells convert into uterine tissue-resident NK cells during murine pregnancy. Loss of TGF-β receptor II expression in

Advances In Gene Editing Strategies For Viral Disease Resistance In Pigs: Knock-Out, Knock-In, And Overexpression Approaches, Zhao Namula, Takeshige Otoi, Aya Nakai, Megumi Nagahara, Maki Hirata, Fuminori Tanihara

The Thai Journal of Veterinary Medicine

Highly contagious viral pathogens—such as porcine reproductive and respiratory syndrome, classical swine fever, and African swine fever—continue to pose serious threats to the swine industry and cause major global economic losses. Conventional disease control approaches, such as vaccination and biosecurity, are limited by viral heterogeneity and immune escape mechanisms. Gene editing technologies, most notably the CRISPR/Cas9 system, offer an innovative means of introducing innate viral disease resistance or resilience in pigs. The continuous improvement of these tools can provide a sustainable strategy to enhance animal welfare and global food security and reduce reliance on traditional control measures. This review provides …

Noda News Summer 2026

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

Rurality And Redistricting: California's Proposition 50, Rural Identity, And Democratic Legitimacy, Lisa R. Pruitt

Maine Law Review

When California voters embraced mid-decade congressional redistricting in 2025, the greatest media attention landed on the state’s First Congressional District, CA-01. It is residents of that district who are likely to feel the consequences of the new maps most profoundly. In the form established by the California Citizens Redistricting Commission in 2021, CA-01 occupied more than 26,000 square miles in the state’s northeastern corner. The district included a number of inland counties stretching from Modoc, tucked into the corner formed by the Oregon and Nevada state lines, to Colusa, in the Great Central Valley. The cluster of ten counties—hereinafter “old …

Should I Stay Or Should I Go? The National Flood Insurance Program And Where We Go When The Next Storm Hits, Kevin Fitzpatrick

Ocean and Coastal Law Journal

This article argues that what makes the difference in success between these two regimes is how strictly the scientific advice underlying catch limits the advice is adhered to, and the influences allowed unto decisionmakers in the catch limit negotiation process. Whereas the United States uses the scientific advice about the MSY as a strict upper limit in determining annual catch limits, the EU does not. This allows stakeholders in the EU’s CFP governance, in particular fishing industry actors, to influence regulators to raise TACs above adequately precautionary levels in the name of “balancing” sustainable fishing with short-term economic interests. The …

"Tac-Ing" On Coherence: Achieving Sustainable Baltic Sea Fisheries Management By Hooking Precautionary Science And Greater Transparency In Eu Total Catch Negotiations, Patrick Seroogy

Ocean and Coastal Law Journal

This article argues that what makes the difference in success between these two regimes is how strictly the scientific advice underlying catch limits the advice is adhered to, and the influences allowed unto decisionmakers in the catch limit negotiation process. Whereas the United States uses the scientific advice about the MSY as a strict upper limit in determining annual catch limits, the EU does not. This allows stakeholders in the EU’s CFP governance, in particular fishing industry actors, to influence regulators to raise TACs above adequately precautionary levels in the name of “balancing” sustainable fishing with short-term economic interests. The …

Alaska's Hidden Gems: Advocating For The Protection Of Deep-Sea Corals, Both In The Courtroom And Beyond, Lauren Beizer

Ocean and Coastal Law Journal

Coral reefs are ecologically, financially, and aesthetically one of the world’s greatest resources. Off the coast of Alaska, many unique species of deep-sea cold-water corals exist and provide various public health benefits, contribute vital ecosystem functions to their surrounding environment, and serve as economic tourist attractions. Alaska’s corals reefs are exceedingly valuable to the earth due to their overall ecological value. However, these unique coral species significantly lack state and federal protections–which have recently been under consideration in several lawsuits at the federal level. American Oceans Campaign v. Daley and Oceana, Inc. v. National Marine Fisheries Service et al., are …

Editor's Page, Art Mcphee

Witness

No abstract provided.

Efficacy Of Sirolimus Versus Paclitaxel-Coated Balloons For Coronary Revascularization: An Updated Meta-Analysis With Grade Assessment, Matthew Aldo Wijayanto, Christopher Daniel Tristan, Erlangga Masykur Kynaya, Annisa Aghnia Rahma, Putri Saskia Harimurti, Arwin Saleh Mangkuanom, Amir Aziz Alkatiri, Doni Firman, Bambang Budi Siswanto

Journal of the Saudi Heart Association

Drug-coated balloons are an emerging strategy for coronary revascularization. Despite their increasing use, the comparative efficacy of sirolimus- versus paclitaxel-coated balloons (SCB vs PCB) remains uncertain. This updated meta-analysis evaluated clinical and angiographic outcomes of SCB and PCB in percutaneous coronary intervention (PCI). A comprehensive search of PubMed, Scopus, and ScienceDirect was performed on August 28, 2025. Studies directly comparing SCB and PCB were included. The primary endpoint was target lesion failure (TLF), which was defined as cardiac death, target vessel myocardial infarction (TVMI), or target lesion revascularization (TLR). On follow-up angiography, secondary endpoints consisted of minimal lumen diameter (MLD), …

Mental Health And Psychosocial Well-Being Of Domestic Workers In Dar Es Salaam, Tanzania: Why It Matters And Why We Should Make It A Priority, Magolanga Shagembe

Tanzania Journal of Sociology

This phenomenological study explores the mental health and psychosocial well-being of domestic workers aged 15–18 years in Dar es Salaam, Tanzania. Drawing on Bronfenbrenner’s ecological systems theory and Erikson’s psychosocial development theory, the study examines how domestic workers negotiate self-acceptance, personal growth, purpose in life, quality of relationships, environmental control, autonomy and resilience within unequal labor and care arrangements. Data were generated through in-depth interviews with 29 domestic workers and analyzed thematically. The findings reveal that mental health and psychosocial well-being among domestic workers are shaped through complex interactions between structural vulnerability, interpersonal relationships, migration experiences, economic necessity, and future …

Medicalisation And The Practice Of Labour Augmentation In Mwanza, Tanzania, Latifa Abdulla Mohamed, Richard Sambaiga, Karen Marie Moland, Siri Lange

Tanzania Journal of Sociology

Since the late 1900s, maternal health has increasingly been medicalised as a result of growing global concerns about poor maternal outcomes. An example of this medicalisation process is the use of oxytocin for labour augmentation. This practice of administering oxytocin to shorten the duration of labour is increasingly questioned. Feminist scholars have often questioned the routine use of oxytocin, depicting it as unnecessary and may constitute inappropriate use of the drug that undermines women’s autonomy and contributes to negative birth experiences. However, these feminist arguments overlook individual agency and the complex ways in which actors encounter and interact with oxytocin …

Evaluation Of Diclazuril And Amprolium Against Eimeria Spp. In Vietnamese Broilers: Implications For Intestinal Integrity And Claudin Gene Expression, Nguyen Thi Hoa, Pham Hoang Son Hung, Le Dinh Phung, Le Duc Thao, Nguyen Van Chao, Tran Thi Na, Tran Cao My Linh, Ho Thi Dung

The Thai Journal of Veterinary Medicine

This study aimed to assess the resistance status of Eimeria spp. in Vietnam to diclazuril and amprolium and to evaluate their effects on intestinal recovery following infection. One hundred 12-day-old chicks were randomly allotted to four groups: a non-infected negative control (NC), an infected untreated as positive control (PC), an infected group treated with diclazuril (DI), and an infected group treated with amprolium (AM). At day 14, chicks from all groups except NC were orally challenged with 2 × 10⁴ sporulated Eimeria oocysts (E. tenella, E. maxima, E. acervulina, and E. mitis). On day 7 …

Phenomenological Analysis Of Trust In Science For The Design Of Ai-Based Health And Social Policies, Kochav Koren

All Duquesne Faculty Scholarship

The promises of artificial intelligence (AI) as a solution to challenges facing health systems increasingly link technological innovation with improvements in efficiency and access. However, the legitimacy of AI-supported health policies depends not only on scientific competence but also on public trust in scientific institutions. Using data from the international Trust in Science Project (71,922 respondents across 68 countries), this study analyses multidimensional trust and communication ecologies to reconstruct relational configurations of trust, termed ‘Figures of Relevance’. Findings reveal that whilst scientific competence is widely recognised, perceptions of institutional openness vary markedly, shaping heterogeneity in trust. The study identifies four …

Electrospinning Of Covalent Organic Frameworks (Cofs) For Adsorption Of Heavy Metal Ions, Samar A. Salim

Nanotechnology Research Centre

This study reported the synthesis, electrospinning, and heavy metal adsorption of covalent organic frameworks (COFs) integrated into poly(methyl methacrylate) (PMMA) nanofibers. COF-1 and COF-2 were synthesized by solvothermal and reflux techniques, respectively, and subsequently incorporated into PMMA via electrospinning with different loadings (0.1%, 0.5%, and 1.0%). The synthesized PMMA_COF nanofibers were analyzed utilizing X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and diffuse reflectance spectroscopy (DRS). PMMA_COF nanofibers with fiber diameters of 350-450 nm were obtained. The structural and morphological investigations validated the effective integration of COFs into the PMMA matrix, with COF-1 demonstrating superior dispersion …

Beyond The Cycle: How Menstruation Influences Gender Identity And Well-Being In Binary And Non-Binary Adults, Rin Nguyen

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Approximately 1.8 billion people worldwide menstruate, including transgender and gender-diverse (TGD) people, yet their experiences remain underrepresented in research. Given that menstruation can affect gender alignment and psychological well-being, understanding its impact on TGD people is critical. Gender congruence, or alignment between one’s gender identity and expression, is a key factor influencing well-being, with research linking it to reduced depression and anxiety. Furthermore, emerging research on gender euphoria, the joy experienced when gender congruence is experienced, suggests it may serve as a protective factor for mental health and well-being. Gender euphoria has been associated with reduced psychological distress and increased …

The Art Of Overturning Precedent: A Comparative Analysis Of The Warren And Roberts Court Upending Established Law, Jacob Spry

University of Dayton Law Review

No abstract provided.

Extrafloral Nectaries In Woody Plants: Toward An Integrated Framework For Ant-Mediated Plant Defense, Fangming Liu, Qifei Cai, Victor Busov, Zhen Liu

Michigan Tech Publications

Extrafloral nectaries (EFNs)—secretory structures that recruit predatory arthropods as indirect defenders against herbivory—have been studied almost exclusively in herbaceous systems, leaving a critical gap in our understanding of plant defense in woody plants. In trees, secondary growth, ontogenetic regulation, and seasonal phenology generate structural and temporal heterogeneity in EFN expression poorly captured by existing frameworks. We synthesize evidence across structural, chemical, and functional dimensions of EFN biology to develop an integrated framework for perennial trees. Our analysis suggests that methodological limitations in EFN detection likely bias the current chemical record of woody EFNs, while incomplete chemical characterization constrains the evaluation …

Effect Of Virtual Reality Intervention Of Postoperative Pain In Pediatric Surgical Patients, Tara L. Kempker

Dissertations

Problem: Pediatric surgical procedures are associated with preoperative anxiety. Preoperative anxiety is associated with higher postoperative pain. Multiple studies have found that decreasing preoperative anxiety using Virtual Reality (VR) Intervention also decreases postoperative pain scores and use of rescue analgesics in postoperative care units (PACU). However, there is no standardized protocol for use of VR interventions and in our institution, VR was not utilized at all.

Methods: This quality improvement (QI) initiative utilized a quasi-experimental design and convenience sampling. Quantitative data was collected during visits for scheduled operative visits for pediatric surgical patients ages seven to 18 years …

Identification Of Prognostic Factors For Disease Recurrence-Free Survival (Drfs) In Breast Cancer Patients Using The Cox Proportional Hazards Model, Dwi Cahyaning Putri, Veny Prabaningrum, Samsul Arifin

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Breast cancer remains one of the most common malignancies among women worldwide, with recurrence remaining a major clinical challenge. Despite various treatment efforts, the mortality rate from breast cancer remains high, particularly among patients with worse clinical and molecular conditions. This study aims to identify factors influencing the survival of breast cancer patients using the Cox proportional hazards model. The study analyzes clinical and molecular data of breast cancer patients to identify key risk factors affecting Disease Recurrence-Free Survival (DRFS). Analysis was conducted using Kaplan-Meier, the Log Rank test, and the Cox proportional hazards model. The results showed that nodal …

Extrafloral Nectaries In Woody Plants: Toward An Integrated Framework For Ant-Mediated Plant Defense, Fangming Liu, Qifei Cai, Victor Busov, Zhen Liu

Michigan Tech Publications

Extrafloral nectaries (EFNs)-secretory structures that recruit predatory arthropods as indirect defenders against herbivory-have been studied almost exclusively in herbaceous systems, leaving a critical gap in our understanding of plant defense in woody plants. In trees, secondary growth, ontogenetic regulation, and seasonal phenology generate structural and temporal heterogeneity in EFN expression poorly captured by existing frameworks. We synthesize evidence across structural, chemical, and functional dimensions of EFN biology to develop an integrated framework for perennial trees. Our analysis suggests that methodological limitations in EFN detection likely bias the current chemical record of woody EFNs, while incomplete chemical characterization constrains the evaluation …

Fecal Fatty Acids And Other Risk Factors Associated With Multiple Sclerosis Score, Progression And Diagnosis Among Hispanic Adults, Juliana Ayala-Viqueira

Walden Dissertations and Doctoral Studies

Multiple sclerosis (MS) is a chronic neurological condition with insufficient research regarding risk factors influencing MS severity score (MSSS), progression and diagnosis among Hispanic adults living in the United States. This cross-sectional study assessed factors associated with MS score, progression and diagnosis using secondary data from the International Multiple Sclerosis Microbiome Study (iMSMS). Guided by the ecological model, the study included N = 576 participants with MS. Manuscript 1 explored the association between body mass index (BMI), sodium consumption, and the MS severity score in a Hispanic adult population. A multiple linear regression was conducted to examine whether age and …

Examining Inmate Labor In Emergency Management: Contributions, Challenges, And Ethical Considerations, Boris Eugene Valiance

Walden Dissertations and Doctoral Studies

Incarcerated individuals remain inconsistently engaged in disaster preparedness, response, and recovery, creating both an operational gap and an ethical challenge regarding labor equity, safety, voluntariness, and human dignity. Guided by RBT and EMT, the purpose of this qualitative case study was to explore how incarcerated individuals are utilized in emergency management and to examine stakeholder perceptions of the operational, ethical, and policy implications of inmate labor programs. The research questions examined current utilization patterns, stakeholder-perceived benefits and drawbacks, and ethical concerns influencing participation decisions. Data were collected through semi structured interviews with purposefully sampled emergency management professionals, policymakers, and correctional …

Relationship Between Employee Engagement, Gender, And Intention To Quit In The Retail Industry, Lataya V. Mills

Walden Dissertations and Doctoral Studies

Intention to quit remains a significant challenge for retail organizations, contributing to recruitment and training costs, workforce instability, and operational disruptions. The purpose of this quantitative correlational research project was to examine the relationship between employee engagement, gender, and intention to quit among frontline retail employees in the Mid-Atlantic United States. Grounded in employee engagement theory, participants included 71 frontline retail employees. Data were collected using the Utrecht Work Engagement Scale, an Intention to Quit Scale, and demographic questions. Composite scores were calculated for employee engagement and intention to quit, and the data were analyzed using descriptive statistics, reliability analysis, …