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A Comparison Of The Discriminative Stimulus Properties Of The Atypical Antipsychotic Clozapine And The Glutamate Agonist N-Methyl D-Aspartate In C57bl/6 Mice., Sarah A. Vunck Apr 2009

A Comparison Of The Discriminative Stimulus Properties Of The Atypical Antipsychotic Clozapine And The Glutamate Agonist N-Methyl D-Aspartate In C57bl/6 Mice., Sarah A. Vunck

Theses and Dissertations

The glutamate system dysfunctions present in schizophrenia raise new questions about possible glutamatergic actions of the atypical antipsychotic clozapine. While clozapine has been shown to partially substitute for the discriminative stimulus of the glutamate agonist N-methyl D-aspartate (NMDA) in rats, NMDA discrimination has not previously been established in mice. The present study was designed to explore the possible role of NMDA activity in clozapine’s discriminative stimulus. Two groups of C57BL/6 mice were trained to discriminate either 2.5 mg/kg CLZ from vehicle or 30 mg/kg NMDA from vehicle in a standard two-lever drug discrimination task. NMDA drug discrimination was successfully established …


Examination Of The Discriminative Stimulus And Cross-Tolerance Inducing Properties Of N-Desmethylclozapine In C57bl/6 Mice., Jason Wiebelhaus Apr 2009

Examination Of The Discriminative Stimulus And Cross-Tolerance Inducing Properties Of N-Desmethylclozapine In C57bl/6 Mice., Jason Wiebelhaus

Theses and Dissertations

Due to its unique receptor binding profile and its relationship to clozapine, N-desmethylclozapine (NDMC) has been examined as a possible antipsychotic drug (APD). Clozapine has been trained as discriminative stimulus in our lab, but NDMC has not yet been established as a discriminative stimulus. In experiment 1, 12 C57BL/6 mice were trained to discriminate 10.0 mg/kg NDMC from VEH using a standard-two lever operant procedure to assess antipsychotic substitution. The typical APD clozapine fully substituted for NDMC at 2 doses tested (2.5 and 5.0 mg/kg), while typical APD haloperidol failed to substitute for NDMC. In Experiment 2, 11 mice were …


Obesity, Adiposity, And Satiety In Mouse Models Of Smith-Magenis Syndrome And Dup(17)(P11.2) Syndrome, Brooke Burns Apr 2009

Obesity, Adiposity, And Satiety In Mouse Models Of Smith-Magenis Syndrome And Dup(17)(P11.2) Syndrome, Brooke Burns

Theses and Dissertations

Smith-Magenis syndrome (SMS) is a complex disorder caused by haploinsufficiency of RAI1 and characterized by sleep disturbances, behavioral abnormalities, mental retardation, and obesity in teens and adults. Rai1+/- mice are obese after 20 weeks. Dup(17)(p11.2) syndrome is a complex disorder associated with overexpression of RAI1. A transgenic mouse model of dup(17)(p11.2) syndrome overexpresses Rai1 and results in a mouse that is growth delayed. In order to characterize the obese phenotypes of mouse models of SMS and the role of RAI1 in obesity, daily food intake and serum levels of insulin, glucose, PPY, and leptin were measured; adiposity was studied by …


Swaying The Masses: The Effect Of Argument Strength And Linguistic Abstractness On Attitudes, Jessica Barber Apr 2009

Swaying The Masses: The Effect Of Argument Strength And Linguistic Abstractness On Attitudes, Jessica Barber

Theses and Dissertations

Two studies were conducted to investigate how the use of different types of language affects attitudes. Participants scrutinized arguments supporting a hypothetical toothpaste that differed in terms of argument strength (strong versus weak) and linguistic abstractness (abstract versus concrete) and subsequently evaluated the toothpaste. In addition, half of the participants in the second study were subjected to a cognitive load manipulation (i.e., rehearsing a ten-digit number) in order to limit their level of cognitive elaboration. Results indicated that strong arguments and those containing concrete descriptions led to more positive attitudes about the toothpaste, whereas weak messages comprised of abstract terms …


Structural And Functional Considerations In The Design Of Collagen-Based Electrospun Scaffolds, Chantal Ayres Apr 2009

Structural And Functional Considerations In The Design Of Collagen-Based Electrospun Scaffolds, Chantal Ayres

Theses and Dissertations

Electrospinning can be used to selectively process a variety of natural and synthetic polymers into highly porous scaffolds composed of nano-to-micron diameter fibers. This process shows great potential as a gateway to the development of physiologically relevant tissue engineering scaffolds. In this study we examine the structural and functional considerations regarding electrospun scaffolds for dermal template applications using novel quantification techniques. In order to characterize scaffold structure, a technique utilizing the fast Fourier transform was developed to systematically quantify fiber alignment and evaluate how different electrospinning parameters impact the structure and material properties of an electrospun scaffold. Gelatin was suspended …


A Model Of Organizational Competencies For Business Intelligence Success, Lewis Chasalow Apr 2009

A Model Of Organizational Competencies For Business Intelligence Success, Lewis Chasalow

Theses and Dissertations

Business intelligence (BI) systems comprise one of the largest and fastest growing areas of IT expenditure in companies today. Companies’ experiences with deriving benefits from these systems are still mixed. One of the differences between BI and other types of information systems is that how BI systems are used, not just whether they are used, can have a major impact on the benefits derived. Therefore the characteristics of BI users and the organizations within which they work can have a disproportionate impact on the benefits derived from investments in BI. Organizational competence is one way to evaluate the characteristics of …


Efficacy Of A Brief Intervention For Insomnia Among Psychiatric Outpatients, James Nile Wagley Apr 2009

Efficacy Of A Brief Intervention For Insomnia Among Psychiatric Outpatients, James Nile Wagley

Theses and Dissertations

Psychiatric patients are particularly affected by symptoms of insomnia. Because insomnia is often secondary to other conditions and was once thought to be less treatable, this condition has received little attention in terms of treatment and research. Additionally, psychiatric patients have typically fewer resources to seek treatment. Generally, insomnia is treated with medications that may have biological side effects and offer little restorative sleep. Behavioral or cognitive interventions have often been overlooked. This experiment uses profile analysis to test the hypothesis that psychiatric outpatients randomized to a treatment group would have decreased levels of sleep difficulties (measured by PSQI) when …


Disordered Eating And Substance Use: A Multivariate Longitudinal Twin Desigh, Jessica Baker Apr 2009

Disordered Eating And Substance Use: A Multivariate Longitudinal Twin Desigh, Jessica Baker

Theses and Dissertations

Eating disorders and substance use disorders both exhibit a clear sex-difference in prevalence. Eating disorders are more common in females while substance use disorders are more common in males. Previous research has also established a strong association between these two disorders, especially within females. Much less research has examined comorbity in males. The etiology and reasons for these sex-differences and for the comorbidity of eating and substance use disorders remain unclear. The present report aimed to examine disordered eating (DE), substance use (SU), and their comorbidity further, in both sexes, using disorder eating attitudes and behaviors and substance use rather …


Factors Affecting Dissolved Oxygen Metabolism In Coastal Plain Streams Of Virginia, Julie Frank Apr 2009

Factors Affecting Dissolved Oxygen Metabolism In Coastal Plain Streams Of Virginia, Julie Frank

Theses and Dissertations

I investigated seasonal and inter-site variation in factors influencing diel dissolved oxygen (DO) metabolism at four streams in the Virginia Coastal Plain. Data were collected monthly from January to August 2008 to characterize DO metabolism (diel DO amplitude, production, respiration), incident solar radiation (PAR), dissolved nutrients, fine benthic materials (mass, C:N, Chlα) and hydrology (discharge, water transit time, transient storage). Reach-scale metabolism estimates were determined using the one-station diurnal DO technique and transit time and transient storage were determined by conservative tracer additions. Incident solar radiation was the primary determinant of DO metabolism as streams experiencing higher light levels (Herring …


Intake Decision Making In Child Protective Services: Exploring The Influence Of Decision-Factors, Race, And Substance Abuse, Michael Howell Apr 2009

Intake Decision Making In Child Protective Services: Exploring The Influence Of Decision-Factors, Race, And Substance Abuse, Michael Howell

Theses and Dissertations

Child protective services begin with an intake (screening) decision to accept or reject maltreatment reports. This crucial decision may lead to significant positive or negative outcomes for children and families. Little is known about characteristics that intake decision-makers share or factors that influence the decision-making process. Racially-biased intake practices have been blamed for contributing to African American children’s disproportionate overrepresentation in the child welfare system. Concerns have emerged that social workers may hold negative stereotypes about African Americans and parents who use drugs. Stereotypical biases may influence decisions in reports alleging parental drug use and/or involving African American families. This …


Effects Of Mentoring On The Development Of Leadership Self-Efficacy And Political Skill, Suzzette Chopin Apr 2009

Effects Of Mentoring On The Development Of Leadership Self-Efficacy And Political Skill, Suzzette Chopin

Theses and Dissertations

This study considered the effects of mentoring on protégés’ beliefs in their abilities to be leaders and on their development of interpersonal skills. This study explored, in 260 business graduate students, the relationship between (a) mentoring and leadership self-efficacy and (b) mentoring and political skill. Participants completed surveys including the Self-Efficacy for Leadership Scale, the Political Skill Inventory, and the Mentoring Functions Questionnaire. Comparisons between non-mentored and mentored individuals showed that having a mentor is associated with increased political skill (p < .05) but not increased leadership self-efficacy (p > .05). Among mentored individuals, higher quality mentoring relationships are associated with significantly higher leadership-self efficacy (p < .01) but not with significantly higher political skill (p > .05). The presence …


Commonwealth Times 2009-04-09 Apr 2009

Commonwealth Times 2009-04-09

Commonwealth Times, 1969-

No abstract provided.


Youth Leadership Development And Peer-Led Initiatives, Kathryn Conley Apr 2009

Youth Leadership Development And Peer-Led Initiatives, Kathryn Conley

Theses and Dissertations

The current study explored the experiences of high school peer leaders (N = 45) chosen to participate in an eight-week peer-led tobacco intervention program, Living Free of Tobacco, Plus! (LIFT+). The study used a repeated measures design to examine changes in leadership self-efficacy, perceived leadership skill, and goal-setting from baseline to post-test. Leaders’ susceptibility to future tobacco use, self-efficacy to resist and avoid tobacco, and confidence and interest in following nutritional guidelines were also examined at two time points. To strengthen self-report measures, peer and teacher evaluations of observed leadership behavior were collected. Results suggest that participation as a peer-leader …


Frontline Nursing Leaders And Staff Retention In An Acute Care Community Hospital, Beth Torres Apr 2009

Frontline Nursing Leaders And Staff Retention In An Acute Care Community Hospital, Beth Torres

Theses and Dissertations

The current and projected nursing shortage makes it imperative for healthcare organizations to examine factors that promote staff retention. Previous studies identify nursing leadership as a key component influencing staff retention and turnover. This study supplements these studies by identifying key behaviors and attitudes of frontline nursing leaders that influence staff retention. Using a grounded theory qualitative approach, the researcher interviewed 19 frontline nursing leaders in an acute care community hospital. The researcher also explored the extent to which nursing leaders felt current leadership education and training programs support their practices that promote staff retention. The goal of the study …


Commonwealth Times 2009-04-06 Apr 2009

Commonwealth Times 2009-04-06

Commonwealth Times, 1969-

No abstract provided.


Parents And Peers As Moderators Of The Relation Between Peer Victimization And The Development Of Revenge Goals In Middle School Students, Suzanne Linkroum Mar 2009

Parents And Peers As Moderators Of The Relation Between Peer Victimization And The Development Of Revenge Goals In Middle School Students, Suzanne Linkroum

Theses and Dissertations

The majority of students experience peer victimization at least once during middle school. Existing research has established a strong link between exposure to peer victimization and poor psychosocial outcomes, including, but not limited to, maladaptive coping processes. Although little empirical attention has been devoted to examining how peer victimization impacts the development of social goals, the few existing studies have shown a positive relation between peer victimization and revenge goals. To further advance this research, several concurrent and longitudinal models delineating the relations among peer victimization, physical aggression, parental attitudes toward aggression, peer deviance, and revenge goals were examined in …


Influence Of Parental Substance Abuse On Substance Use And Psychiatric Severity In Drug-Dependent Pregnant Women, Courtney E. Smith Mar 2009

Influence Of Parental Substance Abuse On Substance Use And Psychiatric Severity In Drug-Dependent Pregnant Women, Courtney E. Smith

Theses and Dissertations

The purpose of this study was to examine the relationship between history of parental substance abuse and substance use and psychiatric severity measures in a sample of treatment-seeking, pregnant women who meet DSM-IIIR criteria for lifetime opioid and cocaine abuse and/or dependence (N=260). The study examined whether a dose-response relationship was observed between number of parents affected by substance use problems (0, 1, and 2) and degree of women’s substance use and psychiatric severity. Results did not support a dose-response relationship between density of parental problems and substance use and psychiatric severity. However, some differences in severity were seen at …


A Service-Learning Approach To An Arts-Based Technology Course To Increase Pre-Service Teacher Receptivity To Teaching Technology, Elizabeth Essex Mar 2009

A Service-Learning Approach To An Arts-Based Technology Course To Increase Pre-Service Teacher Receptivity To Teaching Technology, Elizabeth Essex

Theses and Dissertations

The following question and sub-question guide this thesis project: 1) How does a service-learning approach in an arts-based technology course increase pre-service teacher receptivity to teaching technology? 2.) What are some barriers to teaching technology for pre-service teachers? A positive service-learning experience provides good learning models which have the potential to address the barriers to teaching technology for pre-service teachers by influencing their self-efficacy. Included in this thesis is a unit plan which responds to these research questions. There are many barriers to teaching technology for teachers including lack of funds, availability and quality of computer hardware and software, teaching …


The Approximation Rule: Examining An Alternative To The “Best Interest Of The Child” Custody Standard, Elizabeth Archer Feb 2009

The Approximation Rule: Examining An Alternative To The “Best Interest Of The Child” Custody Standard, Elizabeth Archer

Theses and Dissertations

While the Best Interest of the Child (BIOC) standard has been used since the 1970’s, alternatives such as the Approximation Rule have recently been proposed to remediate perceived weaknesses in BIOC. This study examines the applicability of the Approximation Rule using cross-sectional data collected from 517 children (age 10-18) of divorced parents using the Co-Parenting Behavior Questionnaire (CBQ). Data for all co-parenting and parenting variables (n = 517) were analyzed to determine relationships by time since divorce and custodial relationship. Physical custody was associated with significant differences in children’s’ ratings of both co-parenting and parenting effectiveness. Results for time since …


Commonwealth Times 2009-02-23 Feb 2009

Commonwealth Times 2009-02-23

Commonwealth Times, 1969-

No abstract provided.


Evaluating Oral, Non-Combustible Potential Reduced Exposure Products Marketed To Smokers, Caroline Cobb Feb 2009

Evaluating Oral, Non-Combustible Potential Reduced Exposure Products Marketed To Smokers, Caroline Cobb

Theses and Dissertations

Potential reduced exposure products (PREPs) are marketed to reduce smoking’s harm, despite little information concerning their effects. This study adapts previously reported clinical laboratory methods used to evaluate combustible PREPs to investigate the acute effects of four non-combustible PREPs (Ariva, Camel Snus, Marlboro Snus, Commit nicotine lozenge) relative to own brand cigarettes, sham smoking, and one combustible PREP that delivers no measurable nicotine (Quest). Twenty-eight smokers participated in 7 Latin-squared ordered, 2.5-hr sessions in which each product was administered twice (60-minute inter-administration interval). Sessions differed by product and were separated by > 48 hours. Plasma nicotine, heart rate, expired air carbon …


Commonwealth Times 2009-02-09 Feb 2009

Commonwealth Times 2009-02-09

Commonwealth Times, 1969-

No abstract provided.


Commonwealth Times 2009-01-29 Jan 2009

Commonwealth Times 2009-01-29

Commonwealth Times, 1969-

No abstract provided.


Predictors Of Discrepancies In Parents’ And Children’S Reports Of Child Emotion Regulation, Shannon Hourigan Jan 2009

Predictors Of Discrepancies In Parents’ And Children’S Reports Of Child Emotion Regulation, Shannon Hourigan

Theses and Dissertations

The ability to effectively regulate one’s emotions has been linked with many aspects of well-being. However, disagreement in parents’ and children’s reports of children’s emotion regulation presents significant measurement and conceptual challenges. This investigation aimed to identify predictors of these discrepancies from among demographic, psychopathology, and child emotional awareness measures and to examine patterns of discrepancies among three emotion types (i.e., anger, sadness, and worry) and three regulation “strategies” (i.e., inhibition, dysregulated expression, and coping). Sixty-one mother-child dyads (41 girls, mean age 9.3 years) participated. As hypothesized, age, child and parent report of psychopathology, and poor emotion awareness all emerged …


Commonwealth Times 2009-01-26 Jan 2009

Commonwealth Times 2009-01-26

Commonwealth Times, 1969-

No abstract provided.


Commonwealth Times 2009-01-22 Jan 2009

Commonwealth Times 2009-01-22

Commonwealth Times, 1969-

No abstract provided.


Commonwealth Times 2009-01-15 Jan 2009

Commonwealth Times 2009-01-15

Commonwealth Times, 1969-

No abstract provided.


Commonwealth Times 2009-01-12 Jan 2009

Commonwealth Times 2009-01-12

Commonwealth Times, 1969-

No abstract provided.


Virginia Commonwealth University Graduate And Professional Programs Bulletin [2009], Virginia Commonwealth University Jan 2009

Virginia Commonwealth University Graduate And Professional Programs Bulletin [2009], Virginia Commonwealth University

VCU Bulletins

Graduate and professional programs bulletin for Virginia Commonwealth University for the academic year 2009-2010. It includes information on academic regulations, degree requirements, course offerings, faculty, academic calendar, and tuition and expenses for graduate and professional programs.


Menorah Review (No. 70, Winter/Spring, 2009) Jan 2009

Menorah Review (No. 70, Winter/Spring, 2009)

Menorah Review

A Poem by Richard E. Sherwin -- Believing Christian... Agnostic Believer -- From the Classics -- New and Notable Books -- Oy Vey Is Mir -- The Ancient Grudge: The Merchant of Venice and Shylock's Christian Problem