Dregs / Lessons From The Things Around Us, Juan-Manuel Pinzon

Theses and Dissertations

The writing in Lessons From the Things Around Us is in support of the work in my MFA thesis show, dregs. I detail the progression of my making and thinking over the last two years. I expand on the material and personal relationships that have manifested themselves in the work and influenced my approach to the things that surround me. Finally, I point to a more expansive definition of Craft, rooted in its material sensibilities, and the possibilities already present in the field that this definition creates.

Defiantly Childlike: Using Aesthetic Resistance To Heal, Sarah K. Reagan

Theses and Dissertations

This thesis examines an alternative processing mechanism surrounding the act of healing after traumatic experiences in life. Using a methodology of iterative patterning and tool-pathing, a collection of inflatable garments and wooden mannequins analyzes defense mechanisms learned in early childhood development. This work highlights an essential body of recent scholarship that takes cuteification seriously to restore a childlike approach to mastering fear. This paper will review the definitions of cuteness and childlike humor and then describe how visual culture has implemented these components to subvert established power.

Connections Exposed | A Library For The People, Stephanie Wilburn

Theses and Dissertations

MOTIVATION

The U.S. economy, democracy, and the health and happiness of citizens depends on maintaining social capital, the networks of bonds between community members. Social capital creates the trust that facilitates action and cooperation for mutual benefit. Since the 1960s, there has been a decline in-person socialization and social bonds both within and between demographic groups in the US resulting in reduced social capital (Putnam, 2000).

One measure to combat declining social capital is to create third places where incidental and repeated social interactions build and reinforce bonds between community members (Oldenburg, 1997).

With the reduction of accessible and inclusive …

An Exploration Of A Researcher-Instructor Partnership In Implicit Racial Bias Awareness And Mitigation In College Stem Classrooms, Jacqueline Johnson Wilson

Theses and Dissertations

Seventy-six percent of all minority students who enter college with declared majors in science, technology, engineering, and mathematics (STEM) do not graduate with STEM degrees. Black students represent 40% of minority attrition from STEM. Implicit racial bias was indicated as a contributor to the challenges faced by Black students. The purpose of this study was to explore whether a researcher-instructor partnership brought awareness to and the potential for mitigation of implicit racial bias in course delivery and instructor interactions with Black students in STEM classes. A case study design was used over three phases to gather survey, observational, and interview …

Towards New Antimalarial Drug: Depolarization Of Liposomal Membranes By Aminooxoethylcarbamothioate In The Presence Of Fe3+ Ions, Aaron Wilson

Theses and Dissertations

Despite the efforts of scientists around the world 409,000 people died of malaria in 2019 alone. According to the WHO 90% of those deaths occurred in Africa. Despite the high number of available treatments, malaria continues to plague many parts of the world. This is due in part to drug resistance developed among mosquito populations as well as limited access to medicines that do work. Furthermore, when traveling to malaria prone areas, pretreatment with a chemoprophylaxis is common practice. However, often the side effects to malaria pretreatment are severe. A new approach to the treatment of malaria is a compound …

Mindfulness Training To Enhance Emotion Regulation In A Polarizing Political Context: A Multimethod Investigation, Hadley Rahrig

Theses and Dissertations

The U.S. continues to show an upward trend in political polarization, perceived as a moral divide between liberal and conservative ideological groups. This moralization of political identity has contributed to the escalation of negative emotions (e.g., fear, anger, and hatred) directed towards political outgroup members. Although negative emotions are potent motivators of political intolerance, these emotions are nevertheless subject to regulation. Mindfulness offers a promising yet understudied emotion regulation strategy which may facilitate open receptivity towards opposing partisans. The present randomized controlled trial (RCT) examines the effects of short-term mindfulness training (MT) vs structurally equivalent Cognitive Reappraisal training (CT) on …

Dungeons And Devised Theatre: A Study Of Tabletop Gaming And Its Application In Playwriting And Character Development, Sabrina E. Becker

Theses and Dissertations

This thesis is an exploration of the connections and application of tabletop gaming in theatre. It looks at the initial process that was used in devising a play from tabletop gaming and also the applications of using tabletop gaming to further character development. This paper serves as a journal of first-hand accounts and interviews during this process so you may be inspired to build your own process either based in what you read here or discovering your own. There is a sample excerpt of the play to show what can be accomplished as well as other artistic works that came …

Considering Queerness - Actor Training's Issues And Alternatives, Jacob Leblanc

Theses and Dissertations

Educators in academic theatre programs, whether queer or non-queer, trans or cisgender, may not intentionally consider queerness in their pedagogical practices. What follows is an examination of current issues in academia that can affect queer students negatively and disproportionately. Anecdotal evidence is provided to demonstrate different issues that may be present in the classroom experiences of queer students. The Stanislavski system is critiqued through a contemporary, queer lens to locate possible shortcomings in the acting technique when it is applied by queer performers. Queer alternatives to the Stanislavski system are vetted and offered to queer students who might seek something …

It Takes A Muscle: Wholes, Holes, And Other Voids, Saar Shemesh

Theses and Dissertations

IT TAKES A MUSCLE¹

In the BELLY of the BEAST, the HUMAN

in the deep end of a SWIMMING POOL

in a GRAVE, looking up/out from within

at the base of a CRATER, ABYSS, PIT

the room as a CRADLE, INCUBATOR

architecture as MOTHER MOULD.²

____________________________

¹ Title is borrowed and abbreviated: Spectral Display, “It Takes A Muscle To Fall In Love,” 1982.

² For what American-English delineates as ‘mold,’ British-English uses ‘mould’ and is more specific in its technicality. The former doesn’t distinguish in spelling between mold (fungus) and mold (mould). I’m not particularly a fan of …

Shackled: To A Front-Row Seat Of My Own Horror Film, Dellil L. Mohammed

Theses and Dissertations

This document serves as internal view point, stemming from my experiences as a black muslim, first generation Ethiopian American, overall identity, and it’s disorienting implication on my interpretation of my view-self and the world. This is also informed by my struggling with the realities of type-1 diabetes and the sporadic and often inadequate support of the American health system. All of these intersecting experiences have led to me making work as an agent for advocacy, empathy and social justice. This work is also informed and dressed with the elements of horror, sci-fi, & fantasy. See and hear the voice in …

Characterizing Senescence Induction And Senolytic Sensitivity In Murine Lung Cancer Cell Lines, Rana A. Estaleen

Theses and Dissertations

While cancer patients often experience tumor reduction after receiving chemotherapy, tumors can eventually emerge from a state of dormancy. Cancer cells treated with the topoisomerase II poison, etoposide (ETO), enter senescence, which is a durable and prolonged cell cycle growth arrest. Different murine lung cell lines were screened for their levels of senescence induction by ETO, and those showed promising senescence induction were then treated with the senolytic, ABT263, to promote apoptosis. The hypothesis of this work was that non-small cell lung cancer cell lines will have different degrees of senescence and that the magnitude of the response to senolytics …

Human Papillomavirus 16 E2 Regulates Host Cell Pathways Important For Cancer Progression And Treatment Sensitivity Which May Contribute To Cancer Outcomes, Christian Fontan

Theses and Dissertations

Human papillomaviruses (HPVs) are causative agents in around 5% of all cancers, including cervical and oropharyngeal. A feature of HPV cancers is their better clinical outcome compared with non-HPV anatomical counterparts. In turn, the presence of E2 predicts a better clinical outcome in HPV-positive cancers; the reason(s) for the better outcome of E2-positive patients is not fully understood.

Previously, we demonstrated that HPV16 E2 regulates host gene transcription that is relevant to the HPV16 lifecycle in N/Tert-1 cells. One of the genes repressed by E2 and the entire HPV16 genome in N/Tert-1 cells is TWIST1. In these studies, we demonstrate …

Therapeutic Injectable Iron-Chelating Hydrogels, Debbie Campbell-Rance

Theses and Dissertations

ABSTRACT

Therapeutic Injectable Iron-Chelating Hydrogels for Improved Central Nervous System Regeneration

By

Debbie S. Campbell-Rance

A dissertation submitted in partial fulfillment of the requirements of the degree of Doctor of Philosophy at Virginia Commonwealth University 2021.

Director: Xuejun Wen, M.D., Ph.D., AIMBE Fellow, Alice T. and William H. Goodwin Jr. Endowed Chair Professor in Regenerative Medicine, Institute for Engineering and Medicine, Department of Chemical and Life Science Engineering

Severe traumatic brain and spinal cord injuries are major global public health and socioeconomic problems in terms of mortality and morbidity. Currently there are two main lines of treatment under development for …

Using Molecularly Imprinted Polymers For The Selective Extraction Of Analytes, Haley A. Mulder

Theses and Dissertations

Sample preparation is a critical steps in bioanalysis. Traditional methods such as solid-phase extraction and liquid-liquid extraction are laborious and ultimately incapable of properly separating target analytes from matrix and interferents. The co-extraction of these components interferes with the analytical instrument’s ability to properly detect and quantitate analytes. Molecularly imprinted polymers (MIPs) are synthetic polymers that have been “imprinted” with a template analyte in a co-polymer system. MIPs are capable of selectively extracting analytes from complex biological matrices and can be employed in off-line, benchtop extractions or for on/in-line instrument extractions. MIPs offer faster and more selective sample preparation, leading …

Academic Health Science Centers And Health Disparities: A Qualitative Review Of The Intervening Role Of The Electronic Health Record And Social Determinants Of Health, Wies Rafi

Theses and Dissertations

Literature on the magnitude of negative health outcomes from health disparities is voluminous. Defined as the health effects of racism, environmental injustice, forms of discrimination, biases in science, and sociological or socioeconomic predictors across populations, health disparities are part of an ongoing and complicated national problem that health equity programs are specifically designed to address. Academic Health Science Centers (AHC) institutions are a complex and unique educational-healthcare ecosystem that often serves as a safety net for patients in vulnerable and lower-income communities. These institutions are often viewed as one of the most uniquely positioned entities in the U.S. with an …

Understanding Chinese International Students' Engagement And Belongingness In U.S. Universities, Yingying Jiang

Theses and Dissertations

Little research has been conducted on Chinese international students’ engagement and belongingness in U.S. universities. This study used a non-experimental quantitative survey research design and adapted survey items from past literature to target Chinese international students’ experiences. Prior to the survey administration, pretesting including expert reviews and a think-aloud were carried out to validate the survey. A total of 76 Chinese students from various universities participated in the survey data collection. The quantitative analytical processes included Confirmatory Factor Analysis (CFA) to ensure construct validity; measurement invariance testing between groups and Structural Equation Modeling (SEM) included four major factors/predictors (English proficiency, …

Alcohol And Other Addictive Behaviors Among Bariatric Surgery Patients, Rachel M. Arnold

Theses and Dissertations

Research has repeatedly highlighted a high rate of comorbidity of addictive behaviors in both clinical and non-clinical samples. While polydrug use has received significant attention in recent years, less is known about rates of comorbidity with behavioral addictions such as eating, work, exercise, or sex. Individuals with a history of bariatric surgery may provide a unique opportunity to examine the potential co-occurrence of addictive behaviors. High rates of food addiction symptoms and changes in alcohol use patterns post-surgically have highlighted a potential gap in our understanding of bariatric patients and their needs post-surgically. Using a composite measure of addictive behaviors, …

Incorporating Ontological Information In Biomedical Entity Linking Of Phrases In Clinical Text, Evan French

Theses and Dissertations

Biomedical Entity Linking (BEL) is the task of mapping spans of text within biomedical documents to normalized, unique identifiers within an ontology. Translational application of BEL on clinical notes has enormous potential for augmenting discretely captured data in electronic health records, but the existing paradigm for evaluating BEL systems developed in academia is not well aligned with real-world use cases. In this work, we demonstrate a proof of concept for incorporating ontological similarity into the training and evaluation of BEL systems to begin to rectify this misalignment. This thesis has two primary components: 1) a comprehensive literature review and 2) …

Modification Of Culture Medium And Identification Of Microbial Contaminants For Improved In Vitro Propagation Of Freshwater Mussels, Raquel M. Wetzell

Theses and Dissertations

In vitro propagation efforts play an essential role in conserving and restoring threatened freshwater mussel populations by circumventing the need for a fish host. Across a broad range of taxa, transformation is induced with an artificial M199 medium and rabbit serum. However, such formulation may not be sufficient in culturing critical species with more specific physiological requirements. In this study, multiple serum mixtures were tested to improve in vitro transformation of two freshwater mussel species: yellow lampmussel (Lampsilis cariosa) and tidewater mucket (Atlantaconcha ochracea). These species were selected because they parasitize similar fish host species but …

Towards The Systematic Evaluation Of Variable Modes Of Mechanical Conditioning On The Compositional, Microstructural And Mechanical Properties Of Engineered Tissue Vascular Grafts., Sarah Saunders

Theses and Dissertations

Coronary artery bypass surgery (CABG) remains one of the most common cardiac surgical procedures performed worldwide, frequently involving multiple bypasses, and commonly employing the patient’s internal mammary artery, radial artery, or saphenous vein. CABG is often not possible because native vessels were already employed in previous interventions or are diseased themselves. Synthetic vascular grafts are currently integral tools of vascular surgery and have had relative success in large-caliber applications providing substantial benefit to aortic or iliac grafting; however, small diameter (< 6 mm) arterial grafts have not yet translated into clinical effectiveness due to thrombosis and anastomotic intimal hyperplasia. ETVGs present an exciting potential alternative in vascular grafting by offering a blood vessel substitute that could exhibit all the functional characteristics of native vasculature. In addition to relieving supply limitations associated with coronary artery bypass surgery ETVGs are especially ideal for pediatric patients with congenital heart disease who require grafts that grow as they do, eliminating the need for reoccurring invasive surgeries.

Though the role of biomechanics in regulating cellular behavior promoting non-thrombogenicity, vasoactivity, and ECM synthesis and maintenance is well …

Branched Chain Amino Acid Strain State Monitoring With Raman Spectroscopy And Plasmonic Bowtie Nanoantenna Devices For Early Disease Detection, Caroline A. Campbell

Theses and Dissertations

This work centers on the development and the down-selection of nano-manufactured devices to be used in conjunction with Raman spectroscopy for probing a branched chain amino acid. The nano-manufactured devices integrate plasmonic nanoantennas for the purpose of amplifying molecular fingerprints, which are otherwise difficult to detect, through Surface Enhanced Raman Spectroscopy (SERS). Plasmonic nanostructures can be utilized for a variety of biomedical and biochemical applications to detect the characteristic fingerprint provided by Raman Spectroscopy. The nano-manufactured devices create an electric field that amplifies minute perturbations and raises the signal above background noise. This may provide a deeper understanding of signal …

Assessing Medical Discrimination, Mistrust, And Healthcare Engagement As Predictors Of Covid-19 Vaccination Among Transgender And Gender Diverse Individuals, Shelby A. Smout

Theses and Dissertations

As of March 11^th 2020, the World Health Organization (WHO) declared COVID-19 a global pandemic. Early studies conducted among LGBT+ communities indicated that individuals of color and transgender individuals were more likely to express hesitation towards a possible COVID-19 vaccine. Such hesitation can be explained by historical medical mistreatment of people of color and LGBT+ communities which contributes to higher medical mistrust within these populations. The present study assessed vaccination behaviors among a sample of transgender and gender diverse individuals (N=385) and results indicated an association amongst experiences of discrimination in healthcare, medical mistrust, COVID-19 mistrust, barriers to vaccination, …

“There Was Some Sort Of Missing Middle”: Lived Experiences Of Jewish Youth With Intellectual And Developmental Disabilities, Aliza Lambert

Theses and Dissertations

Though religion and spirituality contribute to overall well-being (Koenig, 2012; Koenig & Cohen, 2002), social support (Biggs & Carter, 2016; Koenig & Cohen, 2002; Taub & Werner, 2016), quality of life (QOL; Myers & Sweeney, 2000), coping strategies (Krok, 2008), and lower rates of depression and anxiety (Brown et al., 2013; Young et al., 2000), religion and spirituality are seldom included in curriculum in counselor education and supervision doctoral programs (Adams et al., 2015; Henriksen et al., 2015). In the present study, the researcher uses a multiple-case study design to describe the lived experiences of Jewish youth with intellectual and …

Mending Art Classrooms: An Exploration Of The Benefits Of Collaborative Artmaking For Underinvested Black Youth In Richmond, Virginia, Jazmine M. Beatty

Theses and Dissertations

This arts-informed research study explored the experiences of local community artists and educators working to radically transform and heal the experiences of underinvested Black students in Richmond through collaborative arts engagement. Through a series of seven one-on-one interviews with Black teaching artists in the Richmond community, I was able to uncover how collaboration has and can continue to improve the well-being and livelihoods of Black students in Richmond. Also, by tapping into the local Mending Walls mural project, I was able to make a tangible connection between the Richmond community, art, and collaboration. An analysis of the interviews led to …

Understanding Structure/Process-Property Relationships To Optimize Development Lifecycle In Yttria-Stabilized Zirconia Aerogels For Thermal Management, Rebecca C. Walker

Theses and Dissertations

Aerogels are mesoporous materials with unique properties, including high specific surface area, high porosity, low thermal conductivity, and low density, increasing these materials’ effectiveness in applications such as catalyst supports, sorption media, and electrodes in solid oxide fuel cells. Zirconia (ZrO₂) aerogels have special interest for high-temperature applications due to the high melting point of ZrO₂ (2715°C) and stability between 600°C and 1000°C, where other aerogel systems often begin to sinter and densify. These properties and unique pore structure make zirconia aerogels advantageous as thermal management systems, especially in aeronautics and aerospace applications. However, to be effective …

Putting The "Video" Back In Video Games: Opportunities And Challenges For Visual Studies Approaches To Video Game Analysis, Francis A. Longaker

Theses and Dissertations

I argue for the application of visual studies in video game analysis. This approach presents opportunities for the intersectional analysis of video game visuals as games are brought into dialogue with other visual media like film and painting. This approach also presents challenges due to ontological distinctions between different media as well as due to academic divisions regarding the study of different art and media objects. Despite the challenges presented, a visual studies approach is particularly useful as a critical window into contemporary visual culture at large.

I outline the fields of game studies and visual studies, marking their distinctions …

Family History Of Substance Problems Among African Americans: Associations With Drug Use, Drug Use Disorder, And Prescription Drug Misuse, Rebecca Mahrs-Gould

Theses and Dissertations

Background: Understanding individual risk for substance use and substance use disorders is important in the efforts of reducing risk and prevention of these problems. A family history of alcohol and/or drug problems often increases the risk for these problems, however the majority of research in this area is conducted in samples that are predominantly White. African Americans face disparate outcomes from substance use and substance use disorders, and the risks for substance problems may not be the same as for Whites. A systematic review of the literature identified nine studies that examined a family history of either substance problems or …

Phantom Scripting, Huiyu Yang

Theses and Dissertations

scripted performances enacted by human beings for the purposes of ordering the world. This “world” is seen as being comprised of social things such as male and female relationships; personal or individual things such as the untaught dispositions inherent in human beings; or nonhuman things such as rain, animals, or spiritual powers.

What Motivates Saudi Females' Intentions To Get Mammography? A Randomized Control Trial To Evaluate Effective Preventative Messages, Saleh Bin Khulayf

Theses and Dissertations

Background. In Saudi Arabia, breast cancer mortality is a public health concern where females often discover breast cancer at an advanced stage due to ignoring preventative testing such as mammography. While increasing mammography awareness is essential in Saudi Arabia, almost nothing is known about the effectiveness of health communication messages in mammography's context. This research tested whether exposure to Entertainment-Education (E-E) message or educational infographic messages would influence Saudi females' intentions to get mammography.

Method. This research relied on a randomized control trial among n=240 Saudi females older than 40. Respondents were randomly assigned to watch YouTube E-E message or …

Examining The Impact Of Parental Racial Socialization And Critical Consciousness On Black Adolescents’ Coping With Racism-Related Stress, Chandler Alexandra Golden

Theses and Dissertations

In addition to universal stressors, Black adolescents also experience racism-related stressors. The physical and emotional consequences of racism-related stressors can be harmful to Black youth. To mitigate racism-related stress, Black youth may engage in various forms of coping. Critical consciousness and racial socialization are culturally relevant factors that have been protective against the negative impact of racism-related stress, with coping as one mechanism that undergirds this protection. Moreover, research has also begun to theorize critical action as a type of racialized coping. Past research has largely examined the impact of critical consciousness and racial socialization on coping separately and yielded …