Digital Commons Network^™

To, From: Of Time, Of Distance, Of Body And Mind, Fanxi Sun

Theses and Dissertations

This paper introduces the concepts, theories, and techniques associated with my thesis project “To, From.” The paper consists of three parts: Time as Structure, Distance as Premise, and Body and Mind. Each chapter is written in a mixture of personal narration and a general introduction to materials that are directly or implicatively relevant and important to the creation of my project. In this experimental narrative comprises film screening and live performance with multi-channel sound, I tell a story of non-story. Words and the exchange of words, movements and non- movements, objects that are being handled and subjects that are handling... …

The Impact Of A Parent-Only Pediatric Obesity Intervention Program On Quality Of Life In Racially Diverse Children, Taylor Vashro

Theses and Dissertations

Pediatric obesity has been associated with significant decrements in pediatric quality of life (QOL) comparable with severe pediatric diseases such as cancer. Parenting interventions have yielded health benefits for children with obesity; however, few studies have investigated the impact of parent-focused interventions on QOL in children with overweight and obesity. This study investigated the impact of a 6-week intensive parenting intervention program on the QOL of 5-12 year old, predominantly Black children with overweight and obesity. Parents were randomized into either the parenting intervention (NOURISH+) or a control group, and QOL, as well as variables related to child and parenting …

From Silence To Forte: Developing An Inclusive Space For Persian Musicians To Flourish, Sholeh Salimi

Theses and Dissertations

Music serves as a reflection of culture and conveys various emotional and intellectual states, such as a nation's perspective, social attitudes, and historical background. However, the Iranian revolution in 1979 led to the ban of music by the new regime, limiting the output and audience for Iranian music. In addition, the emergence of Western music accessibility through technology posed challenges for traditional Persian music, and the government's restrictions on music further compounded the problem. To support and advance the preservation and dissemination of Iranian music, this study aims to explore how an interior designer can create a space that enables …

Frewayni's Garden: Preserving Tigrayan Culture During A Period Of Ethnocide, Gabrielle F. Tesfaye

Theses and Dissertations

The recent and ongoing genocidal war in Tigray, Ethiopia, has witnessed the destruction and looting of countless historical religious sites, ancient manuscripts, and artifacts, leaving Tigray’s remaining cultural heritage extremely vulnerable. Such cultural loss erases a shared understanding across generations, robbing them of their history and identity. My work contributes to the safeguarding of Tigray’s cultural heritage and collective memory, informed by literature on cultural preservation efforts in post-war societies, and a series of interviews with Tigrayans in the diaspora and in Ethiopia.

The outcome of this thesis is embodied in a series of distinct jebenas, traditional Tigrayan clay coffee …

The Lived Experience Of Postpartum Sleep For Black And White Women, Ashley R. Macpherson

Theses and Dissertations

This qualitative study utilized a phenomenological research approach (van Manen, 1990), and intersectional feminist lens (Collins, 2000; Crenshaw ,1989; hooks, 2000), to uncover the lived experience of sleep in the postpartum period. Participants were 10 mothers who were less than 12 months postpartum. Data collection consisted of in-depth interviews. Data analysis procedures followed recommendations by van Manen (1990, 1997). In order to increase the trustworthiness and rigor of the study, the researcher engaged in reflexive journaling, member checking, and peer debriefing. The results were organized into six themes; 1) the importance of the sleep environment, 2) anxiety and hypervigilance, …

Reassessing Replication: Addressing The Replication Crisis From A Statistical Perspective, Alicia Richards Phd

Theses and Dissertations

In 2015, Open Science Framework directly replicated 100 psychology studies and found astonishingly low replication rates. Since, researchers have suggested factors that may have influenced the low rates, including the metrics used to assess replications. The definitions used to decide whether a replication study was successful all suffer from flaws. Therefore, we propose a new metric for assessing replication that can estimate the likelihood a study successfully replicated rather than forcing a binary choice and accounts for study design limitations.

Using equivalence study techniques, we first propose a new metric to assess replication, defining a successful replication as one where …

Studying Gene Function In Streptococcus Sanguinis Using Rna-Sequencing Analysis, Ahmed Ismail

Theses and Dissertations

The oral cavity hosts hundreds of bacterial species, amongst them are the Streptococci family. More specifically, S. sanguinis is a benign bacteria in the oral cavity to protect the tooth surface from S. mutans. which is a pathogen causing dental caries. While S. sanguinis is harmless in the oral cavity, it becomes pathogenic once entering the bloodstream and causing Infective Endocarditis (IE). To further study S. sanguinis and eventually develop an effective drug to treat IE caused by S. sanguinis, a gene expression study was conducted. In order to study gene expression, RNA-sequencing was conducted, and appropriate methods to remove …

Face Anti-Spoofing And Deep Learning Based Unsupervised Image Recognition Systems, Enoch Solomon

Theses and Dissertations

One of the main problems of a supervised deep learning approach is that it requires large amounts of labeled training data, which are not always easily available. This PhD dissertation addresses the above-mentioned problem by using a novel unsupervised deep learning face verification system called UFace, that does not require labeled training data as it automatically, in an unsupervised way, generates training data from even a relatively small size of data. The method starts by selecting, in unsupervised way, k-most similar and k-most dissimilar images for a given face image. Moreover, this PhD dissertation proposes a new loss function to …

Investigating Tgf-Β1 And Fibronectin Signaling In Low Oxygen Environments, Caitlin E. Williams

Theses and Dissertations

Breast cancer is the second leading cause of death in women, second to lung cancer. It’s one of the most well-known cancers, with almost 300,000 new cases estimated to be diagnosed in 2023. Breast cancer often begins in ductal epithelial cells, and these cells will typically undergo a cellular transformation process known as epithelial-mesenchymal transition (EMT) in early stages. Breast cancer becomes deadly when it reaches a metastatic stage. As a part of the metastatic process, transformed cells will conduct remodeling of the extracellular matrix (ECM) to allow for migration of an otherwise non-migratory cell type.

As dense tumors form, …

Seeing Themselves: White Preservice Teachers As Raced Individuals And As Members Of Their Future School Communities, Laurie Koth

Theses and Dissertations

Students of color, of poverty, with disabilities continue to slide into the school to prison pipeline (STPP.) Very often, an antecedent step is harsh exclusionary discipline that removes them from the classroom. Teachers, who play a major role in the decision whether to keep students in or eject them from the classroom and the school, are among multiple forces driving students toward or away from the STPP. A salient feature of the issue is that nearly 80% of teachers are white and their most vulnerable students are not. Rooted in critical race and care theories, and buttressed by self determination …

An Arbitrary Aesthetic: Cultural Reproduction And Hegemonic Canonical Formations In The Western Theatrical Academy, Sim C. Rivers

Theses and Dissertations

Theatre as an artistic practice has often been celebrated as an art of and for the people, being a modality that in theory the common person has access to learn, explore and experience. In recent years I have become preoccupied with the growing rarification and privileging of this art form, particularly in how it is cognized and taught in the academic world. As such, I set out to investigate the mechanisms at work at levels structural, artistic, and personal that determine how theatre is taught and understood within the western academy.

This thesis seeks to examine and unpack the perceived …

Factors Associated With Turnover Intention Of Medical Laboratory Professionals During The Covid-19 Pandemic: A Mixed Methods Approach, Keandra Walthall

Theses and Dissertations

The COVID-19 pandemic disrupted and strained healthcare systems worldwide. Frontline healthcare workers have experienced increased rates of psychological distress and burnout during the COVID-19 pandemic, which have led to high turnover intention and workforce shortages. Medical Laboratory Professionals have endured similar experiences during the COVID-19 pandemic; however, there has been limited research exploring these factors for this group of professionals. This study utilized a convergent mixed methods approach to investigate the impact of psychological distress and burnout on the turnover intentions of Medical Laboratory Professionals in the United States during the COVID-19 pandemic, as well as to explore motivational factors …

Fascism In Sci-Fi: "Mobilizing Passions" In Robert A. Heinlein's Starship Troopers, Alton C. Ayers

Theses and Dissertations

This thesis responds to criticism of Robert A. Heinlein’s Starship Troopers (1959) as a “fascist” novel by further investigating the claim through a close reading of the novel that applies political theory scholarship on fascism. Chapters I and II introduce the novel along with its general reception and controversy. These chapters consider the accusations of “fascism” given to the novel while at the same time understanding that a clear, exact definition of “fascism” has long been grappled with by scholars since the rise of the regimes in Nazi Germany and Fascist Italy. Chapters III and IV apply political theory to …

Motivations And Conflicts In Prison Medical Contracting, Meagan D. Sok

Theses and Dissertations

State correctional departments are responsible for all medical care incarcerated individuals require. Many systems outsource their medical

State correctional departments are responsible for all medical care incarcerated individuals require. Many systems outsource their medical program. Literature indicates that many of these contracts experience significant issues that negatively impact state resources, including both personnel and money.

This dissertation explores the relationship between prison administrators' motivations and the structure, outcomes, efficiencies, and partner conflicts that arise in the contractual process. Using a framework developed from Incomplete Contract Theory, Contracts as Reference Points Theory and the concept of “essential tension,” this dissertation hypothesizes …

Anti-Immigration-Related Stressors And Latine Immigrant Well-Being: The Role Of Family & Community Resilience, Lisa S. Fuentes

Theses and Dissertations

Anti-immigrant rhetoric and policies have continued to adversely impact Deferred Action for Childhood Arrivals (DACA) and Temporary Protection Status (TPS) beneficiaries (Arevalo et al., 2015; Cleary, 2017; Li, 2015; Sangalang et al., 2018). There have been numerous attempts to revoke DACA, TPS, and other policies that temporarily protect immigrant families. Although the number of resilience literature has grown, more strength-based approaches are still needed. Additionally, given that familismo (familism) and collectivism are key cultural values for Latine families (Campos et al., 2019; Corona et al., 2017), it is imperative to explore family and community resilience among Latine immigrants to gain …

Characterizing The Effects Of Antiandrogens And Senolytics To Enhance The Therapeutic Response To Castration-Resistant Prostate Cancer, Justin M. Silverman

Theses and Dissertations

Prostate cancer is the most frequently diagnosed cancer in males and the second most common cause of cancer deaths. Androgen deprivation therapy, whether through surgical or chemical castration, is the mainstay for treatment of advanced prostate cancer; however, despite an initial response, most patients eventually develop a progressive PSA rise, and castration- sensitive prostate cancer gives rise to castration-resistant prostate cancer. The standard of care therapy includes the antiandrogens such as enzalutamide and abiraterone acetate as well as the microtubule poison, docetaxel, and various immunotherapies; however, while prostate cancer research is progressing, there continues to be a compelling need for …

Breaking Bread & Boundaries : Finding Home In Every Bite, Steffi Ann Braganza

Theses and Dissertations

Raised outside of their “passport” countries, Third Culture Individuals (TCIs) often experience a lack of rootedness and belonging, and home is often everywhere and nowhere. Childhood food memories can provide the sense of connection and identity TCIs crave. Four Qatar-raised TCIs, from very different backgrounds share memories of their childhood comfort foods, now hybridized dishes, that reflect their unique third culture experiences. Each dish, in turn, inspired the creation of a bespoke set of cooking /dining ware designed to trigger a specific sensory memory: the sight, smell, touch, or sound associated with the original comfort dish. This specialized cooking/dining ware …

Refashioning Style From The Outside-In: A Pakistani Diasporic Response, Sidra Sohail Khawaja

Theses and Dissertations

Pakistan’s traditionalists and modernists hold opposing political, religious, social and nationalist views creating a constant tension within the culture. This tension creates a fashion industry with two extremes, one side reflecting traditional influences and the other reflecting western trends. I address the tension by analysing the craft and context of traditional Pakistani men’s clothing and incorporating traditional construction techniques into garments that reflect aspects of both points of view. In a series of five looks, I extract from influences like Persian, North Indian, Afghani, Colonial and Neo-Colonial, to generate hybridized garments that offer a new perspective, blending traditional elements with …

The Living Legends Of Sholoukh – شلوخ الأساطير Facial Scarification In Sudan, Ayah S. Elnour

Theses and Dissertations

Sholoukh — ritual face scarring—is a dying art form in Sudan.

Used to distinguish members of one tribe from another,

Sholoukh reflects the tribal pride of an individual. In the past,

sholoukh was seen as important as having a passport for a tribe

member, however, it was not always applied by choice. Using

just a razor blade, the wisest, most senior tribal elder would scar

the face of a child, initiating them into the tribe for life.

As this tribal art form fades away, the dwindling Sholoukh-bearers

have become living legends in Sudan. To honor them, I create

a collage …

We Leave In Peace, Dustin Dunbar

Mighty Pen Project Anthology & Archive

A soldier steps up when members of his unit are wounded.

Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in sharing their stories and experiences of military experience so both writer and audience may benefit.

Testing The Efficacy And Synergistic Components Of Sesamol And Black Rice Extract On Human Colon Cancer Cells, Sera Lim, Philip M. Gerk

UROP Posters

Purpose: Systemic treatment of colorectal cancer involves chemotherapeutic agents which elicit serious and negative side effects from the toxicity of the drug. To address this issue, we are testing dietary supplements for their efficacy against human colon cancer cell lines and also their potential synergistic effects when combined with conventional chemotherapy. Dietary supplements (specifically sesamol and black rice extract) exhibit anticancer, anti-inflammatory, and chemo-preventive properties. Meanwhile, one of the cancer resistance mechanisms is the upregulation of drug elimination mechanisms, leading to multi-drug resistance. We hypothesize that dietary compounds will act as chemo-enhancers, thus enhancing potency of the chemotherapy drug(s) on …

Vcu And The Virginia Course Materials Survey, Jessica Kirschner

Open and Affordable Course Content at VCU

No abstract provided.

Isoprenylation Inhibition Significantly Reduces Ige Mediated Mast Cell Function And Allergic Disease, Jordan Dailey

Theses and Dissertations

Allergic disease is the 6^th leading cause of chronic illness in the US and accounts for billions of dollars in healthcare annually. Mast cells are tissue resident innate immune cells linked to allergic disease and activated by IgE and other ligands. Upon activation, they release histamine, cytokines, chemokines, proteases, and lipid mediators evoking allergic symptoms. New ways of targeting mast cells could greatly benefit allergic disease therapy. Previous findings supported repurposing statin drugs, such as Fluvastatin, as a therapeutic treatment of allergic disease reduced allergic symptoms in vitro and in vivo. We found that Fluvastatin suppressed IgE-mediated mast cell …

Molecular Mechanisms Of Prdm16 As A Tumor Suppressor In Pancreatic Ductal Adenocarcinoma, Eric Hurwitz

Theses and Dissertations

The transcription factor Prdm16 functions as a potent suppressor of transforming growth factor-beta (TGF-b) signaling, whose inactivation is deemed essential to the progression of pancreatic ductal adenocarcinoma (PDAC). Using the Kras^G12D-based mouse model of human PDAC, we surprisingly found that ablating Prdm16 did not block but instead accelerated PDAC formation and progression, suggesting that Prdm16 might function as a tumor suppressor in this malignancy. Subsequent genetic experiments showed that ablating Prdm16 along with Smad4 resulted in a shift from a well-differentiated and confined neoplasm to a highly aggressive and metastatic disease, which was associated with a striking deviation …

Vesptures, Nyasha T. Chigama Ms

Theses and Dissertations

Abstract

This is an invitation into the delicate space of living between two worlds, of having feelings of happiness and sadness at the same time. Delicate emotions and situations which are not easy to share but are paramount in my research of what it takes to want more out of being just a parent, come from a certain country than the one I am living in, and navigate between two cultures. This is a journey around some of the experiences I have faced when I found myself in a different space other than the one I grew up in. The …

Dermatologic Manifestations Of Rheumatic Disease: Cutaneous Manifestations Of Vasculitides, Julianna S. Kang, Julia Nunley, Tiffany Ho, Mavra Masood, Fnu Nutan, Beth Rubinstein

Open Textbooks and Course Materials

This OER is a part of the Dermatologic Manifestations of Rheumatic Disease project, which provides overviews of the identification, diagnosis, and workup for different rheumatologic diseases, with a focus on providing examples from persons of color (POC). This work seeks to fill gaps and exclusionary practices in medical education practices and resources and diagnostic frameworks in regards to skin of color. This lack of representation bodes significant repercussions on the ability of future physicians to deliver equitable care for an increasingly diverse US population. Each module consists of a similar Powerpoint format, which includes key objectives, hypothetical disease cases, an …

Racial Experiences And Racial Identity Experiences Of “New” African Americans In The United States, Sosna Marshet, Kenna Yadeta

UROP Posters

The challenges faced by Black immigrants in the United States are significant, beginning with isolation and loneliness and intensified by pervasive discrimination. This study examines the impact of racism on the racial identity of Black immigrants in the United States. Using the Multidimensional Inventory of Black Identity (MIBI), various dimensions of Black identity were measured among 119 Black first and second-generation immigrants aged 18 to 51. The results showed a positive correlation between experiences of racism and the centrality dimension of Black identity, a negative correlation with the humanist, and a positive correlation with Nationalist dimensions of Black identity. These …

Isoprenylation Inhibition Suppresses Fcεri-Mediated Mast Cell Function And Allergic Inflammation, Aditya Kotha, Jordan M. Dailey, Aslamuzzaman Kazi, Said Sebti, John J. Ryan

UROP Posters

Allergic disease is driven by cell signaling cascades that activate immune cells. One key player is mast cells, which is activated by IgE antibodies signaling through the high affinity IgE receptor, FceRI. Therefore, targeting FceRI-mediated cascades can offer for novel treatments for allergic disease. Statins have been demonstrated to reduce the severity of asthma, a common allergic airway disease. Statins are an FDA approved class of drugs with the intended purpose of lowering blood cholesterol. We previously found that while statins inhibit mast cell function in allergic disease, these anti-inflammatory effects vary widely amongst differing mouse strains and human donors, …

It’S “Hip Hop,” Not “Hip-Hop”, Tasha Iglesias, Travis Harris

Journal of Hip Hop Studies

“It’s ‘Hip Hop,’ Not ‘hip-hop’” explains how two Hip Hop scholars, Tasha Iglesias and Travis Harris, collaborated to get the official academic spelling of Hip Hop changed from “hip-hop” to “Hip Hop.” While they were graduate students, they grew frustrated with reading numerous academic texts that did not represent Hip Hop in the same way the culture did outside of academia. Iglesias and Harris are Hip Hop and involved with the culture outside of the classroom. The clash between these two worlds led them to petition the American Psychological Association and eventually speak with Merriam Webster dictionary to change the …

Funk What You Heard: Hip Hop Is A Field Of Study, Journal Of Hip Hop Studies

Journal of Hip Hop Studies

The complete general issue of volume 9 issue 1.