Digital Commons Network^™

Exploring Polyamorous Relationship Experiences Of Lesbian, Gay, Bisexual, And Pansexual Individuals, Jiale Man

Theses and Dissertations

Polyamory is a type of relationship under the consensual non-monogamy relationship umbrella that assumes the possibility, validity, and worthwhileness of maintaining romantic, sexual, and intimate relationships with multiple people simultaneously. In Western society, the prevalence and domination of mononormativity have led to the marginalization of relationships alternative to monogamy (i.e., polyamory). As a result, individuals in polyamorous relationships continue to experience bias, stigma, and discrimination at varying levels. With a rise in public interest in CNM in the past two decades, scientists and researchers have slowly started to examine various topics related to CNM, including its prevalence, public attitudes toward …

Coming Out To Treatment: Identifying Facilitators & Characterizing Experiences Of Sexual And Gender Minoritized Individuals In Opioid Use Disorder Treatment Before And During The Covid-19 Pandemic, Jaclyn S. Sadicario

Theses and Dissertations

Sexual and Gender Minority (SGM) individuals are disproportionately impacted by substance use disorders vs. their non-SGM counterparts. Additionally, SGM folks face more barriers to access for treatment than others due to minority stressors including discrimination, internalized stigma, and marginalization related to their sex and gender minority statuses. It is important for researchers and treating providers alike to understand how these different factors are impacting the treatment of substance use disorders in SGM populations. With this in mind, this two phase study employed a mixed-methods approach to (1) describe the population of SGM folks enrolled in a MOUD treatment program with …

“It's Just Not Enough”: Examining The Experiences Of School-Based Sexual Health Education And Conversation Engagement With Trusted Adults Among Black Boys In Richmond, Va, Sharyn A. Dougherty

Theses and Dissertations

The Centers for Disease Control and Prevention estimate that youth make up a quarter of the sexually active population, yet account for half of the 20 million new sexually transmitted infections in the United States.In 2021, youth age 15-19 living in Virginia’s central region, which includes the Richmond Metropolitan area, had the second highest number of chlamydia cases and fourth highest number of gonorrhea cases among all age groups, with the highest rates among Black youth. The aim of this study is to explore the experiences of Black youth in Richmond, VA with school-based sexual health education (SHE) and their …

Integrating Historically Marginalized Students’ Funds Of Knowledge For Culturally Responsive Teaching And Learning, Martinique Ann Sealy

Theses and Dissertations

The United States historically has not always recognized the unique knowledge, or Funds of Knowledge (FoK; Moll et. al, 1992) that Black (and other historically marginalized) students’ have as assets to classroom learning and much of today’s mainstream curriculum represents White cultural norms as the basis (Sjursen, 2021). Because of this reality, marginalized students must navigate mainstream cultural norms alongside their own culture to be successful in the classroom. This three-paper dissertation includes 1. a systematic literature review of Black U.S. k-8 students language and identity in relation to achievement, 2. a qualitative case study centered on middle school urban …

Role Of The Ormdls In Keratinocytes, Souad Hatmi

Theses and Dissertations

The epidermis, the outermost layer of the skin, serves as a vital barrier protecting the body from environmental stressors, pathogens, and dehydration. Keratinocytes, the predominant cell type in the epidermis, play a central role in maintaining skin integrity and barrier function. In normal human skin, keratinocytes move from the basal layer to the stratum corneum, the top layer of the epidermis. In their travel, keratinocytes undergo a process of terminal differentiation, loss their ability to proliferate, secrete sphingolipids into the extracellular space, and gradually loss their nucleus and organelles. Sphingolipids, particularly ceramides, are key components of the intercellular lipid lamellae …

Modulation Of Epigenetic Regulatory Pathways As A Therapeutic Strategy In Breast Cancer, Ryan M. Finnegan

Theses and Dissertations

Anti-estrogens or aromatase inhibitors in combination with cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are the current standard of care for estrogen receptor-positive (ER+) Her-2 negative metastatic breast cancer. In triple negative breast cancer, cytotoxic drugs and ionizing radiation are often used as standard of care. Although these therapies prolong progression-free survival, the growth-arrested state of residual tumor cells is clearly transient. Tumor cells that escape what might be considered a dormant state and regain proliferative capacity often acquire resistance to further therapies. Epigenetic regulation can modulate the effects of cancer therapeutics. Our studies are based upon the observation that …

Novel Strategies In Head And Neck Tumor Therapy; Contribution Of Senescence In Therapy Response, And Resistance Development After Cisplatin Treatment, Fereshteh Ahmadinejad

Theses and Dissertations

Therapeutic outcomes achieved in head and neck squamous cell carcinoma (HNSCC) patients by concurrent cisplatin-based chemoradiotherapy initially reflect both tumor regression and tumor stasis. However, local, and distant metastasis and disease relapse as well as cisplatin-induced resistance are common in HNSCC patients. In the current work, we demonstrate that cisplatin treatment induces senescence in both p53 wild- type HN30 and p53 mutant HN12 head and neck cancer models. We also show that tumor cells can escape from senescence both in vitro and in vivo. We further established a cisplatin-resistant cell line from HN30 parental cell line that underwent brief senescence …

Laying Out A Space: Spectral Geographies, Fictions Of The Soul, Erin D. Yerby

Theses and Dissertations

Laying out a Space: Spectral Geographies, Fictions of the Soul, arises out of my artistic practice, and thoughts behind my current project and MFA exhibition, Spectral Geographies.

Linking the problem of the world ‘out there’ or external space, to inner experience through painting as both medium and practice, my work expresses what I call inner geographies, spaces where intimate immensities, folding inside and outside, find expression. I think of my paintings as beginning with this gesture of laying out a between-space where the intimacies of waking dreams and visions are opened by, and grow into, actual places, …

I'M Not Sure It Was A Hoopoe Or A Decanter, Ali Kaeini

Theses and Dissertations

“I’m not sure it was a Hoopoe or a Decanter” explores the experience of cultural displacement through the lens of an Iranian artist and immigrant. Drawing on ancient Iranian stories, Persian poetry, and cultural artifacts, my paintings and drawings reflect the uncertainty of the contemporary political and religious conditions in Iran, as well as the challenges faced by individuals forced to flee their homeland due to war, political instability, and social conditions. My work weaves references to ancient Iranian objects, Persian miniatures' structural forms and patterns, and Islamic architecture, using traditional and contemporary materials to create large, unconventional paintings. Through …

Rabble: A Companion To Pwa-Tem (2023)

Rabble, 2014-

Rabble is a companion chapbook publication to the magazine Pwatem. From the preface of most issues: "'Tell the rabble my name is Cabell."- James Branch Cabell to his editor, to help people learn how to pronounce his name. Cabell used the word derogatively but we are taking it back. These pages will showcase the writing and illustrations of our rabble-the ordinary students of VCU."

Aerosol Synthesis Of Tungsten Bronze Particles For Nir Shielding, Hao Tu

Theses and Dissertations

This dissertation emphasizes the need for efficient energy use in buildings and transportation due to global warming and the energy crisis. It suggests that improving energy efficiency can help reduce energy consumption and emissions and support sustainability. The dissertation introduces various transparent materials that can block near-infrared (NIR) radiation from solar radiation to save energy and money, and it highlights the growing market value of such products. The dissertation compares tungsten bronze with other NIR shielding materials and shows its advantages. The dissertation introduces a cheap and environmentally friendly method for continuously producing tungsten bronze particles via aerosol synthesis. Particle …

L'Atelier Réel – Apprendre Le Français Au Niveau Intermédiaire, Kathryn Murphy-Judy

Open Textbooks and Course Materials

This resource is a proficiency-framed, communicative, and task-based e-textbook for Intermediate French II.

Because learners at this level primarily communicate in sentence-level responses about routine, everyday situations, the four units of this e-textbook focus on strengthening skills across the three modes of communication—interpretive, interpersonal, and presentational—while deepening intercultural competencies. Unit themes include:

• presenting oneself and exploring bilingual, intersectional identity;
• engaging in written, oral, and mediated exchanges on topics of personal interest
• examining perspectives, products, and practices of francophone cultures and comparing them with one’s own; and
• mapping linguistic and cultural competencies onto students’ future personal and professional goals.

The Clinical Inquiry Process Diagram (Version 4), Roy E. Brown

VCU Libraries Faculty and Staff Publications

The purpose of the diagram is to provide a clear understanding of the clinical inquiry process and to highlight the similarities and differences between research, performance improvement, and evidence-based practice. While it is not meant to be comprehensive, it serves as a tool to facilitate a shared understanding of when a particular question may lead to one of these three areas of clinical inquiry.

The author would like to acknowledge the following for their ideas and willingness to provide feedback to improve this latest version of the diagram.

• Kady Martini, DNP, RN, EBP-CH, NEA-BC (The Ohio State University School of …

Buckets In A Deep Well: Essays About Shakespeare’S History Play Characters And An Original Drama, Brian C. Bassett

Theses and Dissertations

Buckets in a Deep Well is a set of essays that examines various characters portrayed in Shakespeare’s history plays, as well as parallel figures in 20th and 21st century works. Each essay primarily focuses on a single character’s response to a power structure: Richard Gloucester to the Tudor England of his audience in Richard III; Richard Nixon’s campaign-produced version of himself to 20th century American democracy in “Checkers;” Falstaff to organized society in Henry IV, Part 1; Marlo Stanfield to the drug economy of early 2000’s Baltimore in The Wire; the Duke of York to the disrupted monarchy of The …

The Cultural Diplomacy Of U.S. Peace Corps: Understanding The Role Of Peace Corps Volunteers As Strategic Geopolitical Assets, Corey B. Miles

Theses and Dissertations

Beginning in the Summer of 1961, the United States government has deployed volunteer humanitarians around the world to serve the mission of U.S. Peace Corps and has since contributed to communities in 143 partner countries while enjoying widespread popularity. Its mission of promoting world peace and friendship is pursued through three operational goals: technical training, cultural exportation, and cultural importation. Since 2016, with the election of U.S. President Donald Trump, and continuing through the Covid-19 pandemic, which produced the first global service interruption in agency history, the value of the Peace Corps service model has been fundamentally challenged. As a …

Risk And Resilience: An Exploration Of Adverse Childhood Experiences, Protective Factors, And Internalizing Symptoms In Black Youth, Irene A. Jacobs

Theses and Dissertations

The study examines mechanisms of risk and resilience that influence the psychological well-being of Black youth. Previous literature has established a link between adverse childhood experiences (ACEs) and mental health outcomes in youth (Kerker et al., 2015; Thakur et al., 2020). A substantial amount of the ACEs literature solely focuses on risk factors (e.g., mental impairment, low SES, health risk behaviors) for poor outcomes associated with ACEs. Despite Black youth experiencing high rates of ACEs (Liu et al., 2019), the ACEs literature examining mechanisms of their resilience is sparse (Meeker et al., 2021). Given the state of the ACEs literature, …

Probing The Porphyromonas Gingivalis Nitrosative Stress Response Network, Alexandra Galina

Theses and Dissertations

Objective: To persist in the oral cavity, the perio-pathogen Porphyromonas gingivalis must have an efficient nitrosative stress response mechanism. To better understand how P. gingivalis responds to nitrite (NO₂^-) we must determine what genes are involved in the nitrosative stress response network.

Methods: Through genomic screening, a list of genes was generated that were hypothesized to be part of the nitrosative stress response network and believed to be involved in nitrate/nitrite metabolism or redox state of the cells. Protein coding regions were replaced with the ermF sequence by allelic exchange mutagenesis. 15 mutants were created …

Crafting Community: A Ceramics Center, Nadia Mechboukh

Theses and Dissertations

For artisans, being part of a community can facilitate engaging with the public. Networking and collaborating with peers are vital for building meaningful relationships that can lead to mutual inspiration and learning opportunities. By strengthening the connection between society and various forms of craft, we can weave invisible threads that link the stories that craft tells with the time and place in which they were created. Pottery is a craft that has existed for thousands of years. Ceramics and clay have carried the history of communities and their ways of living through centuries and have been used as identifiers of …

Supporting Students Who Are Deafblind To Increase Their Access To The General Education Curriculum Through Trained Interveners: A Mixed Methods Study, Ira Padhye

Theses and Dissertations

The purpose of this mixed-methods research study was to identify the educational trends of children and young adults who are deafblind and identify strategies to improve the outcomes through interviews of nationally qualified interveners who have received training in deafblind specific strategies. Secondary data from the 2017-2021 National Center on Deafblindness and interview transcripts were used for data analysis and then integrated to identify the supports students who are deafblind should access. Trends in age of identification, primary eligibility category, school settings and access to state standardized assessments showed a plateau and displayed no significant improvement in educational outcomes. Nationally …

Waiting To Exhale, Abigail H. Ogle

Theses and Dissertations

We breathe as a measure of time, it keeps us alive, and fabricates the pattern of our lives. We are punctuated by “snarls,” “glitches,” or moments of irregularity – of trying to catch one's breath, having it taken away, or gasping for it. It is the punctuation of sighs, huffs, sniffs, scoffs, screams, and deep intakes that appear as glitches in the breathing system.

In our daily rhythm of breathing, the presence of the glitch, defined as potentiality, can create space for something unexpected or new to arise. Using the wind from fans and approximately 1,260 square feet of silk, …

Illusion: Immersive Experience, Tessa S. Trowbridge

Theses and Dissertations

Can society learn from art, and if so, what type of knowledge can be gained from art? It is currently understood that art and design can help humans explore, discover, and understand philosophical and imaginative topics. There is a general agreement that art can create insight and awareness in ways that logical and rational statements cannot, and from these unique interactions, humans can see the world with a new perspective (Worth, n.d.). This thesis will investigate the claim that art can inspire human imagination and allow viewers to gain insight into a surreal reality using designed, physically immersive spaces.

Immersive …

Nuff Love: From Me To You, Katherine S. Thompson

Theses and Dissertations

The thesis exhibition, Nuff Love: From Me to You, explores the profound impact of diasporic memory on identity within the family structure, particularly for those who were born after immigration. This unpacking of memories is achieved through photographs, collages, and installations that reveal the distant and absent attributes that reside within the home. As a second-generation American of Afro-Jamaican descent, this thesis navigates how the dual identity becomes too complex and is never allowed to exist in a binary state. The constant state of in-betweenness between both cultures led to further questioning of selfhood beyond the Caribbean identity maintained by …

Emanata Presents: Ruin (2023)

Emanata, 2014-

Started by illustrator and comics artist Chris Kindred in 2014 with Weird, Vol. 1, Emanata is VCU’s first-ever comics anthology.

Pwatem: An Anthology Of Literature And Art (2023)

Pwatem (Poictesme), 2006-

Pwatem is an anthology of literature and art from undergraduate students at Virginia Commonwealth University. Pwatem publishes poetry, prose and art of all kinds from talented undergraduate students of all majors.

The Compass, Summer 2023

The Compass, 2018-

The Compass is an annual orientation guide for VCU students produced by the Student Media Collective in the VCU Student Media Centered. The guide is distributed physically during summer orientation sessions for new and transfer students. The publication includes short articles, illustrations, letters of welcome from students and administrators, comics, and advertisements from VCU and Richmond organizations.

Sense Of Belonging As Behaviorist Construct: “Doing Belonging” And Its Application For College Students With Disabilities, Chris Parthemos Phd

Theses and Dissertations

Sense of Belonging has been widely linked to academic performance, retention and persistence for college students. Students with disabilities are less likely to enroll than peers, and are more likely to drop out. Similar to other historically-marginalized groups, these students report lower sense of belonging than peers. Research with this population suggests that they may be seeking ways of building community and belonging at their universities which are self-driven. This notion of “doing belonging”, as it is described in the sociological literature, appears at first glance to be compatible with behaviorist approaches to student support. Although not without controversy, behavior …

Formation Of Vasculogenic Mimicry: Role Of Melanoma Differentiation Associated Gene-9 In Human Melanoma, Jinkal Shah

Theses and Dissertations

Malignant melanoma (MM) is the most aggressive skin cancer and the most frequent skin disorder in Caucasians. MM is associated with aggressive and progressive disease states, leading to major cancer-related morbidity and mortality. Recent investigations identify an alternative pathway -vasculogenic mimicry (VM), which is considered a cancer hallmark that can independently facilitate tumor neovascularization by the formation of fluid-conducting and vascular endothelial cells. MM cells undergoing VM can dedifferentiate into numerous cellular phenotypes and acquire endothelial-like features, resulting in the formation of the de novo matrix-rich vascular-like networks, such as plasma and red blood cells. The co-generation of endothelial cells, …

Developing Novel Femtosecond Time-Resolved Mass Spectrometry Techniques For Analysis Of Energetic Materials, Shane L. Mcpherson

Theses and Dissertations

Energetic materials and the unimolecular dissociation dynamics attributed to their initiation and subsequent bimolecular detonation have been a subject of interest for defense agencies such as the Department of Defense (DoD) for decades. The timescale in which these initial dynamics exist ranges from several picoseconds to dozens of femtoseconds, necessitating equally fast time-resolved experiments to capture and characterize these events. Our lab specializes in one such laser-based technique: femtosecond time-resolved mass spectrometry (FTRMS). FTRMS is an essentially nondiscriminatory pump-probe laser technique with nearly infinite modifications via pulse shaping, intensity, and wavelength modulation that can readily examine previously undefined dissociation pathways …

Improving The Use Of Diffusing Wave Spectroscopy As A Multiphase Process Analytical Technology, Robert Emerson Mcmillin Iii

Theses and Dissertations

The study of multiphase formulations is a difficult task due to inhomogene- ity. Typical methods of study, such as microscopy, suffer from sampling drawbacks and are ill-equipped at probing the system in its native state. Additionally, more concentrated sys- tems, including optically-dense emulsions and suspensions, render common light-scattering techniques, such as dynamic light scattering (DLS), useless. Lastly, macroscopic phase track- ing or transmission intensity techniques can only obtain partial information about a system. Herein, the use of diffusing wave spectroscopy (DWS), a multiple scattering adjunct to DLS, to study optically dense multiphase systems is explored. Three different systems are exam- …

Evaluation Of Cytokeratin-Specific Antibody And Autofluorescent Signals As Predictors Of Time Since Deposition For Saliva Samples, Dillon Ryder

Master of Science in Forensic Science Directed Research Projects

In a forensic investigation, STR profiles generated from biological evidence can frequently be informative to identify an individual or provide an investigative lead. However, STR typing does not provide information to answer activity-level questions which can be highly important to a criminal case, such as the Time Since Deposition (TSD) of biological evidence. Determining the relative time in which a biological sample was left at a crime scene would provide additional information regarding the timeline of a crime and a person of interest’s relationship to the scene. One proposed method of estimating TSD is to use flow cytometry to analyze …