Digital Commons Network^™

Enhancing Chemotherapeutic Efficacy Of Doxorubicin Through Combination Therapy With Rapamycin And Sildenafil, While Providing Cardioprotection In Breast Cancer Models, Rebecca Mathew

Theses and Dissertations

Doxorubicin (DOX) is a common chemo-drug for breast cancer, but it causes severe cardiotoxicity. This study explores combining Sildenafil (Sild) and Rapamycin (Rapa), which inhibit phosphodiesterase-5 (PDE5) and mTOR, respectively, to boost DOX’s anticancer, but provide cardioprotection. Triple negative human (MDA-MB-231) and murine (4T1) breast cancer cells were treated with DOX (1 µM) with/without Rapa (100 nM) and Sild (10 µM) for 24-72 hours to analyze cell death, cell viability assays and protein expression. Human epidermal growth factor receptor 2-positive breast cancer (SKBr3) spheroids were treated with the same concentrations of DOX and/or AG825 (5µM) with/without Rapa and/or Sild for …

The Regulation Of Laryngeal Cancer Cell Phenotype And Proliferation By 24r,25-Dihydroxyvitamin D3 Is Correlated With Erα Isoform Expression, Cydney Dennis

Theses and Dissertations

Laryngeal cancer is the most common type of head and neck cancer and is associated with poor prognosis due to common delayed diagnoses. The sex disparities associated with laryngeal cancer are constantly growing, as the risk of malignancy in males is continually increasing compared to women. Due to the high chance of late-stage diagnosis requiring aggressive treatments, there is a high demand for less aggressive treatment options and early-stage diagnostic markers. The apparent sex disposition of the larynx, the correlation between sex hormones, and the risk of malignancy in aging men suggest that estrogen may play a role in laryngeal …

Energy Efficient Spintronic Devices For Non-Volatile Memory And Hardware Ai, Walid Al Misba

Theses and Dissertations

Nanomagnetic devices have emerged as a promising alternative to conventional complementary metal-oxide-semiconductor (CMOS) devices due to their low energy dissipation and inherent non-volatility. However, the widespread adoption of these devices requires high-density, high-speed, reliable, scalable, and energy-efficient technologies. This thesis investigates the use of nanomagnetic memory devices as both conventional Boolean memory and multistate memory for hardware AI applications.

Magnetic tunnel junctions (MTJs) are nanomagnetic memory devices that can be switched reliably and energy-efficiently using stress-mediated switching. However, realistic material inhomogeneity and scalability pose challenges for stress-mediated switching of MTJs scaled to lateral dimensions below 50 nm. We demonstrate that …

The Many Impacts Of The Covid-19 Pandemic On Latinx College Students’ Mental Health: Exploring The Role Of Sleep, Social Support, And Familismo, Mayra S. Ramos

Theses and Dissertations

College students experienced a multitude of disruptions to their daily life, and changes to their physical (i.e., sleep quality) and mental health (e.g., anxiety and depressive symptoms) because of the COVID-19 pandemic. Though the field has identified the factors that have contributed to negative physical and mental health changes, there remains much to be known about social and cultural protective factors that could buffer the negative role of the COVID-19 pandemic on Latinx college students. The current study contributed to the literature on the mental health outcomes of Latinx college students by identifying a possible mediator and moderators between the …

Mild Traumatic Brain Injury In Yucatan Minipigs: Assessing Changes In Approachability And Mechanical Nociception Following Diffuse Central Fluid Percussion Injury, Mark D. Pavlichenko

Theses and Dissertations

Traumatic brain injury (TBI) is a major healthcare concern affecting millions. Symptoms of TBI include sensory sensitivity and social changes that may persist long-term. Due to similarities in cytoarchitecture, metabolism, and inflammation, higher order minipig models are advantageous for translational TBI research, however, there remains a shortage of information regarding their behavioral and sensory sequelae following injury. Therefore, in this study, we assessed changes in sociability and somatosensation in adult male and female Yucatan minipigs for up to one-week following a sham or central fluid percussion injury (cFPI). Specifically, the voluntary human approach task (VHAT) and the forced human approach …

T Cell Polarization Regulates The Inflammatory Response And Tissue Regeneration At The Peri-Implant Interface, Derek Avery

Theses and Dissertations

Unresolved healing and localized chronic inflammation are common occurrences after biomaterial implantation, resulting in unfavorable clinical outcomes such as implant failure or fibrous encapsulation. T cells are adaptive immune cells found in lymph nodes, thymus, spleen, bone marrow, and around biomaterials, significantly impacting the degree of inflammation and wound healing. T cells are vital for inflammatory cytokine production and modulation of innate immune cells, including neutrophils and macrophages. T cells can be differentiated into two primary subsets, CD4⁺ and CD8⁺ T cells, playing distinctive roles in various pathologies and disease states. While T cells have been characterized well …

Using Asset-Based Community Development To Increase Student Engagement And Improve Student Experience In Schools, Jacqueline Hopkins

Theses and Dissertations

The following is a dissertation in the three-paper dissertation format. The first section will give background information on the issue of alienation in schools and how asset-based community development (ABCD) could be an effective tool for educators to combat alienation and disengagement, especially with students with marginalized identities. This first section will also show the significance of the three papers as a whole and how they connect to one another. The first paper is the conceptual literature review, the second paper is an empirical study of the ABCD model in schools, and the dissertation will end with a practitioner's article …

How Ebony Transcends In The Ivory Tower: Unveiling Transformational Black Women Forging Leadership Paths In Historically White Institutions, Lauren N. Jackson

Theses and Dissertations

Considerable literature has amplified the perceived challenges and deficits of Black women as they advance in their careers within historically white institutions (HWI). As a result, there is a notable absence of anti-deficit explorations of the inherent abilities and strengths that contribute to Black women’s professional mobility. Grounded in anti-deficit achievement framework and Black feminist leadership, this study aimed to illuminate the assets and factors that influence the professional ascension of seven, current/former senior-level Black women in a HWI within the Southeastern region of the U.S. By adopting a qualitative, phenomenological framework, this study provides in-depth insights into the participants’ …

Bridging The Gap In Epsilon-Near-Zero Nonlinear Materials, Adam R. Ball

Theses and Dissertations

Studying how light and matter interact has been of interest to humans for thousands of years. From the invention of the first mirror, burning ants with a magnifying glass, to optical fiber communication, light has been central to mankind. Researchers have sought to take this to the extreme with nonlinear optics where intense laser light interacts with materials. The study of this thesis is to understand a new generation of materials that has come to light. Epsilon-near-zero (ENZ) materials have shown promise for ultrafast light manipulation in tandem with modern day CMOS compatible electronics. Here, I seek to bridge the …

Title: I: L1-Norm Matrix Completion For Recommender Systems Ii: Conjecturing-Based Classification, Fatemeh Valizadeh Gamchi

Theses and Dissertations

Recommendation systems are essential for providing personalized user experiences, but their performance can be affected by outliers especially in traditional collaborative filtering methods that use the L2-norm. To address this challenge, we developed two new algorithms, SharpEl1rs and SharpEl1rs-Impute, based on the L1-norm to improve resistance against extreme values and effectively handle missing data. Our experimental setting was designed to compare these proposed methods with existing techniques. Then our algorithms are applied to real datasets to assess their performance, with findings indicating that our proposed models offer improved accuracy in some cases and solid performance in others for industrial-scale recommendation …

Examining Parent Behavior And Adolescent Outcomes In A Pediatric Obesity Intervention, Madison W. Weinstock

Theses and Dissertations

Pediatric obesity is a major public health concern that affects over 14.4 million children and adolescents in the United States. Multiple short- and long-term health complications are associated with obesity. Therefore, effective treatment methods are needed in order to ameliorate the effects of said complications, particularly among adolescents. This dissertation investigated potential associations between parent eating behaviors and the outcomes of adolescents enrolled in a pediatric weight loss trial (TEENS+; PI: Bean, R21HD084930). The TEENS+ intervention offered a comprehensive behavioral weight intervention for parent-adolescent dyads. Given the well-established importance of parents in the development of an adolescent’s health behavior, this …

Correlates Of Coffee And Energy Drink Use Among Individuals With Severe Alcohol Use Disorder, Enkelejda Ngjelina

Theses and Dissertations

Research on caffeine consumption among college students and young adults has primarily focused on caffeinated energy drinks (EDs) and their combination with alcohol, demonstrating a strong association with heavy and problematic alcohol use. However, little attention has been directed toward older adults. Furthermore, studies have shown that regular ED consumers are more likely to meet the criteria for alcohol dependence compared to their peers. Despite this association, little is known about ED consumption among individuals with Alcohol Use Disorder (AUD), particularly those undergoing treatment, and even less is understood about other caffeine sources such as coffee. This study aimed to …

Systemic Contributors To Health Equity: A Conceptual Framework And Moderation Analysis, Rachel Regal

Theses and Dissertations

This dissertation presents a line of research exploring systemic factors that influence health and health equity across the lifespan. A linking document prefaces two-manuscripts as follows. Manuscript 1, A Model for Enhanced Trauma-Informed Care: An Asset-Based, Transdisciplinary Approach to Health Equity, presents a synthesis of literature on multisystem resilience, social determinants of health, and adverse / positive childhood experiences to build an alternative framework to promote healing and health equity using an asset-based approach within enhanced trauma-informed systems of care and educational models. By adopting this enhanced framework, the counseling field and others can be responsive to emerging trends and …

Roleplaying Builds Character: Avatar Performance In Dungeons & Dragons As An Art-Form For Self-Development., Maria F. Pagola Garcia

Theses and Dissertations

This paper examines the impact of the performance and embodiment of Dungeons & Dragons characters on their player’s self-development and self-confidence. Focusing on the game’s 5th edition, this narrative inquiry study is concerned with the applications of D&D as an artistic tool to build both community in formal and informal spaces of art education and individual players’ self-development through the avatars being portrayed during game time.

Ten adult participants ranging from age 23-28 were selected using a mix of direct recruitment and voluntary response. They filled out a digital survey introducing themselves and their main D&D characters, then a 45-minute …

Early Technology Exposure And Academic Performance In Generation Alpha: Reduced Attention Span And Ability To Multitask, Sanjana Gupta

UROP Posters

The increasing prevalence of handheld devices in the lives of young children inspired this research, particularly regarding their potential impact on attention spans and cognitive development in Generation Alpha. Early exposure to tablets and smartphones before the age of seven coincides with critical periods of neuroplasticity, during which the brain is highly receptive to environmental influences. This matters because attention and cognitive skills formed in childhood lay the foundation for academic success and long-term personal development, and the shift toward digital learning platforms in schools may have significant consequences.

This study aimed to investigate whether early exposure to handheld devices …

Exploring Perceptions Of Advanced Coursework Enrollment Practices: A Multiple Case Study, Tomika Ferguson, David B. Naff, Jenna Lenhardt, Amy E. Jefferson, Isaiah Moore, Andrea Herndon, Richard Ashburn, Jessica Harris, Jenna Conlee, Courtney Forstmann

MERC Publications

This report from the Metropolitan Educational Research Consortium highlights findings from a multiple case study exploring enrollment practices related to advanced coursework matriculation in a suburban middle school and rural high school. In connection with the MERC Equitable Access and Support for Advanced Coursework study, this multiple case study included perspectives from students, parents, and educators as they reflected on the factors that support and inhibit access for advanced courses in their schools.

Parasocial Relationships In Variety Live Streaming: How It Can Affect Attitudes And Buying Intention Toward Sponsors, Megan Burroughs, Deborah Diazgranados

UROP Posters

Online streaming and video platforms have become a popular form of entertainment as opposed to traditional media like movies and TV shows. Similar to traditional media, viewers often relate to and form one-sided relationships with actors/creators, known as parasocial relationships. Actors and creators can then leverage that relationship to advertise and market products to their audience. The primary objective of this study was to understand if perceived credibility and loyalty towards a streamer fuel parasocial relationships and how perceived credibility and parasocial relationships with an online live streamer influence attitude towards a sponsored brand and purchasing intention. It was predicted …

Images Of Maps And Connotative Tendencies In Early Republican America, Kerr Houston

Art Inquiries

No abstract provided.

Jamie Robertson: Make For Higher Ground, Elizabeth S. Hawley

Art Inquiries

No abstract provided.

An Interview With Brianna Harlan, Mysoon Rizk, Brianna Harlan

Art Inquiries

No abstract provided.

An Interview With Jennida Chase, Sunny Spillane, Jennida Chase

Art Inquiries

No abstract provided.

Translating Antiquity Onto Souvenirs: The Collectively Shaped Reception Of The Doves Of Pliny On Micromosaics, Lauren K. Disalvo

Art Inquiries

No abstract provided.

Laurie Anderson: The Weather, Annie Dell'aria

Art Inquiries

No abstract provided.

From House Party To World Dominance: Celebrating 50 Years Of Hip Hop: A Bibliography, Cassandra Chaney

Journal of Hip Hop Studies

In 2023, the culture celebrated the 50th birthday of Hip Hop. While there is an ongoing argument of when Hip Hop started, Hip Hop culture marked Clive “DJ Kool Herc” Campbell’s legendary 1973 party at 1520 Sedgwick Avenue in the Bronx, NY as the day to commemorate its humble beginnings. This work provides a bibliographical list of published articles, interviews, book reviews, forthcoming books, and live performances from various artists that made a major impact on Hip Hop. In particular, the bibliography highlights the mark that Hip Hop has made on fashion, the economy, language, and the unique contributions that …

Foreword, Courtney Terry

Journal of Hip Hop Studies

Foreword for volume 10 issue 1.

Commonwealth Times 2023-11-29

Commonwealth Times, 1969-

No abstract provided.

Ritual: Full Journal

International Journal of Lifelong Learning in Art Education

No abstract provided.

Food For Thought: Rituals In Place Based Learning, Natalia Pilato

International Journal of Lifelong Learning in Art Education

In my mother’s kitchen lasting bonds among family, friends, and newcomers are created. Using that space as a point of departure, I explore the significance of pedagogical places outside of classrooms that serve as flavorful ingredients for performative and participatory learning. This article articulates ways in which rituals associated with Sicilian cultural traditions are interwoven and complicit in establishing dispositions for socially engaged learning and teaching in the arts, showing how an ethic of care can transcend generations. With a focus on place-based learning, making art and enjoying food are investigated to show how healthy productive relationships, appreciation for beauty, …

Pearl And Murray Greenberg Award Lectures, Susan Whiteland, Eli Burke

International Journal of Lifelong Learning in Art Education

No abstract provided.

Commonwealth Times 2023-11-08

Commonwealth Times, 1969-

No abstract provided.