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Novel Sulfated 4-Hydroxycinnamic Acid Oligomers As Potent Anticoagulants, Brian Lawrence Henry Jan 2007

Novel Sulfated 4-Hydroxycinnamic Acid Oligomers As Potent Anticoagulants, Brian Lawrence Henry

Theses and Dissertations

The occurrence of thrombosis in several pathophysiological conditions creates a huge need for anticoagulation therapy. Thrombin and factor Xa have been prime targets for regulation of clotting through the direct and indirect mechanism of inhibition. This work investigates chemo-enzymatically prepared oligomers of 4-hydroxycinnamic acids (DHPs) as potential anticoagulants. Oligomers were prepared through peroxidase-catalyzed oxidative coupling of 4-hydroxycinnamic acids. The products resulting from this reaction are called CDs, FDs and SDs. Structurally, these sulfated DHPs are unique and do not resemble any of the anticoagulants known in the literature.DHP oligomers were found to increase clotting times at concentrations comparable to heparin. …

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Concurrent Whitening And Orthodontic Treatment, Jason Thomas Gladwell Jan 2007

Concurrent Whitening And Orthodontic Treatment, Jason Thomas Gladwell

Theses and Dissertations

The aim was to evaluate whether a whitening system, when used during the final stages of orthodontics, would yield results comparable to whitening alone. Patients were assigned to either the control (n=20) or experimental (n=26) groups. At T1, patients were given a ten day supply of Trèswhite™ by Opalescence®, instructions on use, and initial shade determination was made and photographs were taken. At T2 and T3, shade determination was accomplished and updated photographs were taken. Whitening of the teeth occurred in both groups on average, but significantly more whitening was experienced in the experimental group (p < 0.004). An average of 87% of teeth whitened during orthodontic treatment compared to 97% of control teeth (p < 0.01) were judged to be uniform in appearance. In conclusion, the data do not contraindicate the concurrent accomplishment of teeth whitening during orthodontic treatment.

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Effects Of Cxcl8 Overexpression On Tumor Cell Proliferation And Migration In An Hnscc Cell Model, Emil Paul Christofakis Jan 2007

Effects Of Cxcl8 Overexpression On Tumor Cell Proliferation And Migration In An Hnscc Cell Model, Emil Paul Christofakis

Theses and Dissertations

Head and neck squamous cell carcinoma is the 6th most common malignancyworldwide. Recently, a link between cancer and inflammation has been found. Mediatingthis relationship are the chemotactic cytokines known as chemokines. CXCL8 (Interleukin-8), a CXC ELR+ Chemokine mainly responsible for neutrophil chemoattraction, has beenimplicated in increased tumor proliferation, migration and angiogenesis. The current studytests the effects of CXCL8 on the tumor proliferation and metastasis. By genetically modifying cells to knockdown or overexpress the CXCL8 gene we tested its biological rolein head and neck cancer progression. Overexpression of CXCL8 in HN4 tumor cells withlow endogenous CXCL8 levels was found to increase …

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Intervals, Knox Garvin Iii Jan 2007

Intervals, Knox Garvin Iii

Theses and Dissertations

I prefer to make my work specifically for an exhibition about a place. I'll spend days, sometimes months, exploring this place without preconceptions - walking the roads or trails or fields, falling in love with aspects of the landscape, considering questions the place suggests before I begin to contemplate how to make them into images. The actual making of images helps me to refine thought that is often elusive, contradictory, or enigmatic. Each pinhole photograph, painting, sketchbook, found object, sculpture, or drawing provides its own tools for reflection. Over time, these processes form hundreds of images. Some will begin to …

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Interactions Of Mtfabh With Its Substrates And Inhibitors Reveal Novel Mechanistic Insights, Sarbjot Singh Sachdeva Jan 2007

Interactions Of Mtfabh With Its Substrates And Inhibitors Reveal Novel Mechanistic Insights, Sarbjot Singh Sachdeva

Theses and Dissertations

Tuberculosis emerged from its grave to be one of the deadliest diseases of the present time after recently developing a synergy with AIDS. A fatty acid condensing enzyme-mtFabH has been proposed to connect the key processes involved in biosynthesis of mycolic acids, an important component of mycobacterial cell wall. It condenses long acyl Coenzymes A (CoA; up to C20CoA) with malonyl Acyl Carrier Protein (ACP) to form the elongated β-ketoacyl-ACP which further undergoes rounds of elongation to form mero-mycolate branch of mature mycolic acids. Owing to its proposed central position in mycolic acid synthesis, mtFabH has attracted considerable attention as …

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Beyond Narrative, Jacob Adam Joseph Dodd Jan 2007

Beyond Narrative, Jacob Adam Joseph Dodd

Theses and Dissertations

My graduate film at Virginia Commonwealth University, "Nunna Mia e la Barca," explores the traditions behind narrative and documentary film construction. With this project, my goal was to blend narrative story telling techniques - for example continuity editing - with that of documentary approaches in order to communicate the story of my Italian grandmother, Nunna, and her journey on the Andrea Doria in 1956. These documentary approaches focus more on the specific details of Nunna's American home as I have experienced them growing up. Everything in the motion picture frame has been lit, composed, rehearsed, and edited as in any …

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Reviving The Seventies, Aimee M. Huber Jan 2007

Reviving The Seventies, Aimee M. Huber

Theses and Dissertations

Design Analysis of the VCU Mainstage production process for The Nerd The comedic farce, The Nerd, written by Larry Shue and directed by Drew Fracher here at VCU, is the production I intend to analyze in terms of the scenic design process. From the initial conception of ideas, to their development through collaboration, to completion of construction, and ultimately, opening night, I plan to breakout my process step by step. I'd like to communicate the transformation of a literary play into the three-dimensional world in my mind.I. Introduction A. Overall description of process as it applies to this particular interaction …

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In Search Of The Ooey Gooey Good, Lauren Ashley Clay Jan 2007

In Search Of The Ooey Gooey Good, Lauren Ashley Clay

Theses and Dissertations

This thesis explores ideas of everydayness, the mundane, and the repetitive emptiness of consumer culture. It looks at the malaise that plagues everyday life and examines several attempts throughout history to break from its grips which revolve around a search for a more ideal state. This research includes utopias of modernism, the transcendental, the communal living of Shakers and Early Christians, ascetic monks and The Desert Fathers. These ideas have shaped my studio practice as I construct installations based on worlds which allude to the eternal, the otherworldly, and the fragility of our physical world when compared to more eternal …

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Induction Of Heme Oxygenase By A Carbon Monoxide-Releasing Molecule, Robert Andrew Kulina Jan 2007

Induction Of Heme Oxygenase By A Carbon Monoxide-Releasing Molecule, Robert Andrew Kulina

Theses and Dissertations

We have recently demonstrated that heme oxygenase is expressed in both healing wounds and in pressure ulcers. Heme oxygenase has been shown to have important cytoprotective functions in myocardial ischemia-reperfusion injury and organ allograft survival. The cytoprotective effects of heme oxygenase are multifactorial. Besides reducing levels of pro-oxidant heme, heme oxygenase products (bilirubin, carbon monoxide, and iron) have been demonstrated to possess anti-oxidant, anti-inflammatory, anti-apoptotic, and anti-proliferative properties. These properties make heme oxygenase an attractive therapeutic target for the prevention and treatment of chronic wounds. The purpose of this study was two-fold: evaluate the effects of carbon monoxide (CO) on …

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The Effect Of A Nominal Fee On Treatment Choices For Children Needing Dental Rehabilitation, D'Audra M. Cole Jan 2007

The Effect Of A Nominal Fee On Treatment Choices For Children Needing Dental Rehabilitation, D'Audra M. Cole

Theses and Dissertations

Objective: The purpose of the study was to determine if a co-payment resulted in a differential preference for general anesthesia (GA) or oral sedation (OS) and, if so, to examine whether age, the number of appointments, perceived risks of treatment, child's awareness during treatment, or insurance type appeared to play a role in this preference.Methods: Using a cross-sectional survey design, questionnaires were distributed to caregivers of patients in the waiting room of the Virginia Commonwealth University Pediatric Dental Clinic. Two different questionnaires were distributed randomly. Both surveys described a scenario with the need for dental treatment under general anesthesia (GA) …

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Toward A New Kinship Constellation, Nellie Helen Frances Appleby Jan 2007

Toward A New Kinship Constellation, Nellie Helen Frances Appleby

Theses and Dissertations

This thesis attempts to elaborate on my artwork during my graduate studies, while contextualizing it within the framework of the art world and the works of other artists. A main project during this time was to minimize the singular interpretation and framing of a fine art photographic print, while expanding its possibilities of meaning through the addition of important ephemera and objects such as plants, drawings, moving imagery, conversation and the unknown.

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Beaut-Ease, Amanda Rae Douglas Jan 2007

Beaut-Ease, Amanda Rae Douglas

Theses and Dissertations

The Beaut-Ease product line consists of several machines that are a hybrid between beauty products and infomercial products. Both industries flourish on a level of falsehood that teeters on the brink of hilarity.

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Elementary School Principals' Perceptions Of The Instructional Role Of The School Library Media Specialist, Audrey Puckett Church Jan 2007

Elementary School Principals' Perceptions Of The Instructional Role Of The School Library Media Specialist, Audrey Puckett Church

Theses and Dissertations

Studies conducted in numerous states by various researchers demonstrate that library media specialists who take an active role in the instructional process positively impact student achievement in their schools. Principals are the instructional leaders of their schools, yet the research indicates that they are not knowledgeable regarding the role of the library media specialist. This study explored Virginia elementary school principals' perceptions of the instructional role of the library media specialist, the effect of library schedule on these perceptions, and the origin of these perceptions. Principals who responded to the study strongly endorsed the role of library media specialist as …

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Victims' Perspectives On The Process Of Seeking A Protective Order: Predictors Of Perceived Empowerment, Sara-Beth Plummer Jan 2007

Victims' Perspectives On The Process Of Seeking A Protective Order: Predictors Of Perceived Empowerment, Sara-Beth Plummer

Theses and Dissertations

This study examined victims' perceived sense of empowerment during the process of seeking a Preliminary Protective Order. A cross sectional survey design with stratified sampling was used to gather information from women seeking Preliminary Protective Orders in Richmond City, Virginia. During a six month period 89 women agreed to participate, for a response rate of 83 percent. In general, the sample consisted of women who identified themselves as African-American, single, with either a high school/GED degree, and/or some college education.Overall, the women found the steps during the process of seeking an Order, either easy or very easy. In general, the …

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Amendment (2007) Jan 2007

Amendment (2007)

Amendment, 2004-

Amendment is a VCU student-produced progressive literature and art journal that provides a platform for students to promote equality, tolerance, and social progression through artistic expression.

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Virginia Dental Journal (Vol. 84, No. 4, 2007) Jan 2007

Virginia Dental Journal (Vol. 84, No. 4, 2007)

Virginia Dental Journal

No abstract provided.

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Supporting Data-Intensive Wireless Sensor Applications Using Smart Data Fragmentation And Buffer Management, Mbonisi Masilela Jan 2007

Supporting Data-Intensive Wireless Sensor Applications Using Smart Data Fragmentation And Buffer Management, Mbonisi Masilela

Theses and Dissertations

Recent advances in low power device technology have led to the development of smaller powerful sensors geared for use in Wireless Sensor Networks. Some of these sensors are capable of producing large data packets in a single reading. This becomes a challenging problem given the constraints imposed by current MAC and Transport Layer implementations since a single data packet can exceed the MTU of the protocol stack. Little has been done in the way of addressing this issue in Wireless Sensor Networks. This paper proposes a novel solution to this issue. Proposed is a Lightweight Data Transportation Protocol that uses …

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The Characteristics Necessary For A Mathematics Specialist, D. Southwell Jan 2007

The Characteristics Necessary For A Mathematics Specialist, D. Southwell

Journal of Mathematics and Science: Collaborative Explorations

No abstract provided.

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The Alchemy Of The Everyday, Nanda Soderberg Jan 2007

The Alchemy Of The Everyday, Nanda Soderberg

Theses and Dissertations

Everyday objects inspire and inform what I do. The personal histories and associations we may have with ordinary things are of great personal interest to me. Often times, these items reflect the social class, education, and background of the owners. I am drawn to these objects and the possibility of elevating them in a way that transcends their implied meanings (their worth, importance, and status). The transformation of the mundane is a method of working that allows associations to remain intact while bringing new meaning and perspective to the object. My method of working becomes an alchemic process aimed at …

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This Art Is For The Birds, Shawn Earl Heller Jan 2007

This Art Is For The Birds, Shawn Earl Heller

Theses and Dissertations

I use bright colors to portray birds. Typically, the birds are modeled after herons, peacocks, woodpeckers, and roadrunners. I am interested in the curvilinear forms or colorful plumage of these birds. Why birds? I wonder that myself. The rational part of me wants to know why I use bird imagery, while the intuitive side of me likes the fact that if is unknown, I haven't been able to answer that burning question. In my sculpture, wire connectors, kitchen funnels, electrical tape, caps, marker parts, cleaning bottles, and watering cans are just some of the many plastic items I use. In …

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The Lynks Reader, Anne Marie Reamey Jan 2007

The Lynks Reader, Anne Marie Reamey

Theses and Dissertations

Many adults and children have problems reading and comprehending books, signs, written directions, etc. These same individuals have difficulty processing written materials as a result of right hemisphere interference. The Lynks Reader (DLR Co., Richmond, VA) is a commercially developed device which has been used to help individuals move from their right to their left hemisphere and to increase reading fluency and comprehension. The objective of this project was to evaluate the best way to use the various forms of the Lynks Reader. Using the device demonstrated an increase in reading fluency and comprehension by increasing the left hemisphere dominance. …

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"Shut It Down, Open It Up": A History Of The New Left At The University Of Virginia, Charlottesville, Thomas M. Hanna Jan 2007

"Shut It Down, Open It Up": A History Of The New Left At The University Of Virginia, Charlottesville, Thomas M. Hanna

Theses and Dissertations

This thesis is a history of social and political activism in Charlottesville during the 1960s focusing on new left student organizing at the University of Virginia. It is a work of social history that establishes a community that has been generally ignored in traditional histories of the new left as one of the most influential centers of new left activism in the South and asserts that this prominence was due to years of activism by local liberals, civil rights advocates, and students during the city's unique experiences on the front lines of the southern desegregation, civil rights, and anti-war struggles. …

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Creative Matrix, Bonnie Gay Mcginn Jan 2007

Creative Matrix, Bonnie Gay Mcginn

Theses and Dissertations

My personal life experiences are reflected in my art. I use symbolic and expressive marks in developing my abstract imagery, which acts as a visual language. The combining of my past and current art work, fused together, has become what I call a creative matrix. I see my images as choreographed compositions using a mixed media approach. The open-ended interpretation of my art have expanded the never ending possibilities of creation.

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Constraints On Breastfeeding Choices For Low Income Mothers, Carol Grace Hurst Jan 2007

Constraints On Breastfeeding Choices For Low Income Mothers, Carol Grace Hurst

Theses and Dissertations

The choice to breastfeed a baby is a woman's concern with impact reaching beyond each individual mother and child to longer term health and mental health outcomes for society. The U.S. government has made increasing breastfeeding rates one of its major public health goals for 2010. Breastfeeding is a health disparity issue with mothers who are poor, young, less educated or Black less likely to breastfeed. This project examined impacts of sexual perceptions of breastfeeding, social support, and work on breastfeeding choices made by a sample of low income mothers. A cross-sectional survey design was employed to examine potential barriers …

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Blogging In The Writing Classroom: A Move Toward Dialogue, Design, And Citizenship, Meghan E. Foster Jan 2007

Blogging In The Writing Classroom: A Move Toward Dialogue, Design, And Citizenship, Meghan E. Foster

Theses and Dissertations

A bridge connecting student's new multi-modal abilities and schooling can be built. Students choose between school and other activities outside of the classroom walls (and sometimes even inside the classroom) and schoolwork seems to be losing ground in the battle of spare time more and more. Students could benefit from an electronic space that incorporates their media know-how, their studies, and others in the classroom. Blogs, or weblogs, provide just that type of space by relying on the user's insightful writing and creativity to retain a dynamic position in the Internet blogging community. Blogs have the ability to better the …

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Lets Make It Outback Tonight, Michael Douglas Erickson Jan 2007

Lets Make It Outback Tonight, Michael Douglas Erickson

Theses and Dissertations

When I was younger, shortly after my father died, my mother bought me a t-shirt that I loved and wore till it was worn out. On the shirt there was an image of a man, strapped into an electric chair, holding pieces of bread in each hand. A sign above him read, "Making the best of a bad situation." That statement became a mantra I held onto in the early years after my father's death. It still guides my personal philosophy---humor is key to survival. Particularly a type of humor that celebrates the fact that "shit happens", while highlighting and …

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Roles And Attitudes Of Males And Females In The Anarchist Punk Community, Donna M. Manion Jan 2007

Roles And Attitudes Of Males And Females In The Anarchist Punk Community, Donna M. Manion

Theses and Dissertations

Sexism is a widespread social problem that exists throughout the world today. It persists within the dominant culture, as well as in various subcultures, including the punk subculture (Daugherty 2002; Leblanc 1999; McRobbie 1991; Rosenberg and Garofalo 1998). Nijole Benokraitis and Joe Feagin's (1995) theory of sexism posits that subtle sexism is the unequal and harmful treatment of women that is typically less visible than blatant sex discrimination. This particular type of sexism may often go unnoticed, as society has internalized subtle sexist behaviors. Empirical research on subtle sexism has been conducted in various settings, such as the employment, academic, …

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Reunion: A Journey Through History, Symbolism, And Fear, Vanessa Laure Fassie Jan 2007

Reunion: A Journey Through History, Symbolism, And Fear, Vanessa Laure Fassie

Theses and Dissertations

The contents here in examine the artistic process undertaken by Vanessa Fassie to create the mixed media work, reunion. The subjects of fear, archetypal symbolism, personal and collective histories were examined through research, archival evidence, video, sound, movement, and installation. reunion, examines not only the powers of personal and collective histories through the symbolic language of archetypes, but also how fear manifests and evolves through time. The culmination of this work was the creation of an installation within the Anderson Gallery at Virginia Commonwealth University. This Thesis was created through the use of Microsoft Word 2004.

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Adverse Anesthesia Outcomes: A Retrospective Study Of An Ambulatory Surgical Center Versus A Dental Office Setting, Gaurav Agarwal Jan 2007

Adverse Anesthesia Outcomes: A Retrospective Study Of An Ambulatory Surgical Center Versus A Dental Office Setting, Gaurav Agarwal

Theses and Dissertations

Purpose: The purpose of this study was to compare the adverse events that occur with general anesthesia for dental rehabilitation between a hospital setting and dental clinic setting. Methods: A retrospective chart review was performed examining patients who had received dental rehabilitation with general anesthesia at the Virginia Commonwealth University Department of Pediatric Dentistry. Subjects were either treated in the Pediatric Dental Clinic or the Hospital Ambulatory Surgery Center (ASC) from July 2005 to December 2006. Anesthesia records of induction, intubation, maintenance, emergence and recovery were compared between the two settings.Results: There were a total of 422 charts reviewed with …

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Differentiated Educational Strategies In The Elementary Art Classroom, Mary Amber Bush Jan 2007

Differentiated Educational Strategies In The Elementary Art Classroom, Mary Amber Bush

Theses and Dissertations

This thesis provides elementary art teachers strategies for teaching lessons in a method called "differentiation". The purpose of differentiation is to tailor lesson plans to try and meet unique needs of the students. Lessons can be differentiated through content, process, or product. A teacher may choose one of these three areas and provide different approaches to the lesson to meet different learning needs of the students. To meet different learning needs in an efficient way, students are grouped for lessons based on their readiness, interests, or their learning styles. This thesis provides greater detail on content, process, product, readiness, interests, …

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