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The Production And Filtration Efficiency Testing Of Nonwoven Electrospun Fiber Mats, Jan Uecker Jul 2009

The Production And Filtration Efficiency Testing Of Nonwoven Electrospun Fiber Mats, Jan Uecker

Theses and Dissertations

In this thesis the production and filtration performance of electrospun nylon-4,6 nanofiber mats was experimentally studied. The average fiber diameter of nylon-4,6 fibers is controlled by altering the polymer concentration in solution. Adding small amount of pyridine to the electrospinning solution controlled fiber beading and other defects. These fibers were then deposited onto a wide variety of conductive and dielectric substrate materials. A corona ion source was used to eliminate surface charging effects observed at the surface of all substrates. The resulting fiber mats, uniform in size and distribution as verified by SEM imaging, are tested for filtration efficiency and …

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The Regulation Of Platelet Activating Factor Acetylhydrolase By Oxidized Phospholipids, Rachael Griffiths Jul 2009

The Regulation Of Platelet Activating Factor Acetylhydrolase By Oxidized Phospholipids, Rachael Griffiths

Theses and Dissertations

Platelet-activating factor acetylhydrolase (PAFAH) is elevated in atherosclerosis and may play a role in pathogenesis of this disease. Molecular mechanisms regulating the expression of this lipoprotein-associated PLA2 are indistinct. Mildy oxidized low density lipoprotein (oxLDL) and monocytes (the primary source of PAFAH) are co-localized in early atheromas. Monocytes are activated by oxidized phospholipids (oxPL) in the oxLDL particle. We hypothesized that oxPL-activated monocytes are the source of increased levels of PAFAH in atherosclerosis. We found that PAFAH expression is significantly induced by OxPAPC and in particular long-chain fractions of oxPAPC in monocytes and cytokine-differentiated DC, but not cytokine-differentiated MO. Furthermore, …

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Specific Levels Of Therapeutic Ultrasound Stimulate The Release Of Inflammatory And Angiogenic Mediators From Macrophages In Culture, Thomas Turner Jul 2009

Specific Levels Of Therapeutic Ultrasound Stimulate The Release Of Inflammatory And Angiogenic Mediators From Macrophages In Culture, Thomas Turner

Theses and Dissertations

Therapeutic ultrasound (TUS) is a treatment modality that is used to accelerate tissue healing. TUS is thought to affect cellular processes of tissue healing, especially those that occur in the inflammatory and early proliferative phases. TUS can be applied using various parameter selections including intensity, wavelength, duty cycle and treatment duration and no clear consensus exists on optimal parameters for healing enhancement. Macrophages are important mediators of inflammation and their actions are critical to normal progression into the proliferative phase of healing. They complete many functions during these periods of tissue healing, among those being release of cytokines and growth …

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Assessment Of Pre-Pcr Whole Genome Amplification Of Single Pollen Grains Using Flowering Dogwood (Cornus Florida), Candace Dillon Jul 2009

Assessment Of Pre-Pcr Whole Genome Amplification Of Single Pollen Grains Using Flowering Dogwood (Cornus Florida), Candace Dillon

Theses and Dissertations

Studies of gene flow in natural plant populations often focus on either historical or abiotic dispersal methods (e.g. wind, water, gravity), but there is little information available on contemporary, animal-mediated pollen dispersal patterns. Emerging molecular laboratory techniques allow unprecedented insights into spatial patterns of pollen-mediated gene flow. However, to date, technical challenges have limited their widespread application. The genome of a pollen grain can be amplified via whole genome amplification (WGA) prior to traditional amplification via polymerase chain reaction (PCR) to prevent the stochastic effects associated with low copy number amplification. Even still, WGA can suffer from low success rates …

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The Genome Scale Metabolic Model Of Cryptosporidium Hominis: Inv209, Niti Vanee Jul 2009

The Genome Scale Metabolic Model Of Cryptosporidium Hominis: Inv209, Niti Vanee

Theses and Dissertations

The apicomplexan Cryptosporidium is a protozoan parasite of humans and other mammals. Cryptosporidium species cause acute gastro-enteritis and diarrheal disease in healthy humans and animals, and cause life-threatening infection in immuno-compromised individuals such as people with AIDS. It has a one-host life cycle and invades intestinal epithelial cells causing diarrhea, or more rarely the pulmonary epithelium. Cryptosporidium carries out all the asexual reproductive stages like several other apicomplexans. Current annotation of this organism predicts it to contain 3884 genes of which only 1581 genes have predicted functions. By using a combination of bioinformatics analysis, biochemical evidence, and high-throughput data, a …

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Exploring The Methylation Status Of Rai1 And The Rai1 Consensus Binding Sequence, Eri Kamura Jul 2009

Exploring The Methylation Status Of Rai1 And The Rai1 Consensus Binding Sequence, Eri Kamura

Theses and Dissertations

Smith Magenis Syndrome (SMS) is a multiple congenital anomalies/ mental retardation disorder caused by deletion or mutation of the RAI1 gene on chromosome 17p11.2. The majority of patients with SMS phenotypes have a deletion or mutation of RAI1. However, some patients have been observed with SMS-like phenotypes and yet have no deletions or mutations in the RAI1 gene. One possible explanation could be aberrant methylation of RAI1 since RAI1 is present and yet may be silenced. In order to study this possibility, patient cell lines were treated with 5-Aza-2’-deoxycytidine. RNA was extracted and real-time PCR was used to check the …

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Structural Interactions Between The Α3Β1 Integrin And Mmp-2: A Potential Functional Role In Cell Adhesion, James Bowman Jul 2009

Structural Interactions Between The Α3Β1 Integrin And Mmp-2: A Potential Functional Role In Cell Adhesion, James Bowman

Theses and Dissertations

During cardiac development and in cardiac disease changes in hemodynamic load initiate events leading to remodeling of the ECM. This study addresses the hypothesis that interactions between Integrins and Metalloprotienases function to modulate cell adhesion in the cultured cardiac fibroblast. The fibroblast is positioned to detect and respond to changes in the mechanical load on the heart. Functionally the cardiac fibroblast is the primary cell type responsible for the production, maintenance, and remodeling of the cardiac interstitium. Matrix Metalloproteinases, specifically the Gelatinases, are expressed in concert during development and in disease with changes in the hemodynamic loading of the heart. …

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Retinoic Acid Induced 1 Gene Analysis In Humans And Zebrafish, Bijal Vyas Jul 2009

Retinoic Acid Induced 1 Gene Analysis In Humans And Zebrafish, Bijal Vyas

Theses and Dissertations

Smith-Magenis syndrome (SMS) is a complex mental retardation syndrome caused by deletion of 17p11.2 region or mutation of the RAI1 gene (retinoic acid induced 1). Individuals with SMS typically exhibit speech and motor delays, mental retardation, characteristic craniofacial and skeletal anomalies, and a distinct neurobehavioral phenotype that includes sleep disturbances, stereotypes, and maladaptive and self-injurious behaviors. RAI1 is thought to be a transcription factor modulating the expression of genes involved in a variety of cellular functions. Previous studies have shown the RAI1 gene being induced by retinoic acid (RA), a derivative of vitamin A. RA plays a significant role in …

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Drawing Conclusions, Mary Coppage Jul 2009

Drawing Conclusions, Mary Coppage

Theses and Dissertations

My book arts explore the creative process. I am interested in what drives an artist to create and what can paralyze that creative action by blocking the process. I examine such issues as finding one’s personal muse and overcoming procrastination and self-doubt. Implements of exploration such as maps, compasses, and globes are materials included in this series of sculptural books. I also offer meticulous renderings of cacti, a personal symbol of resilience and power, as an illustration of finding and accepting my muse as “The Everyday.” Drawn in pencil on gessoed wooden panels, these detailed drawings are examples of discoveries …

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Intracellular Targets Of Sphingosine-1-Phosphate, Graham Michael Strub Jul 2009

Intracellular Targets Of Sphingosine-1-Phosphate, Graham Michael Strub

Theses and Dissertations

The bioactive lipid mediator sphingosine-1-phosphate (S1P) has emerged as a key regulator of a variety of important physiological functions, including cell growth, cell survival, cell motility, angiogenesis, lymphocyte trafficking, and mast cell function. S1P is formed by two different sphingosine kinases (SphKs) and binds to a family of 5 differentially expressed G-protein coupled receptors (S1PRs). The majority of research to date has focused on the activation of these receptors, but there is compelling evidence to suggest that S1P exerts intracellular functions independent of S1PRs. However no bona fide intracellular targets of S1P have been identified. In my dissertation, I have …

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Commonwealth Times 2009 07-01 Jul 2009

Commonwealth Times 2009 07-01

Commonwealth Times, 1969-

No abstract provided.

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Th2 Specific Immunity And Function Of Peripheral T-Cells Is Regulated By The P56lck Sh3 Domain, Margaret Mccoy Jul 2009

Th2 Specific Immunity And Function Of Peripheral T-Cells Is Regulated By The P56lck Sh3 Domain, Margaret Mccoy

Theses and Dissertations

Proper T-cell activation and effector function are essential for effective immunity. T-cell antigen receptor (TCR) signals are known to regulate the outcome of differentiation, but the mechanisms remain unclear. Recent work from our lab demonstrates that the Src family protein tyrosine kinase, p56Lck, is able to specifically link TCR signals to activation of the Mitogen Activated Protein Kinase (MAPK) pathway through the function of its SH3 domain. The MAPK pathway is known to be involved in T-cell activation downstream of TCR ligation and has previously been implicated in T-helper type 2 (Th2) effector function. We have utilized an Lck SH3 …

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Identification Of Apoptosis Pathway In Treacher Collins Syndrome, Khaled Alsayegh Jun 2009

Identification Of Apoptosis Pathway In Treacher Collins Syndrome, Khaled Alsayegh

Theses and Dissertations

Treacher Collins Syndrome (TCS) is a rare autosomal dominant disorder characterized by severe craniofacial defects. The syndrome is associated with mutations in the TCOF1 gene, which encodes a nucleolar phosphoprotein called treacle. Model organisms have been generated to model the disease and have revealed knowledge about the etiology and pathogenesis of the disorder. The craniofacial abnormality observed in TCS patients is found to be caused by an increased level of apoptosis in the neuroepithelium and from this it has been suggested that treacle is important for proper formation and proliferation of neural crest cells that will ultimately contribute to the …

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Transcriptional, Epigenetic, And Signal Events In Antifolate Therapeutics, Alexandra Racanelli Jun 2009

Transcriptional, Epigenetic, And Signal Events In Antifolate Therapeutics, Alexandra Racanelli

Theses and Dissertations

A targeted approach to the development of antifolate therapies has been sought for many years. Central to the success of such development is an understanding of the molecular mechanisms dictating the sensitivity of cells to antifolates and the fundamental differences of these processes between normal and neoplastic phenotypes. This dissertation addressed transcriptional mechanisms and cell-signaling events responsible for the efficacy of antifolate therapies. Transcriptional processes and cell signaling pathways are often aberrant in neoplastic tissues, providing a potential point of distinction between a normal and neoplastic cellular state. Folylpolyglutamate synthetase (FPGS) catalyzes the formation of poly-γ-glutamate derivatives of folates and …

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Factors Influencing Placental Transfer Of Lopinavir: Binding, Uptake And Efflux, Abhishek Gulati Jun 2009

Factors Influencing Placental Transfer Of Lopinavir: Binding, Uptake And Efflux, Abhishek Gulati

Theses and Dissertations

HIV protease inhibitors are an important component of Highly Active Antiretroviral Therapy used to treat HIV infected pregnant women. They have a low placental transfer and are highly plasma protein bound. The purpose of this thesis was to characterize the factors limiting placental passage and fetal exposure to lopinavir. These factors include lopinavir plasma protein binding and uptake, cellular binding, and efflux of lopinavir in the placental trophoblast cells. First, we determined the unbound fraction of lopinavir in cord blood and characterized the binding of lopinavir to α1-acid glycoprotein (AAG) and human serum albumin (HSA), and displacement by ritonavir. Serum …

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Roles Of Krüppel Like Factors Klf1, Klf2, And Klf4 In Embryonic Beta-Globin Gene Expression, Yousef Alhashem Jun 2009

Roles Of Krüppel Like Factors Klf1, Klf2, And Klf4 In Embryonic Beta-Globin Gene Expression, Yousef Alhashem

Theses and Dissertations

Krüppel like factors (KLFs) are a family of 17 proteins whose main function is gene regulation by binding to DNA elements in the promoters of various genes. KLF transcription factors recognize CACCC-elements and act as activators or repressors of the gene expression. Among the 17 family members, KLF1, KLF2, and KLF4 share high homology to each other. KLF1 is the founding member of the family and is an erythroid-specific protein. KLF2 is expressed in erythroid, endothelial, and other cells. KLF4 is expressed in endothelial, smooth muscle, and other cells. In this thesis, the functions of these KLFs were reviewed in …

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Investigating The Role Of Electric Fields In Directing Schwann Cell Behavior, Nishant Magar Jun 2009

Investigating The Role Of Electric Fields In Directing Schwann Cell Behavior, Nishant Magar

Theses and Dissertations

This study examines the potential of Schwann cells (SCs) to be manipulated by electric fields (EFs) in order to improve recovery from spinal cord injury (SCI). It had long been believed that the central nervous system (CNS) is incapable of regeneration, but recent studies have proven otherwise. SC transplants are known to be useful in promoting axon regeneration after SCI, but is not sufficient for functional recovery. EFs are known to exist in vivo, and have been known to drastically affect the morphology and behavior of cells in various tissues. It was the hypothesis of this study that the conditioning …

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Father-Daughter Attachment And Sexual Behavior In African-American Daughters, Karen Hill-Holliday May 2009

Father-Daughter Attachment And Sexual Behavior In African-American Daughters, Karen Hill-Holliday

Theses and Dissertations

Although a relationship has been found in some studies between paternal attachment and female sexual behavior, knowledge of this relationship in African Americans has been limited. The purpose of this research was to determine if there was a relationship between father-daughter attachment, parent teen sexual risk communication and early sexual activity, condom use, history of sexually transmitted infection, global/sexual self-esteem and teen pregnancy in African-American females. An anonymous consent and survey was administered online to N=113 African American college women (age 18-21) attending a southeastern university. Measurements included the Parent Attachment Questionnaire (Father), Rosenberg’s Self-Esteem, Sexual Self-Esteem Inventory (short scale), …

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[2009-05-15] May 15, 2009 Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors May 2009

[2009-05-15] May 15, 2009 Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors

VCU Board of Visitors Minutes

Official minutes of the VCU Board of Visitors and its Executive Committee.

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[2009-05-15] Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors May 2009

[2009-05-15] Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors

VCU Board of Visitors Minutes

Official minutes of the VCU Board of Visitors and its Executive Committee.

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Video Scene Detection Using Closed Caption Text, Gregory Smith May 2009

Video Scene Detection Using Closed Caption Text, Gregory Smith

Theses and Dissertations

Issues in Automatic Video Biography Editing are similar to those in Video Scene Detection and Topic Detection and Tracking (TDT). The techniques of Video Scene Detection and TDT can be applied to interviews to reduce the time necessary to edit a video biography. The system has attacked the problems of extraction of video text, story segmentation, and correlation. This thesis project was divided into three parts: extraction, scene detection, and correlation. The project successfully detected scene breaks in series television episodes and displayed scenes that had similar content.

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Creative Insubordination, John Henry Blatter May 2009

Creative Insubordination, John Henry Blatter

Theses and Dissertations

In today’s lexicon a ‘Daily Constitutional’ usually refers to a daily walk. But in actuality, a ‘Daily Constitutional’ is something that one does on a daily basis that is beneficial to one’s constitution or healthful(1); and one’s constitution being the aggregate of a person’s physical and psychological characteristics(2). With this definition, the daily constitutional refers to any daily activity that improves a person’s physical or mental health. At various stages in my life I may have understood my constitutional to be any number of things and it was not until I came into my own did I truly discover my …

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The Certainty Of Uncertainty, Julie Nagle May 2009

The Certainty Of Uncertainty, Julie Nagle

Theses and Dissertations

In this paper I investigate the limitations of memory, physical and psychological effects on individuals’ perception that effect memory, and the impact of those limitations on our ability to recall objective truth. The paper is introduced with an explanation of my interest in the subjective narrative voice in historical accounts and questions the possibility of a completely objective voice. In the first chapter, a fantastical biographical story of the life of Tycho Brahe is used as an example of the difficulty in parsing truth from legend. Descriptions of changes in scientific methods exemplify the uncertainty of scientific fact. I propose …

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Heritage Braided, Akiko B. Jackson May 2009

Heritage Braided, Akiko B. Jackson

Theses and Dissertations

The awareness of marginality, oppression, and hierarchy at an early age directly influences the creation of work specific to my identity as a woman of color. Born and raised on an island in the Pacific Ocean, I was aware of my sense of location and space relative to the world. The vast ocean separating me from the ‘mainland’ created a specific understanding of marginality, of what is “main” and what is “minor,” and how these categorical placements continued from my youth to ongoing perpetuation. The work I create has a subtle and persistent investigation into my identity as a socio-economic …

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Collapse, Mia Feuer May 2009

Collapse, Mia Feuer

Theses and Dissertations

Through large sculptural works that are often caricatures of representational objects, my work explores the complicated moments and tangled histories of childhood Jewish schooling in Winnipeg and travels to Israel and Palestine as an adult. My thesis exhibition Collapse, as well as most of my graduate work, examines my investigation through manmade constructions that control and restrict or unite and connect the movement of others. Sculptures about a destroyed bridge’s imagined longing for exotic places, a giant onion serving as a resuscitation mechanism against tear gas or a construction crane to Armageddon are some examples of work that explore the …

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On A Saturday, Thoughts And Revelations, Maria Pithara May 2009

On A Saturday, Thoughts And Revelations, Maria Pithara

Theses and Dissertations

A favorite poet, a strange woman on the beach, pictures I love to look at. Back yard voyeurism, some thoughts on portraiture and why I couldn’t be a photographer. Strange rituals that make sense. Unexpected revelations. Two kinds of light. This essay presents part of the constellation of thoughts, images and ideas that have informed my most recent video installation, Saturday.

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Nature Calls, Angela White May 2009

Nature Calls, Angela White

Theses and Dissertations

I am wandering wonderingly through the unplanned material atmosphere shaped by differences in temperature and moisture. The chaotic nature of weather phenomena is the catalyst for visual exploration of the subterranean catacombs of reality. The work is metaphor of nature and its creation of form and substance. Observing art and nature: I am allowing nature to be the instigator of art.

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On The Beginning Of Contemporary Tibetan Art: The Exhibitions, Dealers, And Artists., Martha Allison May 2009

On The Beginning Of Contemporary Tibetan Art: The Exhibitions, Dealers, And Artists., Martha Allison

Theses and Dissertations

Contemporary Tibetan art has been internationally exhibited since the year 2000, and it continues to receive increasing recognition among international galleries and collectors. This thesis focuses on three major contributing factors that have affected the rising success of the contemporary Tibetan artists. The factors include ways in which popular stereotypes have influenced Western museum exhibitions of Tibetan art; dealers have marketed the artworks; and artists have created works that are both conceptually and aesthetically appealing to an international audience. Drawing from exhibition catalogs, interviews and art historical scholarship, this thesis looks at how the history of these factors has affected …

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In Pursuit Of Harmony: Calligraphy & Typography, Feifei Fan May 2009

In Pursuit Of Harmony: Calligraphy & Typography, Feifei Fan

Theses and Dissertations

Chinese calligraphy and Western typography have been evolving for around five thousands years. During this time, they have developed quite different characteristics. Compared with the geometrical form and precision of Western printing types, Chinese calligraphy features abstract shapes and spontaneous strokes. These differences result in a gap that prevents a harmonious and organic relationship between them. This project explores the possibilities of combining these two historical visual systems, demonstrates specific methods and approaches for creating compelling formal relationships, and endeavors to establish a friendly, organic and harmonious dialogue between Chinese calligraphy and Western typography. The outcome of this project is …

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Understanding Death Anxiety In Women With Gynecologic Cancer, Hana Kim May 2009

Understanding Death Anxiety In Women With Gynecologic Cancer, Hana Kim

Theses and Dissertations

For most of us, thoughts about our own mortality are largely unconscious, an invisible backdrop to our daily living. However, when forced to face a potentially life threatening event, these otherwise underlying thoughts about human transience rise to consciousness. Given the seemingly inherent link between receiving a cancer diagnosis and developing an increased awareness of one’s own mortality, the present study sought to address the following research question, “What are the experiences and processes by which women with gynecologic cancer construct meaning and manage death anxiety in the face of their cancer diagnosis?” Based on an interpretive grounded theory paradigm, …

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