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Inhibition Of The Calcium Plateau Following In Vitro Status Epilepticus Prevents The Development Of Spontaneous Recurrent Epileptiform Discharges, Nisha Nagarkatti Sep 2009

Inhibition Of The Calcium Plateau Following In Vitro Status Epilepticus Prevents The Development Of Spontaneous Recurrent Epileptiform Discharges, Nisha Nagarkatti

Theses and Dissertations

Status epilepticus (SE) is a major clinical emergency resulting in continuous seizure activity that can cause brain injury and many molecular and pathophysiologic changes leading to neuronal plasticity. The neuronal plasticity following SE-induced brain injury can initiate epileptogenesis and lead to the ultimate expression of acquired epilepsy (AE), characterized clinically by spontaneous, recurrent seizures. Epileptogenesis is the process wherein healthy brain tissue is transformed into hyperexcitable neuronal networks that produce AE. Understanding these alterations induced by brain injury is an important clinical challenge and can lend insight into possible new therapeutic targets to halt the development of AE. Currently there …


Commonwealth Times 2009-09-17 Sep 2009

Commonwealth Times 2009-09-17

Commonwealth Times, 1969-

No abstract provided.


Therapeutic Strategies Aimed To Facilitate Axonal Regeneration And Functional Recovery Following Traumatic Spinal Cord Injury, Woon Chow Sep 2009

Therapeutic Strategies Aimed To Facilitate Axonal Regeneration And Functional Recovery Following Traumatic Spinal Cord Injury, Woon Chow

Theses and Dissertations

Traumatic spinal cord injury (SCI) is a physically debilitating, emotionally devastating, financially costly, and life-changing condition that afflicts more than 1,000,000 people in the United States alone. Owing to the characteristic neuropathology and low regenerative capacity of the central nervous system, many victims of SCI are left permanently paralyzed. Though the tissue damage caused by the initial insult almost certainly cannot be reversed, intensive research in recent years to elucidate the cellular and molecular events that follows has provided new grounds for optimism. Accordingly, in this dissertation, we present a number of potential treatment strategies aimed to address some of …


Commonwealth Times 2009-09-14 Sep 2009

Commonwealth Times 2009-09-14

Commonwealth Times, 1969-

No abstract provided.


Commonwealth Times 2009-09-10 Sep 2009

Commonwealth Times 2009-09-10

Commonwealth Times, 1969-

No abstract provided.


Commonwealth Times 2009-09-03 Sep 2009

Commonwealth Times 2009-09-03

Commonwealth Times, 1969-

No abstract provided.


Shafer Court Connections (2009-09) Sep 2009

Shafer Court Connections (2009-09)

Shafer Court Connections, 1994-2010

For alumni of the Academic Campus of Virginia Commonwealth University.


Ink (2009-09) Sep 2009

Ink (2009-09)

Ink, 2008-

The student-run features magazine covering the fashion, art, music and culture worlds at VCU and in Richmond. Published annually in print and updated regularly online.


Commonwealth Times 2009-08-31 Aug 2009

Commonwealth Times 2009-08-31

Commonwealth Times, 1969-

No abstract provided.


Commonwealth Times 2009-08-27 Aug 2009

Commonwealth Times 2009-08-27

Commonwealth Times, 1969-

No abstract provided.


The Role Of Porphyromonas Gingivalis Lysine Specific Protease, Kgp In Hemin Transport And Pigment Accumulation, Anuj Phull Aug 2009

The Role Of Porphyromonas Gingivalis Lysine Specific Protease, Kgp In Hemin Transport And Pigment Accumulation, Anuj Phull

Theses and Dissertations

Porphyromonas gingivalis, a gram-negative anaerobic bacterium, is implicated as a major etiological agent in the initiation and progression of severe forms of periodontal disease. It has been reported that gingivitis and periodontal disease affect roughly 50.3% and 35% of the adult population, respectively. Therefore, approximately over 85% of the adult population may suffer from some form of gingival disease. Porphyromonas gingivalis, an established periodontopathogen, requires hemin for growth. Although multiple hemin uptake systems appear to be present in this organism, their specific role in hemin uptake and virulence remains unknown. Pigmentation is thought to result from the accumulation of iron …


Commonwealth Times 2009-08-24 Aug 2009

Commonwealth Times 2009-08-24

Commonwealth Times, 1969-

No abstract provided.


Commonwealth Times 2009-08-20 Aug 2009

Commonwealth Times 2009-08-20

Commonwealth Times, 1969-

No abstract provided.


A Sense Of Place: A Personal Exploration, Analysis And Re-Interpretation Of Diverse Places, Hyejin Park Aug 2009

A Sense Of Place: A Personal Exploration, Analysis And Re-Interpretation Of Diverse Places, Hyejin Park

Theses and Dissertations

Every city/place has unique, distinctive qualities. Individuals acquire a sense of place in accordance with their own experiences and perspectives, which may not be the same as the experiences and viewpoints of another person. In this project, I explore, analyze, and re-interpret three places that have creatively and emotionally influenced me and remained in my memory: Times Square, New York City; Insadong, Seoul, South Korea; and Broad Street, Richmond, Virginia. To comprehend and draw a sense of place, I observe, feel, and document the characteristics of each place through different methods and processes, based on my own experiences. In addition, …


[2009-08-12] August 12, 2009 Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors Aug 2009

[2009-08-12] August 12, 2009 Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors

VCU Board of Visitors Minutes

Official minutes of the VCU Board of Visitors and its Executive Committee.


[2009-08-12] Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors Aug 2009

[2009-08-12] Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors

VCU Board of Visitors Minutes

Official minutes of the VCU Board of Visitors and its Executive Committee.


[2009-08-12] Meeting Of The External Relations Committee, Virginia Commonwealth University. Board Of Visitors Aug 2009

[2009-08-12] Meeting Of The External Relations Committee, Virginia Commonwealth University. Board Of Visitors

VCU Board of Visitors Minutes

Official minutes of the VCU Board of Visitors and its Executive Committee.


Mobile Exhibition System, Sanford Jillian Columbus Aug 2009

Mobile Exhibition System, Sanford Jillian Columbus

Theses and Dissertations

Through the development and design of a Mobile Exhibition System (MES) in this thesis, I will demonstrate the benefits and possibilities of a flexible and mobile system within an exhibition environment. A flexible system will be able to adapt to a wide range of content, while at the same time, maintaining a synergy between its form and function. By the reuse and reappropriation of shipping containers as the exhibition envelope, the goal of mobility can be achieved, reaching out to those who might not otherwise experience learning through an exhibition environment.


Contexture, Kimberly Winters Aug 2009

Contexture, Kimberly Winters

Theses and Dissertations

As I work with mixed media and computer technology, I am reminded at how evolved our lives and society have become in spite of how incredibly primal our individual needs remain. I began addressing those needs with drawing and painting; now, I find myself flung into a digital world of hard drives and pixels. Working with electronic imagery satisfies my immediate need to explore many options simultaneously but at the same time there is a detachment, a distance if you will, between me and my work. Developing a tactile-rich surface for a digital image by applying paint, wax, and surface …


Reflection-Refraction, Heather Beaman Aug 2009

Reflection-Refraction, Heather Beaman

Theses and Dissertations

I find my inspiration by looking at the world around me. I take snapshots, compose photographs, and collect physical objects from my surroundings. I interpret these materials by layering printmaking, mixed media, and alternative photographic processes. I use the simplification of the human form when developing the composition. As my work takes shape, I present a universal person placed in a situational narrative. Layering the human figure with my travels and experiences creates a pause or an intimate moment that the viewer shares with the art work.


Design By Accident, Mengfu Zhang Aug 2009

Design By Accident, Mengfu Zhang

Theses and Dissertations

Accident is a metaphor for life. From an arbitrary point in time, we potentially preview the entirety of existence. There is a Chinese idiom called “ blessing or bane,” which implies that a misfortune may perhaps soon turn into a blessing. Focusing on accident as a design method implies making the best out of a bad situation. An accident reveals invisible circumstances and potentialities in the world, both familiar and unfamiliar. Looking into the unpredictable world, I can begin to release my control, take a breath, and see what might happen if I do not fight the situation. I am …


Optical Transmissions, Eric May Aug 2009

Optical Transmissions, Eric May

Theses and Dissertations

Artist Statement My art is deeply rooted in graphic design. Along the way I have experimented in block printing, screen printing, and painting. I use highly saturated colors and patterns to create optical illusions. One major influence on my work is the Op Art movement from the 1960s. From Op Art I take the ideas of how color and shape can work together to create visual effects. Music is another influence on my work. I try to create rhythms and the illusion of pulsating beats, visually. I want there to be a sensation of movement within the work where some …


Adenosine Dimethyltransferase Ksga: Biochemical Characterization Of The Protein And Its Interaction With The 30s Subunit, Pooja Desai Aug 2009

Adenosine Dimethyltransferase Ksga: Biochemical Characterization Of The Protein And Its Interaction With The 30s Subunit, Pooja Desai

Theses and Dissertations

Ribosomes form the core of the protein biosynthesis machinery and are essential to life. Ribosome biogenesis is a complex cellular process involving transcription of rRNA, pre-rRNA processing, rRNA modification and simultaneous assembly of ribosomal proteins. RNA nucleotide modification is observed in all domains of life. While there is enormous conservation of ribosome structure, very few post-transcriptional rRNA modifications have been conserved throughout evolution. A notable example of such rare conservation is the dimethylation of two adjacent adenosines in the 3’-terminal helix, a highly conserved region of the small subunit rRNA. Enzymes that carry out these dimethylations are equally conserved and …


Mutagenesis And Spectroscopic Studies Of Mycobacterium Tuberculosis Sterol 14alpha Demethylase., Anuja R. Modi Aug 2009

Mutagenesis And Spectroscopic Studies Of Mycobacterium Tuberculosis Sterol 14alpha Demethylase., Anuja R. Modi

Theses and Dissertations

P450s are heme containing enzymes which affect oxidation of substrates via catalytic intermediates having transient lifetimes. These oxidative catalytic intermediates are formed by a sequential interplay of electrons and protons at the active site of the enzyme bearing molecular dioxygen. The proton transfer to the active site from bulk solvent is coordinated by an “acid-alcohol” pair of active site residues which are conserved in all P450s. Sterol 14α-demethylases (CYP51) are P450 enzymes which catalyze oxidative deformylation of lanosterol in the cholesterol/ergosterol biosynthetic pathway. Both cholesterol and ergosterol are important regulators of membrane fluidity. CYP51 differs from other P450s in that …


Effects Of Biofilm Age And Composition On Oyster Larval Setting, Alaina Hart Jul 2009

Effects Of Biofilm Age And Composition On Oyster Larval Setting, Alaina Hart

Theses and Dissertations

The lack of success in restoring oyster, Crassostrea virginica, populations to Chesapeake Bay and its tributaries has raised many questions about why many restoration efforts have failed. A number of studies have focused on the larval stage of oysters and considered the variables that impact oyster setting behavior in an effort to understand why oyster populations have not recovered. Studies that have examined setting surfaces suggest that biofilms promote oyster larval settlement; however, similar studies with barnacle larvae have found an inhibitory relationship. The present study utilized field-produced biofilms of different ages to determine if natural biofilms inhibit or promote …


Directing Autobiographical Theatre, Shanea Taylor Jul 2009

Directing Autobiographical Theatre, Shanea Taylor

Theses and Dissertations

This is an exploration of the director's role in autobiographical theatre. The director is in a unique position when storytelling on a personal level is being executed theatrically. I explored this topic over the course of directing three plays, each of which contained a strong personal storytelling element, which broadened my perspective of the director's role. The three plays were Slashtipher Coleman’s The Neon Man and Me, Birth by Karen Brody, and Will Power to Youth Richmond presents: William Shakespeare’s Romeo and Juliet. Traditionally, the director’s role includes a myriad of tasks. These tasks can include and are not limited …


Patterns Of Differential Involvement In Terrorist Activities: Evidence From Dhkp/C And Turkish Hezbollah, Ismail Yilmaz Jul 2009

Patterns Of Differential Involvement In Terrorist Activities: Evidence From Dhkp/C And Turkish Hezbollah, Ismail Yilmaz

Theses and Dissertations

This study examines the patterns of involvement in terrorist activities for the Revolutionary People’s Liberation Party/Front (DHKP/C) and Turkish Hezbollah members. The study is based on the assumption that terrorists differ in terms of their involvement in terrorist activities. In this sense, there are full-time and part-time terrorists. Full-time terrorists act professionally and do the assignments given by their commanders. Part-time terrorists, on the other hand, act on a non-professional basis and have their own motivations to participate in terrorist activities. For part-timers, there are various factors that may have an effect on their degree of involvement in terrorist activities. …


Crafting Authenticity, Allison N. Schumacher Jul 2009

Crafting Authenticity, Allison N. Schumacher

Theses and Dissertations

Authenticity is what we want from the world around us, from others, and crucially from ourselves and what we make. As it relates to graphic design, I define authenticity as a perceived match between form and purpose. For the designer, its quality is found in the process of simultaneously developing a concept and crafting the design/object.


The Potential Role For Capb In Pathogenesis Of Francisella Tularensis, Eric Fleming Jul 2009

The Potential Role For Capb In Pathogenesis Of Francisella Tularensis, Eric Fleming

Theses and Dissertations

Francisella tularensis was a facultative intracellular pathogen and a gram-negative coccobacillus which has been categorized by the CDC as a potential class A select agent due to its highly infectious properties and high mortality rates. Francisella tularensis was also responsible for the zoonotic disease tularemia, which was usually transmitted by arthropod vectors or via contact with infected animals. Francisella tularensis subspecies novicida has been used by many researchers in genetic pathogenesis experiments to try to elucidate genes responsible for virulence factors. One of these virulence factors was a capsular material which has been thought to be involved in either increasing …


Predictors Of Smoking Initiation In African American Adolescents, Jennifer Kienzle Jul 2009

Predictors Of Smoking Initiation In African American Adolescents, Jennifer Kienzle

Theses and Dissertations

Cigarette smoking and other forms of tobacco use are responsible for over 440,000 deaths per year in the U.S. Health consequences associated with cigarette smoking include cardiovascular disease, respiratory disease, and cancer. Despite awareness of the health risks, approximately 21% of the U.S. adult population smokes. Efforts to-date to reduce smoking-related disease and illness have focused on prevention and intervention strategies that encourage cessation. Adolescence is a critical period for both intervention and prevention. Because more than three-fourths (80%) of adult smokers reported starting to smoke prior to the age of 18, prevention and brief intervention is likely to be …