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Voice On The Skin, Sarah Turner
Voice On The Skin, Sarah Turner
Theses and Dissertations
“The body can write on the skin from the inside—the soul, the mind, and the passions rise to the surface in boils, blushes, and rashes, and the invisible inside speaks by writing from the other side of the page”. -James Elkins Skin not only covers but reveals what is behind it. I utilize its language as indicator of flaws and pathologies. I depict and manipulate this, not just as it already exists with the human body, but as projections of my psychological states onto inanimate objects. Proposing that sight is a kind of touch, we touch with our minds, through …
Insulin-Like Growth Factor Binding Protein-3 (Igfbp-3) Plays An Essential Role In Cellular Senescence: Molecular And Clinical Implications., Amanda Garza
Theses and Dissertations
Normal somatic cells have a limited proliferative capacity in vivo and in vitro, termed senescence and later, thought to contribute to molecular and cellular organismal aging. There are several studies that demonstrate the importance of the GH/IGF axis in longevity, aging and cellular senescence. One primary component of the IGF signaling involves IGFBP-3. It is well documented that IGFBP-3 levels are significantly increased in senescent human diploid fibroblasts however IGFBP-3 function is not known in this system. Interestingly, Werner syndrome fibroblasts, commonly used as a model of cellular aging, have upregulated IGFBP-3 levels in young and late passage cells compared …
Expression & Purification Of Recombinant Plasmodium Falciparum Erythrocyte-Binding Ligands, Seward Joann Cofie
Expression & Purification Of Recombinant Plasmodium Falciparum Erythrocyte-Binding Ligands, Seward Joann Cofie
Theses and Dissertations
Plasmodium falciparum, the most virulent malarial parasite, is capable of invading all known human blood types. Erythrocyte invasion depends on specific parasite ligand and erythrocyte receptor interactions. These interactions are mediated by Region II of the P. falciparum erythrocyte binding ligands. Although invasion does not seem dependent upon a singular ligand, their individual contributions to the invasion process are yet to be explained. In this study, Region II of P. falciparum binding ligands BAEBL and JESEBL were transiently expressed as hexahistidyl recombinant proteins in COS-1 cells. Purification by column chromatography yielded 0.52 mg of BAEBL and 0.433 mg of JESEBL. …
Listening To Their Voices: Gang Members’ Perceptions Of Their Schooling And Their Teachers, Martha Wall-Whitfield
Listening To Their Voices: Gang Members’ Perceptions Of Their Schooling And Their Teachers, Martha Wall-Whitfield
Theses and Dissertations
Although gangs have long been present, gangs exert an increasingly significant influence on the culture of students who attend schools, especially in urban environments. This case study investigation involved a purposeful sampling of four young men who were involved in gangs. By spending time with each young man in several interviews, I was able to gain insight into his perceptions of schooling, his teachers, and his view on caring in schools. The individual interviews focused on each student’s experiences in schooling through the lens of care. This research took in-depth look at these four gang members in their individual schooling …
Exploring The Mechanism Of Alginate Acetylation In Pseudomonas Aeruginosa, Janice Paletta
Exploring The Mechanism Of Alginate Acetylation In Pseudomonas Aeruginosa, Janice Paletta
Theses and Dissertations
The opportunistic pathogen P. aeruginosa is the leading cause of morbidity and mortality in cystic fibrosis patients. During chronic infection of the cystic fibrosis lung, P. aeruginosa undergoes conversion to a mucoid phenotype, constitutively producing the exopolysaccharide alginate, composed of the uronic acids D-mannuronate and L-guluronate. This alginate production contributes significantly to virulence in the cystic fibrosis lung. Evidence suggests that the acetylation state of the mannuronate component of the alginate influences the ability of components of the immune system to phagocytose the organism. To garner new and relevant information regarding the mechanism of alginate acetylation in Pseudomonas aeruginosa, a …
Rose Herbert Community Center, Jeannie Jones
Rose Herbert Community Center, Jeannie Jones
Theses and Dissertations
The “Rose Herbert Community Center” is the culmination of a project questioning how a building can be restored to its original integrity when its initial function has become extinct. This thesis considers the Broad Street Station in Richmond, Virginia and explores the options and implications of returning the building to a hub of interaction within the community. Concepts such as functionally malleable spaces, the transition from a very public environment to a more private area, and the creation of intentional interaction versus coexistence are explored.
Job And Personal Resources And Demands: The Effects On Job Satisfaction And Job Search Behavior Of Certified Nursing Assistants (Cnas) Working In Nursing Homes, Natsuko Ryosho
Theses and Dissertations
The purpose of the current study was to examine how job resources, job demands, personal resource, personal demands, and demographic characteristics predict job satisfaction and job search behavior of certified nursing assistants (CNAs) working in nursing homes. The study used data from the 2004 National Nursing Assistant Survey (NNAS). The job demands-resources (JD-R) model (Demerouti, Bakker, Nachreiner, & Schaufeli, 2001) provided the basis for the conceptual framework of the study. First, a series of multinomial logistic regression analyses were performed to determine how the five categories of predictor variables predicted the levels of job satisfaction among CNAs. Next, a series …
The Audsleys, The Blackies And The Practical Decorator And Ornamentist, Gay Acompañado
The Audsleys, The Blackies And The Practical Decorator And Ornamentist, Gay Acompañado
Theses and Dissertations
The Practical Decorator and Ornamentist (Glasgow, 1892), one of the jewels in James Branch Cabell Library, embodies the work of the distinguished British designers George Ashdown Audsley and Maurice A. Audsley; the eminent Scottish publishing firm of Blackie & Son; and the illustrious French printing house of Didot. The thesis argues that the Decorator is one of the great nineteenth-century design books. Chapter one focuses on G. A. Audsley’s five masterworks and illustrates the contributions of a distinguished family of architects. There has not been a study of the Audsleys in ten years, and the present study goes further than …
Movement Without Motion: The Rhetoric Of Conservative Counter-Claims To Global Warming Theory, William Edwards
Movement Without Motion: The Rhetoric Of Conservative Counter-Claims To Global Warming Theory, William Edwards
Theses and Dissertations
Many U.S. conservatives view government mandates to reduce emissions of greenhouse gases as a threat to the economy of the developed world. Conservative think tanks have adopted a common rhetoric to instill doubt about proposed mandates in the minds of elected officials, the media, and the public. Using a survey of the websites of 14 conservative think tanks, this thesis analyzes counter-claims to global warming theory to identify rhetorical artifacts that typically characterize conservative responses to issues, and to show how rhetorical theory can help anticipate the nature of such responses. The research identifies unifying speech codes – such as …
Characterization Of Adherence, Cytotoxicity And Biofilm Formation By Gardnerella Vaginalis, Jennifer Patterson
Characterization Of Adherence, Cytotoxicity And Biofilm Formation By Gardnerella Vaginalis, Jennifer Patterson
Theses and Dissertations
Worldwide, bacterial vaginosis (BV) is the most common vaginal disorder in women of childbearing age. BV is of major clinical importance due to its ability to significantly affect pregnancy outcome and enhance the transmission and acquisition of HIV. BV is characterized by a dramatic shift in the vaginal microflora; in most BV cases, the predominant bacterial species is Gardnerella vaginalis. It has been demonstrated that G. vaginalis forms an adherent biofilm on the vaginal epithelium of women with BV. Furthemore, evidence suggests that the high rate of recurrence associated with BV is related to incomplete eradication of the biofilm. The …
The Effect Of Power On Exploratory Behavior, William Clay
The Effect Of Power On Exploratory Behavior, William Clay
Theses and Dissertations
The relations between power, exploratory behavior, and willingness to take risks were investigated. It was hypothesized that high power would be associated with increases in exploratory behavior, and that this relationship would be mediated by participants’ willingness to take risks. In Study One, one-hundred forty-one undergraduates (66% female) completed questionnaires to assess trait power and willingness to take risk, as well as a computer-based research paradigm, BeanFest, to assess exploration. Willingness to take risks correlated positively with exploration. However, the predicted relations involving power were not observed. In Study Two, power was experimentally manipulated. One-hundred thirty-three undergraduates (61% female) were …
Characterization Of The Staphylococcus Aureus Immunodominant Surface Antigen B, Isab, Nicole Lawrence
Characterization Of The Staphylococcus Aureus Immunodominant Surface Antigen B, Isab, Nicole Lawrence
Theses and Dissertations
Staphylococcus aureus is a significant cause of morbidity and mortality world-wide. This opportunistic pathogen is capable of causing several severe diseases that are exacerbated by its diverse and widespread antibiotic resistance profile. Therefore it is necessary to identify novel therapeutic targets to effectively treat S. aureus disease. Lorenz et al first described the Immunodominant Surface Antigen B, IsaB, because it was 1 of 4 unique proteins immunogenic during septicemia and not colonization, suggesting that IsaB may be a virulence factor and a possible novel therapeutic target. Interestingly, IsaB has no homology to proteins of known function and appears to be …
Genetic Variations Of Cyp2b6 Enzyme And The Response To Meperidine In Oral Sedation, Heath Whitfield
Genetic Variations Of Cyp2b6 Enzyme And The Response To Meperidine In Oral Sedation, Heath Whitfield
Theses and Dissertations
Purpose: The purpose of this study was to determine the relationship of the CYP2B6 genotype to the clinical response to meperidine in pediatric dental patients. Methods: Forty-nine patients, ASA I/ II, 41–101 months old, received an oral sedative regimen containing meperidine for dental treatment. The North Carolina Behavior Rating Scale (NCBRS) and Overall Effectiveness of Sedation Scale (OESS) were used to assess their behavior and sedation outcome. Saliva DNA samples were genotyped by PCR-RFLP. Results: We found the following genotype distributions: homozygous wild-type 1*1 (n = 19, 39%), heterozygous 1*6 (n = 25, 51%), and homozygous variant 6*6 (n = …
Differential Roles Of The Two Major Endocannabinoid Hydrolyzing Enzymes In Cannabinoid Receptor Tolerance And Somatic Withdrawal, Joel Schlosburg
Differential Roles Of The Two Major Endocannabinoid Hydrolyzing Enzymes In Cannabinoid Receptor Tolerance And Somatic Withdrawal, Joel Schlosburg
Theses and Dissertations
While there is currently active debate over possible therapeutic applications of marijuana and cannabis-based compounds, consistently their primary drawbacks have been the psychoactive properties, dependence, and abuse potential. Prolonged administration of ∆9-tetrahydrocannabinol (THC), the primary psychoactive constituent in marijuana, demonstrates both tolerance and physical withdrawal in both preclinical and clinical studies. Repeated THC administration also produces CB1 receptor adaptations in the form of reduced activation of receptors, along with a downregulation of membrane surface receptors, in many brain regions involved in THC-associated behaviors. The increased need for drug to maintain therapeutic effects, and a withdrawal syndrome following discontinuation of use, …
An Exploration Of The Influences Of Race, Class And Gender Identity On The Help-Seeking Behavior Of Lgbtq Survivors Of Violence, Xavier Guadalupe
An Exploration Of The Influences Of Race, Class And Gender Identity On The Help-Seeking Behavior Of Lgbtq Survivors Of Violence, Xavier Guadalupe
Theses and Dissertations
Without a doubt, violence continues to be a brutal reality in our society. It reaches and affects millions across our nation and around the world. For centuries, scholars, researchers and academics have studied and analyzed the existence of violence in many capacities. While violence affects every individual, group, and community the dynamics and the realties that are carried out vary tremendously across race, income levels, gender, gender identity and expression, sexual orientation and national origin to name a few. The existence, impact and repercussions of violence in different communities carry varying meanings, perceptions and significance. This paper explores the influences …
Small Molecule Inhibitors Of Mapk And Pi3k Pathways Enhance Mda-7 Lethality In Renal Cell Carcinoma, Patrick Eulitt
Small Molecule Inhibitors Of Mapk And Pi3k Pathways Enhance Mda-7 Lethality In Renal Cell Carcinoma, Patrick Eulitt
Theses and Dissertations
Renal cell carcinoma accounted for an estimated 57,760 new cases and estimated 12,980 deaths in the United States in 2009. Current treatment options for systemic renal cell carcinoma yield markedly low response percentages; however, recent cytokine therapy experiments have produced promising results. A novel adenovirus, Ad.5/3-mda-7, has been synthesized to efficiently infect renal cancer cells with the mda-7 gene. This gene encodes for the cytokine MDA-7/IL-24 that has the ability to specifically target transformed cells. Assays performed with this adenovirus resulted in an increased percentage of cell death in renal cancer cells when compared to infection with Ad.5/3-cmv empty vector. …
Lilian Westcott Hale And Nancy Hale: From Victorian To Modern In Art And Text, Norah Hardin Lind
Lilian Westcott Hale And Nancy Hale: From Victorian To Modern In Art And Text, Norah Hardin Lind
Theses and Dissertations
Lilian Westcott Hale (1880-1963) and her daughter Nancy Hale (1908-1988) built successful careers during a period of transition in America, as Victorian mores were replaced by new modern freedoms. Greater independence for women had evolved during the preceding century, before the influential cultural factors which occurred during the early twentieth century like urbanization and world war. This interdisciplinary analysis of Lilian Hale‘s artwork and Nancy Hale‘s writings demonstrates the imprint of the surrounding world on their work. Lilian Hale‘s art is influenced by her Victorian childhood, and Nancy Hale‘s fiction reveals many conflicts of the modern era. The study of …
Commonwealth Times 2010-04-19 [Front Page Has 2010-04-15]
Commonwealth Times 2010-04-19 [Front Page Has 2010-04-15]
Commonwealth Times, 1969-
No abstract provided.
Museums In The Classroom: Preservation Virginia’S John Marshall House Trunk, Denisse Marie De Leon
Museums In The Classroom: Preservation Virginia’S John Marshall House Trunk, Denisse Marie De Leon
Theses and Dissertations
Since the No Child Left Behind Act (NCLB) was passed in 2001, museum educators have faced new challenges in designing programming that incorporates state standards of education while remaining faithful to the integrity of the museum’s collection and mission. Some museums have created programs that address these educational standards and can be used in school classrooms. This project is a case study of how one Virginia museum, Preservation Virginia, created a classroom program that addresses the state mandated Standards of Learning (SOLs). The report of this project includes discussion of the current debates that surround NCLB and its relationship to …
Proteasome-Dependent Entry Of Herpes Simplex Virus, Mark Delboy
Proteasome-Dependent Entry Of Herpes Simplex Virus, Mark Delboy
Theses and Dissertations
Herpes simplex virus entry into cells is a multistep process that engages the host cell machinery. The proteasome is a large, ATP-dependent, multisubunit protease that plays a critical role in the maintenance of cell homeostasis. A battery of assays were used to demonstrate that proteasome inhibitors blocked an early step in herpes simplex virus entry that occurred after capsid penetration into the cytosol but prior to capsid arrival at the nuclear periphery. Proteasome-dependent viral entry was not reliant on host or viral protein synthesis. MG132, a peptide aldehyde that competitively inhibits the degradative activity of the proteasome, had a reversible …
From The Old To The New World: The Transformation Of Kongo Minkisi In African American Art, Mary Mccurnin
From The Old To The New World: The Transformation Of Kongo Minkisi In African American Art, Mary Mccurnin
Theses and Dissertations
Minkisi (sing. nkisi) were sacred objects that housed ancestral spirits and were used for divination, healing and social justice by the Kongo people of Central Africa. When the Kongo were brought as slaves to the New World, they contributed significantly to the development of African American artistic and spiritual culture. In the Caribbean, aspects of minkisi have been retained in the creolized spiritual beliefs of Haitian Vodou, Cuban Palo Monte Mayombe and Brazilian Candomble. In North America, evidence of Kongo influence is apparent in examples of folk art and culture, including quilts, mojo hands, Afro-Carolinian face vessels, memory jugs and …
Afro-German Biracial Identity Development, Rebecca R. Hubbard
Afro-German Biracial Identity Development, Rebecca R. Hubbard
Theses and Dissertations
An increase in the biracial population has heightened our awareness of unique issues that pervade the experience of these individuals. The importance of environmental influences on biracial identity development has been established, but investigations concerning racial socialization of biracial individuals are scarce. This study, utilizing a qualitative design, explores racial identity development of biracial Afro-Germans living in Germany. The purpose of the study is to understand the strategies that biracial individuals use to negotiate their racial identity, factors that influence their development, cultural influences, and racial socialization processes. Interviews with biracial Afro-Germans were conducted using phenomenological interviewing techniques. Twelve themes …
Dan Graham's Video-Installations Of The 1970s, Michael J. Shaffer
Dan Graham's Video-Installations Of The 1970s, Michael J. Shaffer
Theses and Dissertations
This dissertation examines the video-installations created by American artist Dan Graham in the 1970s. It investigates the artist's relationship to Minimalism by analyzing themes Graham highlights in his own writings and in interviews. In particular, I explore how the artist's understanding of Herbert Marcuse, Walter Benjamin, and R.D. Laing informed his post-Minimalist work and how concepts gleaned from these sources are manifest in his video-installations. Also undertaken are discussions of the artist's interest in aestheticized play, the just-past present, the debate between Behaviourism and phenomenology, surveillance, and Modern architecture. In addition, I investigate Graham's position in Conceptual art, use of …
Breaking Art Apart, Michael Gettings
Breaking Art Apart, Michael Gettings
Theses and Dissertations
The human figure, allegory, myth, and the appropriation of other artist’s compositions are elements in my work. I aim to update traditional stories to conform to contemporary times and culture. In addition, I am striving to create a new method to visually express figurative storytelling. Breaking from the traditional flat painting surface, I use multiple shaped panels. The surface is broken into different shaped panels at varying distances from each other and from the wall. This allows for more exploration into shape and negative space while depicting the dramatic height of a story. As part of this method, my paintings …
Differences In Peer Perception Of Alcohol Use, Personal Alcohol Use, And Levels Of Intoxication Among Students At Virginia Commonwealth University From 2002 To 2004., William Evans
Theses and Dissertations
This study involves the examination of National Collegiate Health Assessment (NCHA) data collected by the VCU Wellness Resource Center. This study will compare trends in college student health behavior perceptions and personal activity regarding alcohol use, as self-reported via the NCHA data, with a particular focus on a comparison between 2002, which is the year that the Wellness Resource Center (then known as the Office of Health Promotion) first implemented an alcohol education campaign based upon a “social norms” theoretical framework, and 2004, after 18 months of intensive campaigning. Thus, the aim of the project is to examine the changes …