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The Impact Of Hurricane Katrina On The Nurse Anesthesia Community In New Orleans, Marjorie Geisz-Everson
The Impact Of Hurricane Katrina On The Nurse Anesthesia Community In New Orleans, Marjorie Geisz-Everson
Theses and Dissertations
Hurricane Katrina devastated New Orleans in 2005. Certified Registered Nurse Anesthetists (CRNAs) and Student Registered Nurse Anesthetists (SRNAs) were impacted by the storm. CRNAs were required to be on duty during the storm and SRNAs’ education was disrupted by the storm. This dissertation is a compilation of three papers that represent the initial exploratory research into the impact of natural disasters on CRNAs and future CRNAs. The first article was a focused ethnography utilizing focus groups and described the shared experiences of CRNAs who were on duty in New Orleans during Hurricane Katrina and the psychosocial impact the storm had …
Time Preserved, Tanya Rogish
Time Preserved, Tanya Rogish
Theses and Dissertations
My paintings are a combination of transparent images merged with paint and wax. As each piece of art develops, the process is the same. The beginning relies on memory or some connection to my past. Then, the progression evolves through a symbolic infancy with an emerging learning experience, which ultimately transforms into a creative piece, along the road less traveled…to the journey’s end. The transparency comes from the image transfer process, which produces a “ghostly” or antique image due to the deteriorated effect of the image in the transfer. The photographic transfers suggest the image without being so bold as …
Determination Of Structure Of Hepatitis B Virus E Antigen, Asheel Patel
Determination Of Structure Of Hepatitis B Virus E Antigen, Asheel Patel
Theses and Dissertations
Hepatitis B virus is a member of the hepadnavirus family. The hepatitis B virus core gene codes for two proteins viz. core protein and pre-core protein. These proteins assemble to form particles viz. HBcAg and HBeAg respectively. The structure of the HBcAg has been widely studied but very little is known about the structure of HBeAg. Therefore, the aim of this study was to identify the disulfide bonding patterns in HBeAg. Recombinant HBeAg was isolated from E.coli and used for this study along with various mutants of HBeAg. There are four cysteines present in HBeAg each at position -7, 48, …
Adenovirus-5 Infection Affects Lipid Metabolism In Hepatic And Adipose Tissues, Marianna Sukholutsky
Adenovirus-5 Infection Affects Lipid Metabolism In Hepatic And Adipose Tissues, Marianna Sukholutsky
Theses and Dissertations
Our recent studies have shown a link between Adenovirus-5 (Ad-5) and elevated lipids, which prompted the hypothesis that Ad-5 infection might augment hepatic and/or adipose tissue lipid metabolism. To test our hypothesis, mice were infected with Ad-5 and screened for changes in lipogenesis and plasma markers associated with the metabolic syndrome. We observed increased expression of sterol regulatory element binding protein 1 (SREBP-1) in infected liver tissues, but not in adipose tissues and this correlated with elevated plasma and hepatic triglyceride levels. Elevated expression of adiponectin was seen in Ad-5 infected adipose tissues and this correlated with phosphorylated AMPK in …
Insequential Sequence, Gary Garbett
Insequential Sequence, Gary Garbett
Theses and Dissertations
Since childhood, my passion to create has driven me to search for the simplest truths within the world I live in. Throwbacks of pop culture have always decorated my life and their influences are directly reflected in my work. The nightly news, advertisements, pulp magazines, film, and music all play an extremely important role in my work as each influence becomes a layer of spirit and emotion in my mixed media paintings and photography. It’s those ordinary and mundane gifts that I find in each normal day that spill the truth and the essence of my life into my art. …
Application Of An Inverse-Hysteresis Iterative Control Algorithm For Afm Fabrication, Seth Ashley
Application Of An Inverse-Hysteresis Iterative Control Algorithm For Afm Fabrication, Seth Ashley
Theses and Dissertations
An iterative control algorithm (ICA) which uses an approximate inverse-hysteresis model is implemented to compensate for hysteresis to precisely fabricate features on a soft polymer substrate using an atomic force microscope (AFM). The AFM is an important instrument in micro/nanotechnology because of its ability to interrogate, manipulate, and fabricate objects at the micro/nanoscale. The AFM uses a piezoelectric actuator to position an AFM-probe tip relative to the sample surface in three dimensions. In particular, precision lateral control of the AFM-probe tip relative to the sample surface is needed to ensure high-performance operation of the AFM. However, precision lateral positioning of …
Individual Contributions To Stigma And Attitudes Toward Help-Seeking Among Rural Emerging Adult College Students, Margaret Gsell
Individual Contributions To Stigma And Attitudes Toward Help-Seeking Among Rural Emerging Adult College Students, Margaret Gsell
Theses and Dissertations
Rural communities are by definition less densely populated and more geographically isolated than non-rural communities, which often translates into higher rates of poverty and poor access to health care, especially mental health care. Previous research has found that persons residing in rural communities endorse higher rates of stigmatized beliefs towards individuals with mental illness and subsequently lower rates of professional help-seeking when compared to persons residing in non-rural communities. This study evaluated whether these attitudes were also present among emerging adults (18-24 years old) who had lived in a rural community for at least 10 years and were currently enrolled …
Mothers' Adaptation In The Neonatal Intensive Care Unit: An Examination Of The Effects Of Meaning Making, Control And Self-Enhancement On Depression, Claire Russell
Theses and Dissertations
With over 400,000 infants being hospitalized in the NICU annually, it is important to understand adjustment in their mothers. Taylor’s cognitive theory of adaptation asserts that three factors, meaning making, control, and self-enhancement, influence positive adjustment in a crisis situation such as a NICU hospitalization. Since it has never been examined, the purpose of the current study was to test the utility of Taylor’s model in mothers with an infant in the NICU. Data was collected from mothers with an infant in the NICU (N = 181) and the main hypothesis was that meaning making, control, and self-enhancement would explain …
The Regulation Of The Alternative Splicing Of Caspase 9, Rachel Goehe
The Regulation Of The Alternative Splicing Of Caspase 9, Rachel Goehe
Theses and Dissertations
The pro-apoptotic, caspase 9a, and the anti-apoptotic, caspase 9b, are derived from the caspase 9 gene by alternative splicing. This study demonstrates that the alternative splicing of caspase 9 is dysregulated in a large percentage of non-small cell lung cancer (NSCLC) tumors of the adenocarcinoma type. Furthermore, modulation of the levels of splice variants of caspase 9 had dramatic effects on the anchorage-independent growth and tumorigenic capacity of NSCLC cells. Due to these findings, the molecular mechanisms regulating the post-transcriptional processing of caspase 9 were therefore examined and an exonic splicing silencer (ESS) regulating the pre-mRNA processing of caspase 9 …
Antifolate Modulators Of Amp-Activated Protein Kinase Signaling As Cancer Therapeutics, Scott Rothbart
Antifolate Modulators Of Amp-Activated Protein Kinase Signaling As Cancer Therapeutics, Scott Rothbart
Theses and Dissertations
Since its discovery, it was appreciated that the antifolate pemetrexed had multiple targets within folate metabolism. This laboratory was instrumental in showing that pemetrexed elicited its primary action as a thymidylate synthase inhibitor. Unusual for an antifolate, pemetrexed showed significant clinical activity against malignant pleural mesothelioma and non-small cell lung cancer. Accordingly, the FDA recently issued first-line approvals for pemetrexed in these diseases, leading us to question whether the effects of pemetrexed on other folate-dependent targets could explain this atypical clinical activity of the drug. Studies in this dissertation showed that in addition to thymidylate synthase inhibition, pemetrexed was also …
B Cell Adam10 Activity Is Increased By Kainate Receptor Activation: Potential Role Of This Pathway In Th2 Immunity And Cancer, Jamie Sturgill
B Cell Adam10 Activity Is Increased By Kainate Receptor Activation: Potential Role Of This Pathway In Th2 Immunity And Cancer, Jamie Sturgill
Theses and Dissertations
CD23 has long been appreciated to be a natural, negative regulator of IgE synthesis. This understanding is due in part to animal models in which CD23 deficient or CD23 transgenic animals display exacerbated or reduced IgE levels respectively. Interestingly, CD23 is susceptible to proteolytic cleavage from the cell surface. When this occurs, CD23 loses its regulatory capability and the solubilized form can lead to pro-inflammatory events through its cytokinergic activity on macrophages. Thus, targeting this specific cleavage would be beneficial to the control of allergic disease by stabilizing CD23 at the cell surface. Inhibitor studies performed by our group as …
Ink (2010-09)
Ink, 2008-
The student-run features magazine covering the fashion, art, music and culture worlds at VCU and in Richmond. Published annually in print and updated regularly online.
The Roads Are Bumpy Ones: A Study Of Body Image Through Abstract Performance, Alexis Goldstein
The Roads Are Bumpy Ones: A Study Of Body Image Through Abstract Performance, Alexis Goldstein
Theses and Dissertations
An overwhelming number of contemporary adolescents struggle with difficult issues. Many of these problems are socially related whereas others can be directly related to the degradation of the family unit. Among the most damaging of issues is distorted body image, which infect youth, often causing them to communicate aggressively, and even landing them in compromising situations. I have sought to challenge my students to redefine themselves through expressive movement and the creation of abstract rhythmic sounds. In teaching these techniques, I have given my former students the means to combat negative thoughts and actions, as well as an excellent tool …
A Midsummer Night's Dream On The Radio: Technology In Voice And Speech, David Becker
A Midsummer Night's Dream On The Radio: Technology In Voice And Speech, David Becker
Theses and Dissertations
Recent advances in sound technology have had significant implications for the teaching of voice and speech that are only now becoming apparent. As more students become “plugged in” it becomes more difficult, both for the instructor and the student, to communicate, let alone find a voice. We are becoming increasingly addicted to communicating through our devices, rather than through the traditional and accepted modes of the past: using the human voice. In light of these rapid and various new developments, voice training, especially at the introductory level, needs to be examined anew. A number of traditional approaches and teaching methods …