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Articles 3721 - 3750 of 7325
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The Natural Polyphenol Resveratrol Potentiates The Lethality Of Hdac Inhibitors In Acute Myelogenous Leukemia Cells Through Multiple Mechanisms., Alae Abod Yaseen
The Natural Polyphenol Resveratrol Potentiates The Lethality Of Hdac Inhibitors In Acute Myelogenous Leukemia Cells Through Multiple Mechanisms., Alae Abod Yaseen
Theses and Dissertations
This study examined the mechanisms underlying the interactions between the natural polyphenol Resveratrol and HDAC inhibitors in both U937 myelomonocytic leukemia cell line and blood samples from AML patients and normal cord blood. Simultaneous exposure to Resveratrol and HDAC inhibitors (Vorinostat-SAHA or Panobinostat-LBH589) resulted in potentiating the lethality caused by any single agent of the combination, this interaction found to be synergistic at multiple concentrations. Exposing U937 cells to minimal toxic doses of Resveratrol and HDACIs results in release of mitochondrial pro-apoptotic proteins AIF and cytochrome c, pro-apoptotic caspase activation especially caspase-8, and induction of DNA damage. These events were …
Ink (2011-05)
Ink, 2008-
The student-run features magazine covering the fashion, art, music and culture worlds at VCU and in Richmond. Published annually in print and updated regularly online.
Phytoremediation Of Pcb Contaminated Soil: Effectiveness And Regulatory Policy, Nathan Pinsker
Phytoremediation Of Pcb Contaminated Soil: Effectiveness And Regulatory Policy, Nathan Pinsker
Theses and Dissertations
The purpose of this paper was to combine available peer-reviewed literature on PCB phytoremediation and make direct comparisons using ANCOVA statistics in order to determine if and what plants are presently a viable option for the remediation of PCB contaminated soils. Pumpkin (Curbita pepo cv Howden) consistently had the top root and shoot concentrations, as well as total plant accumulation. Their consistency shows that they can be reliable in the field and the most viable option. Tall fescue and sedge were also top contenders. Due to the small sample size for many plants and accounting for several confounding variables, very …
Role Of Two-Component System Response Regulators In Virulence Of Streptococcus Pneumoniae Tigr4 In Infective Endocarditis, My Trinh
Theses and Dissertations
Streptococci resident in the oral cavity have been linked to infective endocarditis (IE). While viridans streptococci are commonly studied and associated with IE, less research has been focused on Streptococcus pneumoniae. Two-component systems (TCSs), consisting of a histidine kinase (HK) protein and response regulator (RR) protein, are bacterial signaling systems that may mediate S. pneumoniae TIGR4 strain virulence in IE. To test this hypothesis, TCS RR mutants of TIGR4 were examined in vivo through use of rabbit models. There were 14 RR proteins identified and 13 RR mutants synthesized because SP_1227 was found to be essential. The requirement of the …
Rebonding Anomic Communities With Theatre Of The Oppressed, Amanda Hauman
Rebonding Anomic Communities With Theatre Of The Oppressed, Amanda Hauman
Theses and Dissertations
This thesis explores whether Augusto Boal’s Theatre of the Oppressed (TO) can help anomic communities, affected by deindustrialization and globalization, in the U.S. Midwest, specifically looking at Saginaw, MI. After presenting a paper at the American Symposium for Theatre Research (ASTR) conference in 2009, the author attended a Theatre of the Oppressed facilitator training in Port Townsend, WA under the direction of Marc Weinblatt. She then conducted her own Theatre of the Oppressed workshop in Saginaw, MI to analyze the abilities of Theatre of the Oppressed in an anomic community. Each experience is detailed and followed by the author’s conclusions …
Determining The Effect Of Double-Stranded Rna Treatment In Ovarian Cancer, Charlotte Roberts
Determining The Effect Of Double-Stranded Rna Treatment In Ovarian Cancer, Charlotte Roberts
Theses and Dissertations
DETERMINING THE EFFECT OF DOUBLE-STRANDED RNA TREATMENT IN OVARIAN CANCER By Charlotte Faye Roberts, B.A. A thesis submitted in partial fulfillment of the requirements for the degree of Masters of Science in Biochemistry at Virginia Commonwealth University.Virginia Commonwealth University, 2011Major Director: Jessica K. Bell, Ph.D.Assistant Professor, Department of Biochemistry & Molecular Biology. Epithelial ovarian cancer is a lethal gynecological malignancy. Due to its asymptomatic nature it is typically detected in the latter metastatic stages. Standard treatment protocol involves surgical cytoreduction, followed by a combination of taxane and platinum-based chemotherapeutics. Initially this treatment is successful however, most patients face recurring tumors …
Maternal Influences On The Development Of Infant Oral Biofilm, James Dibelka
Maternal Influences On The Development Of Infant Oral Biofilm, James Dibelka
Theses and Dissertations
Purpose: The purpose was to examine the maternal influences on the development of infant oral biofim and dominant bacterial strains of at risk populations. Methods: The study used a cross-sectional design to examine factors influencing biofilm colonization and the identification of bacterial strains transmitted from mother to child. Participants were enrolled in Children’s Health Involving Parents of Greater Richmond (CHIP). Plaque and saliva samples were collected from mothers and their children ages 6-36 months. The colonized oral bacteria strains of the mother infant dyads were then compared. Oral bacterial strain identification was completed using the HOMIM Forsythe microbe identification array. …
Distinguishing Between Homeless And Unstably Housed Men On Risk Factors For Homelessness, Valerie Holton
Distinguishing Between Homeless And Unstably Housed Men On Risk Factors For Homelessness, Valerie Holton
Theses and Dissertations
This study explored the risk factors for homelessness in single men, the largest group of people experiencing homelessness and a group about which little is known regarding their risks for homelessness. A case control design was used to differentiate risk factors between men who were homeless and men who were unstably housed. Risk factors included cumulative risk, negative life events, and demographic factors. Two models were tested using discriminant function analysis (DFA). The Cumulative Risk Model did not significantly differentiate between the two groups. However, the Negative Life Events Model yielded one discriminant function that significantly differentiated between the groups …
Spatial Parameters In Therapeutic Spaces: Design Of A Residential Treatment Facility For Eating Disorder Patients, Sarah Beth Basinger
Spatial Parameters In Therapeutic Spaces: Design Of A Residential Treatment Facility For Eating Disorder Patients, Sarah Beth Basinger
Theses and Dissertations
Can the built environment positively influence the treatment of an eating disorder? Does the built environment play a role in the quality of care, the rehabilitation process and the lasting affects of treatment in eating disorders and if so, what role does it play? What are the important parameters to consider in designing such a space? Currently there are few facilities designed specifically for the treatment of this disorder. Of those facilities, there is a lack of research regarding the effects of the built environment. Therefore, the process of answering these questions must begin by assessing parameters in architectural precedents …
Women, Wealth And Social Norms Theory: Financial Behaviors And Perceptions Of Affluent Women In Their Prime Years, Scarlett Schwartz
Women, Wealth And Social Norms Theory: Financial Behaviors And Perceptions Of Affluent Women In Their Prime Years, Scarlett Schwartz
Theses and Dissertations
Financial security in retirement is an important social issue, yet many affluent women may have behaviors, attitudes or perceptions that could be detrimental to their financial security—putting them at risk for poverty in their retirement years. A survey was developed and implemented in 2009 to investigate the behaviors, attitudes, and perceptions regarding financial management among affluent ($250,000 or more of household investable assets) United States women in their prime years (aged 50–69) to determine if Social Norms Theory could be applied to this population. Three hypotheses were tested: 1.) most affluent prime-of-life women have “healthy” financial behaviors and attitudes; 2.) …
Resolution, Jason Robinson
Resolution, Jason Robinson
Theses and Dissertations
This paper is an exploration of the concepts and motivations behind the video installation and performance that made up my MFA Thesis Exhibition. My primary interest as a filmmaker is in the “invisible art” of editing. In my practice I employ iconic imagery such as old home movies and classic Hollywood films, as my source material. This “found footage” is deconstructed, drastically altered, and reassembled into a new movie that tells my story while still maintaining the memory of the original images. My process and philosophy concerning the salvage and repurposing of video is analyzed and discussed. I also examine …
Electrophysiological Characterization Of Enteric Neurons Isolated From The Immortomouse, Edward G. Hawkins
Electrophysiological Characterization Of Enteric Neurons Isolated From The Immortomouse, Edward G. Hawkins
Theses and Dissertations
The availability of murine genetic models is extremely advantageous to studying gastrointestinal function, but the benefits afforded by studying enteric neurons in mice has been hindered by their accessibility. Fetal (E13) and 2 day post-natal (P2) enteric neuron cell lines (IM-FEN and IM-PEN, respectively) were recently developed from the H-2Kb-tsA58 immortomouse. Our goal was to identify the electrophysiological properties of these cell lines and clarify their utility as a model of enteric neurons. IM-PEN cells stained positively for the neuron specific markers βIII-tubulin and PGP9.5 and were negative for the glial cell marker S100. Detection of mRNA for TRPA1, TRPV1, …
Processing And Classification Of Physiological Signals Using Wavelet Transform And Machine Learning Algorithms, Abed Al-Raoof Bsoul
Processing And Classification Of Physiological Signals Using Wavelet Transform And Machine Learning Algorithms, Abed Al-Raoof Bsoul
Theses and Dissertations
Over the last century, physiological signals have been broadly analyzed and processed not only to assess the function of the human physiology, but also to better diagnose illnesses or injuries and provide treatment options for patients. In particular, Electrocardiogram (ECG), blood pressure (BP) and impedance are among the most important biomedical signals processed and analyzed. The majority of studies that utilize these signals attempt to diagnose important irregularities such as arrhythmia or blood loss by processing one of these signals. However, the relationship between them is not yet fully studied using computational methods. Therefore, a system that extract and combine …
Suc Khoe La Quan Trong Hon Sac Dep! Health Is Better Than Beauty! Improving Breast And Cervical Cancer Screening Outcomes Among Vietnamese Women, Anh Nguyen
Theses and Dissertations
Vietnamese women experience cancer screening disparities and inconsistent adherence to screening guidelines. The goal of this study was to implement and evaluate a breast and cervical cancer screening intervention to promote cancer screening knowledge, attitudes, self-efficacy, intention, and behavior for Vietnamese women. Secondary objectives of the study included examining the relationships between cultural variables (e.g., acculturation, ethnic identity, religiosity, and collectivism) and cancer screening variables. The study enrolled 102 women from the greater Richmond metropolitan area. Participants were assigned to an intervention group or a print material control group. In the intervention session, participants were exposed to information on female …
Exploring The Functional Interaction Between Camk-Ii And P53, Raymond Lai
Exploring The Functional Interaction Between Camk-Ii And P53, Raymond Lai
Theses and Dissertations
Calcium (Ca2+)/calmodulin-dependent kinase 2 (CaMK-II) is a multifunctional member of a family of Ca2+/calmodulin-dependent serine/threonine protein kinases that respond to transient intracellular calcium signaling. CaMK-II has been reported to be involved with transcription regulation, cell motility, neuronal development, cell cycle regulation, and more recently early development of vertebrates (Easley et al., 2008; Rothschild et al., 2009; Francescatto et al., 2010). Through previous work in the lab using tandem mass spectrometry and “substrate-trapping mutants”, tumor suppressor protein 53 (p53) was identified as a novel CaMK-II binding partner in tissue culture. In this study, I sought to provide characterization of the functional …
The Role Of The Propeptide And Its Residues In Activation And Secretion Of Elastase, An M4 Metalloprotease Secreted By Pseudomonas Aeruginosa, Emily Boice
Theses and Dissertations
Pseudomonas aeruginosa secretes several proteases associated with pathogenesis, but the most abundant and active is elastase (M4 metalloendopeptidase). Elastase (lasB), is first synthesized as a preproenzyme, with a signal peptide, an 18-kDa N-terminal propeptide, and a 33-kDa mature domain. The propeptide functions as an intramolecular chaperone that is required for the folding and secretion of elastase, but ultimately is proteolytically removed and degraded. Previous research has identified the conserved residues in the propeptide of elastase as compared to other M4 protease precursors and showed some among them to be important for the production of active elastase. In this project, the …
Mapping The Distant, Llorens Ana Esteve
Mapping The Distant, Llorens Ana Esteve
Theses and Dissertations
This Thesis presents several approaches through art making to deal with light and space and other things, and the relations that their interaction may generate
The Effects Of Sdf-1Α Treatment On The Migration Of Neural Stem/Progenitor Cells After Traumatic Brain Injury, Corey Evans
The Effects Of Sdf-1Α Treatment On The Migration Of Neural Stem/Progenitor Cells After Traumatic Brain Injury, Corey Evans
Theses and Dissertations
Traumatic Brain Injury (TBI) is one of the leading causes of death and disability among young adults and has been a significant field in medical research over the past decades. Intensive studies focusing on how to repair tissue damage resulting from head injuries have discovered that the central nervous system (CNS) retains a regenerative capacity throughout life due to the persistent presence of neural stem/progenitor cells (NS/NPCs) in the neurogenic regions. In the normal brain, cells generated in the subventricular zone (SVZ) migrate along the rostral migratory stream (RMS) to the olfactory bulb and cells in the subgranular zone (SGZ) …
Characterization Of A Blast Wave Device And Blast Wave Induced Traumatic Brain Injury In A Rat Model By Magnetic Resonance Imaging And Spectroscopy, Frank Corwin
Theses and Dissertations
Blast wave induced traumatic brain injury (bTBI) is a modality of injury that has come into prominence at the current time due to the large number of military and civilian personnel who have experienced the localized shock wave produced by explosive devices. The shock wave will travel concentrically outward from the explosive center, being absorbed and transmitted thru soft objects, such as tissue, and reflecting off stationary obstructions. Transmission and absorption in tissues can result in a number of physiological measureable injuries, the most common of which being what is frequently called “blast lung”. Blast lung involves the spalling effect …
Going Places, Amy Laserna
Going Places, Amy Laserna
Theses and Dissertations
Artist Statement I forget my keys and usually misplace my telephone but I know exactly where my camera is at any given moment. I capture moments for my artwork as well as my own personal benefit. Not all the images will be translated into paint or clay and not all the images are those filled with beauty. However, a bicycle leaning on the corner of a house in Key West and a two hundred dollar pair of shoes from when I was single are a few of the memories that evolved from snapshot to artwork. My photographs inspire my colorful …
The Influence Of Perceptual Accuracy On Willingness To Seek Help Among College Freshmen, Kathryn Conley
The Influence Of Perceptual Accuracy On Willingness To Seek Help Among College Freshmen, Kathryn Conley
Theses and Dissertations
OBJECTIVE: The current study explored the applicability of the social norms approach to a new domain of study: psychological help-seeking. A number of questions that must be answered to determine whether the social norms model can be applied effectively to the help-seeking domain guided the study. METHOD: Data were collected from freshmen at five colleges and universities in the Mid-Atlantic region (N = 3021) during freshman orientation week. The study used a cross sectional design to examine personal attitudes and behaviors related to help-seeking as well as perceptions about others’ attitudes and behaviors related to help-seeking. RESULTS: Most participants reported …
How Virginia Public School Superintendents Spend Their Time, Eric Armbruster
How Virginia Public School Superintendents Spend Their Time, Eric Armbruster
Theses and Dissertations
The purpose of this research is to examine how Virginia public school superintendents spend their time. The primary goal of this study is to determine the differences in how superintendents allocate their time in regards to their involvement with specific tasks. This descriptive study is designed to determine the level of involvement of superintendents throughout the state of Virginia in the areas of fiscal management, facility management, personnel, student personnel and special services, support services, instruction and curriculum, and community relations. This study investigates how much time is spent by superintendents in specific performance areas as defined by the Guidelines …
Predicting The Diffusion Of Next Generation 9-1-1 In The Commonwealth Of Virginia: An Application Using The Deployment Of Wireless E9-1-1 Technologies, Dorothy Spears-Dean
Predicting The Diffusion Of Next Generation 9-1-1 In The Commonwealth Of Virginia: An Application Using The Deployment Of Wireless E9-1-1 Technologies, Dorothy Spears-Dean
Theses and Dissertations
This study examines the deployment of Wireless E9-1-1 Phase One and Wireless E9-1-1 Phase Two as a diffusion of innovation. The research method used in this study is a cross-sectional study employing secondary data in a discriminant function analysis. The study population is Virginia units of local governments (95 counties and 39 cities) that had not deployed Wireless E9-1-1 Phase One or Wireless E9-1-1 Phase Two as of January 1, 2001. The period of time included in this study is from 2001 to 2006. The purpose of the study is to assess the overall accuracy of the three principle theories …
Layers Of Meaning, Joan Wiberg
Layers Of Meaning, Joan Wiberg
Theses and Dissertations
My artwork reflects my search for my own artistic voice. Life demands examination from me at inconvenient times, but with the intention of growing as a person I proceed willingly, and as an artist, equipped with a paintbrush. My search has led me to discover new materials and techniques and my structured self-reflection has uncovered a new source of inspiration. I now combine the physical layering of art materials with layers of personal meaning as well. My work has an autobiographical theme which I have interpreted through the filter of my sense of humor. Working so intimately with my own …
Dialogue In The Galleries: Developing A Tour About Contemporary Art For The Virginia Museum Of Fine Arts, Elizabeth Reilly-Brown
Dialogue In The Galleries: Developing A Tour About Contemporary Art For The Virginia Museum Of Fine Arts, Elizabeth Reilly-Brown
Theses and Dissertations
This museum thesis project considers the challenges involved in developing engaging museum tours. The purpose of this project was to develop a fifty-minute, guided gallery tour that uses inquiry-based instruction to engage participants in dialogue and critical thinking about artworks. The tour was designed specifically for the Virginia Museum of Fine Arts (VMFA) in Richmond, Virginia, using artworks selected from the museum’s twenty-first-century art collection that relate to the theme hybridity. This project contributes to the museum studies field by exemplifying how gallery tours can stimulate active learning, encourage visitors to find meaning in artworks, and form their own conclusions …
Do Body Image And Gender Role Attitudes Mediate The Relationship Between Media Exposure And Sexual Risk Behavior In College Students?, Vivian Rodriguez
Do Body Image And Gender Role Attitudes Mediate The Relationship Between Media Exposure And Sexual Risk Behavior In College Students?, Vivian Rodriguez
Theses and Dissertations
Despite growing awareness of the HIV/AIDS pandemic and educational efforts to provide accurate information about sexually transmitted diseases (STD), young adults continue to engage in risky sexual practices that increase their vulnerability of acquiring an STD, including inconsistent condom use. Research has gathered ample evidence to suggest that the media, in particular television consumption, is directly linked with sexual risk, yet less is known about the potential mechanisms that may be driving this link. The present study examines body image and gender role attitudes as two potential mediators of this relationship. Three-hundred and four undergraduate students (73% female; 64% White) …