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Role Of Nucleosome Remodeling Factor (Nurf) In Tumorigenesis Using A Breast Cancer Mouse Model, Aiman Alhazmi Jul 2012

Role Of Nucleosome Remodeling Factor (Nurf) In Tumorigenesis Using A Breast Cancer Mouse Model, Aiman Alhazmi

Theses and Dissertations

Understanding the impact of epigenetic mechanisms on tumorigenesis is essential, as epigenetic alterations are associated with tumor initiation and progression. Because epigenetic changes are reversible, they are potential targets for cancer therapy. Nucleosome Remodeling Factor (NURF) is a chromatin-remodeling complex that regulates gene expression by changing nucleosome positioning along the DNA sequence. Previous studies have shown a role for NURF in embryonic development as well as regulating genes involved in tumor progression. In this work we investigated the impact of eliminating NURF function in tumorigenesis in vivo. BALB/c mice challenged with syngeneic 67NR breast cancer cell lines, injected into the …

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Cell Death And Growth Arrest Pathways Mediating The Actions Of Stilbene 5c In Hct-116 Colon Cancer Cells, Moureq Alotaibi Jul 2012

Cell Death And Growth Arrest Pathways Mediating The Actions Of Stilbene 5c In Hct-116 Colon Cancer Cells, Moureq Alotaibi

Theses and Dissertations

Abstract The stilbene derivative, cis-3, 4’, 5-trimethoxy-3’-aminostilbene (stilbene 5c), is a potentially potent antitumor agent that acts via binding to the colchicine-binding pocket in microtubules. Earlier studies have shown that stilbene 5c induces cell death in ovarian cancer cells and leukemic cells. The present study was designed to investigate the effectiveness of this microtubule poison against the HCT-116 human colon cancer cell line and its mechanisms of action. Time course studies demonstrated that stilbene 5c produces a biphasic decrease in cell viability. The capacity of the cells to proliferate was not restored upon removal of the drug after 6 days …

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An Analysis Of The Perceptions Of African American Churches In Their Delivery Of Health And Human Services In Southeast Dc, Dennis Parker Jul 2012

An Analysis Of The Perceptions Of African American Churches In Their Delivery Of Health And Human Services In Southeast Dc, Dennis Parker

Theses and Dissertations

President Bush’s Executive Order 13279 (December 12, 2002) encouraged the government to work with faith-based organizations to provide human services (i.e., Temporary Assistance for Needy Families, employment, homelessness services, and health care) to serve America’s low-income populations. Faith-Based Initiatives, and now President Obama’s Faith and Neighborhood Partnerships Initiative have created the foundation for further partnerships between faith-based organizations and local, state, and federal governments. Limited information exists regarding the overall effectiveness of the programs in encouraging churches, specifically African American churches, to engage in services delivery. This study explores the perceptions of church leaders that influence faith-based organizations, specifically African …

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Transferrin Binding Protein B Structure, Function, And Export In Neisseria Gonorrhoeae, Meredith L. Weck Jul 2012

Transferrin Binding Protein B Structure, Function, And Export In Neisseria Gonorrhoeae, Meredith L. Weck

Theses and Dissertations

Iron, an essential nutrient for most microorganisms, is sequestered in the host by iron-binding proteins, such as lactoferrin and transferrin. Neisseria gonorrhoeae utilizes transferrin as an iron source and its iron acquisition system is composed of two transferrin binding proteins: TbpA and TbpB. TbpA is a TonB-dependent, outer membrane transporter and TbpB is a bilobed, surface exposed lipoprotein. TbpB can distinguish between apo- and holo-transferrin which is involved in increasing the efficiency of iron uptake through the Tbps. It is anchored in the outer leaflet of the outer membrane by its lipid moiety. We aimed to identify the mechanism of …

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Behavioral Phenotyping Of The Discriminative Stimulus Properties Of The Atypical Antipsychotic Drug Clozapine In 129s2/Hsv Mice, Kevin Webster Jul 2012

Behavioral Phenotyping Of The Discriminative Stimulus Properties Of The Atypical Antipsychotic Drug Clozapine In 129s2/Hsv Mice, Kevin Webster

Theses and Dissertations

The 129S2 inbred mouse strain is often used as a background strain in the production of genetically altered mice (i.e. knockout and transgenic mice). It is important to establish the behavioral phenotype of wild-type mice before making comparisons to genetically altered mice. Also, those comparisons can assist in the evaluation and interpretation of the in vivo effects of drugs. The drug discrimination assay measures the subjective effects of drugs and provides a measure of underlying neuropharmacological mechanisms responsible for the discriminative stimulus properties of drugs. The present study established the atypical antipsychotic drug clozapine as a discriminative stimulus in male …

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The Impact Of Sincerity Of Terrorists On Committing Terrorist Activities In Turkey, Ahmet Turer Jul 2012

The Impact Of Sincerity Of Terrorists On Committing Terrorist Activities In Turkey, Ahmet Turer

Theses and Dissertations

This study explores the impact of sincerity of terrorists on committing terrorist activities in Turkey. The researcher is a Chief of Police in Turkey and has worked in the Anti-terror Department for a considerable part of his professional career. His professional experience has shown that the more sincere a terrorist is the more violent or heedless the terrorist activity is. Thus this research academically and statistically examines this observation and finds that sincerity affects level of violence. Attachment and adherence to the terrorist organization turn even the characteristically non-violent people into blood seeking terrorists.

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Angiogenesis In Response To Varying Fiber Size In An Electrospun Scaffold In Vivo., Damien Brown Jul 2012

Angiogenesis In Response To Varying Fiber Size In An Electrospun Scaffold In Vivo., Damien Brown

Theses and Dissertations

Injury to the spinal cord results in partial or complete loss of sensory perception and motor function. After spinal cord injury (SCI), damaged tissue dies and a cavity will form. This cavity prevents the regeneration of tissue and any functional recovery. One way to address the cavity is the insertion of an electrospun scaffold that our lab has created. This provides a substrate for regenerating tissue to grow on, and it is thought that reestablishing the blood supply within the scaffold will allow cells necessary for regeneration to thrive. This could ultimately lead to meaningful recovery for patients who have …

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The Evolution Of Conservative Attitudes As A Complement To Cognitive Threat Detection Mechanisms, Russ Clay Jul 2012

The Evolution Of Conservative Attitudes As A Complement To Cognitive Threat Detection Mechanisms, Russ Clay

Theses and Dissertations

Conservatism reflects a general attitude structure characterized by a preference for traditional social practices and an aversion to uncertainty and threat. Though the social environment undoubtedly plays a role in shaping conservative attitudes, recent studies suggest that trait-level characteristics may contribute to their development as well. The present research investigated trait-level cognitive threat detection ability as a factor which may influence the development and maintenance of conservative social attitudes. A computer simulation indicated that socially conservative attitudes may function as a strategy for increasing the survival rate of an individual with poor threat detection ability living in a relatively dangerous …

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Mda-7/Il-24; A Promising Cancer Therapeutic Agent, Hossein Hamed Jun 2012

Mda-7/Il-24; A Promising Cancer Therapeutic Agent, Hossein Hamed

Theses and Dissertations

Glioblastoma multiforme (GBM) is an aggressive cancer that affects millions of patients per year. Conventional therapies combining chemotherapeutic agents with radiation can only extend survival by a few months; therefore, there is a dire need for an effective means of treating this deadly disease. Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24), currently in the early stages of FDA pre-IND drug trials, has proven to be an effective cancer specific cytokine, able to trigger the onset of mitochondrial dysfunction and/or autophagy. GBM’s have mutations that often result in the activation of cytoprotective cell signaling pathways, preventing cancer therapeutics and even MDA-7/IL-24 treatments from being …

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Digital Native Preservice Teachers: An Examination Of Their Self-Efficacy Beliefs Regarding Technology Integration In Classroom Settings, Sarah Parker Southall Jun 2012

Digital Native Preservice Teachers: An Examination Of Their Self-Efficacy Beliefs Regarding Technology Integration In Classroom Settings, Sarah Parker Southall

Theses and Dissertations

The purpose of this mixed-method study was to investigate digital native preservice teachers’ self-efficacy beliefs regarding their technology experiences and skills at the beginning and at the end of their field placement semester. Digital natives, as defined by Prensky (2001), are students born after 1980 who have been raised with digital media and spend a great deal of time engaging with digital devices. Factors that could impact changes in these participants’ technology integration self-efficacy beliefs were also analyzed. This study used pre- and post-surveys, face-to-face interviews with a portion of the respondents, and a document review of course materials and …

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Validation Of 3'-Deoxy-3'-[18f]-Fluorothymidine Positron Emission Tomography For Image-Guidance In Biologically Adaptive Radiotherapy, Marian Axente May 2012

Validation Of 3'-Deoxy-3'-[18f]-Fluorothymidine Positron Emission Tomography For Image-Guidance In Biologically Adaptive Radiotherapy, Marian Axente

Theses and Dissertations

Accelerated tumor cell repopulation during radiation therapy is one of the leading causes for low survival rates of head-and-neck cancer patients. The therapeutic effectiveness of radiotherapy could be improved by selectively targeting proliferating tumor subvolumes with higher doses of radiation. Positron emission tomography (PET) imaging with 3´-deoxy-3´-[18F]-fluorothymidine (FLT) has shown great potential as a non-invasive approach to characterizing the proliferation status of tumors. This thesis focuses on histopathological validation of FLT PET imaging specifically for image-guidance applications in biologically adaptive radiotherapy. The lack of experimental data supporting the use of FLT PET imaging for radiotherapy guidance is addressed by developing …

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Whiff Of Black Ice, Alina Tenser May 2012

Whiff Of Black Ice, Alina Tenser

Theses and Dissertations

This document is a concentration of thoughts, peripheral and direct, that occurred around the making of my thesis exhibition at the Anderson Gallery, Whiff Of Black Ice. While these thoughts meekly occupy space on the following pages, I assure the reader that they are quite physical, even extending three-dimensionality to them. My awareness of their form and their containment within the inner space of the mind, which also extends to the body, becomes central to understanding their meaning and, finally, knowing them.

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Reflections Of Self, Melissa Athey May 2012

Reflections Of Self, Melissa Athey

Theses and Dissertations

I vacillate between all extremes, beauty vs. ugly, internal vs. external, micro vs. macro. It is these disparate notions that inspire what I make. We cannot ever see ourselves objectively, but does that mean we shouldn’t try? This thesis is my attempt to dissect what I created in my 2 years at Virginia Commonwealth University, my exploration of the illness within and the psychological nature of how we go about hiding our insecurities.

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Warm Compression – Damp Gestures, Melanie Mclain May 2012

Warm Compression – Damp Gestures, Melanie Mclain

Theses and Dissertations

Thoughts on vulnerability, emotions, social interaction, self-awareness, skin, touching, bodily functions, and the combination of all these ideas into a confined space filled with heat and humidity just enough to leave you feeling damp and perhaps a bit sore.

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You Can Eat Off The Counter I Wiped It Down This Morning, Jessica Kain May 2012

You Can Eat Off The Counter I Wiped It Down This Morning, Jessica Kain

Theses and Dissertations

Alternative to meeting a calculus of quality roundness and curves are everywhere. Peaches, pinks, browns, ochres, greens. Klein Blue. --------- An experiment like a party; the hows and whys of picking bedfellows yields a list of possibilities— iterations of better, advantages in flesh volume. Inventory whittled down to give us stories, aspirations, allegiances. --------- Just to see it and touch it. Build in different ways, depending. Grow, cover, carve, cast—let for flexibility. Limbs in one direction sawed off, turned round, glued back on. If it looks like two more ways of how I want it there’s more work to be …

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Racial Socialization In A Black-White Interracial Family In Virginia, Rebecca Hubbard May 2012

Racial Socialization In A Black-White Interracial Family In Virginia, Rebecca Hubbard

Theses and Dissertations

The Black-White biracial population is the largest and fastest growing subgroup of multiracial individuals in the United States. Despite substantial research literature on the positive relationship between Black racial identity and psychological wellbeing, Black-White biracial individuals are underrepresented in studies that provide evidence for this relationship. Root (1998) put forward an Ecological Metamodel of Biracial Identity, comprised of several factors related to contextual (e.g. class, regional history of race-relations, parental identity, extended family) and intra-psychic processes (e.g. social skills, coping skills). The ecological metamodel served as the theoretical framework for the current study. This study is a comprehensive investigation of …

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In Tub And Wig Out, Ryan Crowley May 2012

In Tub And Wig Out, Ryan Crowley

Theses and Dissertations

Using short stories, descriptions of objects and thoughts on process, I aim to establish a few ideas about the way I see and think through making in the studio.

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Freedom Of Interpretation, Georgi Ivanov May 2012

Freedom Of Interpretation, Georgi Ivanov

Theses and Dissertations

The photographic series Ideal Cities that I started in 2011 is inspired by the conflict between my idea of the “west” and my evolving experience in the United States. What struck me was the popularity of what I see as model experience – a spatial experience controlled by the Spectacle. In the terms of the Situationist International and its most prominent figure Guy Debord, the Spectacle is the collapse of reality into the streams of images, products and activities sanctioned by centralized monopolist business or state bureaucracy. Thus, personal experience is replaced with preconceived notions, which control the way people …

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Development Of A Multiple Contact Haptic Display With Texture-Enhanced Graphics, David Burch May 2012

Development Of A Multiple Contact Haptic Display With Texture-Enhanced Graphics, David Burch

Theses and Dissertations

This dissertation presents work towards the development of a multiple finger, worn, dynamic display device, which utilizes a method of texture encoded information to haptically render graphical images for individuals who are blind or visually impaired. The device interacts directly with the computer screen, using the colors and patterns displayed by the image as a means to encode complex patterns of vibrotactile output, generating the texture feedback to render the image. In turn, the texture feedback was methodically designed to enable parallel processing of certain coarse information, speeding up the exploration of the diagram and improving user performance. The design …

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Parental And Family Predictors Of Adolescent Weight Loss And Health Change In A Multidisciplinary Obesity Intervention, Jacqueline Woods May 2012

Parental And Family Predictors Of Adolescent Weight Loss And Health Change In A Multidisciplinary Obesity Intervention, Jacqueline Woods

Theses and Dissertations

The home environment, parental health attitudes, and parental diet and exercise behaviors have been associated with childhood obesity. The current study utilized a family systems framework to examine the effect of these variables on weight and health changes in a primarily Black sample of 530 parent-adolescent dyads enrolled in a multidisciplinary weight loss intervention. Parent-reported psychosocial variables and demographic information were used to test models predicting changes in adolescents’ body mass index, cholesterol, and percentage body fat over the first six months of the intervention. The effect of parent participation in a psycho-education parent group on adolescent health outcomes was …

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Synthesis And Biological Evaluation Of Second Generation Anibamine Analogues As Novel Anti-Prostate Cancer Agents, Shilpa Singh May 2012

Synthesis And Biological Evaluation Of Second Generation Anibamine Analogues As Novel Anti-Prostate Cancer Agents, Shilpa Singh

Theses and Dissertations

Prostate cancer is the most prevalent non-cutaneous cancer among men. Since the 19th century when Virchow first introduced the concept of inflammation in cancer, chemokines and their receptors have garnered a lot of interest. Chemokine receptor CCR5 has been especially implicated in many disease states and recently found to be over expressed in prostate cancer cell lines. Anibamine, a natural CCR5 antagonist discovered in 2004, has been found to have significant anti-prostate cancer activity at micromolar level. To optimize this compound and also discover a novel pharmacophore, exploration of the original structure was carried out. Significant modifications were made to …

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The Need For Collaboration In Planning Efforts During Natural Disasters: An Evaluation Of The City Of Richmond, Virginia, Jocelyn Leitch May 2012

The Need For Collaboration In Planning Efforts During Natural Disasters: An Evaluation Of The City Of Richmond, Virginia, Jocelyn Leitch

Theses and Dissertations

This thesis evaluates whether or not information data sharing is effectively used between federal, state, and local government agencies and non-governmental agencies in a metropolitan area during and immediately after a major natural disaster. Also, whether vulnerable populations were identified and considered during emergency management. The chosen study area is the City of Richmond, VA, and the disaster response is based on flooding episodes that occurred in the city over the last decade following hurricanes and tropical depressions. Questionnaires were administered to representatives of federal, state, and local agencies and NGOs. The questionnaires consisted of a Likert-style series of 10 …

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Reckless Hope, Jesse Potts May 2012

Reckless Hope, Jesse Potts

Theses and Dissertations

This thesis is an approximation of several years spent in the studio. It represents an equitable exercise of memory and speculation.

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Function Of Insulin-Like Growth Factor Binding Protein 7 (Igfbp7) In Hepatocellular Carcinoma, Dong Chen May 2012

Function Of Insulin-Like Growth Factor Binding Protein 7 (Igfbp7) In Hepatocellular Carcinoma, Dong Chen

Theses and Dissertations

Title of Dissertation: FUNCTION OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 7(IGFBP7) IN HEPATOCELLULAR CARCINOMA By Dong Chen. Purpose: Hepatocellular carcinoma (HCC) is a highly virulent malignancy with no effective treatment, thus requiring the development of innovative and effective targeted therapies. The oncogene Astrocyte Elevated Gene-1 (AEG-1) plays a seminal role in hepatocarcinogenesis and profoundly downregulates Insulin-like Growth Factor Binding Protein-7 (IGFBP7). The present study focuses on analyzing potential tumor suppressor functions of IGFBP7 in HCC and the relevance of IGFBP7 downregulation in mediating AEG-1 function. Experimental Design: IGFBP7 expression was detected by immunohistochemistry in HCC tissue microarrays by real-time PCR …

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N-Terminal Processing Of Ribosomal Protein L27 In Staphylococcus Aureus, J. Harry Caufield May 2012

N-Terminal Processing Of Ribosomal Protein L27 In Staphylococcus Aureus, J. Harry Caufield

Theses and Dissertations

The bacterial ribosome is essential to cell growth yet little is known about how its proteins attain their mature structures. Recent studies indicate that certain Staphlyococcus aureus bacteriophage protein sequences contain specific sites that may be cleaved by a non-bacteriophage enzyme (Poliakov et al. 2008). The phage cleavage site was found to bear sequence similarity to the N-terminus of S. aureus ribosomal protein L27. Previous studies in E. coli (Wower et al.1998; Maguire et al. 2005) found that L27 is situated adjacent to the ribosomal peptidyl transferase site, where it likely aids in new peptide formation. The predicted S. aureus …

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Characterization Of Superhydrophobic Surfaces Fabricated Using Ac-Electrospinning And Random Particle Deposition, Mohamed Samaha Jr. May 2012

Characterization Of Superhydrophobic Surfaces Fabricated Using Ac-Electrospinning And Random Particle Deposition, Mohamed Samaha Jr.

Theses and Dissertations

Surfaces with static contact angle greater than 150 degrees are typically classified as superhydrophobic. Such coatings have been inspired by the lotus leaf. As water flows over a superhydrophobic surface, "slip effect" is produced resulting in a reduction in the skin-friction drag exerted on the surface. Slip flow is caused by the entrapment of a layer of air between water and the surface. Superhydrophobicity could be utilized to design surfaces for applications such as energy conservation, noise reduction, laminar-to-turbulent-transition delay, and mixing enhancement. A popular method of manufacturing a superhydrophobic surface is microfabrication in which well-designed microgrooves and/or poles are …

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Comparison Of Root Canal Irrigation Systems In Reducing Intracanal Microorganisms Using Saline-An In Vitro Study, Pranav Desai May 2012

Comparison Of Root Canal Irrigation Systems In Reducing Intracanal Microorganisms Using Saline-An In Vitro Study, Pranav Desai

Theses and Dissertations

Mechanical and chemical debridement plays an important role in reducing intracanal microorganisms. Effective root canal irrigation depends on both the root canal irrigant and irrigation system. The objective of this study was to evaluate the debridement efficiency of four root canal irrigation systems, Endovac®, PiezoFlow™, EndoActivator® and traditional needle irrigation using saline as an irrigant. Seventy-five, single canal, extracted, mature teeth were selected. Teeth were standardized to canal lengths of 15 mm and instrumented to Master Apical File size #40 with 4% taper. Teeth were mounted in a centrifuge tube using PVS impression material. Teeth were randomly divided into four …

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Preferentially Orienting Ag Nanoparticles Using Caf2 Nanorods, Mathias Auer May 2012

Preferentially Orienting Ag Nanoparticles Using Caf2 Nanorods, Mathias Auer

Theses and Dissertations

A study was done to examine the effect of surface orientation as well as heterogeneous epitaxy at an interface between two materials with a large lattice mismatch. Silver nanoparticles of different diameters were grown in an effort to study methods of preferentially orienting the geometry of metal nanoparticles. Arrays of calcium fluoride nanorods were grown on silicon substrates using oblique angle thermal vapor deposition. The chamber operated at an ultra high vacuum pressure of 10^-10 Torr during the deposition of the rods and an oblique angle of 75° was kept between the silicon substrate normal and the direction of incident …

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In Vivo Immunotoxicological Evaluation Of Electrospun Polycaprolactone (Epcl) And Investigation Of Epcl As A Drug Delivery System For Immunomodulatory Compounds, Colleen Mcloughlin May 2012

In Vivo Immunotoxicological Evaluation Of Electrospun Polycaprolactone (Epcl) And Investigation Of Epcl As A Drug Delivery System For Immunomodulatory Compounds, Colleen Mcloughlin

Theses and Dissertations

Electrospun materials have potential use in many biomedical applications such as soft tissue replacements or as scaffolds to target drug delivery to local sites. Electrospinning is a polymer processing technique that can be used to create materials composed of fibers with diameters ranging from the micron to the nanoscale. We investigated the effects of microfibrous and nanofibrous electrospun polycaprolactone (EPCL) on innate, cell-mediated, and humoral components of the immune system. Results demonstrated that in both young (12 week) and old (6 month) mice, EPCL had no effect on various immune parameters. With its lack of immunotoxicity, EPCL presents an excellent …

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Non-Invasive Intracranial Pressure Method And Monitor, Tarun Sinha May 2012

Non-Invasive Intracranial Pressure Method And Monitor, Tarun Sinha

Theses and Dissertations

The eyes are acoustically continuous with the brain and inner ear tissues in regard to matched impedances, based on tissue densities, thus, vibration of one site will be reflected in all sites. With this being the case, the vibrational energy response of the eye due to an external source can be used to determine a correlation or draw a conclusion concerning the vibrational energy response of the brain would be. And since there is a correlation between the vibrational energies, any changes in the acoustical energy in the eye can possibly be used to determine the changes in acoustical energy …

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