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The Impact Of Ambiguous Versus Blatant Race Related Stress On Ego Depletion In African American Adults, Benita Belvet
The Impact Of Ambiguous Versus Blatant Race Related Stress On Ego Depletion In African American Adults, Benita Belvet
Theses and Dissertations
The aim of the current study was to examine variations in the impact of ambiguous versus blatant race related stressors on ego depletion in a sample of African American adults. Blatant race related stress was compared with ambiguous race related stress in regards to the relative impact on the constructs of ego depletion and perseverative cognition. Perseverative cognition was also examined as a potential mediating variable in the relationship between race related stress and ego depletion. Additionally, attributional ambiguity was hypothesized to moderate the effect of race related stress on perseverative cognition. The study implemented an experimental design, and assessed …
Role Of Autophagy In The Response Of Hs578t Breast Tumor Cells To Radiation, Shweta Chakradeo
Role Of Autophagy In The Response Of Hs578t Breast Tumor Cells To Radiation, Shweta Chakradeo
Theses and Dissertations
Breast cancer is the most commonly observed cancer type in women and is the second leading cause of cancer death in women. Radiation can be used to debulk tumors prior to surgery as well as to treat patients after surgery and/or chemotherapy. Previous studies from our laboratory have shown that the anti –malarial drug chloroquine sensitizes breast cancer cell lines to radiation by suppression of autophagy which is a conservative catabolic process that can be cytoprotective. The scientific literature has demonstrated that many tumor cell systems undergo cytoprotective autophagy and that pharmacological or genetic inhibition of autophagy leads to other …
Cellular Effects Of Platinum Chemotherapeutics: Alterations By Antidepressants And Heparan Sulfate Proteoglycans, Brigitte Engelmann
Cellular Effects Of Platinum Chemotherapeutics: Alterations By Antidepressants And Heparan Sulfate Proteoglycans, Brigitte Engelmann
Theses and Dissertations
The work discussed here is divided into two projects. The first project involves the interactions between antidepressants and the platinum based chemotherapeutics while the second project begins to investigate possible implications of a recently discovered uptake mechanism for positively charged platinum drugs. Gaining understanding of the interactions between antidepressants and platinum-based chemotherapeutics is important due to the frequency with which they are prescribed together. Although using a combination regimen of antineoplastics is beneficial to the patient, not all drug interactions are. For instance, many of the serotonin reuptake inhibitors have been shown to decrease the efficacy of tamoxifen. Desipramine, a …
Ink (2012-09)
Ink, 2008-
The student-run features magazine covering the fashion, art, music and culture worlds at VCU and in Richmond. Published annually in print and updated regularly online.
Mass Spectroscopic Identification And Quantification Of Protein Carbonyls, Zafer Ugur
Mass Spectroscopic Identification And Quantification Of Protein Carbonyls, Zafer Ugur
Theses and Dissertations
It is well established that free radical mediated oxidative stress plays a critical role in aging and age-related diseases. Among the post-translational protein modifications, carbonylation has attracted a great deal of attention due to its irreversible and irreparable nature. Despite the fact that protein carbonylation is associated with a series of physiological and pathological processes, there are still issues to be clarified such as why certain proteins are more vulnerable to modification, what are the locations of the protein modifications, and how does the nature of the oxidant affect the preferred site of modification. In this study, we will seek …
A Study Towards Development Of An Automated Haptic User Interface (Ahui) For Individuals Who Are Blind Or Visually Impaired, Ravi Rastogi
A Study Towards Development Of An Automated Haptic User Interface (Ahui) For Individuals Who Are Blind Or Visually Impaired, Ravi Rastogi
Theses and Dissertations
An increasing amount of information content used in schools, work and everyday living is being presented in graphical form, creating accessibility challenges for individuals who are blind or visually impaired, especially in dynamic environments, such as over the internet. Refreshable haptic displays that can interact with computers can be used to access such information tactually. Main focus of this study was the development of specialized computer applications allowing users to actively compensate for the inherent issues of haptics when exploring visual diagrams as compared to vision, which we hypothesized, would improve the usability of such devices. An intuitive zooming algorithm …
Investigating The Transcriptional Regulation By Oxyr In Porphyromonas Gingivalis., Anuya R. Paranjape
Investigating The Transcriptional Regulation By Oxyr In Porphyromonas Gingivalis., Anuya R. Paranjape
Theses and Dissertations
Periodontal diseases are bacterially induced, inflammatory diseases which are responsible for loss of alveolar bone and connective tissue supporting the teeth which results in loss of teeth. Gram negative anaerobic bacteria are highly associated with these diseases. One of them is Porphyromonas gingivalis belonging to the phylum Bacteroidetes. Infection by P. gingivalis is recurrent after physical removal of the bacteria from the oral cavity and even after antibiotic treatment as development of resistance is not rare. Hence complete understanding the biology of this bacterium is of significance. This gram negative obligate anaerobe, being aerotolerant, manages to survive inside the oral …
Integrated Fiber Electrospinning: Creating Spatially Complex Electrospun Scaffolds With Minimal Delamination, Casey Grey
Integrated Fiber Electrospinning: Creating Spatially Complex Electrospun Scaffolds With Minimal Delamination, Casey Grey
Theses and Dissertations
Tissue engineering scaffolds come in many shapes and sizes, however, due to difficulty manufacturing the microstructure architecture required in tissue engineering, most scaffolds are architecturally non-dynamic in nature. Because the microstructural architecture of all biological tissues is inherently complicated, non-dynamic tissue engineering scaffolds tend to be a poor platform for tissue regeneration. The current method for manufacturing dynamic tissue engineering scaffolds involves electrospinning successive layers of different fibers, an approach that exhibits no fiber transition between layers and subsequent delamination problems. In this study we aim to address the design challenges of tissue engineering scaffolds through our novel integrated fiber …
Combinatorial Analysis Of Tumorigenic Micrornas Driving Prostate Cancer, William Budd
Combinatorial Analysis Of Tumorigenic Micrornas Driving Prostate Cancer, William Budd
Theses and Dissertations
Prostate cancer is the leading non-cutaneous malignancy affecting men in the United States. One in every six men will be affected by prostate cancer. Due to the high incidence of prostate cancer, there is a need to develop biomarkers capable of identifying tumors from benign prostatic lesions. miRNAs are small molecules that regulate protein translation and impact cellular integrity when dysregulated. It is widely thought that miRNAs have the potential to serve as biomarkers. This study utilizes a unique combinatorial analysis of miRNA dysregulation to identify key miRNAs involved in prostate tumor initiation, progression and metastasis. Numerous dysregulated miRNAs potentially …
Modeling The Resistance To Hydrostatic Pressures For Superhydrophobic Coatings With Random Roughness, Thomas Michael Bucher Jr.
Modeling The Resistance To Hydrostatic Pressures For Superhydrophobic Coatings With Random Roughness, Thomas Michael Bucher Jr.
Theses and Dissertations
A superhydrophobic coating can be produced using a hydrophobic material textured with surface roughness on the micro-/nano-scale. Such a coating on the outside of a submersible body may result in reduced skin-friction drag due to a trapped layer of air in the coating. However, this layer may become unstable when subjected to elevated hydrostatic pressures, and a coating’s performance is compromised beyond a certain threshold (critical pressure). This thesis presents a numerical model for predicting the pressure tolerances of superhydrophobic coatings comprised of randomly deposited hydrophobic particles or fibers. We have also derived a set of force-balance-based analytical equations for …
Ocean Acidification: Understanding The Coastal Carbon Pump In A High Co2 World, Rachel Cooper
Ocean Acidification: Understanding The Coastal Carbon Pump In A High Co2 World, Rachel Cooper
Theses and Dissertations
Since the 1800s, carbon dioxide emissions due to human activities have contributed significantly to the amount of carbon in the atmosphere. Approximately a third of this carbon is absorbed by the ocean, through air-sea fluxes at the ocean surface (Sabine, 2004). Increased CO2 has changed the carbon chemistry of the ocean and hence the pH. pH is expected to drop by 0.4 by the year 2100. It is unclear how this lower pH will affect carbon cycling and sequestration with respect to the biological carbon pump. Most studies have focused on open ocean phytoplankton or bacterial communities in large, stationary …
I Am Error, Nathan Altice
I Am Error, Nathan Altice
Theses and Dissertations
I Am Error is a platform study of the Nintendo Family Computer (or Famicom), a videogame console first released in Japan in July 1983 and later exported to the rest of the world as the Nintendo Entertainment System (or NES). The book investigates the underlying computational architecture of the console and its effects on the creative works (e.g. videogames) produced for the platform. I Am Error advances the concept of platform as a shifting configuration of hardware and software that extends even beyond its ‘native’ material construction. The book provides a deep technical understanding of how the platform was programmed …
Preparation And Characterization Of A Self-Crimp Side-By-Side Bicomponent Electrospun Material, Yang Han
Preparation And Characterization Of A Self-Crimp Side-By-Side Bicomponent Electrospun Material, Yang Han
Theses and Dissertations
Bicomponent composite fibers have been widely used in the textile industry and are gaining increasing attention on biomedical applications. In this research, polycaprolactone/poly (lactic acid) side-by-side bicomponent fibers were created for the application of a biodegradable scaffold. The side-by-side structure endowed the fiber with self-crimps when it was processed under certain conditions. This material was produced by electrospinning and collected on a high speed rotating mandrel to get highly oriented fibers. A mechanical stretch at the same direction was done followed by a wet heat treatment for polymer retraction. Crimped fibers were demonstrated by scanning electron microscopy. The quantitative porosity …
In Vitro In Vivo Methods And Pharmacokinetic Models For Subcutaneously Administered Peptide Drug Products, Amit Somani
In Vitro In Vivo Methods And Pharmacokinetic Models For Subcutaneously Administered Peptide Drug Products, Amit Somani
Theses and Dissertations
Over the last several years, injectable drugs have been a growing area for the treatment of various therapeutic conditions and they are projected to comprise an even larger proportion among the drugs that will be available in the years to come. The injectable drugs are administered by various routes such as intramuscular (IM), intravenous (IV), subcutaneous (SC) and others, however, the majority of these drugs are administered subcutaneously. Even though subcutaneous delivery has been utilized for a number of years, very little is known about the processes governing the absorption of macromolecules from the interstitial space; and the resulting impact …
A Physiological Signal Processing System For Optimal Engagement And Attention Detection., Ashwin Belle
A Physiological Signal Processing System For Optimal Engagement And Attention Detection., Ashwin Belle
Theses and Dissertations
In today’s high paced, hi-tech and high stress environment, with extended work hours, long to-do lists and neglected personal health, sleep deprivation has become common in modern culture. Coupled with these factors is the inherent repetitious and tedious nature of certain occupations and daily routines, which all add up to an undesirable fluctuation in individuals’ cognitive attention and capacity. Given certain critical professions, a momentary or prolonged lapse in attention level can be catastrophic and sometimes deadly. This research proposes to develop a real-time monitoring system which uses fundamental physiological signals such as the Electrocardiograph (ECG), to analyze and predict …
Into The Tangled Web: K-12 Educators, Free Speech Rights, And Social Media, John David Andrews
Into The Tangled Web: K-12 Educators, Free Speech Rights, And Social Media, John David Andrews
Theses and Dissertations
Much attention has recently been given to K-12 educators and their use of social media. This quantitative study surveyed a targeted sample (n = 543) of known social media users to learn about K-12 educators’ use of social media, their legal knowledge of the First Amendment as it relates to free speech and education, and their dispositions toward the First Amendment. Survey respondents self-reported levels of social media use, completed a legal knowledge section, and responded to a series of items used to gauge their disposition toward the First Amendment. These were analyzed through various demographic and contextual factors in …
Characterizing The Interaction Between Ve-Ptp, Tie2 And Ve-Cadherin, Sharif Ossai Muhammad
Characterizing The Interaction Between Ve-Ptp, Tie2 And Ve-Cadherin, Sharif Ossai Muhammad
Theses and Dissertations
Many signaling pathways have been shown to be involved in the formation of the vascular system. Among them are the endothelial specific receptor families such as VEGF, Ang/Tie, as well as other signaling pathways such as semaphorins, which are also involved, in axonal guidance. It is known that the interaction between receptor tyrosine kinase, Tie2, VE-Cadherin, and VE-PTP mediate endothelial cell quiescence and adhesion. However, the structural basis of these interactions is not well understood. The aim of our study is to characterize the binding interactions between these players. Another important part of our study is describing the cross-talk between …
White, Black, And Blue: The Battle Over Black Police, Professionalization, And Police Brutality In Birmingham, Alabama, 1963-1979, Bryan Kessler
White, Black, And Blue: The Battle Over Black Police, Professionalization, And Police Brutality In Birmingham, Alabama, 1963-1979, Bryan Kessler
Theses and Dissertations
This thesis explores the municipal politics and race relations in Birmingham, Alabama, from October 1963 to November 1979. While Birmingham is a centerpiece of the traditional Civil Rights Movement for its staging of the Bull Connor and Martin Luther King, Jr., confrontation in 1963, there has been little examination of the continuing struggles between the black and white communities in the years after the media spotlight. Of particular concern are the battles between the black community, white power structure, and the city’s police department over black policemen, professionalization and modernization, and police brutality. The changing role and tactics of black …
Signal Transduction Effects Induced By Erythropoietin In A Hnscc Model System, Shreya Desai
Signal Transduction Effects Induced By Erythropoietin In A Hnscc Model System, Shreya Desai
Theses and Dissertations
Head and Neck Squamous Cell Carcinoma (HNSCC) is an epithelial skin cancer of the upper aerodigestive tract, and is the sixth most common malignancy in the U.S. HNSCC patients undergoing chemotherapy commonly develop anemia, a condition in which the body lacks mature red blood cells (RBCs). Erythropoietin (EPO) is a systemically circulating hormone in the body that regulates the production of RBCs and is applied to treat anemia. Recently, several studies implicated shortened life expectancy of cancer patients by EPO administration. It may be due to an unexpected activation of survival and proliferation pathways of cancer cells by EPO because …
Role Of Fyn And Lyn In Igg-Mediate Immune Responses, Yves Falanga
Role Of Fyn And Lyn In Igg-Mediate Immune Responses, Yves Falanga
Theses and Dissertations
Anaphylaxis is a rapid, life-threatening hypersensitivity reaction. Until recently, it was mainly attributed to histamine released by mast cells activated by allergen crosslinking (XL) of FcεRI-bound allergen-specific IgE. However, recent reports established that anaphylaxis could also be triggered by basophil, macrophage and neutrophil secretion of platelet activating factor subsequent to FcγR stimulation by IgG/Ag complexes. I have investigated the contribution of Fyn and Lyn tyrosine kinases to FcγRIIb and FcγRIII signaling in the context of IgG-mediated passive systemic anaphylaxis (PSA). I found that mast cell IgG XL induced Fyn, Lyn, Akt, Erk, p38 and JNK phosphorylation. Additionally, IgG XL of …