Digital Commons Network^™

Re:Creation, Heather Boone

Theses and Dissertations

This intent of this project is to explore the importance of handmade objects in the age of information.

Experience As An Experiment, James Walker

Theses and Dissertations

My work is an exploration of new media that demonstrates the influence a community has on visual communication. The community reveals content as objects go unnoticed after they become a permanent part of the landscape and assumptions are made from cultural archetypes. Through exploration, immersion, and reflection, I am able to recognize the invisible and expected, establish a familiarity with a community, and design responses that communicate directly to it.

Autonomous Systems, Karolis Kosas

Theses and Dissertations

The ubiquity of digital media provides an unprecedented possibility to redefine the process and methods of design. Through experience from a series of creative projects, I investigate how certain aspects of the web allow for design to attain a degree of autonomy, thus producing results that go beyond anticipation and expertise of the author. Utilizing an unlimited capacity to store the content and retrieve immediate feedback, the designer’s role can be shifted to that of an initiator defining rules and boundaries, from which the process can evolve independently based on the input of users and data. The design output in …

Transforming Narratives, Lucia Weilein

Theses and Dissertations

Narrative, often considered synonymous with “story,” can be viewed from a structuralist perspective and analyzed independent of any particular content. Breaking narrative into categories of story and discourse, this autonomous structure makes possible a translation of content from one form to another. The various media and form types common in graphic design can serve as both recipient and translator of narratives, converting content into a framework that includes the concept of craftsmanship, aesthetic components and specifications, legibility and composition, and the physical form of the designed object. To examine how this framework functions in practice, I have developed a series …

Wanderings, Jetter Jorge Silva

Theses and Dissertations

While it implies aimless movement, the act of wandering is an act of discovery and can become a search for the unexpected. Wandering, as a metaphor for making, creates opportunities to work in ways where the final outcome is unknown. This can be accomplished by the creation of methods and instructions designed for wandering-the act of discovery. In the field of design, these ideas can be incorporated as methods for making that guide the design process in ultimately unknowable ways, resulting in products that bear little trace of preconception. The role of chance and indeterminacy as methods for relinquishing control …

Cannabinoid Modulation Of Hiv-1 Tat-Stimulated Adhesion Of Macrophage-Like Cells To The Extracellular Matrix, Johnathan Drevik

Theses and Dissertations

HIV-Associated Neurocognitive Disorders (HANDs) are becoming one of the largest problems in patients infected with HIV-1. The ability of infected cells such as monocytes and microglial cells to act as viral reservoirs causes extreme inflammation in the CNS and has led to several different types of neurocognitive problems. Specifically these HIV-1 infected monocytes are able to secrete inflammatory factors such as the regulatory protein Tat which acts as a chemoattractant for monocytes while also promoting the adhesion of leukocytes to the extracellular matrix (ECM). We have shown that one of the major features of the Tat protein is that it …

Assessment Of The Feasibility Of Co-Administration Of Phenolic Dietary Compounds With Phenylephrine To Increase Its Bioavailability, Zhenxian Zhang

Theses and Dissertations

R-(-)-Phenylephrine (PE) is the most commonly used nonprescription oral nasal decongestant in the United States. It is a selective α1-adrenergic receptor agonist and has many years of safe usage. However, the efficacy of PE is controversial, due to its extensive pre-systemic metabolism, which leads to low and variable oral bioavailability (38 ± 9%, mean ± SD). Sulfation plays a very important role in pre-systemic metabolism of PE. The sulfation of PE occurs at its phenolic group, which is the preferred structural feature of many sulfotransferase (SULT) substrates. Compounds with phenolic groups have similar structures to PE, which may share the …

Graphene-Supported Metal Nanoparticles For Applications In Heterogeneous Catalysis, Hany Elazab

Theses and Dissertations

Due to its unique properties and high surface area, Graphene has become a good candidate as an effective solid support for metal catalysts. The Nobel Prize in Physics for 2010 was awarded to Andre Geim and Konstantin Novoselov "for groundbreaking experiments regarding the two-dimensional material graphene". Microwave-assisted synthesis of various metallic nanostructured materials was investigated for CO oxidation applications. These metallic nanostructured materials were used to convert CO to CO2 as an effective approach for carbon monoxide elimination due to its harmful effect on health and environment. In particular, this dissertation is focusing on palladium as a transition metal that …

How Important Is Being "Liked"? The Relation Between Facebook Use And Well-Being, Lauren Oglesby, Allison Crowley, Prachi Desai, Jhaminique Lynwood, Meredith Murgia, Kelsey Richardson

UROP Posters

Facebook is used by approximately 1.06 billion(Craig,2013) to keep in touch with family and friends. However, the question remains whether Facebook is helpful or harmful to people’s well being. According to a research study conducted by Gonzales and Hancock (2010), Facebook use enhances self-esteem by providing multiple opportunities for selective self-presentation through photos and personal details. Another research study by Twenge, Freeman and Campbell (2012) found that participants who spent time on social network sites endorsed more positive self-views. While some research indicates that Facebook has a positive effect on the user other studies suggest that Facebook use is detrimental. …

Cloud Privacy Audit Framework: A Value-Based Design, David Coss

Theses and Dissertations

The rapid expansion of cloud technology provides enormous capacity, which allows for the collection, dissemination and re-identification of personal information. It is the cloud’s resource capabilities such as these that fuel the concern for privacy. The impetus of these concerns are not too far removed from those expressed by Mason in 1986, when he identified privacy as one of the biggest ethical issues facing the information age. There seems to be continuous ebb and flow relationship with respect to privacy concerns and the development of new information communication technologies such as cloud computing. Privacy issues are a concern to all …

What?: Visual Interpretations Of The Miscommunication Between The Hearing And Deaf, Virginia Shou

Theses and Dissertations

This thesis visualizes the communication challenges both latent and obvious of my daily life as a hard of hearing individual. By focusing on a variety of experiences and examples I demonstrate the implications of a hard of hearing individual’s life. The prints, objects and videos that I have created for my visual thesis aim to enrich the understanding of a broader public on issues regularly faced by Deaf people. At the heart of my work my goal is to generate mutual empathy between the hearing and the Deaf.

The Ticking Of The “Biological Clock”: Worry About Future Fertility In Nulliparous Women, Karen E. Kersting

Theses and Dissertations

Abstract

Title: The Ticking of the “Biological Clock”: Worry about Future Fertility in Nulliparous Women

By: Karen Kersting, M.A., M.S.

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University.

Virginia Commonwealth University, 2013.

Major Director: Kathleen M. Ingram, J.D., Ph.D.

Associate Professor of Psychology

Department of Psychology

Modern women are waiting until later in their lives to have children than women of previous generations, a trend influenced by a number of factors including financial stability, dating norms, and career goals and responsibilities. As women age, their fertility may decline …

True Single Search: The Good, The Bad, And The Ugly, Margaret T. Kidd

VCU Libraries Faculty and Staff Presentations

Since the advent of Google, the trend in search engines has been to try to provide as many types of information as possible from a single location. Libraries are no exception, with discovery tools such as Primo and Summon becoming more and more popular. This presentation discusses the pros and cons of using Primo in relation to finding manuscripts and archives materials.

Pedal To The Metal: Our Year Of Dh, John Glover, Kristina Keogh

VCU Libraries Faculty and Staff Presentations

No abstract provided.

Kinetics And Mechanisms Of Accumulation For Liposomal Ciprofloxacin Into Rat Alveolar Macrophages, Sayeed Mossadeq

Theses and Dissertations

The kinetics and mechanism of accumulation for liposomal ciprofloxacin (Lipo-CPFX) into the rat alveolar macrophage NR8383 cells were studied in vitro, in comparison to unformulated ciprofloxacin (CPFX). Upon incubation with CPFX or Lipo-CPFX, cellular drug accumulation was determined from the cell lysates or efflux was from the extracellular media by fluorescence-HPLC. The accumulation for Lipo-CPFX reached the asymptotic values at ≥ 2 hours, which was a result of uptake and efflux. The uptake appeared to be due to liposomes, mediated via cellular energy-independent mechanism like lipid fusion. In contrast, the efflux appeared to be due to ciprofloxacin, partly cellular energy-dependent, …

In-Vitro Pk/Pd Profiling And Modeling Of The Anti-Sickling Agents, 5-Hydroxymethyl Furfural (5-Hmf) And Novel Synthetic Allosteric Effectors Of Hemoglobin (Aeh) In Human Whole Blood, Apurvasena Parikh

Theses and Dissertations

Introduction. 5-HMF and novel INN-compounds are left-shifting AEH, shown to have anti-sickling action by forming transiently covalent Schiff-base adducts with hemoglobin (Hb), thereby increasing the Hb O2-affinity. They are hypothesized to be substrates for aldehyde dehydrogenase (ALDH) in the liver and red blood cells (RBC). Methods. Biopharmaceutical assessments were made for AEH, using calculated physicochemical properties. Their in-vitro hepatic metabolism (mediated by ALDH) was characterized using hepatic cytosol, and in-vitro-in-vivo extrapolations (IVIVE) were made. Inter-species differences in hepatic cytosolic ALDH activity were investigated using acetaldehyde as a model substrate in different mammalian species. Time- and concentration-dependent in-vitro disposition of 5-HMF …

The Metabolic Transitions Regulated By The Estrogen-Related Receptor (Err) In Drosophila Melanogaster, Yan Li

Theses and Dissertations

In multicellular organism, bioenergetic metabolism is strictly regulated toward efficient generation of ATP. However, in certain situations, such as in limiting oxygen or in the rapidly proliferating system like growing juvenile or cancer cells, organisms apply the metabolic strategy that favors the production of biomass (e.g., nucleotides, amino acids, and lipids) over efficiency of ATP generation. The conserved estrogen-related receptors (ERRs) are master regulators in controlling metabolic homeostasis, and good candidates for mediating the metabolic transition induced by hypoxia and development. First, we investigate how dERR influences hypoxic adaptation in Drosophila melanogaster. We find that dERR is required for a …

In Vitro Lung Epithelial Cell Transport And Anti-Inflammatory Activity For Liposomal Ciprofloxacin, Ruba Darweesh

Theses and Dissertations

Liposomal ciprofloxacin (Lipo-CPFX) is being developed for inhalation, with a goal of sustaining the therapeutic activity, compared to unformulated ciprofloxacin (CPFX). However, the kinetics and mechanism of its sustained local lung retention and pharmacological activity are yet to be fully characterized. This project hypothesized that Lipo-CPFX enables slower and sustained lung epithelial transport and uptake, compared to CPFX, thereby producing prolonged local pharmacological actions. The human bronchial epithelial Calu-3 cells were used as monolayers to characterize the kinetics and mechanism of transport and/or uptake, and to assess the effects of such slow kinetics for Lipo-CPFX on its inhibition against lipopolysaccharide …

Impact Of Post-Synthesis Modification Of Nanoporous Organic Frameworks On Selective Carbon Dioxide Capture, Timur İslamoğlu

Theses and Dissertations

Porous organic polymers containing nitrogen-rich building units are among the most promising materials for selective CO2 capture and separation applications that impact the environment and the quality of methane and hydrogen fuels. The work described herein describes post-synthesis modification of Nanoporous Organic Frameworks (NPOFs) and its impact on gas storage and selective CO2 capture. The synthesis of NPOF-4 was accomplished via a catalysed cyclotrimerization reaction of 1,3,5,7-tetrakis(4-acetylphenyl)adamantane in Ethanol/Xylenes mixture using SiCl4 as a catalyst. NPOF-4 is microporous and has high surface area (SABET = 1249 m2 g-1). Post-synthesis modification of NPOF-4 by nitration afforded (NPOF-4-NO2) and subsequent reduction resulted …

Interpreting The War Anew: An Appraisal Of Richmond’S Civil War Centennial Commemoration, Brandon Butterworth

Theses and Dissertations

In existence from 1959 to 1965, the Richmond Civil War Centennial Committee was formed for the purpose of planning and executing Richmond’s Civil War centennial commemoration. In this thesis, the author will examine the history of the Richmond Civil War Centennial Committee (RCWCC) and its efforts to develop a new historical narrative of Richmond and the Civil War. This paper will assess Richmond’s previous attempts to commemorate the Civil War and will argue that the RCWCC contributed to the advancement of Richmond’s Civil War narrative by de-emphasizing past Confederate celebration attempts led by heritage groups and advancing a “reconciliation” narrative. …

Characterization Of The Expression Of The Intercellular Adhesin Locus In Staphylococcus Aureus, Jamie Brooks

Theses and Dissertations

Poly-N-acetylglucosamine (PNAG) is an important Staphylococcus aureus virulence factor. It is a major component of the extracellular polymeric matrix in biofilms, and contributes to resistance to the innate immune response. The proteins encoded in the icaADBC (intercellular adhesin) operon are responsible for PNAG production. Here, we present evidence of a new mechanism of phase variation for switching off PNAG production that involves slipped strand mutagenesis, along with further insight into the regulation and expression of the icaADBC operon. S. aureus strain MN8m (mucoid) is a spontaneous mutant of strain MN8 (non-mucoid). It is characterized by constitutive overproduction of PNAG, resulting …

Commonwealth Times 2012-12-06

Commonwealth Times, 1969-

No abstract provided.

My Beautiful, Jacquetta Harvey

Theses and Dissertations

In creating my work I use bold, bright colors and fundamental shapes and patterns. My images reflect how I view the world and genuinely express my imagination, feelings, and thinking. Working this way allows me to apply a symbolic face to personal concerns, beliefs, fears, ideologies, and philosophies. I see a world where life and art blend to create images of triumph and tragedy, joy and pain, or growth and change. My ideas have grown from the desire to understand myself as a woman, as a Christian, and as a unique individual. Dealing with personal questions, I explore the varying …

Transcendence, James Klinke

Theses and Dissertations

Artist Statement I have often created art with an organic quality because I have felt bound by the earth’s natural elements and forces. These extend to and influence my human qualities which influence my artwork. My paintings and mixed media works symbolize the issues and defects that affect me in various ways and represent my attempt at overcoming them. At its core, my body of work addresses psychological and emotional recovery work. I have been burdened for a long period of time with anxiety, various character defects, and difficulties but I find catharsis through creative expression. Because I have chosen …

Art Criticism, Scholarly Interpretation, And Curatorial Intent: A Reassessment Of The 1998 Jackson Pollock Retrospective At The Museum Of Modern Art, Andrea Alvarez

Theses and Dissertations

In 1998, the Museum of Modern Art held a retrospective exhibition of artworks by Jackson Pollock. Curators Kirk Varnedoe and Pepe Karmel worked in an art historical context that had been significantly shaped by the early critical writings by Clement Greenberg and Harold Rosenberg. The curators’ stated intention for the exhibition installation was to provide “a fresh chance for new generations of artists to come to terms with a legendary figure” and to enable “the broader public to reassess a quintessentially American artist in light of three decades of new scholarship,” without “ hewing to any particular critical dogma.” Despite …

Acid-Base Catalysis In Proton-Coupled Electron Transfer Reactions (Pcet): The Effects Of Brönsted Bases On The Oxidation Of Glutathione And Hydroquinone, Ramos Jonnathan Medina

Theses and Dissertations

This thesis presents the results and discussion of the investigation of the effects of Brönsted bases on the kinetics and thermodynamics of two proton-coupled electron transfer processes: the mediated oxidation of glutathione and the electrochemical oxidation of hydroquinone. Proton-coupled electron transfer (PCET) is the name given to reactions that involve the transfer of electron(s) accompanied by the exchange of proton(s). PCETs are found in many chemical and biological processes, some of current technological relevance such as the oxygen reduction reaction in fuel cells, which involves the transfer of four electrons and four protons (4e-, 4H+); or the splitting of water …

Commonwealth Times 2012-12-03

Commonwealth Times, 1969-

No abstract provided.

There Is A Beginning, Catherine Stark

Theses and Dissertations

Science and nature inspire me to create. I have always found a unique beauty in abstracted views of organic matter. I have built a visual vocabulary for my imagery through examinations of scientific images from topography and biology. In addition, my responses to the natural environment inform my abstract, expressionistic, mixed media paintings. Using oil paint in a nontraditional way, I rub, brush, and manipulate paper surfaces to create subtle texture and color. Then, I add a vast range of materials such as resin, varnish, and enamel to build depth and layers. My works suggest actual surfaces in nature and …

The Role Of Zinc Particle Size And Loading In Cathodic Protection Efficiency, Qiang Wang

Theses and Dissertations

Metallic additives, also known as anticorrosive pigments, can provide sacrificial cathodic protection and complement the barrier protection afforded by heterogeneous organic coatings to metallic substrates. The unique systematic study of the corrosion resistance of an epoxy coating reinforced with different sizes (80nm, 500nm, 10um) and continuous multiple pigment volume concentration (0, 2%, 10%, 20%, 45%) below global critical pigment volume concentration of zinc particles were studied. The thesis is developing the fundamental understanding to optimize corrosion protection and predicting the protection with time. The properties of these cathodic coatings were investigated by a single-frequency electrochemical impedance spectroscopy (EIS) and open …

Ige Enhances B Cell-Derived Exosomal Induced T Cell Proliferation, Brooks Keith

Theses and Dissertations

For many years it has been known that the injection of antigen bound to an antibody leads to more than a 1000-fold increase in antigen specific antibody response. This observation holds true for IgE, which is dependent upon CD23 expression, as this enhancement is not present in mice deficient in CD23. It also has been shown that when mice are injected with IgE-antigen complexes also display an increase in antigen specific T cell proliferation. While there are published studies that demonstrate a role for B cell derived exosomes in the activation and proliferation of T cells, none have focused upon …