Digital Commons Network^™

Wander, Wonder: Beyond The Window, Se Young Lee

Theses and Dissertations

This thesis explores how small, site-specific interventions can reframe everyday spaces through acts of observation, walking, and placement. In response to the increasing detachment from physical environments caused by digitized, image-saturated culture, this research asks how gentle gestures might restore presence and embodied perception in overlooked urban sites.

Drawing on the notion of the flâneur and grounded in theories by Peter Zumthor, Rebecca Solnit, and others, walking is employed as a form of spatial inquiry—a way of thinking through movement, of seeing through slowness. Along a recurring route between home and studio, three underappreciated sites were identified and engaged through …

Targeting The Achilles’ Heel Of Lung Cancer Induced By Oncogenic P53, Brandon G. Velasco

Theses and Dissertations

Mutations of the tumor suppressor gene, TP53, are the most prevalent oncogenic mutations in lung cancer, occurring in up to 70% of human non-small cell lung cancer (NSCLC). The majority of mutations in p53 are missense mutations that cause not only a loss of tumor suppressor function, but also gain of oncogenic functions, like tumorigenicity, immune suppression, and chemoresistance. Previous studies have shown that the depletion of gain-of-function (GOF) p53 or disruption of its ability to transactivate the expression of genes related to oncogenesis eliminates its tumorigenic properties indicating a dependency of human lung cancer cells expressing GOF p53 …

Radical Hope Amid Generational Oppression And Puerto Rican Well-Being, Natalia Gomez Giuliani

Theses and Dissertations

Oppressive systems (e.g., colonialism, racism, capitalism) create a disparate distribution of power that, through various mechanisms, negatively impacts the health and well-being of members of the oppressed group. Boricuas have experienced over 500 years of oppression, with the island currently maintaining a colonial relationship with the United States. As these adverse effects of oppression are identified, the need for protective factors (e.g., hope) has emerged. This study explored how islander Boricuas practice radical hope, understand their history of oppression and resistance, and how they perceived it to impact their overall well-being. Utilizing a phenomenological qualitative approach, I conducted 15 semi-structured …

Intuitive Mixed Reality Interfaces For Creative And Interactive Robotics: Roboart, Magnaforma, And Playmeow, Miles Popielamc

Theses and Dissertations

This thesis details the development and application of intuitive Mixed Reality (MR) interfaces designed to broaden access to robotic control for creative and interactive uses. The central contribution is the RoboART system, a novel MR interface built with the Microsoft HoloLens 2 to program an ABB GoFa collaborative robot for non-expert users, such as artists. The work describes RoboART's application in the Magnaforma project, where it enabled complex artistic expression.

Additionally, the thesis introduces the PlayMeow project, which explores adaptive pet interaction through a laser-guided turret. This system's control strategies were deeply informed by the intuitive paradigms developed for RoboART, …

Visible Modulation Of Epsilon Near Zero Materials, Jonathan M. Weber

Theses and Dissertations

While Epsilon-Near-Zero materials have offered many benefits from their introduction to the field of nonlinear optics, those materials have also narrowed the range of wavelengths often studied. With reliable and proven enhancements to light-matter interaction in the ENZ region, many researchers have had little reason to extend the spectrum measured in experiments. The purpose of this work is to measure the intensity dependent refractive index of Indium Tin Oxide across a broad spectral range, from ultraviolet to near infrared, to improve the understanding of semiconductor nonlinearities far from Lorentz and Drude resonances. Furthermore, the visible region is naturally low-loss in …

Automated Treatment Planning Framework For Cervical Cancer In Brachytherapy, Suman Gautam

Theses and Dissertations

Brachytherapy (BT) is a critical treatment modality for cervical cancer that delivers ionizing radiation directly to the tumor using intracavitary (IC) and/or interstitial (IS) applicators. In high dose-rate (HDR) BT, a remote afterloader guides the radioactive source to specific dwell positions for defined durations, known as dwell times, allowing for a conformal dose to the tumor while minimizing exposure to surrounding organs at risk (OAR). However, due to the inherent nature of ionizing radiation, some dose to OARs is unavoidable, creating a fundamentally conflicting objective in treatment planning: maximizing tumor coverage while minimizing OAR dose. This characterizes the problem as …

Plasmon-Assisted On-Chip Integration Of Quantum Emitter For Scalable Quantum Networking, Samprity Saha

Theses and Dissertations

In recent decades, quantum theory has sparked a revolutionary outlook on our long-standing perception of information processing and communication technologies. Photon-based quantum systems, relying on single photons governed by quantum mechanics, hold immense promise for quantum networks due to their resilience against decoherence and fast propagation speeds. However, challenges persist in realizing practical quantum networks, including the need for scalable, robust, and cost-effective quantum light. To address these challenges with classical photonic concepts, this thesis focuses on a plasmon-assisted approach for on-chip integration of single-photon sources. The study aims to develop a scalable solution for integrating quantum emitters on-chip, leveraging …

How To Touch Your Bile, Aleckxi Dorhofer

Theses and Dissertations

I have been reflecting on my past decade-long struggle with anorexia and bulimia. Reinterpreting this experience through the lenses of mythology and magic, I have constructed these Stygian carcasses (from the river Styx, which serves to separate the living and the dead) using my own bodily proportions in muslin, an intermediary material which requires transformation. In this work, I utilize these forms to symbolically rot for me as my body did, performing a type of sympathetic magic (magic worked from afar on another person) on myself, extending my life and allowing all which occurs between birth and death to affect …

Hyperreality Ain’T Really Real: Postmodernity, Social Media, & Blackness, Micah White

Theses and Dissertations

This qualitative study examines the interplay between postmodernity, social media, and African American identity formation through focus group analysis and Grounded Theory methodology. The research investigates how social media’s postmodern features—fragmentation, hyperreality, commodification, and context collapse—shape identity development among African Americans, who historically navigate cultural disruption and systemic racism. Data from semi-structured interviews with two generational focus groups revealed that participants engaged in sophisticated identity curation to balance authenticity and protection in racially charged digital spaces. Key findings highlight the tension between empowerment and marginalization, as social media served as both a platform for racial affirmation and a source of …

A Multimethod Approach To Examining Racial Coping Socialization Among Black Adolescents, Rachel J. Davis

Theses and Dissertations

Experiences of racial discrimination are pervasive in the lives of Black youth and result in race-related stress. Racial coping has been found to mitigate the negative physical and mental health effects of racial discrimination; thus, it is imperative that we understand the process that Black youth undertake to navigate racialized experiences by utilizing a person-centered approach. Additionally, parents socialize their Black youth to navigate racialized experiences, indeed, previous research has investigated racial and emotion socialization as separate phenomena, however, this does not reflect the integrated nature by which racial and emotion socialization processes are interconnected during parents’ and youths’ discussions …

A Mixed Methods Study: High School Teachers’ Perspectives On Incorporating Mindful Artmaking In Their Classroom As A Mental Health Resource, Sherry A. Bosarge

Theses and Dissertations

Mental health concerns and the need for mental health resources for high school students continue to rise in Virginia. Some of the reported benefits to the current mental health services and resources offered in Virginia schools are increased academic outcomes, attendance, and positive behaviors. The reported barriers to current mental health services and resources are lack of participation, lack of training, time constraints, funding, and resources. This explanatory sequential mixed methods study examined high school teachers’ perspectives on the benefits and barriers to incorporating mindful artmaking in their classrooms as a mental health resource at a local high school. This …

Still An Athlete? An Exploration Of Athlete Identity, Body Appreciation, And Psychological Flourishing In Middle-Aged Former Collegiate Athletes, Kelly Furr

Theses and Dissertations

Collegiate athletes, upon retirement, are encouraged to develop other interests outside of sport to form a well-rounded identity. Yet middle-aged people often struggle to complete recommended strength training and exercise guidelines, and many continue to struggle with body appreciation and psychological well-being beyond adolescence and young adulthood. Using a cross-sectional survey design, 482 former NCAA athletes completed the Athlete Identity Measurement Scale (AIMS), Exercise Identity Scale (EIS), Body-Appreciation Scale (BAS-2), and Flourishing Scale (FS). The study used Structural Equation Modeling (SEM) to determine if athlete or exercise identity positively affects body appreciation and psychological flourishing through the mediating variable of …

A Mixed Method Case Study Of Leadership For Change: Authentic Transformational Leadership In A Local Baptist Church, Hui Sun

Theses and Dissertations

This convergent parallel mixed methods case study explores how a local Baptist church navigated organizational change during and after the COVID-19 pandemic through the lens of authentic and transformational leadership. Grounded in organizational leadership and open systems framework of organizational change, the study examined two primary hypotheses: (1) RBC demonstrated an authentic transformational leadership paradigm in its change processes since 2020, and (2) this paradigm significantly and positively influenced perceived leadership effectiveness.

Qualitative data were collected through semi-structured interviews with six leaders (three pastors, one minister, one staff leader, and one deacon) and 11 raters (five lay leaders, five congregants, …

Using Habituation And Affective Forecasting To Distinguish When The Passive Enjoyment Of Harm Begets The Active Pursuit Of Aggression, Drew M. Parton

Theses and Dissertations

Understanding the antecedents and impellers of aggression is key to preventing violence, and individual differences have been identified as some of the key factors of interest in the study of aggression. Antisocial personality traits such as psychopathy, Machiavellianism, Narcissism, and Sadism have received considerable focus from researchers. Among these traits, Sadism stands above them all as arguably the most malevolent of all trait constructs in psychology. Sadism shows the strongest correlations with aggression among malevolent traits and is uniquely linked to unprovoked aggression, even when it is costly. Sadism thus represents an extreme risk factor for aggression, and studying its …

Facile Synthesis Of Gold, Copper, And Silicon Nanostructures By Laser Ablation In Liquid, Nicholas Simpson

Theses and Dissertations

Metal nanoparticle (NP) synthesis is a continually evolving area of research, owing to the widespread application of NPs in fields such as catalysis, drug delivery, and biosensing. Compared to bulk metal material, NPs contain a larger proportion of surface atoms and exhibit unique optical properties, thus making them ideal for applications where maximizing surface interactions is key. Moreover, their compositions can be altered in several different ways, as evidenced by metal alloy, core/shell, supported, and defective NPs. While conventional synthesis methods are capable of producing NPs in large quantities, they often require conditions of high temperature and pressure, strong reducing …

Therapy-Induced Senescence In Cancer: Developing Senolytic-Based Combination Strategies To Delay Re-Emergence Of Triple-Negative Breast Cancer, Eesha Chakraborty

Theses and Dissertations

Therapy-induce senescence (TIS) represents a major biological outcome of many anticancer treatments and is increasingly recognized as a strategic vulnerability in triple negative breast cancer, which is a highly aggressive subtype with limited therapeutic options and frequent relapse. Here, we probed TIS as a primary cellular response that may ultimately compromise long-term outcomes using standard chemotherapeutic agents in TNBC as well as the antibody-drug conjugate sacituzumab govitecan (SG). Both chemotherapy and SG reliably induced pronounced senescence across TNBC models, yielding durable growth arrest, however, also generating a persistent reservoir of viable tumor cells capable of eventual proliferative recovery, a hallmark …

Exploring The Role Of Host Immune Responses And Bacterial Sensory Pathways In The Development Of Treponema Denticola-Mediated Periodontal Disease, Annie N. Hinson

Theses and Dissertations

Periodontitis is a chronic inflammatory disease driven by dysbiotic microbial communities and maladaptive host responses. Treponema denticola, a spirochete pathobiont, is strongly associated with disease severity. However, the molecular mechanisms underlying its interaction with host tissues and regulation of virulence remain incompletely understood. This work examines both the epithelial immune responses and bacterial transduction systems that shape T. denticola pathogenesis. Transcriptomic analysis of gingival keratinocytes revealed IL-36γ as the most highly induced cytokine following infection with T. denticola. Functional studies demonstrated that IL-36γ induction occurs in a dose- and time-dependent manner through TLR2/6 signaling, requiring the NF-κB, PI3K/Akt, and …

Identity Formation Of A Pre-Service Art Educator: An Arts-Based Approach To Data Visualization As A Means Of Understanding Personal Experience, Kelsey L. Peterson Mays

Theses and Dissertations

This research centers on the emotional experience of the author as a pre-service art educator during her student teaching semester. The research utilized art-based data collection methods and analyzed both written and visual reflections over an eight-week period of teaching art at the elementary school level. The culmination of findings is synthesized in the form of a body of four visual artworks, where each work reflects the data collected over a consecutive period of two weeks. The study investigated the causation and ramifications of certain emotions during a transitional time wherein the author existed in a liminal space between student …

Characterization Of Outer Surface Protein C Of Borreliella Role In Host Tropism, Kathryn Mf Chambers

Theses and Dissertations

The Lyme disease spirochetes, Borreliella spp., are maintained in nature through a complex enzootic cycle involving Ixodes ticks and a diverse set of reservoir hosts. The outer surface protein C (OspC) of the bacterium is an essential virulence factor required for transmission from ticks and early infection of mammals. Deletion of ospC abolishes infectivity, yet the precise molecular mechanisms underlying OspC function remain incompletely defined. In this dissertation, I examined the contribution of OspC type identity to host specificity. OspC is highly diverse, with over 30 genetically stable types described. While intra-type sequences are conserved (>95% amino acid …

Dickkopf1(Dkk1): A Novel Endogenous Ligand To Prime Nlrp3 Inflammasome Via Tlr4, Theingi Aung

Theses and Dissertations

Dickkopf1(DKK1) is a quintessential Wnt antagonist and immunomodulator in various inflammatory diseases. The underlying molecular mechanisms of DKK1-mediated immunomodulation remain elusive. Here, we identified TLR4 as a new receptor for DKK1 to activate NFκΒ pathway-mediated gene expression and pyroptosis via NLRP3 inflammasome in human and mouse macrophages.

DKK1 employed TLR4 to initiate NFκB signaling cascade via MyD88. MyD88-TAK1-NFκΒ pathway activation by DKK1 increased HIF1α, NFκB, and NLRP3 protein expression levels, leading to pyroptosis. Unlike LPS, DKK1 did not induce IRAK4 phosphorylation, while the interaction between MyD88 and IRAK4 was maintained for downstream signaling activation. DKK1 did not induce IRF3 phosphorylation …

From Trans Health To Vaccines: A Theoretically Driven Model Exploring Factors Related To Susceptibility To Medical Misinformation, Catherine Wall

Theses and Dissertations

Medical misinformation represents a significant threat to both individual and public health. While some consequences of this form of misinformation are relatively benign, there can be serious consequences ranging from a decreased trust in healthcare systems to an increased likelihood of epidemic outbreak and death. One such consequence can be seen in the recent legislative actions taken regarding access to transgender healthcare in the United States. Gender affirming care has been shown to benefit the mental well-being of transgender youth and adults; however, the demonstrably false information that underlies these legislative efforts can and has yielded significant harm. But what …

Beliefs Related To Diagnosing Bpd And Complex Ptsd, Bailey Pascuzzi

Theses and Dissertations

There has been speculation that Borderline personality disorder (BPD) and Complex post-traumatic stress disorder (Complex PTSD) are the same disorder or represent separate disorders on a broader trauma spectrum (Frost et al., 2020; Lewis & Grenyer, 2009). BPD and Complex PTSD share several symptoms but differ in their presentation (Ford & Courtis, 2021). Because the two disorders present so similarly, it could be that clinicians have difficulty differentiating them, leading to misdiagnosis (Miller, 2014). This study examined clinicians’ diagnostic decision-making and stigma toward BPD and Complex PTSD. Participants (N = 426) completed an online survey where they diagnosed a written …

“Some Vague Utopia”: Searching For Urania, Moira L. Neve

Theses and Dissertations

Despite the global pendulum swing of gender trouble marked by the United States’ President’s declaration that there are only two sexes, activists have been rejecting assimilation (ie. defining equality as gay marriage or queer people in the military) within queer studies long before 2025. In the first half of the 20th century, a journal by the name of Urania (1916-1940), privately published and circulated to their home base in the United Kingdom and beyond, five editors (Esther Roper, Eva Gore-Booth, Jessey Wade, Dorothy Cornish, and Irene Clyde/Thomas Baty), challenged the gender binary and the resulting assumptions of heterosexual marriage. This …

(Art) Education In The Afterlife Of Massive Resistance: Constructing, Capturing, And Commodifying Racialized Disability In Virginia’S Student Assignment Practices, 1956-1966 And Present Day, Jenna E. Gabriel

Theses and Dissertations

This dissertation explores discursive functions of disability in pupil placement decisions in Massive Resistance Virginia, the relationship between disability and race that was constructed through these moves, and how these relationships surface in the reflections, perceptions, and pedagogy of a practicing art teacher, Nathan, who works at Arts High School (AHS), a Virginia specialty center high school. Under the umbrella of the Discourse Historical Approach, which relies on multiple, interdisciplinary data sources to explore how discourses evolve, I connect a robust archival analysis of historical data collected in the records of Virginia’s Pupil Placement Board (746 boxes, 1956-1966) with present-day …

Liner Notes On Black Trans Girlhood: Afrofuturist Affect & Black Popular Music As A Praxis Of Self-Fashioning, Shawn J. Williams

Theses and Dissertations

Liner Notes on Black Trans Girlhood: Afrofuturist Affect & Black Popular Music as a Praxis of Self-Fashioning interprets Black musical performance in identity-making, with a focus on how music and Black trans identity intersect and informs Black trans girlhood. As such, Black trans girls render ourselves legible, i.e. understood without shame or judgment, by constructing our identities through the music by Black women we listen and dance to, or watch and sing. These musical connections affirm the possibilities of Black femme expression. This expression of Black femininity is due to what I call an Afrofuturist affect, by which I refer …

Molecular Mechanisms Of Kynurenine-Mediated Lifespan Regulation In Yeast, Ryan E. Counterman Jobb

Theses and Dissertations

The kynurenine pathway is a highly conserved pathway that acts as the primary pathway for tryptophan catabolism and has been found to be involved in lifespan regulation across many diverse organisms. Caloric restriction (CR) is the only known dietary intervention to date that both increases the mean lifespan and the health span of multiple organisms, although the molecular mechanisms of these effects are not fully understood. There are known and sometimes contradictory relationships between the kynurenine pathway activity and the life- extending effect of CR but the crosstalk between the two is not well characterized. Understanding these relationships could lead …

Journal 2, Ryan Peschman

Mighty Pen Project Anthology & Archive

A stunningly kaleidoscopic narrative that asks, over and over, what it means to be alive.

Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in sharing their stories and experiences of military experience so both writer and audience may benefit. CONTENT WARNINGS: Animal death, Autopsy related gore, Child …

The Romanticization Of Human-Vampire Relationships: How 'Twilight' And 'The Vampire Diaries' May Prime Young Women To Accept Dating Violence, Natalie M. Bowen

UROP Posters

The first literary vampire can be traced back to 18th century Germany, with Johann Wolfgang von Goethe’s poem “Die Braut von Korinth,” but the stereotypical features of a vampire are traditionally accredited to Bram Stoker’s Dracula. Modern vampires, such as Edward Cullen and Stefan Salvatore of the Twilight and The Vampire Diaries series respectively, have managed to win the hearts of teenage girls all across America with their sex appeal and charismatic nature. According to Bandura’s Social Cognitive Theory, individuals learn new behaviors by modeling and imitating the actions of those around them. This comprehensive literature review investigates the connection …

Analysis Of Differential Gene Expression In Androgen-Independent Clones Derived From The Mycap Pca Cell Line, Jessie L. Tignor, Melanie Sinanian, Richard Inho Joh, David Gewirtz, Jason Reed

UROP Posters

Androgen deprivation therapy (ADT) is a primary treatment strategy for prostate cancer (PCa), yet many tumors eventually develop androgen independence, leading to treatment resistance. To investigate the molecular changes underlying this transition, we analyzed differential gene expression in four androgen-independent (AI) clones derived from the Myc-CaP prostate cancer cell line using RNA sequencing. Gene expression profiles were compared to the parental Myc-CaP line, and differentially expressed genes (DEGs) were identified using DESeq2 and edgeR. The AI clones exhibited significant downregulation of senescence-associated genes, including Ezh2 and lamin B1, suggesting a loss of senescence-related chromatin repression. Additionally, upregulation of Wnt pathway …

Attention's Loop: A Sculptor's Reverie On The Coexistence Of Substance And Spirit, Elizabeth King, Katherine Wetzel

Attention's Loop

This is a book about attention and memory. I am a sculptor, so it is also a book about size, dirt, artifice, work, and eye. The text is a set of stories and interruptions that pile up to make a play of overlapping loops. My organizing principle is the image of the round-trip, so one may open the book and step into it at any point. Most of Katherine Wetzel’s photographs are of a single sculpture. It is a self-portrait, a particular kind of round-trip, and it is small: one-half life-size. Called Pupil, it is jointed and movable, and …