Digital Commons Network^™

Emanata Presents: Mirage (2017)

Emanata, 2014-

Started by illustrator and comics artist Chris Kindred in 2014 with Weird, Vol. 1, Emanata is VCU’s first-ever comics anthology.

Drawings For Paintings In The Age Of Rembrandt, Saskia Beranek

Art Inquiries

No abstract provided.

Making Movie Money: A 25-Year Analysis Of Rappers' Acting Roles In Hollywood Movies, Tia Tyree

Journal of Hip Hop Studies

No abstract provided.

Addict Rap?: The Shift From Drug Distributor To Drug Consumer In Hip Hop, Calvinjohn Smiley

Journal of Hip Hop Studies

No abstract provided.

The Vulgar Voice On The New Black Realist Soundtrack: Sounds Of Resistance, Policing And Crime In Spike Lee's Clockers, James Millea

Journal of Hip Hop Studies

No abstract provided.

White Chicks With A Gangsta' Pitch: Gendered Whiteness In United States Rap Culture (1990-2017), Melvin L. Williams

Journal of Hip Hop Studies

No abstract provided.

Journal Of Hip Hop Studies

Journal of Hip Hop Studies

No abstract provided.

Walter De Maria: Meaningless Work, Amanda Dalla Villa Adams

Art Inquiries

Book review of Walter De Maria: Meaningless Work, by Jane McFadden.

Rabble: A Chapbook Companion To Pwa-Tem (2017)

Rabble, 2014-

Rabble is a companion chapbook publication to the magazine Pwatem. From the preface of most issues: "'Tell the rabble my name is Cabell."- James Branch Cabell to his editor, to help people learn how to pronounce his name. Cabell used the word derogatively but we are taking it back. These pages will showcase the writing and illustrations of our rabble-the ordinary students of VCU."

Belle Isle, Point Lookout, The Press And The Government: The Press And Reality Of Civil War Prison Camps, Marlea S. Donaho

Theses and Dissertations

The study of Civil War prisons is relatively new within the broader study of the Civil War. What little study there is tends to focus on bigger prison camps. It has been established in the historiography that prisoners suffered across the divided nation, but it has not been ascertained how the decisions and policies of the government, as well as the role of the press in those decisions, effected the daily lives of Civil War prisoners. Belle Isle, a Confederate Prison, and Point Lookout, a Union prison, will be analyzed for key differences to provide a fuller picture of life …

An Interview With Eloisa Guanlao, Karissa Bushman

Art Inquiries

No abstract provided.

Insecurities: Tracing Displacement And Shelter, Elizabeth Berkowitz

Art Inquiries

No abstract provided.

American Women Artists, 1935-1970: Gender, Culture, And Politics, Lucy Curzon

Art Inquiries

Book review of American Women Artists, 1935-1970: Gender, Culture, and Politics, edited by Helen Langa and Paula Wisotzki.

Arts: A Guide For Conservators, Curators, And The Curious, Kari Rayner

Art Inquiries

Book review of Arts: A Guide for Conservators, Curators, and the Curious, by Roy S. Berns.

Dispatches, Sunny Spillane

Art Inquiries

No abstract provided.

Cross Country: The Power Of Place In American Art, 1915-1950, Naomi Slipp

Art Inquiries

No abstract provided.

Emporium, John C. Orth

Theses and Dissertations

Abstract

EMPORIUM

By John Orth, BFA

A thesis submitted in partial fulfillment of the requirements for the

degree of Master of Fine Arts at Virginia Commonwealth University.

Virginia Commonwealth University, 2017.

Major Director: Michael Jones McKean, Associate Professor,

Sculpture + Extended Media

My MFA thesis project is a ten-minute video installation entitled Emporium, in which I adorn, strap, tie, hang, and wrap the bodies of performers with my sculptures, and then let loose these hybridized bodies in the non-linear dream-time of cinema. Riffing on the fantastical taxonomy of Jorge Luis Borges’s The Celestial Emporium of Benevolent Knowledge, I …

Comparisons Of Isogenic Trisomic And Disomic Cells From People With Mosaicism For Down Syndrome Unmask Cellular Differences Related To Trisomy 21, Kelly A. Rafferty

Theses and Dissertations

It is known that age-related changes impacting multiple organ systems occur earlier in people with Down syndrome (Ds), but the biological basis underlying this trisomy 21-associated propensity for premature aging is poorly understood. Given that the trisomic/normal cells from people with mosaic Ds (mDs) are identical with regards to environmental exposures and genes (except for chromosome 21 copy number), comparisons of these isogenic trisomic/disomic cells allow one to “unmask” the cellular consequences of trisomy 21 by removing extraneous factors. The primary aim of this study was to determine if trisomy 21 results in an increase in the acquisition of age-related …

The Moon Cuts Like Pye, But Not Cherry, Jacqueline Avery Collins

Theses and Dissertations

In our work we prefer asking questions to telling stories.

As a means to invigorate and cross-examine our current reality, our hystories, and our definitions of ‘self’ we peer through a disparate lens cultivating pockets: compartments longing to be filled, gaping holes between maybes, masked, and bound to their binding. We relate these pockets anatomically to that of the 
sublingual space or potential space. It is here, at the tip of digestion, where transmogrification ensues. This evolution manifests as a series of states of possible beings and territories through live scenario. Traversing the possibilities of potentiality: the intermediary that rejects …

Taf2: A Potential Oncogene For Hepatocellular Carcinoma, Saranya Chidambaranathan Reghupaty

Theses and Dissertations

Astrocyte Elevated Gene 1 (AEG1) is an oncogene for hepatocellular carcinoma (HCC). Its role in HCC pathogenesis has been well studied. A pan cancer analysis of gene expression in multiple databases identified TATA-box binding protein associated factor 2 (TAF2) as the gene that is most frequently co-expressed with AEG1. TAF2 is a protein that is involved in transcription of genes by RNA polymerase II. It is a factor that is dispensable for basal transcription but, required for activated transcription. It has also been shown to be involved in regulating cyclin levels and hence cell cycle progression. Bioinformatic analysis on data …

A Systems Biology Approach For Predicting Essential Genes And Deciphering Their Dynamics Under Stress In Streptococcus Sanguinis, Fadi El-Rami

Theses and Dissertations

Infectious diseases are the top leading cause of death worldwide. Identifying essential genes, genes indispensable for survival, has been proven indispensable in defining new therapeutic targets against pathogens, major elements of the minimal set genome to be harnessed in synthetic biology, and determinants of evolutionary relationships of phylogenetically distant species. Thus, essentiality studies promise valuable revenues that can decipher much of biological complexities.

Taking advantage of the available microbial sequences and the essentiality studies conducted in various microbial models, we proposed a framework for the prediction of essential genes based on our experimentally verified knowledge of the pathways involved in …

Structural And Functional Alterations In Neocortical Circuits After Mild Traumatic Brain Injury, Michal Vascak

Theses and Dissertations

National concern over traumatic brain injury (TBI) is growing rapidly. Recent focus is on mild TBI (mTBI), which is the most prevalent injury level in both civilian and military demographics. A preeminent sequelae of mTBI is cognitive network disruption. Advanced neuroimaging of mTBI victims supports this premise, revealing alterations in activation and structure-function of excitatory and inhibitory neuronal systems, which are essential for network processing. However, clinical neuroimaging cannot resolve the cellular and molecular substrates underlying such changes. Therefore, to understand the full scope of mTBI-induced alterations it is necessary to study cortical networks on the microscopic level, where neurons …

Health Aid In Africa: Placement, Service Utilization, And Benefit, Carrie Dolan

Theses and Dissertations

While the health sector has attracted significant foreign aid, evidence on the effectiveness of this support is mixed. This dissertation examines the allocation of health aid within the context of placement, service utilization, and benefit. The first paper examined the sub-national allocation of Chinese development aid projects across Africa. I determined how political preferencing of Chinese aid specifically, allocating aid to the birth region of the current political leader differs across sectors such as health, education, and transportation. I find some evidence that aid, more broadly defined, is subject to political preferencing in recipient countries, which could potentially limit its …

Internet-Based Behavior Of It Professionals: Implications For Online Ergonomic Education To Prevent Work-Related Musculoskeletal Disorders, Priyadarshini Pattath

Theses and Dissertations

INTERNET-BASED BEHAVIOR OF IT PROFESSIONALS: IMPLICATIONS FOR ONLINE ERGONOMIC EDUCATION TO PREVENT WORK-RELATED MUSCULOSKELETAL DISORDERS

By Priyadarshini Pattath, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University Virginia Commonwealth University, 2017 Director: Dr. Robin Hurst, Assistant Professor of Adult Learning, Teaching and Learning,

School of Education

The purpose of this study was to explore the preferences of medium of ergonomic education and views about self-directed online training modules to prevent musculoskeletal disorders in computer professionals and understand their perspectives and experiences about online health information seeking using a …

Characterization Of The Role Of Insulin-Like Growth Factor Binding Protein 7 (Igfbp7) Using A Genetic Knockout Mouse Model, Maaged A. Akiel

Theses and Dissertations

In the US, the incidence and mortality rates of hepatocellular carcinoma (HCC) are alarmingly increasing since no effective therapy is available for the advanced disease. Activation of IGF signaling is a major oncogenic event in diverse cancers, including HCC. Insulin-like growth factor binding protein-7 (IGFBP7) inhibits IGF signaling by binding to IGF-1 receptor (IGF-1R) and functions as a potential tumor suppressor for hepatocellular carcinoma (HCC). IGFBP7 abrogates tumors by inducing cancer-specific senescence and apoptosis and inhibiting angiogenesis. We now document that Igfbp7 knockout (Igfbp7-/- ) mouse shows constitutive activation of IGF signaling, presents with pro-inflammatory and immunosuppressive microenvironment, and develops …

Contribution Of A Class Ii Ribonucleotide Reductase To The Manganese Dependence Of Streptococcus Sanguinis, John L. Smith

Theses and Dissertations

Manganese-deficient Streptococcus sanguinis mutants exhibit a dramatic decrease in virulence for infective endocarditis and in aerobic growth in manganese-limited media. Loss of activity of a manganese-dependent, oxygen-dependent ribonucleotide reductase (RNR) could explain the decrease in virulence. When the genes encoding this RNR are deleted, there is no growth of the mutant in aerobic broth culture or in an animal model. Testing the contribution of the aerobic RNR to the phenotype of a manganese transporter mutant, a heterologous class II RNR from Lactobacillus leichmannii called NrdJ that requires B₁₂ rather than manganese as a cofactor was previously introduced into an …

The Development Of The Treatment Integrity - Efficient Scale For Cognitive Behavioral Treatment For Youth Anxiety (Ties-Cbt-Ya), Meghan Smith

Theses and Dissertations

Brief, easy to use, psychometrically strong (i.e., pragmatic) instruments are needed to support implementation research; the current study assessed whether it was possible to develop a pragmatic observational treatment integrity instrument and reduce the amount of time coders spend making treatment integrity ratings (while maintaining score validity) of therapists delivering two protocols of individual cognitive-behavioral treatment (ICBT) for youth anxiety in research and practice settings. The 12-item instrument was derived from four observational treatment integrity instruments with promising score reliability and validity that assess adherence, competence, differentiation, and alliance. A sample of 106 youths (M age = 10.12, SD …

Relb Acts As A Molecular Switch To Drive Chronic Inflammation In Glioblastoma Multiforme (Gbm)., Michael R. Waters

Theses and Dissertations

Inflammation is a homeostatic response to tissue injury or infection, which is normally short- lived and quickly resolves to limit tissue damage. In contrast, chronic inflammation has been linked to a variety of human diseases, including cancers such as glioblastoma multiforme (GBM). GBMs are very aggressive tumors with very low patient survival rates, which have not improved in several decades. GBM tumors are characterized by necrosis and profound inflammation; with cytokines secreted by both GBM cells and the tumor microenvironment. The mechanisms by which chronic inflammation develops and persists in GBM regardless of multiple anti-inflammatory feedback loops remain elusive. This …

Expression Of Matrix Metalloproteinases In Naegleria Fowleri And Their Role In Degradation Of The Extracellular Matrix, Charlton Lam

Theses and Dissertations

Naegleria fowleri is a free-living amoeba found in freshwater lakes and ponds that is the causative agent of Primary Amoebic Meningoencephalitis (PAM). Matrix metalloproteinases (MMPs) have been described in protozoa, such as Plasmodium falciparum, Trypanosoma brucei, and Balamuthia mandrillaris, and have been linked to their increased motility and invasive capability by degrading components of the extracellular matrix (ECM). In addition, MMPs are often upregulated in tumorigenic cells and have been attributed as responsible for the metastasis of certain cancers. In the present study, in vitro experiments indicated that MMPs are linked functionally to the ECM degradation process. …

The Anatomy Of Cbpr: A Case Study Of Cbpr Implementation For Health Promotion With The Peer Community, Cory R. Cummings

Theses and Dissertations

This case study is a qualitative examination of a health promotion project conducted in collaboration with members of the mental health peer community. More specifically, it explores the community based participatory research (CBPR) implementation process used to conduct this health promotion project to gain a deeper understanding of the mechanisms at work in the implementation process. While there has been considerable attention to the principles that guide CBPR (Braun et al., 2012; Israel et al., 2008; LaVeaux & Christopher, 2009), there remains important work to be done in bridging these principles to implementation; what processes or mechanisms translate these principles …