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Commonwealth Times 2008-09-11 [Front Page Has 2008-09-08] Sep 2008

Commonwealth Times 2008-09-11 [Front Page Has 2008-09-08]

Commonwealth Times, 1969-

No abstract provided.


Commonwealth Times 2008-09-08 Sep 2008

Commonwealth Times 2008-09-08

Commonwealth Times, 1969-

No abstract provided.


Commonwealth Times 2008-09-04 Sep 2008

Commonwealth Times 2008-09-04

Commonwealth Times, 1969-

No abstract provided.


Identification Of Pharmacological And Molecular Mechanisms Involved In Nicotine Withdrawal, Kia Jackson Sep 2008

Identification Of Pharmacological And Molecular Mechanisms Involved In Nicotine Withdrawal, Kia Jackson

Theses and Dissertations

Tobacco dependence is the leading cause of preventable death in the United States. Despite currently available smoking cessation therapies, there is a high rate of relapse in smoking among those attempting to quit. While the somatic signs of nicotine withdrawal (insomnia, increased appetite, weight gain) contribute to the continuation of smoking behavior, it has been hypothesized that the affective signs (depression, anxiety, craving, irritability) are greater motivators of relapse and continued tobacco use. There are few studies that assess the molecular and receptor-mediated mechanisms of nicotine withdrawal; therefore, our studies focus on identifying the nicotinic acetylcholine receptor (nAChR) subtypes and …


Analysis Of The Mechanism Of Transferrin-Iron Acquisition By Neisseria Gonorrhoeae, Noto Jennifer Mcmillan Sep 2008

Analysis Of The Mechanism Of Transferrin-Iron Acquisition By Neisseria Gonorrhoeae, Noto Jennifer Mcmillan

Theses and Dissertations

Neisseria gonorrhoeae is an obligate human pathogen that requires iron for its survival within the host. N. gonorrhoeae expresses high-affinity iron acquisition systems to acquire iron from host iron binding proteins. The gonococcal transferrin-iron uptake system is composed of two transferrin binding proteins, TbpA and TbpB. TbpA is a TonB-dependent, outer membrane transporter, while TbpB is a surface-exposed lipoprotein. Unlike TbpA, TbpB is not required for transferrin utilization, but makes the process more efficient. The precise mechanism by which TbpA and TbpB function to mediate transferrin-iron uptake has not been fully characterized. However, the mechanism of iron acquisition from transferrin …


The Scarab (2008-09) Sep 2008

The Scarab (2008-09)

The Scarab, 1952-2010

From the cover: "Official Organ of the Alumni Association of the Medical College of Virginia."


Shafer Court Connections (2008-09) Sep 2008

Shafer Court Connections (2008-09)

Shafer Court Connections, 1994-2010

For alumni of the Academic Campus of Virginia Commonwealth University.


Commonwealth Times 2008-08-28 Aug 2008

Commonwealth Times 2008-08-28

Commonwealth Times, 1969-

No abstract provided.


Developmental Aspects Of Diabetes Knowledge, Kari Morgan Aug 2008

Developmental Aspects Of Diabetes Knowledge, Kari Morgan

Theses and Dissertations

The Test of Diabetes Knowledge (TDK) was studied to determine its appropriateness for children. Early onset diabetes was examined for residual effects on poorer adolescent understanding of diabetes and problem solving that could affect self-care behaviors. Participant groups were created as children (<12) and adolescents (≥12). A second division created a group of adolescents with early onset disease (EOD < 12 years) and with late onset disease (LOD >12 years). Participants were predominantly Caucasian and from middle class families. 51% were boys with an average age of 12.95 years, disease duration of 4.35 years and onset age of 8.58 years. Children scored significantly lower and responded “I don’t know” significantly more often for all levels of knowledge when compared to adolescents. EOD and LOD group …


Program Approach For Childheaded Households In Zambia, Samson Chama Aug 2008

Program Approach For Childheaded Households In Zambia, Samson Chama

Theses and Dissertations

Using an emergent design, this study developed a program approach for young people in the child headed households of Zambia. Phase I dealt with prior ethnography, Phase II focused on independent living services, and Phase III concerned translation to Zambia. A total of 36 participants from Richmond, consisting of 20 Richmond Department of Social Services workers and youth and 16 Africans, were recruited. Three major themes emerged: feasibility, content, and quality. Lessons learned about translational research highlight the need for uniformity in a cultural screen’s composition. This might enhance the richness of perspectives on young people. Lessons for the Department …


[2008-08-21] August 21, 2008 A Regular Meeting Of The Board Of Visitors, Virginia Commonwealth University. Board Of Visitors Aug 2008

[2008-08-21] August 21, 2008 A Regular Meeting Of The Board Of Visitors, Virginia Commonwealth University. Board Of Visitors

VCU Board of Visitors Minutes

Official minutes of the VCU Board of Visitors and its Executive Committee.


Commonwealth Times 2008-08-21 Aug 2008

Commonwealth Times 2008-08-21

Commonwealth Times, 1969-

No abstract provided.


Using Simulation Optimization To Construct Efficient Screening Strategies For Cervical Cancer, Christodoulos Foufoulides Aug 2008

Using Simulation Optimization To Construct Efficient Screening Strategies For Cervical Cancer, Christodoulos Foufoulides

Theses and Dissertations

Cervical cancer is the second most common type of cancer in women worldwide. Because cervical cancer is usually asymptomatic until the disease is in its advanced stages, cervical screening is of central importance towards combating cervical cancer. Alternative screening strategies are evaluated from an economic point of view through cost-effectiveness analysis. In the literature however, studies perform cost-effectiveness analysis on a limited number of de facto or predetermined screening policies. At present, no attempt has been made to construct efficient screening strategies through optimization, before cost-effectiveness analysis is applied. In this study simulation optimization is used to construct efficient screening …


Identification Of Virulence Determinants For Streptococcus Sanguinis Infective Endocarditis, Lauren Turner Aug 2008

Identification Of Virulence Determinants For Streptococcus Sanguinis Infective Endocarditis, Lauren Turner

Theses and Dissertations

Streptococcus sanguinis is the second most common causative agent of bacterial infective endocarditis (IE). Risk of S. sanguinis IE is dependent on pre-disposing damage to the heart valve endothelium, which results in deposition of clotting factors for formation of a sterile thrombus (referred to as vegetation). Despite medical advances, high mortality and morbidity rates persist. Molecular characterization of S. sanguinis virulence determinants may enable development of prevention methods. In a previous screen for S. sanguinis virulence determinants by signature-tagged mutagenesis (STM) an attenuated mutant was identified with a transposon insertion in the nrdD gene, encoding an anaerobic ribonucleotide reductase. Evaluation …


Dropping Knowledge And Breaking Barriers: My First Year Teaching At John Marshall High School, Jeffrey Cole Aug 2008

Dropping Knowledge And Breaking Barriers: My First Year Teaching At John Marshall High School, Jeffrey Cole

Theses and Dissertations

The following thesis draws from my experiences during my first year teaching at an inner city public school, John Marshall High School, from September 2007 to June 2008. It details apprehensions, conflicts, adjustments and corrections, both in my instructional method and personal interaction with students. I seek to illustrate mistakes and insights any first-year teacher might experience, as well as synthesize my own impressions regarding my evolving teaching philosophy.


Fiber Bragg Grating (Fbg) Based Chemical Sensor, Gopakumar Sethuraman Aug 2008

Fiber Bragg Grating (Fbg) Based Chemical Sensor, Gopakumar Sethuraman

Theses and Dissertations

In this work, reagentless fiber optic-based chemical sensors for water quality testing were fabricated by coating fiber Bragg gratings with the glassy polymer cellulose acetate. With this polymeric matrix capable of localizing or concentrating chemical constituents within its structure, immersion of the coated grating in various chemical solutions causes the rigid polymer to expand and mechanically strain the glass fiber. The corresponding changes in the periodicity of the grating subsequently result in altered Bragg-reflected responses. A high-resolution tunable fiber ring laser interrogator is used to obtain room temperature reflectance spectrograms from two fiber gratings at 1550 nm and 1540 nm …


The Relationship Between Perceived Personal Risk Of Getting Prostate Cancer And Prostate-Specific Antigen (Psa) Screening, Yeatoe G. Mcintosh Aug 2008

The Relationship Between Perceived Personal Risk Of Getting Prostate Cancer And Prostate-Specific Antigen (Psa) Screening, Yeatoe G. Mcintosh

Theses and Dissertations

Abstract Title: The Relationship between Perceived Personal Risk of getting Prostate cancer and Prostate-Specific Antigen (PSA) Screening Yeatoe G. McIntosh, MPH Candidate Advisor: Emmanuel Anum, MBChB, MPH, PHD Preceptor: Emmanuel Anum, MBChB, MPH, PHD Background: Prostate cancer is one of the most common cancer diagnoses in the United States. The American Cancer Society estimates that in 2008 28,660 deaths would be attributed to prostate cancer, projecting it to be the leading cause of cancer deaths in U.S. men. Despite the potential threat this cancer presents to men and the potential for improved disease outcomes from early detection, guidelines for screening …


Male Survivors: Walking The Tightrope Of Masculinity, Luke Rogers Jul 2008

Male Survivors: Walking The Tightrope Of Masculinity, Luke Rogers

Theses and Dissertations

Sexual assault of men is a serious social problem and has drawn well deserved attention from many different researchers as well as the general public. Even though there is much concern and interest in this troubling crime, limited research has been conducted on the long-term effects of sexual abuse on male survivors. Using data collected by the Virginia Department of Health, this study investigated the effects of sexual abuse of men. Specifically, this inquiry examined specific emotional and physical conditions as potential consequences of sexual victimization among men and the extent to which those conditions vary between male victims and …


Modeling Pure Vasogenic Edema In The Rat Brain, Charles Nottingham Jul 2008

Modeling Pure Vasogenic Edema In The Rat Brain, Charles Nottingham

Theses and Dissertations

Targeted drug delivery to the brain is difficult to achieve using conventional techniques, largely due to the blood-brain barrier’s (BBB) impediment to drug diffusion into the brain parenchyma. In response, development of convection-enhanced delivery (CED) offers the ability to circumvent the BBB and target specific areas of the brain. Predictability of infusate movement in pathological brain states during CED will maximize the effectiveness of this treatment, and therefore modeling of infusate movement must be characterized. Previous work from our lab effectively modeled CED in rats using the middle carotid artery occlusion model of cytotoxic edema. However, previous models examined for …


Physiological And Molecular Characterization Of Genetic Competence In Streptococcus Sanguinis, Alejandro Rodriguez Jul 2008

Physiological And Molecular Characterization Of Genetic Competence In Streptococcus Sanguinis, Alejandro Rodriguez

Theses and Dissertations

The ability of bacteria to assimilate free DNA from the environment is known as competence. Though many studies have focused on competence regulation in Streptococcus pneumoniae and Streptococcus gordonii, Streptococcus sanguinis has yet to be examined. Physiological characterization of competence in S. sanguinis strain SK36 and its comC mutant, JFP41, led to the genome-wide transcriptional analysis of cells induced to competence via addition of competence-stimulating peptide (CSP). A total of 128 genes were induced at least 2-fold, 74 of which were classified as either “early” or “late” based on their induction patterns. Expression patterns were verified using qRT-PCR. This study …


Promotion Of Tumor Cell Death Through The Induction Of, Tuyen Nguyen Jul 2008

Promotion Of Tumor Cell Death Through The Induction Of, Tuyen Nguyen

Theses and Dissertations

Microtubule poisons have proven to be effective in the treatment of a variety of malignancies. Although taxol-based derivatives promote microtubule stabilization, there is continuing interest in compounds that, like colchicines, act as microtubule destabilizing agents. Previous work from this laboratory showed that the novel microtubule poison, JG- 03-14, was active against breast tumor cells, promoting autophagic cell death. In the current work, we studied the influence of JG-03-14 on p53 wild type HCT116 colon carcinoma cells. A crystal violet sensitivity assay indicated that JG-03-14 induced growth inhibition, with 75% suppression of growth evident at a concentration of 500 nM. Time …


Preventing Weight Gain In First Year College Students: An Internet-Based Intervention, Rachel Gow Jun 2008

Preventing Weight Gain In First Year College Students: An Internet-Based Intervention, Rachel Gow

Theses and Dissertations

The transition to college has been identified as a critical period for increases in overweight status. Overweight college students are at-risk of becoming obese adults, thus prevention efforts targeting college age individuals might be one key to reducing adult obesity rates. The current study developed and implemented an intensive, 6-session, internet intervention. This intervention was evaluated with first year college students assigned randomly to one of four treatment conditions: 1) no treatment, 2) 6-week weight and caloric feedback only, 3) 6-week internet intervention, and 4) 6-week combined feedback and internet intervention. As expected, the combined intervention group had lower BMI …


Applying Movement Success Models To Marian Apparition Movements, Rachel Bobbitt Jun 2008

Applying Movement Success Models To Marian Apparition Movements, Rachel Bobbitt

Theses and Dissertations

This research seeks to explore Marian apparition movements as applied to movement success models. Among the numerous reports of the Virgin Mary appearing to the faithful, a select number of these experiences have developed into social movements. These movements take on similar patterns in their development and are contingent upon group involvement and support. This analysis researches how certain cases of Marian apparitions transition from lone psychic experience into a social movement and seeks to expand upon existing movement success models.


The Response Of Hn4 Cells To Porphyromonas Gingivalis Dna, Cheyanne Warren Jun 2008

The Response Of Hn4 Cells To Porphyromonas Gingivalis Dna, Cheyanne Warren

Theses and Dissertations

Periodontal disease is one of the most common human diseases. Bacteria trigger the onset and progression of the disease and among them Porphyromonas gingivalis has been demonstrated to be a major etiologic agent. Although the interaction of the bacterium with the host is of major importance for the understanding of the disease mechanisms, both the host as well as the pathogen components involved in the interaction remain poorly understood. One of the bacterial components capable of eliciting a host response is unmethylated CpG DNA motifs found in bacteria. Thus, the first aim was to determine the response of oral epithelial …


Plumage Ornamentation As An Indicator Of Female Age And An Influence In Male Mate Choice In Protonotaria Citrea, The Prothonotary Warbler In Virginia., Terry Smith Jun 2008

Plumage Ornamentation As An Indicator Of Female Age And An Influence In Male Mate Choice In Protonotaria Citrea, The Prothonotary Warbler In Virginia., Terry Smith

Theses and Dissertations

Flamboyant plumage and ornamentation is common and well-known in male birds; it serves as a sexual display to attract potential mates. While flamboyant plumage is less common and usually more subtle in female birds, it does occur in some species such as Dark-Eyed Juncos (Junco hyemalis) and Prothonotary Warblers (Protonotaria citrea). Prothonotary Warblers display relatively subtle sexual dimorphism. This study examines variations in tail spot patterns in Prothonotary Warblers and relates those variations to age in females. Females with fewer than six spots tend to be two years old or younger; females with six spots or more tend to be …


Intravenous Administration Of Perfluorocarbon Emulsions As A Non-Recompression Therapy For Decompression Sickness, Cameron Smith Jun 2008

Intravenous Administration Of Perfluorocarbon Emulsions As A Non-Recompression Therapy For Decompression Sickness, Cameron Smith

Theses and Dissertations

Decompression sickness (DCS) results from a sudden decrease in ambient pressure leading to super-saturation of tissues with inert gas and subsequent bubble formation within both tissues and blood. Perfluorocarbons (PFC) are able to dissolve vast amounts of non-polar gases. The administration of intravenous (I.V.) PFC emulsions reduce both morbidity and mortality of DCS, but the mechanism of this protective effect has not yet been demonstrated. Juvenile Dorper cross sheep between 16 and 24 kg (n=31) were anaesthetized and instrumented for physiological monitoring, the administration of I.V. fluids and sampling of arterial and mixed venous blood. Animals were placed in a …


The Scarab (2008-06) Jun 2008

The Scarab (2008-06)

The Scarab, 1952-2010

From the cover: "Official Organ of the Alumni Association of the Medical College of Virginia."


[2008-05-16] May 16, 2008 A Regular Meeting Of The Board Of Visitors, Virginia Commonwealth University. Board Of Visitors May 2008

[2008-05-16] May 16, 2008 A Regular Meeting Of The Board Of Visitors, Virginia Commonwealth University. Board Of Visitors

VCU Board of Visitors Minutes

Official minutes of the VCU Board of Visitors and its Executive Committee.


Evolution Of Urban Design In Practice (Case Studies Of Chicago, Detroit And Cleveland Through Time), Sulabh Aryal May 2008

Evolution Of Urban Design In Practice (Case Studies Of Chicago, Detroit And Cleveland Through Time), Sulabh Aryal

Theses and Dissertations

Throughout the twentieth century various urban design theories came into light. These theories were sometimes original and sometimes derivative of some previous theory.These theories can be broadly categorized in different urban design models. The chronological study of different urban design theories gives us the theoretical and generic evolution of urban design. The practical evolution of urban design in any city can be different from the generic evolution of urban design. This thesis examines the urban design of three Midwestern American cities from their origins to the present day. The urban design of these cities, related to different time periods is …


Storming The Castle: Non-Secular Subversion Of The Pas D'Armes In The Castle Of Perseverance, John Moss May 2008

Storming The Castle: Non-Secular Subversion Of The Pas D'Armes In The Castle Of Perseverance, John Moss

Theses and Dissertations

It is important to remember that the categories of medieval performance were established far removed from their period in history. As a genre, the morality play includes a wide diversity of time, geography, content and performance styles. Such disparities have made it difficult to develop a comprehensive definition, without which comparisons between works cannot be consistent. As scholarship continues to explore these works in context of their performance, it becomes increasingly important to identify which performance styles best inform their production. In examining The Castle of Perseverance within the parameters of pas d’armes, new meanings can be drawn from its …