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Articles 8041 - 8070 of 14289
Full-Text Articles in Entire DC Network
Tolerance Intervals In Random-Effects Models, Kakotan Sanogo
Tolerance Intervals In Random-Effects Models, Kakotan Sanogo
Theses and Dissertations
In the pharmaceutical setting, it is often necessary to establish the shelf life of a drug product and sometimes suitable to assess the risk of product failure at the desired expiry period. The current statistical methodology use confidence intervals for the predicted mean to establish the expiry period and prediction intervals for a predicted new assay value or a tolerance interval for a proportion of the population for use in a risk assessment. A major concern is that most methodology treat a homogeneous subpopulation, say batch, either as a fixed effect and therefore uses a fixed-effects regression model (Graybill, 1976) …
Creation Of A Mouse With A Humanized Fpgs Gene Compatible With Normal Development, Linying Xie
Creation Of A Mouse With A Humanized Fpgs Gene Compatible With Normal Development, Linying Xie
Theses and Dissertations
Abstract: Folylpoly-γ-glutamate synthetase (FPGS) catalyzes the formation of polyglutamate forms of the reduced folates and antifolates such as methotrexate (MTX) and pemetrexed; this allows the retention of folates and antifolate cancer drugs inside the cell. The enzyme activity of FPGS is essential for cell proliferation and survival. The mouse fpgs gene contains two promoters spaced 10 kb apart which are activated in a tissue-specific manner. The upstream promoter (P1) and exons A1a and A1b are used in some differentiated tissues, mainly liver and kidney, whereas the downstream promoter (P2) and exon 1 are used in rapidly dividing cells. In contrast, …
3-D Analysis Of A Functional Reach Test In Subjects With Functional Ankle Instability, Sarah J. De La Motte
3-D Analysis Of A Functional Reach Test In Subjects With Functional Ankle Instability, Sarah J. De La Motte
Theses and Dissertations
CONTEXT: 3-D kinematics and kinetics of the lower extremity during the Star Excursion Balance Test (SEBT) have not been examined in FAI subjects. Additionally, the effects of Kinesio® tape use in subjects with functional ankle instability (FAI) during functional tasks is uninvestigated. OBJECTIVE: To determine if lower extremity kinematics and kinetics differed in FAI subjects using Kinesio® tape during maximal SEBT reach. SUBJECTS: Twenty subjects with FAI (Age=24.2±3.8yrs; Ht=169±11.6cm; Wt=69±12.4kg) and twenty uninjured subjects (Age=25.7±5.6yrs; Ht=170.1.4±8.8cm; Wt=69.9±10.5kg) with no history of ankle sprain. FAI was operationally defined as repeated episodes of ankle “giving way” and/or ankle “rolling over”, regardless of …
In Vitro Models For Inhaled Corticosteroid (Ics) Aerosols: A Study Of Their Biopharmaceutics And Pharmacology, Deepika Arora
In Vitro Models For Inhaled Corticosteroid (Ics) Aerosols: A Study Of Their Biopharmaceutics And Pharmacology, Deepika Arora
Theses and Dissertations
Lung cellular disposition and anti-inflammatory pharmacology of inhaled corticosteroids (ICSs) is complex, comprised of a cascade of aerosol deposition and dissolution, followed by cellular uptake for local pharmacological action. This project hypothesized that the kinetics of dissolution for certain ICS aerosols generated from inhaler products were kinetically rate-determined for their cellular uptake and local pharmacological action. A novel dissolution testing system was developed to determine the dissolution kinetics for the ICS aerosols. A total of 5 ICSs aerosols generated from 6 inhaler products were collected in 2.1-3.3 or 4.7-5.8 µm of aerodynamic diameters at 0.7-19.8 µg on filter membranes by …
The Expression And Function Of Phosphacan/Rptpβ In Adaptive Synaptogenesis After Traumatic Brain Injury, Janna Harris
The Expression And Function Of Phosphacan/Rptpβ In Adaptive Synaptogenesis After Traumatic Brain Injury, Janna Harris
Theses and Dissertations
Traumatic brain injury (TBI) affects 1.5 million Americans annually and is a major health concern. Increasing evidence suggests that the brain extracellular environment regulates plasticity and synaptic recovery following TBI. Here we have focused on phosphacan/RPTPβ, an alternatively spliced group of chondroitin sulfate proteoglycans which are prominent within the mature brain extracellular matrix (ECM). Previous studies show that phosphacan/RPTPβ influences neuronal migration, adhesion, neurite outgrowth, and morphogenesis. However, our understanding of how these important ECM components are involved in recovery from brain trauma remains unclear. In the present study, we used unilateral entorhinal cortex lesion (UEC), a model which induces …
[2008-11-20] November 20, 2008 A Regular Meeting Of The Board Of Visitors, Virginia Commonwealth University. Board Of Visitors
[2008-11-20] November 20, 2008 A Regular Meeting Of The Board Of Visitors, Virginia Commonwealth University. Board Of Visitors
VCU Board of Visitors Minutes
Official minutes of the VCU Board of Visitors and its Executive Committee.
Corrosion Damage Studies Through Microscopy And Stress Analysis, Ronak Patel
Corrosion Damage Studies Through Microscopy And Stress Analysis, Ronak Patel
Theses and Dissertations
Corrosion is the destructive result of chemical reaction between a metal or metal alloy and its environment. Airplanes, power generating plants, chemical process and manufacturing plants, concrete structure, and many others which widely uses aluminum alloy and stainless steel alloys are subjected to corrosion. The estimated cost of corrosion damage is in order of 3 to 5 percent of gross national product (GNP). Out of all forms of corrosion, pitting corrosion is most commonly observed in aluminum alloy 2024 and stainless steel type 316. There is a need to study the stress environment around the pits in order to predict …
Computer-Aided Trauma Decision Making Using Machine Learning And Signal Processing, Soo-Yeon Ji
Computer-Aided Trauma Decision Making Using Machine Learning And Signal Processing, Soo-Yeon Ji
Theses and Dissertations
Over the last 20 years, much work has focused on computer-aided clinical decision support systems due to a rapid increase in the need for management and processing of medical knowledge. Among all fields of medicine, trauma care has the highest need for proper information management due to the high prevalence of complex, life-threatening injuries. In particular, hemorrhage, which is encountered in most traumatic injuries, is a dominant factor in determining survival in both civilian and military settings. This complication can be better managed using a more in-depth analysis of patient information. Trauma physicians must make precise and rapid decisions, while …
Selective Non-Peptide Mu-Opioid Receptor Antagonist: Design, Synthesis And Biological Studies, Lindsey Aschenbach
Selective Non-Peptide Mu-Opioid Receptor Antagonist: Design, Synthesis And Biological Studies, Lindsey Aschenbach
Theses and Dissertations
There are currently many opioid agonists available for clinical use as analgesics. However, many of these opioid agonists have notorious side effects including respiratory depression and may lead to addiction and dependence. Problems associated with these opioid agonists are determined to come from their interactions with the mu-opioid receptor. Opioid antagonists, such as naltrexone, have shown to aid in the treatment of opioid addiction. Although naltrexone has high affinity to the mu-opioid receptor, it lacks selectivity. Novel selective mu-opioid receptor antagonists were designed based on the identification of important pharmacophore elements in several known mu-opioid receptor agonists and antagonists. These …
Discovery And Initial Characterizations Of Neurofascin 155 High And Neurofascin 155 Low, Anthony Pomicter
Discovery And Initial Characterizations Of Neurofascin 155 High And Neurofascin 155 Low, Anthony Pomicter
Theses and Dissertations
This thesis contains the findings from four years of research regarding an oligodendrocyte protein named neurofascin 155. The role of this protein in maintaining adhesion between the myelin sheath of oligodendrocytes and the axons of neurons has become well established in recent years and the research presented here has revealed that while western blots have previously shown one protein/band representing neurofascin 155, there are two proteins/bands. These two proteins have been named neurofascin 155 high and neurofascin 155 low due to their previous inclusion in the single band. The work leading up to their discovery, findings, and the relevance of …
Self-Determination Realized? Consumer Direction: A Case Study Of Virginia, Parthenia Dinora
Self-Determination Realized? Consumer Direction: A Case Study Of Virginia, Parthenia Dinora
Theses and Dissertations
Consumer direction, a model of long-term care service delivery where service recipients and their families/advocates have enhanced control and choice over the services that they receive, is a growing phenomenon in United States. As it becomes greater utilized, it is important to understand the model and study its impacts. This dissertation details the history of the consumer direction movement, describes the current landscape of consumer direction in the United States, and presents a comparison study of users of consumer-directed (CD) services in three of Virginia Home and Community Based Services (HCBS) Medicaid Waivers. Self-determination theory is provided as a theoretical …
Applications Of The Bivariate Gamma Distribution In Nutritional Epidemiology And Medical Physics, Jolene Barker
Applications Of The Bivariate Gamma Distribution In Nutritional Epidemiology And Medical Physics, Jolene Barker
Theses and Dissertations
In this thesis the utility of a bivariate gamma distribution is explored. In the field of nutritional epidemiology a nutrition density transformation is used to reduce collinearity. This phenomenon will be shown to result due to the independent variables following a bivariate gamma model. In the field of radiation oncology paired comparison of variances is often performed. The bivariate gamma model is also appropriate for fitting correlated variances. A method for simulating bivariate gamma random variables is presented. This method is used to generate data from several bivariate gamma models and the asymptotic properties of a test statistic, suggested for …
Variable Selection In Competing Risks Using The L1-Penalized Cox Model, Xiangrong Kong
Variable Selection In Competing Risks Using The L1-Penalized Cox Model, Xiangrong Kong
Theses and Dissertations
One situation in survival analysis is that the failure of an individual can happen because of one of multiple distinct causes. Survival data generated in this scenario are commonly referred to as competing risks data. One of the major tasks, when examining survival data, is to assess the dependence of survival time on explanatory variables. In competing risks, as with ordinary univariate survival data, there may be explanatory variables associated with the risks raised from the different causes being studied. The same variable might have different degrees of influence on the risks due to different causes. Given a set of …