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Articles 7711 - 7740 of 14289
Full-Text Articles in Entire DC Network
Seasons, Paula Golden
Seasons, Paula Golden
Theses and Dissertations
A sense of place and time has been the unconscious focus of my adult life. While living in Hawaii I often searched for ancient rock carving sites. These art forms have the ability to convey the mystery, magic and history of previous times. I use human figures, beads and various textiles with similarities to these petroglyphs as a powerful metaphor for my search to find a place that is home
The Genetic Epidemiology Of Purging Disorder, Anorexia Nervosa, And Obsessive Compulsive Personality Disorder, Sara Trace
Theses and Dissertations
Although a variety of factors influence the development of eating disorders, genetic factors contribute notably to their etiology. Understanding genetic factors associated with eating disorders is important, as they can influence how these disorders are recognized, researched, and treated. This dissertation included two studies addressing important questions within the fields of eating disorders and genetics; specifically, Study 1 addressed the prevalence and heritability of purging and purging disorder in a population-based sample of female twins from the United States; and Study 2 investigated the nature of the co-morbidity between anorexia nervosa and obsessive compulsive personality disorder in a population-based sample …
Dilute Sulfuric Acid Pretreatment Of Switchgrass In Microwave Reactor For Biofuel Conversion: An Investigation Of Yields, Kinetics,, Oscar Martin
Theses and Dissertations
Lignocellulosic materials provide a raw material source for biofuel conversion and offer several advantages over fossil fuels- usage of a renewable resource, reduced greenhouse emissions, a decreased dependence on foreign oil, and stimulation of the agricultural sector. However, a primary technological challenge in converting lignocellulosic biomass into fuel is overcoming the recalcitrance of its matrix to enzymatic hydrolysis. To overcome these problems for chemical processing, naturally occurring cellulose biomass must be pretreated before it can be further processed using enzymatic hydrolysis or bioconversion. The goal of this work was to develop a model that predicts the glucose yield (pretreatment and …
The Effectiveness Of Religiously Tailored Couple Counseling, Joshua Hook
The Effectiveness Of Religiously Tailored Couple Counseling, Joshua Hook
Theses and Dissertations
Large numbers of couples seek treatment from religious counselors who integrate religion and spirituality (R/S) into counseling. The present dissertation reviewed the literature examining the effectiveness of R/S counseling. Several R/S treatments were helpful in treating psychological problems. There was little evidence that R/S treatments outperformed secular treatments. In Study 1, a nationwide survey was conducted that examined the beliefs of Christian counselors about integrating R/S into couple counseling. Christian counselors (N = 630) completed measures of religious commitment, experience in couple counseling, attitudes toward using religious techniques in couple counseling, and the use of theory in couple counseling. Counselors …
A Study Of The Impact Of The Alternative Intervention Program On Improving Student Achievement, Attendance, And Discipline, Beverly Allen-Hardy
A Study Of The Impact Of The Alternative Intervention Program On Improving Student Achievement, Attendance, And Discipline, Beverly Allen-Hardy
Theses and Dissertations
This mixed methods study sought to examine student perceptions of the impact of an alternative intervention program (AIP), and provide a framework meant to inspire programs in other locations. Focusing on attendance, discipline, and academic achievement data, this study examined what factors motivate successful alternative education students to succeed upon their return to the comprehensive setting, and identify support factors that foster resiliency. Qualitative data were collected through three focus groups of students who were either new to the program, enrolled in the program for at least a nine-week period, and students who successfully completed a nine-week placement. Six adult …
Nonhomologous End-Joining: Tdp1-Mediated Processing, Atm-Mediated Signaling, Amy Hawkins
Nonhomologous End-Joining: Tdp1-Mediated Processing, Atm-Mediated Signaling, Amy Hawkins
Theses and Dissertations
This thesis investigates two separate features of nonhomologous end-joining (NHEJ) DNA repair: end processing, and DNA repair kinase signaling. DNA end processing was investigated in a mouse model of hereditary spinocerebellar ataxia with axonal neuropathy (SCAN1), a congenital neurodegenerative disease. SCAN1 is caused by a homozygous H493R mutation in the active site of tyrosyl-DNA phosphodiesterase (TDP1). To address how the H493R mutation elicits the specific pathologies of SCAN1 and to further elucidate the role of TDP1 in processing DNA end modifications, we generated a Tdp1 knockout mouse and characterized their behavior and specific repair deficiencies in extracts of embryonic fibroblasts …
[2009-11-12] November 12, 2009 Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors
[2009-11-12] November 12, 2009 Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors
VCU Board of Visitors Minutes
Official minutes of the VCU Board of Visitors and its Executive Committee.
[2009-11-12] Meeting Of The Academic And Health Affairs Policy Committee, Virginia Commonwealth University. Board Of Visitors
[2009-11-12] Meeting Of The Academic And Health Affairs Policy Committee, Virginia Commonwealth University. Board Of Visitors
VCU Board of Visitors Minutes
Official minutes of the VCU Board of Visitors and its Executive Committee.
[2009-11-11] Meeting Of The Finance, Investment And Property Committee, Virginia Commonwealth University. Board Of Visitors
[2009-11-11] Meeting Of The Finance, Investment And Property Committee, Virginia Commonwealth University. Board Of Visitors
VCU Board of Visitors Minutes
Official minutes of the VCU Board of Visitors and its Executive Committee.
[2009-11-11] Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors
[2009-11-11] Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors
VCU Board of Visitors Minutes
Official minutes of the VCU Board of Visitors and its Executive Committee.
Joint Mixed-Effects Models For Longitudinal Data Analysis: An Application For The Metabolic Syndrome, John Thorp Iii
Joint Mixed-Effects Models For Longitudinal Data Analysis: An Application For The Metabolic Syndrome, John Thorp Iii
Theses and Dissertations
Mixed-effects models are commonly used to model longitudinal data as they can appropriately account for within and between subject sources of variability. Univariate mixed effect modeling strategies are well developed for a single outcome (response) variable that may be continuous (e.g. Gaussian) or categorical (e.g. binary, Poisson) in nature. Only recently have extensions been discussed for jointly modeling multiple outcome variables measures longitudinally. Many diseases processes are a function of several factors that are correlated. For example, the metabolic syndrome, a constellation of cardiovascular risk factors associated with an increased risk of cardiovascular disease and type 2 diabetes, is often …
[2009-11-11] Meeting Of The External Relations Committee, Virginia Commonwealth University. Board Of Visitors
[2009-11-11] Meeting Of The External Relations Committee, Virginia Commonwealth University. Board Of Visitors
VCU Board of Visitors Minutes
Official minutes of the VCU Board of Visitors and its Executive Committee.
Denitration In Colonic Smooth Muscle, Seemab Malick
Denitration In Colonic Smooth Muscle, Seemab Malick
Theses and Dissertations
Tyrosine nitration results in altered function of smooth muscle voltage-gated L-type calcium channel. We explored the possibility that smooth muscle contains denitrase activity to allow functional recovery of the calcium channel without requiring synthesis of new channel proteins. Following peroxynitrite treatment of mouse colonic smooth muscle strips, CaCl2 (1 mM)-induced smooth muscle contraction was significantly reduced by 67% (P ≤ 0.05), which reversed by approximately 86% upon periodic washing within 2 hr period (P ≤ 0.001). The effect of the c-Src kinase inhibitor, PP2, on muscle contraction was also restored after 2 hr post-peroxynitrite treatment consistent with the thesis that …
Development Of Rapid Die Wear Test Method For Assessment Of Die Life And Performance In Stamping Of Advanced/Ultra High Strength Steel (A/Uhss) Sheet Materials, Omer Necati Cora
Development Of Rapid Die Wear Test Method For Assessment Of Die Life And Performance In Stamping Of Advanced/Ultra High Strength Steel (A/Uhss) Sheet Materials, Omer Necati Cora
Theses and Dissertations
Automotive companies are actively pursuing to increase the use of high-strength-lightweight alloys such as aluminum, magnesium, and advanced/ultra high-strength steels (A/UHSS) in body panel and structural part applications to achieve fuel efficiency while satisfying several environmental and safety concerns. A/UHSS sheet materials with higher strength and crashworthiness capabilities, in comparison to mild steel alloys, are considered as a near-term (i.e., ~5 years) choice of material for body and structural components due to their relatively low cost when compared with other lightweight materials such as aluminum and magnesium. However, A/UHSS materials present an increased level of die wear and springback in …
Age-Related Genetic And Epigenetic Chromosomal Changes: A Twin Study, Kimberly Jones
Age-Related Genetic And Epigenetic Chromosomal Changes: A Twin Study, Kimberly Jones
Theses and Dissertations
The primary aims of this study were to examine acquired genetic and epigenetic changes that occur in individuals with increasing age and to determine how these changes are influenced by genetic/environmental factors. Acquired genetic changes were assessed by determining the frequency and chromosomal contents of spontaneously occurring micronuclei in identical and fraternal twins. A total of 115 individuals (48 twin pairs and 19 singletons) were evaluated, ranging in age from 7 to 85 years. As expected, micronuclei frequencies, which are indicative of genomic damage, significantly increased with age (p<0.0001, r=0.446). The majority of micronuclei (32%) contained sex chromosomes and the frequency of sex chromosome-bearing micronuclei significantly increased with age (p<0.0001). The frequency of autosome-containing micronuclei was not significantly influenced by age or gender. However, some autosomes were seen more (chromosomes 4, 8, and 9) or less (chromosomes 17 and 22) frequently than expected by chance (p<0.05). An evaluation of the numerical contents of the sex chromosome-containing micronuclei and their corresponding binucleates showed that the majority of the binucleates had an abnormal chromosomal complement (either hypodiploid or hyperdiploid), with the subset of binucleates having a normal chromosomal complement decreasing with age for both the Y chromosome in males and the X chromosome in females. Model fitting, implemented in Mx, showed the variation in the frequency of micronuclei to be best explained by either additive genetic and unique environmental components, or common and unique environmental factors. Specific environmental exposures and health conditions that were shown to influence micronuclei frequencies, included: multivitamins, leafy green vegetables, fruit, vitamin E supplements, arthritis, heart disease, allergies, and alcohol. To assess acquired epigenetic changes, global methylation profiles of two identical twin pairs were compared and found to differ, indicating that individuals do develop alterations in their methylation profiles with age. Furthermore, the twin pair having a significant difference in their micronuclei frequencies and environmental exposures had more differences in their methylation pattern compared to the twin pair whose micronuclei frequencies and environmental factors did not differ. Overall, genetic and epigenetic changes were shown to occur with age and to be influenced by genetic and lifestyle factors.
Impact Of Statin Therapy On Outcomes In Aneurysmal Subarachnoid Hemorrhage Patients, Abdulkhaliq Alsalman
Impact Of Statin Therapy On Outcomes In Aneurysmal Subarachnoid Hemorrhage Patients, Abdulkhaliq Alsalman
Theses and Dissertations
There is conflicting data on the effects of statins on cerebral vasospasm and clinical outcomes in aneurysmal subarachnoid hemorrhage (aSAH) patients. In this retrospective cohort study, patients were divided into those who received pravastatin (PRAV group) 40mg/d and those who did not (NP group). Data were analyzed using multivariate logistic regression. Eighty-one patients met inclusion criteria. There was a statistically significant decreased in the incidence of vasospasm in the PRAV group; however, this association did not retain significance after adjusting for WFNS, race, elevated WBC, and clipping (59% PRAV vs. 88% NP, p=0.08). There was no statistically significant difference in …
Environmental And Organizational Factors Influencing Similarities And Differences Between Nonprofit Human Service Providers That Are Faith-Based And Those With No Religious Affiliation, Geraldine Lewis Meeks
Environmental And Organizational Factors Influencing Similarities And Differences Between Nonprofit Human Service Providers That Are Faith-Based And Those With No Religious Affiliation, Geraldine Lewis Meeks
Theses and Dissertations
The American social welfare system is a mixed system consisting of loosely coupled government programs, private nonprofit and for-profit organizations, grassroots and religious entities. Although religious entities historically played a key role in the development of the social welfare system, the faith-based initiative of President George W. Bush targeted religious service providers to receive government funding and take on a larger role in service delivery to at-risk populations based on the belief that these providers were substantially different from traditional providers. Using a cross-sectional research design and a survey instrument created for the study, data was collected from 121 nonprofit …
Development Of A Mechanical Cavopulmonary Assist Device For The Failing Fontan Patients, Jugal Kapadia
Development Of A Mechanical Cavopulmonary Assist Device For The Failing Fontan Patients, Jugal Kapadia
Theses and Dissertations
The long term objective of this research is to develop a collapsible, percutaneously inserted, axial flow blood pump to improve blood flow in the cavopulmonary circulation. Through this research, the experimental evaluation of five blood pump prototypes and hemolysis testing of one blood pump prototype were performed. All prototypes demonstrated acceptable hydraulic performance. A comparison of the experimental results with numerical predictions demonstrated a 10-20% deviation, an acceptable range per industry standard. Hemolysis testing of a four bladed adult blood pump showed plasma free hemoglobin level of 20.04 mg/dL and maximum NIH (normalized index of hemolysis) level was 0.017 g/100L. …
The Influence Of Parental Verbal Messages About Fighting And Nonviolent Responses On Adolescent Aggressive And Effective Nonviolent Behavior, Alison Kramer
Theses and Dissertations
Research suggests that adolescent health requires both reducing problem behavior and promoting the development of social competence. There is strong support for the influence of parenting practices on both aggressive and competent behavior. However, there has been little research to date focused on parental messages, or the verbal communication parents provide to their children, about aggressive and effective nonviolent responses to conflict. The present study used hierarchical regression to examine parental messages supporting fighting and parental messages supporting effective nonviolent responses to problem situations in relation to adolescent aggressive and effective nonviolent behavior. These relations were expected to be moderated …