Digital Commons Network^™

Identification Of Prognostic Factors For Disease Recurrence-Free Survival (Drfs) In Breast Cancer Patients Using The Cox Proportional Hazards Model, Dwi Cahyaning Putri, Veny Prabaningrum, Samsul Arifin

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Breast cancer remains one of the most common malignancies among women worldwide, with recurrence remaining a major clinical challenge. Despite various treatment efforts, the mortality rate from breast cancer remains high, particularly among patients with worse clinical and molecular conditions. This study aims to identify factors influencing the survival of breast cancer patients using the Cox proportional hazards model. The study analyzes clinical and molecular data of breast cancer patients to identify key risk factors affecting Disease Recurrence-Free Survival (DRFS). Analysis was conducted using Kaplan-Meier, the Log Rank test, and the Cox proportional hazards model. The results showed that nodal …

Norman Wang V. University Of Pittsburgh

2026 Decisions

USDC for the Western District of Pennsylvania

Usa V. Comprehensive Healthcare Management Services Llc

2026 Decisions

USDC for the Western District of Pennsylvania

Fecal Fatty Acids And Other Risk Factors Associated With Multiple Sclerosis Score, Progression And Diagnosis Among Hispanic Adults, Juliana Ayala-Viqueira

Walden Dissertations and Doctoral Studies

Multiple sclerosis (MS) is a chronic neurological condition with insufficient research regarding risk factors influencing MS severity score (MSSS), progression and diagnosis among Hispanic adults living in the United States. This cross-sectional study assessed factors associated with MS score, progression and diagnosis using secondary data from the International Multiple Sclerosis Microbiome Study (iMSMS). Guided by the ecological model, the study included N = 576 participants with MS. Manuscript 1 explored the association between body mass index (BMI), sodium consumption, and the MS severity score in a Hispanic adult population. A multiple linear regression was conducted to examine whether age and …

Examining Inmate Labor In Emergency Management: Contributions, Challenges, And Ethical Considerations, Boris Eugene Valiance

Walden Dissertations and Doctoral Studies

Incarcerated individuals remain inconsistently engaged in disaster preparedness, response, and recovery, creating both an operational gap and an ethical challenge regarding labor equity, safety, voluntariness, and human dignity. Guided by RBT and EMT, the purpose of this qualitative case study was to explore how incarcerated individuals are utilized in emergency management and to examine stakeholder perceptions of the operational, ethical, and policy implications of inmate labor programs. The research questions examined current utilization patterns, stakeholder-perceived benefits and drawbacks, and ethical concerns influencing participation decisions. Data were collected through semi structured interviews with purposefully sampled emergency management professionals, policymakers, and correctional …

The Stigma Experiences Of The African American Transgender Individual In Mental Health Settings, Linda Shaw Henley

Walden Dissertations and Doctoral Studies

The intersection of race, gender identity, and systemic marginalization has profound implications for mental health outcomes, particularly among African American transgender individuals. Addressing African American transgender individuals’ stigma experiences in mental health settings is important because transgender individuals have dual minority statuses, wherein racism, stigma, transphobia, and institutional neglect converge, significantly impacting their access to affirming and effective mental health treatment. The purpose of this study was to explore the stigma experiences of the African American transgender individual in mental health settings. The phenomenon of interest in this study was stigma experiences in mental health settings with mental health providers. …

Cytoskeletal Protein Expression In Autism Spectrum Disorder: A Psychoneuroimmunological Perspective On Sars-Cov-2, James Birch

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic heightened concerns about health disparities among individuals with autism spectrum disorder (ASD). Limited understanding of the biological factors underlying health variability may hinder efforts to reduce disparities and improve care for neurodivergent populations. Guided by the psychoneuroimmunology framework, this quantitative study investigated whether cytoskeletal gene expression was associated with neuroimmune variability in ASD and SARS-CoV-2 populations. Three genes –Nck-associated protein 1 (NCKAP1), WAS/WASL-interacting protein family member 1 (WIPF1), and actin-related protein 2/3 complex subunit 1B (ARPC1B)—were evaluated using two publicly available Gene Expression Omnibus datasets GSE212645 (ASD vs. sibling-matched controls, N = 40) and GSE152641 (SARS-CoV-2-positive vs. …

Fostering Active Learning In Reproductive Health Classes Among Undergraduates Of A Nigerian Public University: The Role Of Cognitive Restructuring Health Education, Ndubuisi Friday Ugwu, Adewumi Segun Igbinlade, Adijat Bolanle Adams, Uchenna Anselm Anibueze, Gabriel Aderibigbe Oyegbami, Chinyere Chrysantus Onwurah, Sabina Nwakaego Igwilo, Olufemi M. Olubamise, Folasade Adediran, Oladipo Adeyeye Olubodun Phd, Jacob Kehinde Opele, Loveth Nnenna Ugwu, Amos Olorunwa Agbojo

Higher Learning Research Communications

Objective: This study examined the efficacy of the cognitive restructuring health education (CRHE) intervention in improving participatory learning in sexual and reproductive health classes among students at a Nigerian public university.

Methods: The study employed a randomized pretest/posttest control group design involving 130 undergraduates from Federal University Oye-Ekiti, Nigeria. Participants were randomly assigned to either a 2-week intensive health education–based cognitive restructuring program (n = 65) or a waitlist control group (n = 65). Interaction behavior was assessed at pretreatment, at post-treatment, and at a 6-week follow-up using the 14-item Interaction Behavior Checklist (reliability = 0.85). …

Playing For The Planet: Gamified Learning And Global Health Education, Michael Dillon, Laura Bowater

Peninsula Medical School

Dr Michael J Dillon and Professor Laura Bowater emphasise the significance of gamification in global health education amidst increasingly complex challenges

Longitudinal Genomic Surveillance Of Sars-Cov-2 In A University Microcosm Reflects Global Evolutionary Trends, Sankar Prasad Chaki, Melissa M Kahl-Mcdonagh, Benjamin W Neuman, Loni A Taylor, Rebecca S B Fischer, Blake M Hanson, Marlisa S Hardy, Jo Ann Culpepper, Eric Boerwinkle, Kurt A Zuelke

Faculty, Staff and Student Publications

SARS-CoV-2 transmission has declined, yet ongoing viral evolution continues to pose public health challenges. This study conducted long-term (2020-2024) genomic surveillance within a large and globally diverse university community. Viral genomes obtained from clinical (n = 1,786) and surveillance (n = 888) testing samples were classified under clade, lineage, and variant systems, and compared with global genomic data sets. Local patterns broadly paralleled global evolutionary trends, including the phased emergence of major variants, episodic introductions of new lineages, and shifts in dominant clades. Lineage diversity peaked during fall semesters and was highest among undergraduate-aged individuals, with similar distributions …

Early Identification Of Skin Breakdown In The Medical-Surgical Setting, Brandi S. Paul, Kathryn Justice, Nic Money

Group: Samford University Moffett & Sanders School of Nursing

Hospital-acquired pressure injuries (HAPIs) remain a significant patient safety concern in acute care settings. The purpose of this Doctor of Nursing Practice (DNP) project was to reduce HAPI rates through a multidisciplinary intervention focused on the early identification of high-risk patients and improved adherence to pressure injury prevention practices.

Guided by the Iowa Model of Evidence-Based Practice, this quality improvement project was implemented over eight weeks on one medical-surgical unit at two southeastern U.S. hospitals. Adult patients with Braden scores ≤14 were identified as high risk. Nurses initiated the Pink Paper Initiative (PPI), which included visual bedside reminders, multidisciplinary checklists, …

Implementation Of A Follow-Up Call To Improve Glp-1 Medication Compliance, Hanna Weitzman-Flanigan

DNP and Student Works

Background: Obesity is a major driver of healthcare spending in the United States. GLP-1 receptor agonists are effective for weight management; however, high rates of early discontinuation reduce both clinical and economic value.

Methods: A pre–post quality improvement project implemented a nurse-led follow-up call at four weeks.

Results: Adherence improved significantly (p=0.009), weight decreased by 10 pounds (p=0.023), and estimated annual savings per patient were $6,472, contingent on sustained long-term adherence. Total estimated project savings were $80,141.

Conclusion: Nurse-led follow-up calls are a high-value intervention supporting economic sustainability.

Biophysical Insights Into A Cryptic Ligand Site In The Hydrophobic Core Of Human Pcna, Alexis N. Dispensa, Sharon N, Greenwood, Jason Yang, Daniel E. Logatto, James Fusco, E. Railey White, Roderic G. Eckenhoff, Zhiwei Liu, Brian P. Weiser

Department of Anesthesiology Faculty Papers

Proteins contain small pockets that form due to imperfections in residue packing or the rotational and conformational movement of amino acids. In this work, we used the fluorescent probe 1-aminoanthracene (AMA) to detect a small ligand pocket in the hydrophobic core of human proliferating cell nuclear antigen (PCNA), which is a critical protein for DNA replication and repair. Fluorescence measurements of AMA reported that the core of PCNA had a dielectric constant (ε) of 4, which was very apolar and similar to cyclohexane (ε = 2). Protein mutagenesis, photoaffinity labeling, and molecular dynamics simulations localized the binding site for AMA …

From The President

DePaul Magazine

DePaul University President Robert L. Manuel shares how community engagement is central to the university's mission to advance the common good and strengthen the communities the university serves through innovative programs.

Full Issue: Summer 2026

DePaul Magazine

In DePaul Magazine's summer 2026 issue, learn how DePaul is living its Vincentian mission through innovative community engagement and service learning, exemplified by its Irwin W. Steans Center and Speech Language Pathology and Occupational Therapy graduate programs. Also, meet alumna Kate Steinberg who revisits her youth and DePaul days as a rising social media influencer, get the latest news from DePaul's 10 colleges and schools, and much more.

Campaign Corner

DePaul Magazine

Learn more about DePaul's ambitious Mission: Forward philanthropic campaign, including its collaborative leadership structure, two landmark gifts benefiting the university's Catholic mission and School of Music, and an imminent, state-of-the-art basketball practice facility.

Prenatal Predictors Of Fetal And Neonatal Death In Truncus Arteriosus: A Fetal Heart Society Research Collaborative Study., Kelly Cox, Nazia Husain, Deidra Ansah, Tiffany Knight, Alexandra Channing, Bettina Cuneo, Preeta Dhanantwari, Mary Donofrio, Miwa Geiger, Lisa Howley, Lisa K. Hornberger, Simone Javeri, Edward G. Jones, Michelle Kaplinski, Ann Kavanaugh-Mchugh, Maria Kiaffas, Katherine Kosiv, Christina Laternser, Olivia Low, Anita J. Moon-Grady, Shabnam Peyvandi, Nelangi Pinto, Avaliese Porlier, Aaron Prosnitz, Rashmi Rao, David Schidlow, Elena Sinkovskaya, Ranjini Srinivasan, Corey Stiver, Emilio Quezada, Bhawna Arya, Sheetal Patel

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Fetal and neonatal outcomes and factors increasing mortality risk in fetal truncus arteriosus are not well characterized. We aimed to examine the prenatally encountered cardiac spectrum, define extracardiac and genetic associations, explore clinical outcomes and identify prenatal factors associated with worse outcomes in a contemporary large cohort.

METHODS: A multicenter retrospective cohort study was conducted via the Fetal Heart Society Research Collaborative including fetal truncus arteriosus cases encountered between January 1, 2010, and September 1, 2021, within 22 North American cardiac centers. Demographic, clinical, anatomic, and functional fetal echocardiographic variables were analyzed for associations with presurgical death (fetal death/neonatal …

Project Renewal, Inc. V. Blake

All Decisions

In this licensee holdover involving an OMH-regulated supportive housing community residence, landlord served a Notice to Quit based on tenant's discharge from the program, then subsequently executed a new Occupancy Fee Agreement with tenant. The court dismissed because landlord's execution of a new agreement after service of the predicate notice vitiated the Notice to Quit, rendering it a nullity. A landlord who renews an occupancy agreement after service of a termination notice cannot thereafter rely upon the prior notice as the basis for a summary proceeding.

Women Refugees & Immigrants: What Utahns Need To Know, Susan R. Madsen, Deborah Lin

Marketing and Strategy Faculty Publications

Refugee and immigrant women are an integral part of Utah’s communities, contributing as neighbors, workers, entrepreneurs, caregivers, and advocates. They enrich our state through their diverse perspectives, experiences, and talents. Utah has a long tradition of welcoming newcomers, and our communities are stronger when everyone has the opportunity to belong and contribute. At the same time, research shows that many of the challenges facing Utah women and girls disproportionately affect refugee and immigrant women. Understanding the experiences, needs, and contributions of these women is essential to fostering welcoming, supportive communities so that all Utah women and girls can thrive.

Tips For Growing Garden Vegetables In Utah: Soil Fertilization, Gastone Makalaya, Josh Martin, Milena Oliveira

All Current Publications

A successful vegetable garden requires precise nutrient management to achieve maximum yields. Fertilization must provide adequate nutrients to support plant growth throughout the season. Fertilizer applications should be based on soil test recommendations and crop nutrient requirements. This fact sheet provides Utah gardeners with practical guidance and tips on soil fertilization for vegetable gardening.

An Early Lexical Screening Tool For British English: Psychometric Properties And Clinical Utility, Allegra Cattani, Dora Bianchi, Caroline Floccia

School of Psychology

BackgroundExisting direct measures of vocabulary for ages 2–3 years are insufficient as vocabulary increases to include nouns, verbs, adjectives and adverbs, reflecting qualitative changes that support emerging grammatical abilities.AimsThe present study aims to establish the psychometric properties and validate a lexical screening tool for 19–36-month-old British English-speaking children, the WinG (Words in Game) test. Specifically, it examines gender differences in internal consistency, concurrent validity and predictive gender invariance across comprehension and production tasks. In addition, the study evaluates the diagnostic accuracy of the tool by establishing clinical cut-off scores to distinguish children with typical versus at-risk language development. Finally, it …

Pneumococcal Colonization In Pediatric Patients Undergoing Hematopoietic Cell Transplantation, Liset Olarte, Jennifer E Schuster, Ibrahim Ahmed, Kristina G Hulten

Faculty, Staff and Students Publications

Despite the increased risk of invasive pneumococcal disease among pediatric hematopoietic cell transplant (HCT) recipients, pneumococcal colonization has not been evaluated in this population. We prospectively assessed longitudinal pneumococcal colonization in 22 pediatric HCT recipients from conditioning therapy to 100 days post-HCT. A higher likelihood of pneumococcal colonization was observed in the late post-HCT period (weeks 9-14) compared with the early post-HCT period (weeks 1-8), with odds increasing with each additional week after conditioning.IMPORTANCEThis is the first study to longitudinally evaluate pneumococcal colonization in pediatric hematopoietic cell transplant (HCT) recipients from the onset of conditioning therapy to 100 days post-HCT. …

Tau Pathology In Epilepsy: Emerging Mechanisms And Translational Opportunities, Arjune Sen, Xin You Tai, Aristea Galanopoulou, Maria Thom, Eleonora Aronica, Lucy Vivash, Martin Hardmeier, Action Amos, Stephan Rueegg, Matthias Koepp, Yaroslav Winter, Christoph Helmstaedter, Jeffrey L Noebels, Hilal A Lashuel, Terence J O'Brien

Faculty, Staff and Students Publications

The onset of epilepsy in adulthood occurs most commonly after 55 years of age. Given the ageing global population, this disorder represents an increasing burden on healthcare and society. The bidirectional link between epilepsy and dementia is a focus of intense research with underlying tau pathology highlighted as a potential mechanistic link. In this review, we examine the evidence for tau-related neurodegenerative processes in epilepsy beginning with how changes in biochemical and structural properties of the tau protein can lead to abnormal phosphorylation and pathological aggregation. We consider the role of tau in seizure occurrence and cognitive difficulties in experimental …

Tree Layer Composition And Regeneration Status Of Quercus Floribunda Lindl. On Different Aspects Of Nainital Catchment In Kumaun Himalaya, Ambica Agnihotri, Ashish Tewari, Shahbaz Ali

Journal of Environmental Science and Sustainable Development

Oaks are climax-forming species found at various elevations in the Himalayas between 2100– 2700 masl. However, aspect-wise regeneration patterns of Quercus floribunda in the Nainital catchment remain poorly documented. While previous studies focused on oak forest structure, the present study provides new insight into aspect-wise variation in the regeneration stages of Q. floribunda in relation to microclimatic conditions. The present study aims to evaluate tree composition and the regeneration status of Q. floribunda forests across different slope aspects in the Nainital catchment area of the Kumaun Himalaya. Four sites representing different slope aspects were selected in the Nainital catchment. Soil …

Association Between Trainee Involvement During Pediatric And Congenital Cardiac Catheterization And Procedural Outcomes., Natalie Jayaram, John A. Spertus, Kevin F. Kennedy, Andrew C. Glatz

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Participation in the cardiac catheterization laboratory is a requirement of cardiology fellowship training. We sought to determine whether trainee presence is associated with outcomes during pediatric and congenital cardiac catheterization.

METHODS: We identified catheterizations between January 2011 and September 2020 within the IMPACT (Improving Pediatric and Adult Congenital Treatment) Registry. Multivariable multilevel regression was used to determine the association between trainee presence and procedural outcomes.

RESULTS: Of 122 760 catheterizations at 107 academic hospitals, a trainee was present in 71 651 (58.4%) cases. Rates of major adverse events were similar between trainee and nontrainee cases (9.0% versus 8.0%). Contrast …

Pneumococcal Colonization In Pediatric Patients Undergoing Hematopoietic Cell Transplantation., Liset Olarte, Jennifer E. Schuster, Ibrahim Ahmed, Kristina G. Hulten

Manuscripts, Articles, Book Chapters and Other Papers

Despite the increased risk of invasive pneumococcal disease among pediatric hematopoietic cell transplant (HCT) recipients, pneumococcal colonization has not been evaluated in this population. We prospectively assessed longitudinal pneumococcal colonization in 22 pediatric HCT recipients from conditioning therapy to 100 days post-HCT. A higher likelihood of pneumococcal colonization was observed in the late post-HCT period (weeks 9-14) compared with the early post-HCT period (weeks 1-8), with odds increasing with each additional week after conditioning.IMPORTANCEThis is the first study to longitudinally evaluate pneumococcal colonization in pediatric hematopoietic cell transplant (HCT) recipients from the onset of conditioning therapy to 100 days post-HCT. …

Al Kuwait Hospital Dubai, Emirates Health Services 1st Research Week 2025: Research Abstracts Of Clinical And Scientific Advances, Suad Hannawi, Linda Saf Eldin, Alaa Abuquta, Yusra Abdulrahman, Maryam Yaslam, Sabaa Saleh Al-Hemyari, Maimouneh Qazi, Noor Majed Al Mheiri, Ahmed Alamadi, Alia Aljasmi, Sondos Al Salmi, Maria Al-Salmi, Moza Aljamri, Ahmed Ibrahim Abdulrahman, Sharifa Alamadi, Haifa Hannawi

Saudi Medical Journal

No abstract provided.

The Outcome Of Thrombectomy Can Be Improved By Shortening The Door-To-Needle And The Onset-To-Door Time, Sounira Mehri, Josef Finsterer

Saudi Medical Journal

No abstract provided.

Provider-Reported Readiness Of Chronic Healthcare Services In Saudi Arabia Under The Health Sector Transformation Program, Aseel Aldhwaihi, Saad Alghanim

Saudi Medical Journal

Objective: To assess provider-reported readiness of chronic healthcare services in Saudi Arabia within the context of the Health Sector Transformation Program (HSTP), using a validated, context-specific assessment instrument. Methods: A national cross-sectional survey was conducted between November 2024 and February 2025 among 254 healthcare providers across 5 health regions and both public and private healthcare sectors. A 34-item instrument, informed by the Chronic Care Model (CCM) and adapted to the Saudi context, assessed 7 system readiness dimensions. Descriptive statistics, independent-samples t-tests, one-way analysis of variance, and Pearson correlation analyses were performed. Results: Overall system readiness was moderately positive. Health system …

Seasonal Variation Of Diabetic Ketoacidosis Among Children And Adolescents With Type 1 Diabetes: A Single-Center Tertiary Experience, Nour Gazzaz, Fajr A Saeedi

Saudi Medical Journal

Objectives: Diabetic ketoacidosis (DKA) seasonal variations among children and adolescents with type 1 diabetes mellitus (T1DM) have been widely studied; however, findings remain inconsistent. Although several studies reported a higher incidence during colder months, others showed no consistent patterns. This study investigated whether DKA frequency and severity vary across seasons, particularly in humid cities. Methods: This retrospective cohort analyzed children and adolescents with T1DM admitted to a tertiary hospital with DKA (2015–2025). Data included demographics, seasonal admission trends, clinical severity, and outcomes. Statistical analyses involved the Chi-square and ANOVA tests. Results: A total of 369 DKA cases …