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Articles 6961 - 6990 of 14292
Full-Text Articles in Entire DC Network
Identity And Psychological Needs Among National Guard Service Members And Undergraduates, Bradley Antonides
Identity And Psychological Needs Among National Guard Service Members And Undergraduates, Bradley Antonides
Theses and Dissertations
This study measured identity style and identity status within military and academic populations (N = 286) to investigate whether low levels of identity commitment predict dissatisfaction in meeting basic psychological needs. Analysis of identity style and identity status subscales examined the reliability of traditional measures of identity in an atypical emerging adult population. Group comparisons based on participant characteristics (identity commitment, work experience, age, combat experience) explored differences between and within institutions. Results supported the reliability of traditional identity measures in a non-traditional population. A diffuse identity status and diffuse identity style both significantly predicted lower reported levels of psychological …
Characterization Of Hpk2-Rrp2, Two-Component Regulatory System In Treponema Denticola, Sarkar Juni
Characterization Of Hpk2-Rrp2, Two-Component Regulatory System In Treponema Denticola, Sarkar Juni
Theses and Dissertations
Treponema denticola levels in the gingival crevice become elevated as periodontal disease develops. Oral treponemes may account for as much as 40% of the total bacterial population in the periodontal pocket. The stimuli that trigger enhanced growth of T. denticola and the mechanisms associated with the transmission of these signals remain to be defined. A hypothesis was set that the T. denticola ORFs tde1970 (histidine kinase) and tde1969 (response regulator) constitute a functional two component regulatory system that regulates, at least in part, responses to the changing environmental conditions associated with the development of periodontal disease. The results presented demonstrate …
Developmental Remodeling Of Relay Cells In The Dorsal Lateral Geniculate Nucleus (Dlgn) Of The Mouse And The Role Of Retinal Innervation, Rana El-Danaf
Theses and Dissertations
The dorsal lateral geniculate nucleus (dLGN) has become an important model for studying many aspects of visual system development. To date, studies have focused on the development of retinal projections and the role of activity in shaping the pattern of synaptic connections made with thalamocortical relay cells. By contrast, little is known about relay cells and the factors that regulate the growth and establishment of their dendritic architecture. In many systems, such growth seems consistent with the synaptotrophic hypothesis which states that synapse formation and dendritic growth work in a concerted fashion such that afferent input and the establishment of …
Gene Expression In The Right Ventricle During Development Of Pulmonary Hypertension, Jennifer Drake
Gene Expression In The Right Ventricle During Development Of Pulmonary Hypertension, Jennifer Drake
Theses and Dissertations
Pulmonary arterial hypertension (PAH) is a disease of the lung vessels that causes severe effects on the right ventricle of the heart; ultimately, most patients with severe PAH die as a result of right heart failure. However, little is known about the causes of right heart failure. Here, we describe a pattern of gene expression that differs between the normal rat left ventricle (LV) and right ventricle (RV). These genes are known to be involved in the development of the heart as well as adaptations to the heart during stress. This gene expression pattern is used as a baseline to …
A Quantitative Method For Reproducible Ionization Chamber Alignment To A Water Surface For External Beam Radiation Therapy Depth Dose Measurements, James Ververs
Theses and Dissertations
Ionization chambers (ICs) are the most commonly used detectors for radiation therapy dose measurements. Typical IC measurements use cylindrical ICs in a water phantom and therefore require initial IC alignment to the water surface. This alignment has long been ignored and only recently has a qualitative governing recommendation been made. This thesis describes a reproducible methodology for quantitative ionization chamber water surface alignment. Depth-ionization measurements are taken with twenty-eight IC designs under varying conditions including, but not limited to, changes in scan direction, speed, and resolution, radiation beam type, field size, energy, and electron contamination. Measurements are acquired using standard …
[2011-08-25] Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors
[2011-08-25] Meeting Of The Board Of Visitors Of Virginia Commonwealth University, Virginia Commonwealth University. Board Of Visitors
VCU Board of Visitors Minutes
Official minutes of the VCU Board of Visitors and its Executive Committee.
The Interpersonal Process And Predictors Of Consent In Tissue Donation Requests, Lindsey Dorflinger
The Interpersonal Process And Predictors Of Consent In Tissue Donation Requests, Lindsey Dorflinger
Theses and Dissertations
The present study examined the interpersonal process during tissue donation requests and evaluated demographic and interpersonal/behavioral predictors of consent or refusal to donate. One hundred and two audiorecordings of tissue donation requests were evaluated using several different observer measures of interpersonal behavior and decision making. Results showed that tissue requesters (TRs) and next-of-kin (NOKs) tended to match one another’s level of affiliation, and complemented one another on interpersonal dominance. TRs infrequently used negative or disapproving statements during the request, but when they did NOKs were less friendly, more disapproving, and more likely to express concern. Overall there were few differences …
Effect Of Combined Oral Contraceptives On Insulin Clearance In Lean And Obese Pre-Menopausal Women, Vidya Moorthy
Effect Of Combined Oral Contraceptives On Insulin Clearance In Lean And Obese Pre-Menopausal Women, Vidya Moorthy
Theses and Dissertations
Introduction: Obese women are predisposed to greater risks of insulin resistance and compensatory hyperinsulinemia. Likewise, African-Americans, appear to be inherently insulin resistant and hyperinsulinemic even after controlling for obesity. Hyperinsulinemia has been attributed to insulin resistance and a compensatory insulin hyper-secretion by the pancreas, as well as decreased insulin clearance, notably in obesity. Pharmacological agents that may worsen insulin resistance/hyperinsulinemia in obese women is of clinical relevance. Previous data from our group suggested that combined oral contraceptives (COCs) may worsen insulin sensitivity particularly in obese women, but limited information on insulin clearance is available in obese women or African-American women. …
Water Molecules: A Closer Look At Their Behavior At Protein-Protein Interfaces And Their Contributions To The Docked Model Of Pyridoxal Kinase - Serine Hydroxymethyltransferase Complex, Mostafa H. Ahmed
Theses and Dissertations
The work in this thesis is divided into two aims. The first aim is to provide a detailed analysis of water molecules at protein-protein interfaces as well as quantifying their contributions with respect to different residue types. To achieve this aim a data set of 4741 water molecules abstracted from 179 high-resolution (≤ 2.30 Å) X-ray crystal structures of protein-protein complexes was analyzed with a suite of modeling tools based on HINT. The second aim is to observe the effect of adding interfacial water molecules in developing a model for the protein-protein interaction between pyridoxal kinase and serine hydroxymethyltransferase. This …
The Abundance And Infection Status Of Anopheles Spp. Mosquitoes At Three Sites In Loudoun County, Northern Virginia, Priya Krishnan
The Abundance And Infection Status Of Anopheles Spp. Mosquitoes At Three Sites In Loudoun County, Northern Virginia, Priya Krishnan
Theses and Dissertations
Malaria is a re-emerging infectious disease with approximately half of the world's population at risk. In the US, since the 1950’s the Center for Disease Control (CDC) has been reporting between 1,000 and 1,500 cases of malaria every year. A majority of these cases were among US travellers and were attributed to Plasmodium falciparum. In August 2002, two cases of human malaria due to Plasmodium vivax were reported in Loudoun County, Northern Virginia. The Center for Disease Control and Prevention concluded that these cases were acquired locally. This was because of an absence of other risk factors such as international …
Let's Get Physical: The Role Of Physical Activity In The Training Of Graduate Mental Health Students, Cassandra Pasquariello
Let's Get Physical: The Role Of Physical Activity In The Training Of Graduate Mental Health Students, Cassandra Pasquariello
Theses and Dissertations
There is growing awareness of the role of physical activity (PA) in the prevention and treatment of health disorders. Mental health practitioners are well positioned to provide PA counseling and may have ethical obligations to address PA. Researchers have cited insufficient training as a barrier to PA counseling, yet little is known about training in mental health. This exploratory study examines the need for training students in PA counseling. A national sample of 361 current graduate students in psychology, social work, rehabilitation counseling, and psychiatric nursing completed a Web-based survey on their training, knowledge, attitude towards PA, personal PA, and …
Pre- And Post-Migration Attitudes Among Ghanaian International Students Living In The United States: A Study Of Acculturation And Psychological Well-Being, Nicole Fischer
Theses and Dissertations
This qualitative study investigated attitudes among international students prior to their departure and following their arrival in the United States through a phenomenological research approach. Eight participants completed individual interviews in Accra, Ghana, and four participants completed follow-up email correspondence. The purpose of the study was to explain pre-migration expectations, post-migration experiences, and compare similarities and differences between perceptions and actual encounters. The researcher investigated five principle components of pre-migration: satisfaction with life prior to departure from the country of origin, impressions and expectations of the host country and predominate influences, awareness of discrimination in the host country, and culture-specific …
Adjustment Of Families With Children Adopted From Eastern Europe, Maria Kuznetsova
Adjustment Of Families With Children Adopted From Eastern Europe, Maria Kuznetsova
Theses and Dissertations
The purpose of this study was to examine the adjustment of older children and adolescents adopted from Eastern Europe and the impact of their preadoption history and family’s functioning on their adjustment. This is a follow-up study of families first surveyed in 2005 with an addition of new families. One hundred and forty-five families reporting on 194 adopted children (9 to 19 years; 104 girls) participated in this study at Time 2. The project was conducted as an internet-based survey. Parents and adopted children reported on children’s emotional, behavioral and social problems (CBCL and YSR), as well as family environment …
Association Between T Cells-Related Gene Expression And Fibrosis Progression In Hcv Recurrence Disease., Alexander Philip
Association Between T Cells-Related Gene Expression And Fibrosis Progression In Hcv Recurrence Disease., Alexander Philip
Theses and Dissertations
Hepatitis C virus (HCV) is the major cause of chronic hepatitis worldwide and a leading cause for liver transplant. Unfortunately, graft HCV infection is a universal phenomenon despite of pre-transplant prophylactic strategies. Acute HCV infection and innate immune responses elicit an inflammatory scenario that triggers the recruitment of adaptive immune response cells. Of those chronically infected, 30% experience accelerated fibrosis with concomitant cirrhosis development within 5 years post-LT and require re-transplant. With many patients responding unfavorably to antivirals and ineffective vaccines, much attention is now placed on T cell immunity in controlling HCV infection. This study represents a retrospective analysis …
A Pre And Post Exercise Comparison Of Three Assessment Tools Commonly Employed To Assess Vascular Function, Lorena Salom
A Pre And Post Exercise Comparison Of Three Assessment Tools Commonly Employed To Assess Vascular Function, Lorena Salom
Theses and Dissertations
Background: Endothelial dysfunction (ED) is one of the earliest subclinical indicators of impaired cardiovascular health and several non-invasive tools have been developed to evaluate vascular function, including strain gauge plethysmography (SGP), brachial artery flow-mediated dilation (FMD) via ultrasound, and peripheral artery tonometry (PAT). While these tools have extensively been studied during a resting condition, the responses following acute exercise are not as well characterized. Purpose: The purpose of this study was to compare the pre- and post-exercise vascular function values obtained with SGP, FMD, and PAT. Relationships among the primary outcome variables obtained with each assessment tool were also evaluated. …
Molecular Pathways Involved In Calcineurin Inhibitor Nephrotoxicity In Kidney Allograft Transplants, Huong Nguyen
Molecular Pathways Involved In Calcineurin Inhibitor Nephrotoxicity In Kidney Allograft Transplants, Huong Nguyen
Theses and Dissertations
ABSTRACT MOLECULAR MECHANISMS AND GENE SIGNATURES INVOVLED IN CALCINEURIN INHIBITOR NEPHROTOXICITY IN KIDNEY ALLOGRAFT By Huong Le Diem Nguyen, M.S. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Physiology at Virginia Commonwealth University. Virginia Commonwealth University, 2011. Major Director: Valeria Mas, Ph.D. Associate Professor, Department of Surgery and Pathology Director of Molecular Transplant Research Laboratory, Division of Transplant Calcineurin inhibitors (CNI), cyclosporin A and tacrolimus, are potent immunosuppressive agents but induce toxicities causing damages and graft dysfunction, and have been suggested to contribute to late-term loss of graft in kidney transplant …
Managing The Healthcare Needs Of Adolescents With Autism Spectrum Disorder: The Parents' Experience, Julie Strunk
Managing The Healthcare Needs Of Adolescents With Autism Spectrum Disorder: The Parents' Experience, Julie Strunk
Theses and Dissertations
The purpose of this phenomenological study was to describe the experiences of parents who manage the health needs of an adolescent with Autism Spectrum Disorder (ASD). Qualitative interviews were conducted with parents from 10 families of adolescents with ASD residing in Virginia. Data were analyzed using Clark Moustakas’ method of analysis of data in which the phenomenologist asks the following questions: What are the individual’s experiences, and in what context did they experience them? This study maximized credibility by using three strategies: prolonged engagement, peer debriefing, and member checking. “Parents needing help” emerged as the essence of the parents’ experiences. …
Characterizing The Distribution Of Planktonic Fecal Bacteria In The James River, Richmond, Virginia, John Furry
Characterizing The Distribution Of Planktonic Fecal Bacteria In The James River, Richmond, Virginia, John Furry
Theses and Dissertations
Surface waters containing fecal bacteria present significant public health risks. Understanding the sources of and factors affecting the distribution of fecal-indicating bacteria is necessary to predict potential illnesses more effectively. This thesis presents two studies on the distribution of fecal bacteria in the James River through Richmond, Virginia. Chapter 1 describes nearly 11 years of water quality, climate, and hydrologic data that occurred with changes in Escherichia coli concentrations, concluding that Richmond contributes significant quantities of fecal bacteria to the James River, and that the distribution of these bacteria varies seasonally. Chapter 2 details the development of Polymerase Chain Reaction …
Role Of Autophagy In Radiosensitization Of Breast Tumor Cells, Molly L. Bristol
Role Of Autophagy In Radiosensitization Of Breast Tumor Cells, Molly L. Bristol
Theses and Dissertations
In MCF-7 breast tumor cells, ionizing radiation promoted autophagy that was cytoprotective; pharmacological or genetic interference with autophagy induced by radiation resulted in growth suppression and/or cell killing (primarily by apoptosis). The hormonally active form of vitamin D, 1,25D3, also promoted autophagy in irradiated MCF-7 cells, sensitized the cells to radiation and suppressed the proliferative recovery that occurs after radiation alone. 1,25D3 also enhanced radiosensitivity and promoted autophagy in MCF7 cells that overexpress Her-2/neu as well as in p53 mutant Hs578t breast tumor cells. In contrast, 1,25D3 failed to alter radiosensitivity or promote autophagy in the BT474 breast tumor cell …
The Potential For Eutrophication Mitigation From Aquaculture Of The Native Oyster, Crassostrea Virginica, In Chesapeake Bay: Quantitative Assessment Of An Ecosystem Service, Colleen Higgins
Theses and Dissertations
Native oysters have been promoted as a means to improve water quality in Chesapeake Bay. This project added important insights into the potential of oyster aquaculture to process and remove nutrients from Bay waters. Results clarified that nutrient removal of nitrogen (N), phosphorous (P), and carbon (C) through harvest of cultivated oyster biomass can be quantified and modeled with high levels of statistical confidence. A simple, yet accurate, method is now available for estimating the amount of nutrients removed via harvesting aquacultured oysters. Based on model estimates, 106 harvest sized oysters (76 mm TL) remove 132 kg TN, 19 kg …
Mosaicism For Trisomy21: Utility Of Array-Based Technology For Its Detection And Its Influence On Telomere Length And The Frequency Of Acquired Chromosome Abnormalities, Chariyawan Charalsawadi
Mosaicism For Trisomy21: Utility Of Array-Based Technology For Its Detection And Its Influence On Telomere Length And The Frequency Of Acquired Chromosome Abnormalities, Chariyawan Charalsawadi
Theses and Dissertations
The primary aim of this study was to determine the effectiveness of array-based technology for detecting and quantifying the presence of mosaicism. This aim was achieved by studying individuals having mosaicism for Down syndrome. SNP arrays were performed on 13 samples from individuals with mosaicism for trisomy 21, 13 samples from individuals with normal chromosome 21complements (negative controls) and 5 samples from individuals with full or partial trisomy 21 (positive controls). In addition, BAC arrays were processed on 6 samples from individuals with mosaicism for trisomy 21, 3 negative controls and 1 positive control. These studies have shown that array-based …
The Role Of Faith Leaders In Partnerships Among Health Promotion Researchers And Faith Communities, Rebecca Foco
The Role Of Faith Leaders In Partnerships Among Health Promotion Researchers And Faith Communities, Rebecca Foco
Theses and Dissertations
Faith communities are often used as used as sites for health promotion research and the leaders of those faith communities play an important role in successful campus/faith community partnerships. This study examined (a) faith leaders’ definitions of health, (b) ways in which faith leaders envision campus/faith community partnerships to be structured, and (c) faith leaders’ perceptions of the roles that faith leaders may assume in such partnerships. Grounded theory methodology was used. In depth interviews were conducted with ten clergy members. The findings revealed that clergy embraced a holistic definition of health. They expressed a desire to participate in studies …
The Effects Of Hypothermia On Status Epilepticus-Induced Acquired Epilepsy, Kristin Phillips
The Effects Of Hypothermia On Status Epilepticus-Induced Acquired Epilepsy, Kristin Phillips
Theses and Dissertations
Status epilepticus (SE) is a type of neurological injury characterized by continuous seizure activity and can lead to molecular and pathophysiological alterations leading to plasticity changes. SE can lead to the development of AE by the process of epileptogenesis, which is a phenomenon that describes the transformation of normal brain tissue into a hyperexcitable neuronal population. It has been demonstrated both in vivo and in vitro that calcium (Ca2+) dynamics are severely altered during and after SE, and these changes play a major role in the progression of epileptogenesis. It has also been reported that preventing the rise in intracellular …
Medicalization As A Trojan Horse: Changes In Erectile Enhancement Advertising, Robert Wood
Medicalization As A Trojan Horse: Changes In Erectile Enhancement Advertising, Robert Wood
Theses and Dissertations
Medicalization as a Trojan Horse: Changes in Erectile Enhancement Advertising By Robert D Wood, M.S. A Thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University Virginia Commonwealth University, 2011 Major Director: Sarah Jane Brubaker, PhD, Graduate Program of Sociology This thesis investigates the medicalization of “inadequate penis size” through an analysis of online advertising of “male enhancement,” or erectile enhancement (EE) products. The process of medicalization, as defined by Peter Conrad, is the process by which non-medical problems become defined and treated as such (2007). With the advent and success …