Digital Commons Network^™

Obesity And Asthma: Adiponectin Receptor 1 (Adipo R1) And Adiponectin Receptor 2 (Adipo R2) Are Expressed By Normal Human Bronchial Epithelial (Nhbe) Cells At Air-Liquid Interface (Ali) And Expression Changes With Il-13 Stimulation, Jennifer L. Bradley

Theses and Dissertations

Obesity is recognized as an important risk factor for the development of many chronic diseases such as hypertension, Type 2 diabetes mellitus (T2DM) cardiovascular disease, cancer, renal disease, neurologic dysfunction, metabolic syndrome and asthma (3, 4). Circulating serum adiponectin levels in obese asthmatics have been reported to be low. Therefore, we aimed to investigate the role of adiponectin in a mucus hypersecretion model and hypothesized that adiponectin would decrease IL-13 induced MUC5AC expression from differentiated NHBE cells and that increasing concentrations of IL-13 would cause a decrease in Adipo R1 and Adipo R2 expression. MUC5AC expression with exposure to adiponectin …

A Study Of The Action Of Risperidone At 5-Ht2a Receptors, Supriya A. Gaitonde

Theses and Dissertations

Risperidone is an ‘atypical’ antipsychotic and is approved by the USFDA mainly for the treatment of schizophrenia and symptoms of bipolar disorder. Risperidone (an SDA or serotonin-dopamine antagonist) has ~20-fold higher affinity at 5-HT_2A receptors over dopamine D₂ receptors, which makes it more efficacious against the negative symptoms of schizophrenia and less liable to causing extrapyramidal side effects than ‘typical’ antipsychotics.

The major goal of the current investigation was to study the structure of risperidone and to identify the minimum structural features required for 5-HT_2A receptor affinity that retain antagonist action. The structure of risperidone was systematically …

The Effect Of Pre-Deployment Physiology As A Predictor Of Post-Traumatic Stress Disorder Among A Sample Of United States Army National Guard And Reserve Soldiers, David J. Rothman

Theses and Dissertations

Potential risk factors for development of Post-Traumatic Stress Disorder (PTSD) are still unclear. One potential risk factor for the development of PTSD is an individual’s cardiovascular reactivity and recovery in response to stressor tasks. The current study was conducted with 763 Army National Guard and Army Reserve soldiers. Participants completed a stressful induction along with self-report measures prior to deployment. Post-deployment, self-report measures were completed to assess PTSD symptomatology and experiences related to deployment and combat. Multiple regression was used to determine the ability of blood pressure response to stress to predict PTSD symptoms immediately and one-year after return from …

Filter Performance Under Simulated Real-World Conditions, Qiang Wang

Theses and Dissertations

Evaluating the performance of filter media for filtration applications is essential to assure design engineers and users that filter device will deliver promised performance for specific applications under the environmental stress. The study of particle loading characteristics of filter media in the laboratory setting is typically performed under the steady flow conditions, i.e., at the constant particle concentration and flow rate. In reality, filtration products are operated under the situations that the flow rate and mass concentration of particles are varied in time. The success of translating the laboratory data to estimate the performance of filter media in the fields …

N-Methyl 4-Methyl Amphetamine N-Alkyl Chain Extension Differentially Affects Ion Flux At The Human Dopamine And Norepinephrine Transporters, Alan C. Harris Jr.

Theses and Dissertations

Amphetamine (AMPH) and its derivatives embody a remarkable breadth of pharmacology. These molecules exert their effects, both therapeutic and pathological, at the human monoamine transporters, which tune synaptic dynamics by evacuating monoamine neuromodulators from the synapse subsequent to neuronal impulses. These transporters are electrogenic, and the transporter-mediated current can be correlated to a surrogate measure of the change in membrane voltage: Ca⁺⁺ currents from co-transfected L-type Ca⁺⁺ channels. The present work makes use of this assay, with which it is possible to derive pharmacodynamic metrics from both substrates and inhibitors. This work presents data on a heretofore-unstudied class …

Pharmacological Implications Of Adenosine 2a Receptor- Dopamine Type 2 Receptor Heteromerization, Candice N. Hatcher-Solis

Theses and Dissertations

G protein-coupled receptors (GPCRs) are heptahelical, transmembrane proteins that mediate a plethora of physiological functions by binding ligands and releasing G proteins that interact with downstream effectors. GPCRs signal as monomers, complexes of the same receptor subtype (homomers), or complexes of different receptor subtypes (heteromers). Recently, heteromeric GPCR complexes have become attractive targets for drug development since they exhibit distinct signaling and cell-specific localization from their homomeric counterparts. Yet, the effect of heteromerization on the pharmacology of many GPCR homomers remains unknown. Therefore, we have undertaken the task to examine the effect of heteromerization on G_s signaling through the …

Gender Nonconforming, Transgender, And Transsexual Patient Navigation Of The American Health Care System: Locating A Primary Care Provider, Justin M. Vinneau

Theses and Dissertations

This study explores the experiences of gender nonconforming (GNC), transgender, and transsexual (trans) people in the search for a primary care provider in the United States. The current body of literature on transgender health often discusses HIV rates, substance use, mental health/suicide, and few studies have studies primary care seeking behaviors; this study seeks to provide new insight into the primary care (pcp) seeking behaviors of GNC and trans people. The primary theoretical perspectives utilized in this study were West and Zimmerman’s (1987) “Doing Gender” and the Health Beliefs Mode (Ayers et al., 2007; Connor and Norman, 2005; Green and …

Predictors Of Caffeine-Related Withdrawal Symptoms In College Freshmen, David J. Pomm

Theses and Dissertations

While caffeine withdrawal has been well-characterized, research on caffeine intake and factors associated with withdrawal has been limited. The present study examined prevalence rates of caffeine use and identified psychosocial factors associated with having caffeine withdrawal headaches (CWH). Participants were N = 1,989 college freshmen who participated in the 2011 Spit for Science project. Caffeine use was reported by 80% of the sample. Females were more likely than males to consume caffeine, and soda was the primary source of caffeine for both genders. As hypothesized, daily caffeine users were more likely to report CWH than non-daily users. When multivariable analyses …

Continuous Stationary Phase Gradients For Planar And Column Chromatography, Veeren Dewoolkar

Theses and Dissertations

Surfaces that exhibit a gradual change in their chemical and/or physical properties are termed as surface gradients. Based on the changes in properties they are classified either as physical or chemical gradients. Chemical gradients show variations in properties like polarity, charge, functionality concentration and have found potential applications in fields of biology, physics, biosensing, catalysis and separation science. In this dissertation, surface gradients have been prepared using controlled rate infusion (CRI).

CRI is a simple method in which a surface gradient is formed by carrying out the infusion of organoalkoxysilane in a time-dependent fashion using a set infusion rate. Depending …

From Seed To Sky: Impacts Of Explosive Compounds On Vegetation Across Spatial And Developmental Scales, Stephen M. Via

Theses and Dissertations

Explosive compounds are broadly distributed across the globe as a result of nearly two centuries of munitions use in warfare and military activities. Two explosive compounds have seen disproportionate use; RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) and TNT (2-methyl- 1,3,5-trinitrobenzene), being the most commonly found explosives in the environment. The effects of explosives on biota have been studied in great detail; however, there is a general lack of understanding with regard to broader ecological impacts of these contaminants. My dissertation objective was to follow the impacts of explosive compounds on vegetation across scales. Impacts on vegetation at the species scale alter community composition via …

Effects Of Antidepressants On Human Mesenchymal Stem Cell Differentiation On Clinically Relevant Titanium Surfaces, Nancy B. Ayad

Theses and Dissertations

Selective Serotonin Reuptake Inhibitors (SSRIs) are the most frequently prescribed class of drugs worldwide and are implemented in the treatment of depression and other psychiatric disorders. SSRIs relieve depressive symptoms by modulating levels of the neurotransmitter serotonin in the brain. SSRIs block the function of the serotonin transporter, thereby increasing concentrations of extracellular serotonin. However, serotonin levels in the neurons of the brain only account for 5% while the remaining 95% is present outside the brain. Serotonin receptors and transporter are located on bone resident cells (mesenchymal stem cells (MSCs)), osteoblasts and osteoclasts, and serotonergic activity is believed to affect …

The Netflix Effect And Defining Binge-Watching, Brenna C. Davis

UROP Posters

With the accessibility of television programs provided by popular streaming platforms, like Netflix, consumers can watch episodes or seasons of their favorite programming in just one sitting. This new practice of watching television has been referred to as binge-watching, and is defined by Netflix as watching two to six episodes of the same show in one sitting. Netflix’s definition is the most widely used definition of binge-watching, but does not account for the varying lengths of episodes for the different types of programming. There is a lack of standardization in what constitutes a television binge, like the standards that exist …

Incorporation Of Interprofessional Education And Special Care Dentistry Into Standard Dental School Curriculum, Marshall D. Adzima

UROP Posters

According to dentistry, special needs is defined as individuals whose medical, physical, psychological, or social situations may make it necessary to modify normal dental routines in order to provide dental treatment for that individual. The population of special needs patients is increasing. The lack of educated professionals in special care dentistry is leading to severe and untreated systemic and oral health problems in the special needs population. The implementation of interprofessional treatment for special needs individuals has proven to be the most effective method of treatment within the special needs population. This study examines the current application of special care …

Umls::Association - Measuring The Association Between Biomedical Terms, Keith B. Herbert

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UMLS::Association - A Semantic Association Framework for Biomedical Texts

Keith Herbert

Natural Language Processing Lab, Department of Computer Science

Introduction

We present UMLS::Association, a software package to explore the semantic association of biomedical terms with applications for literature-based discovery. Literature-based discovery is an endeavour to ”connect the dots” for scientists between the topics of their research and those of unexpected relevance. However, many approaches rely on the exact wording for the ideas in the research papers being analyzed. The Unified Medical Language System (UMLS) provides a way to map natural language phrases in these papers to sequences of abstract yet …

Examining The Psychological Adjustments Of Neurotypical Siblings Of Individuals With Autism Spectrum Disorder (Asd) And Determining The Efficiency Of Support Groups, Swathi Deo Sambatha

UROP Posters

Neurotypical siblings of individuals with behavioral disorders are reported to have complex, complicated psychological adjustments that vary significantly due to a multitude of sociodemographic factors. In addition, these children are at risk of mental health disorders and negative psychological symptoms. Support groups or extensive social support are known to increase intra-communication and create better sibling dynamics between the neurotypical and autistic siblings. This paper investigates such complications to the psychological adjustment of neurotypical siblings of individuals with autism spectrum disorder (ASD) and determines the implications of the utilization of support groups/social support. The analyzed trends and reportings of multiple studies …

“Doing Time Long After The Crime: How A Prison Sentence Today Is Only The Beginning Of A Felon’S Life-Long Sentence As A Pariah To Society”, Mary C. Pollock

UROP Posters

This research seeks to explore the various difficulties in convicted felons’ life after their transition back into society. The research examines how an ex-convict’s finances, interpersonal relationships with friends, family, and romantic partners, lifetime opportunities, mental health, physical health, and living conditions are affected by the offender’s status as such an offender, as well as to consider ways in which these difficulties can be alleviated for future ex-offenders upon reassimilation into society after a prison sentence. Though indeed a broad topic, this particular brand of research seeks to highlight the exaggerated perception of the ex-con as a permanently damned member …

Subjective Measures Of Mz And Dz Twins During Anxiety-Provoking Tasks, Sravya Uppalapati

UROP Posters

Temporary anxiety is a healthy response to stress; however, continuous anxiety can threaten an individual’s day-to-day living by eliciting negative responses. In the study, monozygotic 84 (MZ) and 153 dizygotic (DZ) adolescent twins pairs, ages 15 to 20 years, participated in anxiety-provoking tasks and subjective experiences of anxiety were measured using subjective units of distress (SUDS). The twin participants were recruited through the Mid-Atlantic Twin Registry (MATR) at Virginia Commonwealth University. The twins participated in a carbon dioxide (CO₂) breathing task and a trier social stress task (TSST). The study aims were to evaluate the relationship between anxiety-provoking …

Relationship Between Caffeine Use And The Total Hours Of Sleep Per Week, Marlene A. Michniak

UROP Posters

Lack of sleep is a common theme throughout college students’ lives. Additionally, college students report being dependent on caffeine to perform their best.The purpose of this study was to determine if there is a link between how much caffeine students are using and how much sleep they are getting. The sample contained data from the 2011-2014 cohorts of the Spit for Science dataset. Both sleep and caffeine use data were collected at several points: first year fall semester (n=1799), third year spring semester (n=1918), and fourth year spring semester (n=859). Sleep data included the hours and minutes of sleep that …

Reduction Of Oxidative Stress And Storage Lesions (Rcsl) In Red Blood Cells - Analysis Of Ascorbic Acid (Aa), N-Acetylcysteine Amide (Ad4), And Serotonin (5-Ht), Shanmuka Gadiraju

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Oxidative stress is a common occurrence in red blood cell (RBC) storage in blood banks throughout the world. Typically RBC units stored under routine standard protocol (stored in SAGM-CPD additive solution) can only be kept up to 42 days for transfusion usage before being discarded. I am studying the effects of Ascorbic Acid (AA), N-acetylcysteine amide (AD4), and Serotonin (5-HT) as additives in blood bank storage because I want to find out if these additives can reduce storage-induced oxidative stress on red blood cells (RBCs), in order to help my reader understand how potential blood storage additives can affect the …

The Relationship Between Exercise And Depression And Anxiety In College Students, Joshua Frank, Dr. Amy Adkins, Nathan Thomas, Dr. Danielle Dick

UROP Posters

The literature shows an inverse association between exercise and mental disorders. The aim of this study is to further elaborate on this association with regards to exercise and its relationship with anxiety and depression in a college sample. The subject group focused on seniors in the Spit for Science data set which incorporated a total of 821 students. Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ) to estimate the overall metabolic equivalents (MET’s) each student spent in walking, moderate, or vigorous activity levels in the previous week. Sum scores were used to measure depression and anxiety. Overall,the …

The Effects Of Eastern Versus Western Cultures On Women's Perceptions And Disclosure Of Mental Illness, Whitney Roxanne Sherrick

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Mental illnesses and the stigma that surrounds them have caused societal unrest since the development of the modern human. However, there remain differences in the way individuals perceive mental illness, allowing various levels of stigma to arise. The focus of this research is to determine the contrast between the views of Western and Eastern cultures concerning mental health status - exploring how cultural expectations for women affect their perception, and disclosure, of mental illnesses. This research involves studies that examined societal expectations for Western and Eastern cultures, and experiments measuring the perceptions of mental illness from individuals with various heritages. …

The Relation Between Infant Construction Strategy And Language Development In Toddlers, Gullnar Syed, Emily C. Marcinowski, Stacey C. Dusing, George F. Michel, Eliza L. Nelson

UROP Posters

Infants learn from interaction with physical objects in their environments. Object construction, or merging individual objects into a single structure, has been linked previously to language. Items and toys can be structured and combined with similarity to word combinations (Greenfield, 1991). Infants initially combine 2 objects and then graduate on to combine 3 pieces or more. Words are put together in comparable ways, with each word corresponding to an object, and a sentence corresponding to a single structure. The purpose of this project is to explore how construction ability in infants affects language ability in toddlers. We hypothesize that the …

The Implementation Of Memantine For Recovering Stroke Patients, Keerthana Shankar

UROP Posters

Recovering stroke patients go through rehabilitation to fix the paretic limbs and adapt to the nerve damage. Recovery consists of repetitive tasks that are designed to guide the plastic brain to adapt to new movements and gain muscle memory in those movements. Rehabilitation is strongly dependent on the brain’s plasticity, which is enacted through increased levels of brain-derived neurotrophic factor (BDNF). BDNF has been proven to be increased through aerobic exercise, a common element found in rehabilitation programs. It is vital that the exercises performed in rehabilitation result in higher brain plasticity due to the limited time window of the …

Socioeconomic Factors Associated With Cataract-Related Blindness Treatment In Women In Rural Regions Of Andhra Pradesh, Kiranpreet Kaur 4198353

UROP Posters

Despite efforts of Vision 2020 in India, the Andhra Pradesh Eye Disease Study (APEDS) extrapolated, in 2000, approximately 18.7 million blind people in India and also, projected an increase to 31.6 million blind people by 2020. Within the state Andhra Pradesh itself, preventable corneal blindness increased to 1.84% from 1.5% in the late 1980s.

Numerous public health studies have been conducted to outline factors that cause and preclude treatment of avoidable corneal blindness in the India. Conclusively, the escalation of corneal blindness can be largely attributed to personal, social, and economic barriers in utilizing available eye-care services. However, due to …

Perceptions Of Harm And Addiction Among Dual Users Of Cigarettes And E-Cigarettes, Julia S. Rozman

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Background: Tobacco harm perceptions are important factors in why individuals may initiate, substitute, and/or engage in dual or poly-tobacco use patterns. Identifying correlates of these perceptions is important for understanding why these cognitions may exist and help provide intervention targets. The purpose of the current study was to examine perceptions of harm and addiction among a sample of cigarette and electronic cigarette (e-cigarette) users and examine whether these perceptions differ by demographics, other substance use, and tobacco use history.

Methods: The current sample consisted of 29 individuals who consented to participate in a clinical laboratory study of dual cigarette and …

Depression Intervention Programs In Low-Income High Schools, Gopika Hari

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It is estimated that 2.6 million adolescents suffer from major depressive episodes each year. Research has noted that symptoms in youth have become indicators of mental health complications later in life. Studies reveal that low income is a risk factor for depression and that socioeconomically-disadvantaged teenagers are more than twice as likely to develop mental illnesses. Only roughly 25% of children with mental illnesses receive adequate help and 80% of these resources come from schools. This study focuses on establishing the importance of depression intervention programs in low-income high schools and on designing novel guidelines for effective protocols. A compilation …

The Effects Of Pet Ownership On Anxiety And Depression Among Trauma-Exposed College Students, Dung N. Nguyentran, Marlene A. Michniak, James J. Jung, Christine Q. Do

UROP Posters

Rates of anxiety and depression are prevalent in college students and can be attributed in part to stress and trauma-related events. However, studies suggest that pet ownership has the possibility of alleviating symptoms of anxiety, depression, negative emotions, and suicide. The purpose of this study was to determine the relationship between pet ownership and levels of anxiety and depression among those who have experienced a traumatic event. The sample was comprised of five hundred and forty-seven VCU students who completed an online survey from Spit for Science during their junior year. Linear regressions were performed to determine the nature and …

How And Why Has American Media Shifted The On-Screen Image Of Asian Americans From Stereotypical Roles To Lead Roles?, Sohail A. Syed

UROP Posters

Growing up as an Asian American, I never really had a role model of sort that I could relate to entirely. There were the general characters in movies that I looked up to but there was never that one character that I could possibly see myself as because there was never any lead characters that looked like me. Every time an Asian character was showed on-screen they were never a normal relatable person; they were always rather a living stereotype or unrealistic. Asians are always portrayed as intellectuals that are very awkward and geeky or one who has a very …

Understanding The Problem Solving Approaches Of Special Educators Through The Lens Of Adaptive Expertise, Serra T. De Arment

Theses and Dissertations

The purpose of this research was to investigate special educators’ problem solving approaches through the lens of adaptive expertise. An explanatory sequential mixed methods design was used with participants of varying experience levels and teaching contexts from one Mid-Atlantic state. Participants responded to a researcher-developed survey about their orientations to problem solving (N = 162), then a purposive sample completed semi-structured interviews (N = 8). Following survey measure refinement and validation, quantitative data were analyzed through descriptive statistics, z-scores, correlation, and chi-square test of independence. Subsequently, qualitative data were analyzed through iterative cycles of hypothesis and open coding. …

Rage And Social Media: The Effect Of Social Media On Perceptions Of Racism, Stress Appraisal, And Anger Expression Among Young African American Adults, Morgan Maxwell

Theses and Dissertations

Recently, social media has become a sociopolitical hotbed for discussions of racism. However, no extant studies have questioned if social media use increases how often African Americans vicariously and/or personally experience discrimination in America. The current study sought to answer this question. By examining the relationships between social media use, general stress, race-related stress, and anger expression, and the mediating role of perceived racism, this study explored if frequent social media use influences young African American adults’: a) perceptions of racism, b) experiences with general and race-related stress, and/or c) expressions of anger. The current study conducted an online survey …