Digital Commons Network^™

A Pre-Transplant Blood-Based Lipid Signature For Prediction Of Antibody-Mediated Rejection In Kidney Transplant Patients, Monther Al Sultan, Daniel Contaifer Jr., Joshua Morriss, Suad Alshammari, Jeffrey Stern, Sindhura Bobba, Pamela Kimball, Anne King, Dhiren Kumar, Marlon Levy, Gaurav Gupta, Dayanjan Wijesinghe

Graduate Research Posters

Purpose. The aim of this study is to demonstrate the potential of the pre-transplant lipidome to predict post-transplant antibody-mediated rejection (AMR) in kidney transplant patients.

Methods. Patients were selected from a prospective observational cohort of a single-center adult kidney transplant center in the United States. The study included 16 kidney transplant patients who develop AMR within 2 years post-transplant and 29 stable control (SC) kidney transplant patients who did not develop AMR at any time within the post-transplant follow up. Selection of group differences on the day of transplant was determined by t-test analysis. Stepwise forward method was used to …

The Associations Between Sexual Victimization And Health Outcomes Among Lgbqa College Students: Examining The Moderating Role Of Social Support, Eryn Delaney, Chelsea Derlan Williams, Della V. Mosley, Sage E. Hawn, Danielle M. Dick, Phd

Graduate Research Posters

Sexual victimization is a prevailing public health concern that differentially impacts sexual minority populations (i.e., people who identify as lesbian, gay, bisexual, asexual, or queer) compared with their heterosexual and cisgender counterparts (McCauley et al., 2018). Studies have shown that sexual violence is associated with depressive symptoms, post-traumatic stress disorder symptoms, and alcohol use (Aosved et al., 2011; Bedard-Gilligan et al, 2011; Carey et al., 2018) among heterosexual college students. However, we know less about the potential effects of sexual victimization on health outcomes among sexual minority college students. Understanding these relations are especially important because sexual minority college students …

Richmond City Health District (Rchd), Bon Secours Richmond City Hospital (Rch), And Virginia Commonwealth Universities (Vcu) Department Of Health Behavior Policy (Hbp): Partnering With Community Health Workers (Chw) To Improve Community Health Outcomes And Reduce Emergency Department (Ed) Use, Anita M. Kumar, Mph, Stephanie Toney, Rn Bsn, Tamera Langhorne, Mba Chw, Bassan Dahman, Ph.D.

Graduate Research Posters

Background: Frequent ED users (5%) are sicker, poorer, not satisfied with the health system and cost 20% of total ED charges.

Objective: A pilot study of feasibility of partnering with CHW to improve health knowledge and outcomes and reduce ED use in low income community.

Methods: RCH ED utilizers were randomized to intervention and control groups. CHW contacted intervention group within 10 days of ED visit, surveyed about access to care, healthy living, and knowledge about chronic disease, and offered education, referrals to insurance and social and economic support. ED utilization and cost were recorded for all patients for 6 …

Expressed Emotion, Mental Health, And Functioning In Families Of Children With And Without Asthma, Katherine W. Dempster, Julia Scheidemantel, Jessica Greenlee, Marcia A. Winter, Ph.D, Robin S. Everhart, Ph.D

Graduate Research Posters

Introduction: Expressed emotion (EE), the affective attitudes and behaviors of one toward another, can affect caregivers’ behaviors toward their child. Research examining associations between EE and child/family outcomes is mixed; these associations may be affected by other influences such as the presence of a chronic disease or parent mental health. In this study of families living in an urban area, we examined associations between EE and child outcomes (anxiety/depressive symptoms) and family functioning, with parent anxiety as a covariate. We evaluated child asthma status as a moderator in these associations as the presence of a chronic illness may strengthen the …

Integrated Multiple Adaptive Design Involving Sample Size Re-Estimation And (Covariate-Adjusted) Response-Adaptive Randomization For Continuous And Binary Outcomes, Christine M. Orndahl

Theses and Dissertations

Historically, clinical trials have been performed based on decisions made prior to the start of the trial. Adaptive designs have been developed to provide increased flexibility, allowing pre-specified changes to occur based on interim data. Each adaptive design addresses a unique pitfall of a non-adaptive design, such as minimizing the chance of an under- or over-powered study by utilizing interim data to update the sample size estimate (sample size re-estimation) or increasing the ethical benefit of a trial by allocating more participants to the better performing treatment group ([covariate-adjusted] response-adaptive randomization). Additional benefit is attainable by combining more than one …

The Relationship Between Access To School Counseling And Students’ Attainment And Persistence In Postsecondary And Stem Education Outcomes, Dana Brookover

Theses and Dissertations

School counselors design and implement comprehensive school counseling programs to support students’ academic, college and career, and personal/social development (ASCA, 2019). This includes the school counselor’s important role in college readiness counseling and science, technology, engineering, and math (STEM) counseling (Falco, 2017; Gilfillan, 2018). The current study focused on the relationships between access to school counseling and students’ long-term college readiness outcomes. Through a Social Cognitive Career Theory (SCCT; Lent et al., 1994) lens, two models to predict (1) college attainment and persistence and (2) STEM major attainment and persistence, were tested through logistic regression analyses. Additionally, this study also …

Evidence Based Practice Question Development & Search Checklist, Roy E. Brown

VCU Libraries Faculty and Staff Publications

The Evidence Based Practice Question Development and Search Checklist is a tool that is used in instructional sessions with nurses in reference to evidence-based practice and literature searching. It is intended as a reference handout.

It is under a creative commons license. If you would like a version that can be rebranded for your organization to use, please contact the author for an editable version.

Supporting Student Mental Health During And After Covid-19, David Bryant Naff, Shenita Williams, Jenna Furman, Melissa Lee

MERC Publications

This report by the Metropolitan Educational Research Consortium (MERC) in the VCU School of Education offers a rapid review of research about supporting student mental health as they return to school during COVID-19. It pulls from literature on natural disasters like hurricane Katrina, the psychological impacts of quarantine, and emergent research on the mental health impacts of the Coronavirus. The report is structured to answer three overarching questions: 1) Why is it important to address the mental health needs of students in schools? 2) How can we expect COVID-19 to impact the mental health of students? 3) What are some …

Effects Of Dietary Sodium Intake On Blood Flow Regulation During Exercise In Salt Resistant Individuals, Kevin P. Decker, Morgan T. Kimmel, Hunter L. Reed, Alex H. Chiu, Austin C. Hogwood, Jennifer B. Weggen, Ashley M. Darling, Ryan S. Garten

Graduate Research Posters

PURPOSE: Dietary sodium intake guidelines is ≤2,300 mg/day, yet is exceeded by 90% of Americans. This study examined the impact of a high sodium diet on blood flow regulation during exercise. METHODS: Six males (25 ± 2 years) consumed dietary sodium intake guidelines for two weeks, with one week salt-capsule supplemented (HS: 6,900 mg/day of sodium) and the other week placebo-capsule supplemented (LS: 2,300 mg/day of sodium). At the end of each week, peripheral hemodynamic measurements [blood flow (BF), shear rate (SR), and flow mediated dilation (FMD)/SR)] of the brachial and superficial femoral artery were taken during handgrip (HG) and …

Relevance Of Health-Related Hashtags On Twitter: A Text Mining Approach, Mauli Dalal, Kweku-Muata Osei-Bryson

Graduate Research Posters

BACKGROUND

Social media platforms facilitate user interaction and impact decision making. Users prefer to use hashtags while sharing posts. Knowing the sentiment towards diabetes, bloodpressure, and obesity is fundamental to understanding the impact of these information on patients and their families. The study seeks to determine the relevance of health-related hashtags on Twitter and analyze sentiments about diabetes, obesity, blood pressure.

METHOD

Tweets were retrieved using synonyms for “diabetes”, “hypertension” and “obesity”. The extended knowledge discovery in data mining (KDDM) model guided our research with research objectives defined in the ‘research problem understanding’ phase. The ‘information seeking’ from Uses and …

Fishbowl Discussions: Promoting Collaboration Between Mathematics And Partner Disciplines, Stella K. Hofrenning, Rosalyn Hobson Hargraves, Tao Chen, Afroditi Vennie Filippas, Rhonda Fitzgerald, John Hearn, Lori J. Kayes, Joan Kunz, Rebecca Segal

Journal of Mathematics and Science: Collaborative Explorations

A National Consortium for Synergistic Undergraduate Mathematics via Multi-institutional Interdisciplinary Teaching Partnerships project (SUMMIT-P) is a collaboration of institutions focused on revising first- and second-year mathematics courses with the help of partner disciplines with prerequisite mathematics courses. This paper describes the fishbowl discussion technique used by the consortium members to encourage interdisciplinary conversation. Vignettes describing the results of conversations that occurred at several consortium member institutions are provided by the co-authors.

Genetic And Cellular Models For The Study Of Ptk2b And Adam10 In Adaptive Thermogenesis And Metabolism, Jared S. Farrar

Theses and Dissertations

In a cellular model, we demonstrate that the non-receptor protein tyrosine kinase 2 beta (PTK2B) plays a critical role in mouse cultured beige adipocyte differentiation. CRISPR/Cas9-mediated knock-out of Ptk2b results in non-differentiating white adipocytes and differentiated beige adipocytes with significantly reduced thermogenic gene and protein expression, enlarged lipid droplet size, and altered mitochondrial respiration. Together, these data in a cell culture system provide evidence for a role of PTK2B in the differentiation of mouse beige adipocytes.

In the process of developing a new mouse model utilizing the adipocyte selective Adipoq-Cre transgenic mouse, strong genetic linkage between a gene …

Mass Spectrometry Based Lipidomic Investigation Of Staphylococcus Aureus Lipid Metabolism And Characterization Of Lipase A, Naren Gajenthra Kumar

Theses and Dissertations

Staphylococcus aureus produces an arsenal of virulence factors and is adept at colonizing multiple hosts by employing specific processes to persist at different sites of infection. Infections caused by this pathogen range from self-limiting infections of the skin like folliculitis to life threatening and chronic conditions like infective endocarditis, non-healing diabetic foot ulcers and atopic dermatitis. As the field continues to expand its understanding of the mechanisms by which this pathogen rapidly develops resistance to new antibiotics, the underlying mechanisms that facilitates niche adaptation and host colonization among healthy individuals remain elusive.

Bacterial and host lipid metabolism presents and area …

Caffeine Use And Associations With Sleep In Adolescents With And Without Attention-Deficit/Hyperactivity Disorder (Adhd), Caroline N. Cusick

Theses and Dissertations

The objective of this study was to compare caffeine consumption in the morning, afternoon, and evening in adolescents with and without Attention Deficit/Hyperactivity Disorder (ADHD) and examine associations with sleep functioning. Participants were 302 adolescents (ages 12-14) with (n=140) and without (n=162) ADHD. Adolescents wore actigraph watches to assess total sleep time and wake after sleep onset and reported on their sleep-wake problems and the number of caffeinated beverages consumed per day in the morning, afternoon, and evening. Parents reported on adolescents’ difficulties initiating and maintaining sleep. Chi-square analyses, odds ratios, and path analyses were conducted. Analyses controlled for sex, …

The Effects Of Exosomes On The Regeneration Of Rat Calvaria, Jill T. Beitz

Theses and Dissertations

Periodontal disease is a bacterial induced chronic inflammatory condition that occurs in a susceptible host, affecting the teeth, gingiva, periodontal ligament, and alveolar bone. The resultant pathological bone defects often require surgical intervention, with the ultimate goal being regeneration of the periodontium through the application of grafting materials and biologics. Mesenchymal stem cells (MSCs) show great potential in regenerative medicine for their ability to enhance cell proliferation and differentiation, increase angiogenesis, and modulate the immune response. Stem cell-derived by-products, known as exosomes are a specific class of lipid-membrane-bound extracellular vesicles that are proliferative and chemotactic, are able to inhibit cytokine …

Characterization Of The Dyrk1a Protein-Protein Interaction Network, Varsha Ananthapadmanabhan

Theses and Dissertations

Human Dual specificity tyrosine (Y)-Regulated Kinase 1A (DYRK1A) is a protein kinase encoded by a dosage-dependent gene. An extra copy of DYRK1A contributes to Down syndrome (DS) pathogenesis while loss of one allele causes severe mental retardation and autism. DYRK1A is involved in phosphorylation of several proteins that regulate cell cycle control and tumor suppression. However, the function and regulation of this kinase is not well understood and current knowledge does not fully explain dosage-dependent function of this important kinase. Our previous proteomic studies identified several novel DYRK1A interacting proteins including RNF169, FAM117B, TROAP, LZTS1, LZTS2 and DCAF7. In this …

Current Trends In The Management Of Invasive Cervical Resorption, Erik J. Foisy

Theses and Dissertations

Purpose: To determine how endodontic practitioners are currently managing cases of invasive cervical resorption. Also, to analyze how invasive cervical resorption (ICR) has been managed at Virginia Commonwealth University (VCU) over the past ten years.

Methods: Both domestic and international endodontists were invited to participate in a 14-question survey developed and administered via REDCap. Survey invitations were sent via email to currently practicing endodontists. Electronic dental records were queried for patients diagnosed with ICR at VCU in the preceding ten years. Results of both were summarized using descriptive statistics (counts and percentages). Fisher’s exact test was used to compare survey …

Cyberbullying: School Administrators' Perceptions Of Law And Prevalence, And Their Roles In Prevention, Intervention And Discipline, Suzan Gragg Denby

Theses and Dissertations

This study was aimed at investigating secondary school administrators’ experiences with and their perceptions of cyberbullying, as well as their intervention and prevention procedures. As technology has become ubiquitous in our society, students’ use has increased and impacted the school environment. Given the potential for cyberbullying and the negative effects of such, schools harbor the responsibility to prevent and intervene in such occurrences. This can be a tricky process.

This study included 12 administrators of secondary schools across eight school divisions in Virginia. Through an interview process, administrators spoke of their experiences with technology and cyberbullying incidents, and how they …

Extracellular Matrix Nanoparticles Effects On The Lung In Vivo, Brittaney E. Ritchie

Theses and Dissertations

Acute respiratory distress syndrome (ARDS) is a life-threatening condition that causes diffuse alveolar damage and a loss of the extracellular matrix (ECM). This leads to pulmonary edema and lung function deterioration. Our lab has created decellularized porcine lung, electrosprayed ECM nanoparticles that have been previously shown to have pro-regenerative capabilities in vitro.

In this study, the ECM nanoparticle effects on young murine lungs were tested in vivo. An ECM nanoparticle suspension, previously used for the in vitro studies, was aerosolized intratracheally into the lungs using a microsprayer. 24 hours later, the lung mechanics, bronchoalveolar lavage fluid, and histology …

Negative Urgency As A Risk Factor For Intimate Partner Aggression: The Untold Story Of Maladaptive Interpersonal Emotion Regulation, Alexandra M. Martelli

Theses and Dissertations

Interpersonal conflict frequently occurs in daily life, especially within intimate relationship contexts. The strategies people use to respond to conflict can either bring couples together or push them further apart. Furthermore, impulsive traits, such as negative urgency, leave individuals vulnerable to conflict. Individuals high in negative urgency have difficulty regulating their emotional reactions to negative experiences, often failing to employ adaptive interpersonal emotion regulation (IER) strategies. No research to date has examined the link between negative urgency and the use of negative IER. Fifty-four couples completed self-report measures of negative urgency, effective interpersonal regulation of negative affect, and intimate partner …

The Correlation Between Maternal Postpartum Depression And Child Psychopathology, T'Keyah I. Vaughan

Theses and Dissertations

Background: Postpartum depression (PPD) is a phenomenon that affects nearly 10-15% of pregnancies in the US. It is characterized by depressed mood or anhedonia and lasting for more than 2 weeks. PPD changes how moms interact with family members and child-rearing behavior. Depression is a phenomenon that is also known to affect the psychopathology of children. However, the specifics of how postpartum depression impacts children remains controversial. Many studies do not control for major depressive disorder which makes it difficult to disentangle the impact depression has within the first year of life. Furthermore, other PPD risk factors may be confounding …

The Immediate And Persistent Effects Of Binge Ethanol Exposure On Myelin Protein Expression In Dba/2j Mice, Aminatta Z. Tejan-Kamara

Theses and Dissertations

Binge drinking is the most lethal of drinking patterns, responsible for 77% of all U.S. alcohol misuse costs. Adolescents have increased sensitivity to ethanol’s rewarding properties and decreased sensitivity to ethanol’s aversive effects likely allowing for their increased binge drinking, as compared to adults. Ethanol consumption during adolescent neurodevelopment can lead to immediate and lasting neurobiological-consequences. We have previously shown that adolescent intermittent binge ethanol exposure decreases myelin-related gene expression in DBA/2J mice. Here, we hypothesize intermittent binge ethanol exposure in adolescent DBA/2J mice will decrease myelin protein expression in the prefrontal cortex (PFC) immediately following binge ethanol and this …

Teachers' Attitudes Toward The Inclusion Of Students With Disabilities In The General Education Classroom In A Rural School District, Robin M. Pelt

Theses and Dissertations

According to the research, inclusion in the general education setting is valuable to the academic and social development of students with disabilities. Teachers play a significant role in the success of students with disabilities in this setting (Coombs-Richardson & Mead, 2001; Fuchs, 2010; Test et al., 2009). Research shows that teachers display positive and negative attitudes toward inclusion based on the severity of the disability category (Cook, 2001; Ernest & Rogers, 2009). The purpose of this study was to examine teachers’ attitudes toward the inclusion of students with disabilities in the general education classroom in a rural school district. An …

Adjusting For Dropout In Randomized Controlled Clinical Trials, Katharine Stromberg

Theses and Dissertations

Dropout is a common issue in randomized controlled clinical trials and can negatively impact the internal validity of a study and potentially bias the treatment effect. When subjects discontinue study participation, they are not being given the opportunity to gain from the investigational therapy as if they had remained in the study, defeating one of the main purposes of clinical trials, providing treatment. Specifically in unblinded studies, such as the wait-list control (WLC) design, dropout is often due to group membership. Subjects allocated to the control group often dropout at higher rates than in the treatment group. Adaptive designs have …

The Intersection Of Social Stress, Mental Well-Being, And Sexual Health Among Black Women In Emerging Adulthood, Brandi Galloway

Theses and Dissertations

With an estimated 37,000 new HIV infections each year, HIV continues to be a major public health concern. HIV affects some populations more than others. Young Black women, in particular, are disproportionately affected by HIV. While being a woman does not typically increase a person’s HIV risk, being Black and being a woman does.

Data indicate that individual-level factors do not fully address the differences in HIV and STIs between Black emerging adult women and their White counterparts. Thus, it is critical to better understand contextual factors such as social stress and mental-wellbeing which might better account for these disparities. …

Biopsychosocial Variables Associated With The Development Of Chronic Low Back Pain In Healthcare Workers, Jena Pauli

Theses and Dissertations

ABSTRACT

Purpose: Worldwide the incidence and prevalence of acute low back injury with pain (ALBIP) is increasing in healthcare workers (HCW). Approximately 27% of ALBIP result in chronic low back pain (CLBP). The primary aim of this study was to identify biopsychosocial factors that contribute to the development of CLBP. A secondary aim was to examine the predictive value of reliable and valid screening instruments to identify individuals at highest risk for CLBP.

Significance: Low back pain is the second most commonly reported pain condition in the United States, one of the leading causes of sick leave and …

Pharmacological Characterization Of Novel Low Efficacy Mor Modulators: Implications For Opioid Use Disorder Treatment, Abdulmajeed Jali

Theses and Dissertations

Opioid use disorder (OUD) is a major public health concern in the Unites States, resulting in an estimated 128 overdose deaths per day. Although presently approved OUD pharmacotherapies are partially effective, they are accompanied by undesirable side effects or low compliance. m-Opioid receptor (MOR) agonists (methadone and buprenorphine) are associated with physical dependence, abuse liability and respiratory depression, whereas the MOR antagonist naltrexone is associated with withdrawal precipitation, dysphoria and low patient compliance. Therefore, development of novel medications with fewer side effects and higher compliance than current OUD pharmacotherapies is needed. The objective of this dissertation was to pharmacologically characterize …

A Comparative Study Of The Influence Of Credential Attainment On Employment Outcomes In Rural And Urban Localities, Carrie S. Douglas

Theses and Dissertations

The significance of credentials has heightened considerably in recent decades with numerous federal and state policy initiatives aimed at increasing credential attainment. Various public workforce programs support these efforts, including the federal Workforce Investment Act (WIA), which provided training to job-seekers from 1998 through 2015. Scholars point to human capital theory to explain how education investments yield economic gains. Screening, signaling, and credentialist theories provide a framework for examining the ways that credentials are used in labor markets. The literature on rural labor markets suggests that conditions are very different from their urban counterparts, with significant challenges existing in terms …

Leveraging Peer-To-Peer Energy Sharing For Resource Optimization In Mobile Social Networks, Aashish Dhungana

Theses and Dissertations

Mobile Opportunistic Networks (MSNs) enable the interaction of mobile users in the vicinity through various short-range wireless communication technologies (e.g., Bluetooth, WiFi) and let them discover and exchange information directly or in ad hoc manner. Despite their promise to enable many exciting applications, limited battery capacity of mobile devices has become the biggest impediment to these appli- cations. The recent breakthroughs in the areas of wireless power transfer (WPT) and rechargeable lithium batteries promise the use of peer-to-peer (P2P) energy sharing (i.e., the transfer of energy from the battery of one member of the mobile network to the battery of …

“It’S Supposed To Be Super Easy And It’S Not”: Black And Latinx Student Experiences In The Doctor Of Physical Therapy Admissions Process, Melissa Yeung

Theses and Dissertations

Data provided by the Physical Therapy Central Application System (PTCAS) suggests that despite the large numbers of applicants to Doctor of Physical Therapy (DPT) programs on an annual basis, a gap remains between the number of White and Black and Latinx applicants who are offered admission to DPT programs. Efforts made by DPT programs to increase the diversity of their incoming cohorts include the use of holistic review processes and enrichment programs to recruit more diverse classes. However, research suggests that the undergraduate experiences of students of color have an impact on their aspirations to graduate and professional schools, and …