Digital Commons Network^™

Analysis And Construction Of Engaging Facial Forms And Expressions: Interdisciplinary Approaches From Art, Anatomy, Engineering, Cultural Studies, And Psychology, Leejin Kim

Theses and Dissertations

The topic of this dissertation is the anatomical, psychological, and cultural examination of a human face in order to effectively construct an anatomy-driven 3D virtual face customization and action model. In order to gain a broad perspective of all aspects of a face, theories and methodology from the fields of art, engineering, anatomy, psychology, and cultural studies have been analyzed and implemented. The computer generated facial customization and action model were designed based on the collected data. Using this customization system, culturally-specific attractive face in Korean popular culture, “kot-mi-nam (flower-like beautiful guy),” was modeled and analyzed as a case study. …

Analysis Of Prescribed Gender Roles Through The Use Of Dissociative Identity Disorder In Contemporary Film, Christian Ruiz

UROP Posters

Art is considered both a mirror to reality and a means of critiquing society. This is especially evident through contemporary filmmakers’ use of dissociative identity disorder (DID) in psychological thrillers from the 1990s to 2012, which is a time frame in which both film and society were notably different from those of the previous decades and in which there has not been extensive cultural study regarding DID. Through the presence of multiple selves, which is characteristic of DID, filmmakers illustrate their main characters’ attempts to resolve a stressful, or traumatic, situation. This study is an examination of the ways in …

Thomas Jeckyll, James Mcneill Whistler, And The Harmony In Blue And Gold: The Peacock Room: A Re-Examination, Cynthia Fischer

Theses and Dissertations

This dissertation uncovers three previously unrecognized innovations of Thomas Jeckyll in the Peacock Room. At the same time, the dissertation admits that sometimes James McNeill Whistler chose a more conventional path in the design of the room than previously acknowledged. The dissertation illuminates the often overlooked principle of Classical Decor, first described in the first century BC by Vitruvius, and analyzes how it was instituted in the Peacock Room. Four major points illustrate this conclusion. First, the meaning of the sunflower in the West is explored to account for the flower’s popularity and absorption into ancient heliotropic lore. Thomas Moore’s …

The Role Of Nitric Oxide Dysregulation In Tumor Maintenance, Christopher Rabender

Theses and Dissertations

The inflammatory nature of the tumor microenvironment provides a cytokine and chemokine rich proliferative environment. Much of the responsibility of this environment is due to the production of Reactive Oxygen Species (ROS). These studies examined the proliferative rich tumor environment from a new perspective of Nitric Oxide Synthase (NOS) dysregulation. NOS’s have the ability to become uncoupled and generate superoxide in lieu of nitric oxide (NO). A requirement of NOS for the production of NO is the cofactor tetrahydrobiopterin (BH4) and when it is missing NOS becomes uncoupled and turns into a peroxynitrite synthase. Here I demonstrate that NOS is …

Foliage As A Modifier Of Erotica And Indicator Of Politics In Fragonard Paintings, Michael Walker

UROP Posters

The French Revolution invoked prejudice against the aristocracy and the Rococo works they purchased, including those by eighteenth century artist Jean-Honoré Fragonard whose compositions display erotic subject matter, fluid brushwork, and preference for the natural world. Today that stigma persists; Fragonard’s works, though included in authoritative texts, are described as superficial and banal. This study examines a collection of four of Fragonard’s paintings and, through consideration of over twenty-one expertly written texts, shows that painted flora symbolically modifies the erotic themes of his works. Flowers, trees, and shrubs recontextualize erotic imagery, suggesting that Fragonard’s paintings contain conceits about the French …

The Art Of Perl: How A Scripting Language (Inter)Activated The World Wide Web, Norberto Gomez Jr.

Theses and Dissertations

In 1987, computer programmer and linguist Larry Wall authored the general-purpose, high-level, interpreted, dynamic Unix scripting language, Perl. Borrowing features from C and awk, Perl was originally intended as a scripting language for text-processing. However, with the rising popularity of the Internet and the advent of Tim Berners-Lee’s World Wide Web (Web), in the 1990s, Perl soon became the glue-language for the Internet, due in large part to its relationship to the Hypertext Transfer Protocol (HTTP) and the Common Gateway Interface (CGI). Perl was the go-to language for on the fly program writing and coding, gaining accolades from the likes …

The Experiences Of Young African American Women Principals, Tanya Roane

Theses and Dissertations

The purpose of this study was designed to gain an understanding of how young African American women principals experience the principalship. Three research questions were explored in this study: (a.) What are the pathways to the principalship for young African American women? (b.) How do African American women experience the principalship? (c.) What are the barriers that young African American women experience and what are their strategies for success? The researcher examined the day-to-day experiences faced by these women as they related to race, gender, and age challenges within the field of education. Using qualitative research with Black Feminist Standpoint …

Paclitaxel-Induced Apoptosis Is Bak-Dependent, But Bax And Bim-Independent In Breast Tumor, Anna V. Miller, Mark A. Hicks, Wataru Nakajima, Amanda C. Richardson, Jolene J. Windle, Hisashi Harada

Philips Institute for Oral Health Research Publications

Paclitaxel (Taxol)-induced cell death requires the intrinsic cell death pathway, but the specific participants and the precise mechanisms are poorly understood. Previous studies indicate that a BH3-only protein BIM (BCL-2 Interacting Mediator of cell death) plays a role in paclitaxel-induced apoptosis. We show here that BIM is dispensable in apoptosis with paclitaxel treatment using bim−/− MEFs (mouse embryonic fibroblasts), the bim−/− mouse breast tumor model, and shRNA-mediated down-regulation of BIM in human breast cancer cells. In contrast, both bak−/− MEFs and human breast cancer cells in which BAK was down-regulated by shRNA were more resistant to paclitaxel. However, paclitaxel …

Effect Of Substrate Stiffness On Early Human Embryonic Stem Cell Differentiation, Nikolai Eroshenko, Rukmani Ramachandran, Vamsi K. Yadavalli, Raj R. Rao

Chemical and Life Science Engineering Publications

Background

The pluripotency and self renewing properties of human embryonic stem cells (hESC) make them a valuable tool in the fields of developmental biology, pharmacology and regenerative medicine. Therefore, there exists immense interest in devising strategies for hESC propagation and differentiation. Methods involving simulation of the native stem cell microenvironment, both chemical and physical, have received a lot of attention in recent years. Equally important is evidence that cells can also sense the mechanical properties of their microenvironment. In this study, we test the hypothesis that hESCs accept mechanical cues for differentiation from the substrate by culturing them on flexible …

Compression Of Multilayered Composite Electrospun Scaffolds: A Novel Strategy To Rapidly Enhance Mechanical Properties And Three Dimensionality Of Bone Scaffolds, Parthasarathy A. Madurantakam, Isaac A. Rodriguez, Koyal Garg, Jennifer M. Mccool, Peter C. Moon, Gary L. Bowlin

Biomedical Engineering Publications

One major limitation of electrospun scaffolds intended for bone tissue engineering is their inferior mechanical properties. The present study introduces a novel strategy to engineer stiffer scaffolds by stacking multiple layers and cold welding them under high pressure. Electrospun polydioxanone (PDO) and PDO:nanohydroxyapatite (PDO:nHA) scaffolds (1, 2, or 4 layered stacks) were compressed either before or after mineralizing treatment with simulated body fluid (SBF). After two weeks in SBF, scaffolds were analyzed for total mineral content and stiffness by Alizarin red S and uniaxial tensile testing, respectively. Scaffolds were also analyzed for permeability, pore size, and fiber diameter. Results indicated …

Virginia Commonwealth University Graduate And Professional Programs Bulletin Courses [2013], Virginia Commonwealth University

VCU Bulletins

Listing of professional and graduate courses for 2013-2014.

Mapping The Literature Of Allied Health: Healthcare Chaplaincy, Emily Johnson, Diane Dodd Mccue, Alexander Tartaglia, Jennifer A. Mcdaniel

VCU Libraries Faculty and Staff Publications

OBJECTIVE: This study examined citation patterns and indexing coverage from 2008 to 2010 to determine (1) the core literature of health care chaplaincy and (2) the resources providing optimum coverage for the literature.

METHODS: Citations from three source journals (2008-2010 inclusive) were collected and analyzed according to the protocol created for the Mapping the Literature of Allied Health Professions Project. An analysis of indexing coverage by five databases was conducted. A secondary analysis of self-citations by source journals was also conducted.

RESULTS: The 3 source journals--Chaplaincy Today, the Journal of Health Care Chaplaincy, and the Journal of Pastoral Care and …

Investigation Of Possible Novel Peptide Inhibitors To Bag-1 Based On Peptidyl-Biomimetics, Jonathan Brunn

Theses and Dissertations

In this Master’s Thesis Research the results can be summarized from two major tasks: (1) In our first task, we utilized our two protein system (BAG-1 and HSP 70) as part of beta testing of a computational software 1 that can take three dimensional x-ray crystallography information about protein complexes and predict the strength of atom –atom interactions between amino-acid residues Open Contact predicts binding hotspots that can be used to identify short amino acid chains or peptides that mimic that particular binding segment of the larger protein. These peptides are called pepidyl-biomimetics. The peptide can potentially act as an …

Parent And Professional Perspectives About Autism Spectrum Disorders In South India: Beliefs, Practices, And Parent-Professional Relationships., Neeraja Ravindran

Theses and Dissertations

The purpose of this qualitative study was to examine the experience of parents and professionals living in a large metropolitan city in South India who were raising and/or working with a child with an autism spectrum disorder. The study explored the unique perspectives of parents and professionals regarding their beliefs and practices about autism, as well as the nature of the parent-professional relationship. Nineteen parents (all mothers) and 21 professionals were interviewed in person at four schools, an early intervention program, a hospital clinic, and a physician’s office. Themes were developed using qualitative software, and reliability was established through multiple …

The Role Of Calcineurin In Dendritic Remodeling And Epileptogenesis In A Rat Model Of Traumatic Brain Injury, John Campbell

Theses and Dissertations

Traumatic brain injury (TBI), a leading cause of death and disability in the United States, causes potentially preventable damage in part through the dysregulation of neural calcium levels. This dysregulation likely affects the activity of the calcium-sensitive phosphatase, calcineurin, with serious implications for neural function. To test this possibility, the present study characterized the role of calcineurin in a rat model of brain trauma, the lateral fluid percussion injury model. Golgi-Cox histochemistry revealed an acute post-TBI loss and delayed overgrowth of dendritic spines on principal cortical cells. The spine loss appeared to require calcineurin activity, since administering a calcineurin inhibitor, …

Virginia Commonwealth University Graduate And Professional Programs Bulletin Courses [2012], Virginia Commonwealth University

VCU Bulletins

Listing of professional and graduate courses for 2012-2013

The Geopolitical Context Of Chamorro Cultural Preservation In Guam, U.S.A., Maria-Elena D. Diaz

Ethnic Studies Review

An unincorporated Pacific Island territory of the United States, Guam has been under American rule since 1 898. While proudly "Chamorro," the descendants of indigenous islanders have been American citizens since 1 950. U.S. foreign policy, Americanization of island institutions, immigration flows from Asia and Micronesia, and economic uncertainty present challenges to the perpetuation of Chamorro culture-a syncretic blend of indigenous, Spanish, and American influences that has endured through centuries of foreign domination. As a gateway from the East to the United States and a frequent destination for Micronesian immigrants from the Compacts of Free Association, Guam regularly receives immigrants …

Commonwealth Times 2011-12-08

Commonwealth Times, 1969-

No abstract provided.

Living With Hiv: Views Through The Blog, Linda Eastham

Theses and Dissertations

The purpose of this qualitative descriptive study was to develop a greater clarity of how HIV infected individuals live and work within the sphere of HIV infection as represented through unsolicited, personal narratives posted on blogs. Existing, single author, personal blogs were identified via a search engine. Blogs were defined as the blog author's postings and all responses, whether written by the blog author or a reader respondent. Inclusion and exclusion criteria were developed to respect indicators of bloggers' intentions for privacy, e.g., blogs which required a password were excluded. A total of 14 blogs met inclusion criteria. Actions to …

Pre- And Post-Migration Attitudes Among Ghanaian International Students Living In The United States: A Study Of Acculturation And Psychological Well-Being, Nicole Fischer

Theses and Dissertations

This qualitative study investigated attitudes among international students prior to their departure and following their arrival in the United States through a phenomenological research approach. Eight participants completed individual interviews in Accra, Ghana, and four participants completed follow-up email correspondence. The purpose of the study was to explain pre-migration expectations, post-migration experiences, and compare similarities and differences between perceptions and actual encounters. The researcher investigated five principle components of pre-migration: satisfaction with life prior to departure from the country of origin, impressions and expectations of the host country and predominate influences, awareness of discrimination in the host country, and culture-specific …

Projection Design For A Contemporary Dance Work By Iván Angelus In Hungary, Tennessee Dixon

Theses and Dissertations

The purpose of this thesis is to document and analyze my projection design for a new dance piece, "VŰ", directed by Angelus Iván and staged at Trafó in Budapest, Hungary. Included is an account of the design process, the concept and projection development described scene by scene, execution, performance and evaluation. The paper ends with reflections on the relatively new field of image projections, and my professional goals in scenic design.

Defining The Bacterial Flora Of Periodontal Pockets In Chronic Periodontitis Patients, Rafael Rodriguez

Theses and Dissertations

PURPOSE: The purpose of this study is to describe the subgingival bacterial biodiversity in untreated chronic periodontitis patients through the use of next generation 16S rRNA molecular analysis, and to determine similarities or differences between deep and shallow pockets within the same patients. METHODS: The analysis involved paired subgingival plaque samples from 24 subjects diagnosed with Generalized Moderate to Severe Chronic Periodontitis. One sample was selected from a single site having a probing depth >5 mm (i.e. Deep Site), and the other from a site with a probing depth <3mm (i.e. Shallow Site) within each subject. Bacterial DNA amplification of the V4-V6 region of the 16S rRNA was performed. The amplicons were sequenced via 454 Roche Genome Sequencer FLX System. The identified sequences were evaluated, and then compared to calculated false discovery rates. RESULTS: A total of 119 independent microbial genera were identified within the samples analyzed. Seven genera were identified to be statistically significant (p<0.05) in their association to deep or shallow sites following t-test and boot strap randomization: Actinomyces (p=0.004), Methylobacterium (p=0.028), Veillonella (p=0.028), and Rothia (p=0.038), and Streptococcus (p=0.033) in Shallow sites; while Mycoplasma (p=0.007) and Fusobacterium (p=0.016) were associated with deep sites. However, taking into account the calculated false discovery rates, it is suggested that none of the 119 microbial genera identified in this study were significantly associated with either deep nor shallow sites. CONCLUSION: The microbial genera identified within this study to be associated with deep and shallow sites follows the traditional pattern anticipated from the literature. However, the calculated false discovery rates suggest that these results may have occurred by chance and not due to a true difference.

Exploring The Functional Interaction Between Camk-Ii And P53, Raymond Lai

Theses and Dissertations

Calcium (Ca2+)/calmodulin-dependent kinase 2 (CaMK-II) is a multifunctional member of a family of Ca2+/calmodulin-dependent serine/threonine protein kinases that respond to transient intracellular calcium signaling. CaMK-II has been reported to be involved with transcription regulation, cell motility, neuronal development, cell cycle regulation, and more recently early development of vertebrates (Easley et al., 2008; Rothschild et al., 2009; Francescatto et al., 2010). Through previous work in the lab using tandem mass spectrometry and “substrate-trapping mutants”, tumor suppressor protein 53 (p53) was identified as a novel CaMK-II binding partner in tissue culture. In this study, I sought to provide characterization of the functional …

Acsl6 Is Associated With The Number Of Cigarettes Smoked And Its Expression Is Altered By Chronic Nicotine Exposure, Jingchun Chen, Darlene H. Brunzell, Kia J. Jackson, Andrew Van Der Vaart, Jennie Z. Ma, Thomas J. Payne, Richard Sherva, Lindsay A. Farrer, Pablo Gejman, Douglas F. Levinson, Peter Holmans, Steven H. Aggen, Imad Damaj, Po-Hsiu Kuo, Bradley T. Webb, Raymond Anton, Henry R. Kranzler, Joel Gelemter, Minf D. Li, Kenneth S. Kendler, Xiangning Chen

Psychiatry Publications

Individuals with schizophrenia tend to be heavy smokers and are at high risk for tobacco dependence. However, the nature of the comorbidity is not entirely clear. We previously reported evidence for association of schizophrenia with SNPs and SNP haplotypes in a region of chromosome 5q containing the SPEC2, PDZ-GEF2 and ACSL6 genes. In this current study, analysis of the control subjects of the Molecular Genetics of Schizophrenia (MGS) sample showed similar pattern of association with number of cigarettes smoked per day (numCIG) for the same region. To further test if this locus is associated with tobacco smoking as measured …

Comprehensive Gene-Based Association Study Of A Chromosome 20 Linked Region Implicates Novel Risk Loci For Depressive Symptoms In Psychotic Illness, T. Bernard Bigdeli, Brion S. Maher, Zhongming Zhao, Edwin J. C. G. Van Den Oord, Dawn L. Thiselton, Jingchun Sun, Bradley T. Webb, Richard L. Amdur, Brandon Wormley, Francis A. O'Neill, Dermot Walsh, Brien P. Riley, Kenneth S. Kendler, Ayman H. Fanous

Human and Molecular Genetics Publications

Background

Prior genomewide scans of schizophrenia support evidence of linkage to regions of chromosome 20. However, association analyses have yet to provide support for any etiologically relevant variants.

Methods

We analyzed 2988 LD-tagging single nucleotide polymorphisms (SNPs) in 327 genes on chromosome 20, to test for association with schizophrenia in 270 Irish high-density families (ISHDSF, N = 270 families, 1408 subjects). These SNPs were genotyped using an Illumina iSelect genotyping array which employs the Infinium assay. Given a previous report of novel linkage with chromosome 20p using latent classes of psychotic illness in this sample, association analysis was also conducted …

Distinct Signatures Of The Immune Responses In Low Risk Versus High Risk Neuroblastoma, Madhu Gowda, Kamar Godder, Maciej Kmieciak, Andrea Worschech, Maria-Libera Ascierto, Ena Wang, Francesco M. Marincola, Masoud H. Manjili

Microbiology and Immunology Publications

Background

Over 90% of low risk (LR) neuroblastoma patients survive whereas less than 30% of high risk (HR) patients are long term survivors. Age (children younger than 18 months old) is associated with LR disease. Considering that adaptive immune system is well developed in older children, and that T cells were shown to be involved in tumor escape and progression of cancers, we sought to determine whether HR patients may tend to show a signature of adaptive immune responses compared to LR patients who tend to have diminished T-cell responses but an intact innate immune response.

Methods

We performed microarray …

Virginia Commonwealth University Graduate And Professional Programs Bulletin Courses [2011], Virginia Commonwealth University

VCU Bulletins

No abstract provided.

Dressed To Cross: Narratives Of Resistance And Integration In Sei Shônagon's The Pillow Book And Yone Noguchi's The American Diary Of A Japanese Girl, Ina Christiane Seethaler

Ethnic Studies Review

The Pillow Book by Sei Shônagon, Empress Sadako's lady in waiting from about 993-1000, offers rich detail about the meaning and power of dress during the Heian period [794-1185]. Throughout Yone Noguchi's novel The American Diary of a Japanese Girl (1902), Morning Glory, a newly arrived Japanese immigrant to the U.S., experiments with a multitude of different identities through clothes. Both narratives appropriate (cross-) dressing as a means of overcoming gender, cultural, and class borders. Shônagon and Noguchi engage in "authorial crossdressing" to inhabit a social, cultural, and national space onto which they only have a precarious hold. It is …

Abstracts

Ethnic Studies Review

Abstracts for Ethnic Studies Review, Vol. 34, No. 1&2, 2011.

Aesthetic And Social Community: Multicultural Poetry And The Anthologizing Of Poems, Yi-Hsuan Tso

Ethnic Studies Review

Scholars from various disciplines have explored the concept of multiculturalism from the perspectives of citizenship, recognition, representation, tokenism, constitutionalism, and other vantage points, with politics and education receiving most of the attention. I While many efforts have been made to explore these aspects of multiculturalism, its significance in poetry, particularly in poetry's composition and critique, has not been duly taken into account. Multicultural poetry designates a critical abstraction in which poetry is classified by relation to a communal culture, history, or customs. In this definition, multicultural poetry is therefore inclusive of poetry written by ethnic minorities, women, non-mainstream religious practitioners, …