Digital Commons Network^™

Mctr3 Mitigates Cigarette Smoke-Induced Pulmonary Inflammation And Damage, Yu Par Aung Myo

Theses and Dissertations

Smoking is deleterious to our lungs and can precipitate in a multitude of diseases, including chronic obstructive pulmonary disease (COPD). COPD is primarily caused by smoking cigarettes and is a major public health issue. Current therapies only treat symptoms without halting or reversing disease progression, thus highlighting a large unmet need to develop new therapies. We address this gap by investigating maresin conjugate in tissue regeneration 3 (MCTR3) which is a newly discovered specialized pro-resoling mediator (SPM) that has the novel property of promoting tissue repair and regeneration in addition to being anti-inflammatory and pro-resolving. For the first time, we …

Plza Rna Chaperone Activity In Borreliella Burgdorferi Is Modulated By C-Di-Gmp, Dhara T. Patel

Theses and Dissertations

Lyme disease (LD) is the most common arthropod-borne disease in North America and is caused by the spirochete, Borreliella burgdorferi. LD spirochetes are maintained in an enzootic cycle of Ixodes species ticks and a vertebrate reservoir. The secondary messenger molecule c-di-GMP plays a crucial role in adaptive responses during the enzootic cycle. PlzA is the sole c-di-GMP-binding protein identified to date that is encoded by all Borreliella burgdorferi isolates. PlzA has both c-di-GMP-dependent and c-di-GMP-independent functions and is required to complete the enzootic cycle. The full range of PlzA regulatory activities has yet to be fully defined. We determined …

Functional Analysis Of Ligand Binding Domain 2 Of Outer Surface Protein C Of Borreliella Burgdorferi, Gavin Z. Chambers

Theses and Dissertations

Lyme disease, caused by the spirochete Borreliella burgdorferi, is the most common vector-borne infection in North America. A critical determinant of early mammalian infection is outer surface protein C (OspC), a highly variable lipoprotein that is indispensable for spirochete survival but whose precise function remains unresolved. OspC has been proposed to mediate diverse roles, including complement evasion, adhesion, tissue dissemination, and antiphagocytic activity, supporting the view that it is a multifunctional virulence factor. Structural studies have identified two putative ligand-binding domains (LBD1 and LBD2), with LBD2 forming a solvent-exposed crown at the membrane-distal end of the OspC dimer.

To …

Virginia Commonwealth University Undergraduate Bulletin (2025), Virginia Commonwealth University

VCU Bulletins

Undergraduate bulletin for Virginia Commonwealth University for the academic year 2025-2026. It includes information on academic regulations, degree requirements, course offerings, faculty, academic calendar, and tuition and expenses for undergraduate programs

Assessing Electronic Nicotine Delivery System Abuse Liability Among People Who Smoke Cigarettes: Impact Of Device Characteristics, Nicotine Flux, And Flavor, Elizabeth Oluwapelumi Ogunleye

Theses and Dissertations

This clinical laboratory study utilizes subjective and behavioral economic measures to assess the abuse liability of own-brand cigarettes and six currently authorized ENDS products, examining how device characteristics, nicotine flux, and liquid flavor influence outcomes among adults who smoke cigarettes. Using a Latin-square-ordered, within-subject design, adults who smoke cigarettes (N = 30; N = 20 preferred menthol cigarettes) attended four clinical sessions: one to evaluate their own-brand cigarette and three to assess six NJOY ENDS products: 2.4% nicotine pods (~58 µg/s; tobacco and menthol flavor), 6% nicotine disposable products (~61-65 µg/s; tobacco and menthol flavor), and 5% nicotine pods (~118-123 …

Acute Effects Of Electronic Nicotine Delivery System Liquid Nicotine Form And Sweetener Among People Who Use Inhaled Tobacco Products, Mary A. Carrico

Theses and Dissertations

Research on tobacco product standards to limit the abuse liability of electronic nicotine delivery systems (ENDS) has primarily focused on nicotine concentration and flavor. Other liquid characteristics, such as protonated nicotine ratio and sweetener additives, are less understood but may serve as regulatory targets. This clinical laboratory study examined the effects of ENDS protonated nicotine ratio and sweetener presence on nicotine delivery, use behavior, and subjective effects.

Thirteen participants completed four sessions that varied by protonated nicotine ratio (0:100 vs. 40:60 freebase to monoprotonated nicotine) and sweetener status (sweetened with 3 mg/mL ethyl maltol vs. unsweetened). Each session included a …

In Praise Of Dust, Hasler Gomez-Perez

Theses and Dissertations

A desire path is a physical manifestation of where a system has failed, but also where it has been refused, where a new path has been made. The wake exists in the post, it is not a singular, untethered event, but a subtle double entendre that lives in the post-death, but also in the pre-life—not a liminal limbo, but a superposition of dying and waking.

This collection was assembled and composed over the course of two years as I navigated my practice, myself, and others. Present here are my thoughts, my experiences, and in many ways my beliefs. IN PRAISE …

How To Remain A Stranger / Encountering, In A Basement, Hannah Rotwein

Theses and Dissertations

How to Remain a Stranger / Encountering, in a Basement consists of two parallel essays. On the lefthand side of the page, How to Remain a Stranger explores the ways that the legend of the Wandering Jew, the Tradescantia genus of plants, peddlers, and exile relate to my practice of collecting, sorting, and combining found objects. On the righthand side, Encountering, in a Basement describes my thesis exhibition at the Institute for Contemporary Art at Virginia Commonwealth University. Focusing on the idea of the encounter, I detail the materials, considerations, and processes behind four of the ten sculptures in the …

Mutual Realm, Tyna Ontko

Theses and Dissertations

mutual realm is a container for my many meandering thoughts on speculative futures, present-day-truth-telling, and the everyday construction of histories. Informed by systems of belief and power that humans have created to grapple with the unknown, the writing illustrates how storytelling builds worlds, assigning value to things by inscribing them with desire. In parts fact and fantasy, sculpture is considered as a form of sorting, making known the ways in which my experience of living between publics whose methods for demarcating boundaries, communally agreed upon superstitions, and algorithms for assigning meaning have marked my unconscious and affect my daily trajectories. …

Strange World, Brooklin Grantz

Theses and Dissertations

My thesis work explores the intersections of masculine and feminine labors as they relate to the structure of domestic space. I utilize materials and processes akin to craft, construction and architecture, and domicile upkeep, noting what is shared between gendered and polarized fields while exploring uses of the grid in various instances as a structure to adhere to and antagonize: a binary. Highlighting the queerness and fluidity of materials and the similarities between seemingly disparate processes, I relate to the objects I make and alter through my own gender fluidity. I do not see masculinity or femininity as autonomous: the …

Imagine Being Free: Decolonizing Actor Training In University And Conservatory Programs, Hope R. Ward

Theses and Dissertations

While blackface is considered the first proper form of American theater, I want to consider how the auction of enslaved Africans functioned as the original form of American theater. The auction block acted as a kind of interactive performance in which enslaved bodies were surveilled and evaluated as a kind of spectacle. In many ways, the auction block inaugurated White viewing practices of the Black body that reverberated in the day-to-day practices of slavery and subsequent visual media like the refashioning of blackface minstrel tropes within contemporary entertainment (plays, television, film). In Imagine Being Free: Decolonizing Actor Training in University …

From Objects To Relationships: Reviving Connectivity Through Collaborative Artmaking, Carolina Blatt-Gross

Journal of Social Theory in Art Education

A shortage of pro-social opportunities during the pandemic brought to the fore a longer, deeper trend toward disconnection. With the broader emphasis on individualized academic achievement compounding pandemic-induced social disenfranchisement, schools and communities are struggling to revive a sense of connectivity and belonging. The arts, on the other hand, have long been associated with social outcomes, historically generating group cohesion and inherently offering participants a sense of unity and synchronicity through collaborative artmaking. Applied to educational settings, pinpointing the concrete aspects of art education that beget social capital and connectedness is a more difficult task. This investigation examines the potential …

Amendment: Literary And Art Journal (2025)

Amendment, 2004-

Amendment is a VCU student-produced progressive literature and art journal that provides a platform for students to promote equality, tolerance, and social progression through artistic expression.

Pwatem: An Anthology Of Literature And Art (2025)

Pwatem (Poictesme), 2006-

Pwatem is an anthology of literature and art from undergraduate students at Virginia Commonwealth University. Pwatem publishes poetry, prose and art of all kinds from talented undergraduate students of all majors.

The Radical Pedagogical Imagination Of Collapse: Refusing Art Education As Prestige Property, Courtnie N. Wolfgang, Hannah K. Sions

Journal of Social Theory in Art Education

Halberstam’s (2022) aesthetic and semiotic reimagining of collapse explores the concept of prestige property- a property that has been designed to suit the desires of investors, architects, and designers, not the needs of those inhabiting the spaces. In this manuscript, we discuss the aesthetics of collapse as Halberstam defines them, extrapolating his examples and providing what might be understood as “(arts) educational collapse”. We employ Halberstam’s concept of the prestige property as a metaphor for the arts and education: that formal educational spaces in the United States of America are prestige properties, created for political and social desires of oppression …

Dynamic Expression Of Transposable Elements Contributes To Molecular And Behavioral Adaptations To Cocaine, Gabriella M. Silva

Theses and Dissertations

The comorbidity of substance use disorder (SUDs) — specifically cocaine use disorder (CUD)— with anxiety and social deficit disorders complicates effective long-term treatment. More research is needed to understand the brain-region and cell type-specific mechanisms underlying these disorders to better address treatment gaps. This dissertation investigates the role of the transcription factor of interest ZFP189, a Krüppel-associated box (KRAB) zinc finger protein (ZFP), in governing pro-social behavior and the development of CUD across interconnected brain regions. We show that ZFP189 directly regulates transposable elements (TEs), repetitive DNA sequences capable of mobilizing and reinserting into the genome, which leads to subsequent …

Post Opera, Suzy Lykins

Theses and Dissertations

Post Opera is a spell and work of embodied research which explores medicalization, desire, labor, and belief. Through methods of performance, sound, text and installation, I facilitate encounters of trans-femininity, spiritual power and connectivity. An opening wound, a set of psychic scalpels, sutures and bandages prepare this text for your consumption, take care to digest her well.

Wondering And Wandering, Madeleine Herisson-Leplae

Theses and Dissertations

For my thesis, I have taken the concept of excavation and used it as a visual metaphor for my artistic process. Using my recurring motifs of a hole, ladder, and the gem, I break down the writing into three sections. First, the hole, a metaphor for entering an image; second, the ladder, process as investigation; and lastly, the gem, which represents wonder and delight. This work is influenced by childhood fantasies, video games, and believing in magic.

Rabble: A Companion To Pwa-Tem (2025)

Rabble, 2014-

Rabble is a companion chapbook publication to the magazine Pwatem. From the preface of most issues: "'Tell the rabble my name is Cabell."- James Branch Cabell to his editor, to help people learn how to pronounce his name. Cabell used the word derogatively but we are taking it back. These pages will showcase the writing and illustrations of our rabble-the ordinary students of VCU."

The Diseased Extracellular Matrix In Chronic Obstructive Pulmonary Disease Modeling, Leigh-Ann M. Antczak

Theses and Dissertations

Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death in the world, with an increasing prevalence as the world’s population ages. In the distal regions of the lungs, COPD is characterized by progressive emphysema due to an imbalance of proteases that continuously degrade essential extracellular matrix (ECM) proteins within the alveolar walls, causing fatal tissue impairment. This dissertation examines the unique properties of this diseased lung ECM in two parts: (1) As a key constituent in inflammatory signaling that leads to increased inflammation and progression of COPD, and (2) as a tool in three-dimensional (3D) in …

Wiring Attachment, Alexander K. Bacon

Theses and Dissertations

This thesis began with a question: can diagrams create understanding, or only reflect it? Through paintings that layer automotive wiring schematics with family photographs, I explore how the human attachment system resists easy mapping. Using digital tools like Photoshop and scanning, alongside analog methods such as papier-collé and photo transfer, I examine how systems built for clarity—like wiring diagrams—contrast with the layered, often messy realities of human relationships. Drawing from attachment theory’s empirical foundation, rather than the metaphorical leanings of psychoanalysis, my work investigates how emotional bonds form, falter, and repair over time. Material loss and layering are not flaws, …

The Dance Of Human Affairs: Public Administration Leaders’ Perceptions Of Candor’S Impact On A Sense Of Belonging, Aaron Dimmock

Theses and Dissertations

This dissertation examines public administration leaders’ perceptions within the executive branch of the state government studied to determine if the components of radical candor, care personally and challenge directly, are associated with the sense of belonging in a public administration setting. Questions from surveys conducted by the state government studied were used to create the variables analyzed in this study. To the researcher’s knowledge, this is the first study to apply components from the Radical Candor® Framework to determine a relationship with sense of belonging in a public administration setting.

The significance of these components was tested through a quantitative, …

Identification Of Mechanisms Associated With Electronic Nicotine Delivery System Use For Weight Control In Young Adults, Gabrielle Maldonado

Theses and Dissertations

Electronic nicotine delivery system (ENDS) use continues to rise among young adults in the United States, raising public health concerns as the harmful effects of ENDS continue to rise while tailored cessation programs lag. Weight control motives may drive ENDS initiation and frequent use, particularly among sexual and gender minority (SGM) populations, who report higher ENDS use, body dissatisfaction, and disordered eating behaviors than those who identify as heterosexual and cisgender. Understanding these behaviors, their mechanisms, and at-risk populations is critical for improving public health. Seven hundred and eight young adults (ages 18–30; M = 26, SD = 3.3) reporting …

Biodistribution And Method Validation Of Xylazine In A Mouse Model Using Liquid-Chromatography-Quadrupole-Time Of Flight Mass Spectrometry, Julia E. Perschbacher

Master of Science in Forensic Science Directed Research Projects

Xylazine is a nonopioid veterinary sedative and an α2 adrenergic receptor agonist. It emerged in the opioid epidemic as an adulterant of illicit fentanyl. As xylazine becomes more involved in fatal overdoses, it is relevant to elucidate its biodistribution post-exposure due to its exacerbation of adverse events, namely respiratory depression, as xylazine’s contributions to existing adverse effects of synthetic opioids is understudied. A bioanalytical method to quantify xylazine and select metabolites in tissue using LC-QToF was validated and applied to a preclinical mouse model in order to characterize xylazine’s biodistribution in whole blood and six tissues at a dose known …

Novel Time-Since-Deposition Signatures For Canine Blood; Implications For Animal Cruelty Investigations, Alysia M. Townsley

Master of Science in Forensic Science Directed Research Projects

Dogfighting is a felony in all 50 states and is often tied to other organized crime activities including gambling, narcotics, and weapons trafficking. Because of the clandestine nature of dogfighting crimes, it may be necessary to determine the age of blood samples from suspected events, not just the source. In this study, flow cytometry was used to identify cellular autofluorescence signatures for estimating TSD (time-since-deposition) in canine blood deposits up to 6 months old. To accomplish this, blood was taken from canines of various chronological ages and breeds, then deposited to create TSD samples ranging between 1 day and 180 …

Expanding The Performance And Functionality Of Air-Jet Dry Powder Inhalers Across Multiple Applications, Ghali H. Aladwani

Theses and Dissertations

This dissertation aims to expand the performance and functionality of air-jet dry powder inhaler (DPI) applications through the development of a next-generation, mesh-nebulizer-based, and scalable spray dryer for the production of pharmaceutical aerosols, along with new spray-dried formulation production methods, novel formulations, and new air-jet DPI components for aerosol delivery to both infants and adults. The first aim focused on the development of a custom small-particle spray drying system capable of integrating vibrating mesh nebulizer technologies in various configurations for the production of excipient enhanced growth (EEG) formulations. This flexible system enabled efficient production of both small- and large-particle powders …

Unpacking The Study Abroad Experience: Exploring How The Perceptions And Awareness Of Faculty, Staff, Advisors And Students Shape Study Abroad Participation At Virginia Commonwealth University, Theresa Franklin, Lauren D. Harris, Stephanie Monn, Amy Snead, Sarah E. A. Steele

Doctor of Education Capstones

The study abroad experience, often credited with providing an inclusive learning opportunity, has the transformative potential to expand students' worldviews, enrich their academic experiences, and foster cross-cultural understanding. This study examines the Global Education Office (GEO) at Virginia Commonwealth University (VCU) and its efforts to increase institutional support, student awareness, and engagement with study abroad programs. The study explores barriers to participation and perceptions of value through secondary analysis of GEO’s post-program student surveys and primary data from a faculty, staff, and academic advisor survey. Guided by Wigfield’s Expectancy-Value Theory and Perry’s Theory of Intellectual and Ethical Development, the research …

From Ink To Code, From Binary To Boundless Reality—Until All Returns To Emptiness, Weitong Sun

Theses and Dissertations

This thesis explores the entangled relationship between language, memory, and technology through the lens of immigrant experience. Moving from programming to visual storytelling, I investigate how dyslexia, bilingualism, and cultural displacement have shaped my ways of reading, writing, and coding.

Beginning with personal reflections on switching from computer science to art, I trace how code offered a form of clarity and expression where written language had once failed me. Yet as I ventured into real-time simulation and XR storytelling, I encountered new forms of mistranslation—where narratives dissolved, mutated, or resisted coherence altogether.

Through a series of experiments in code-driven art, …

The Cut Worm Forgives The Plow, August Neuscheler

Theses and Dissertations

The explorations in this thesis writing are centered on William Blake’s proverb “The cut worm forgives the plow.” It has been reinterpreted as an allegory of history and energy. A theory of their relation is proposed based on forgiveness, a theory that accepts the palimpsest of orders as evidence for the abundance of the present moment. The writing focuses on questions of proportionality, scale, archaeological screening methods, planar cutting, and a critique of entropy as grounds for this theory. Some of its subjects include the Statue of Liberty, Kate Raworth’s donut economic model, sashimi, triangulation, Joseph Beuys’ “7,000 Eichen,” semiconductors, …

A Parting Repast, Debra D. Dowden-Crockett

Theses and Dissertations

Both the thesis document and exhibition comprise the story of my journey through grief, examination of loss, contemplation of death, and transformation through acceptance and relinquishment. I conflate art and emotion to put form to the complex human experience of watching a loved one die, having to say a last goodbye, and the mourning that ultimately follows.

I examine the rituals surrounding death, the role of memory, and the symbolic presence of food as a shared experience of both mourning and nourishment, the intimate moments of mourning, and the gradual process of finding peace and closure.

Featuring works from a …