Digital Commons Network^™

Parental Competencies Of Juvenile Probationers And Adherence To Curt Sanctions And Recidivism Rates, Amy Cook

Theses and Dissertations

The purpose of this exploratory study was to further investigate the notion of parental competencies through the use of the Juvenile Offender Parent Questionnaire as previously developed by Rose and colleagues (2004). The parent questionnaire was administered to 88 parents of juvenile probationers placed on probation in a Virginia county. Exploratory Factor Analysis revealed an eight-factor solution: parental exasperation, parental resignation, mistrust of the juvenile justice system, shame over parenting efficacy, parental monitoring, fear of the child, parent perceptions of child’s exposure to violence, and anger towards child. Regression analyses indicate that parental exasperation and parental resignation were not significant …

A Service-Learning Approach To An Arts-Based Technology Course To Increase Pre-Service Teacher Receptivity To Teaching Technology, Elizabeth Essex

Theses and Dissertations

The following question and sub-question guide this thesis project: 1) How does a service-learning approach in an arts-based technology course increase pre-service teacher receptivity to teaching technology? 2.) What are some barriers to teaching technology for pre-service teachers? A positive service-learning experience provides good learning models which have the potential to address the barriers to teaching technology for pre-service teachers by influencing their self-efficacy. Included in this thesis is a unit plan which responds to these research questions. There are many barriers to teaching technology for teachers including lack of funds, availability and quality of computer hardware and software, teaching …

Commonwealth Times 2009-03-05

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2009-03-02

Commonwealth Times, 1969-

No abstract provided.

Shafer Court Connections (2009-03)

Shafer Court Connections, 1994-2010

For alumni of the Academic Campus of Virginia Commonwealth University.

Commonwealth Times 2009-02-26

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2009-02-19

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2009-02-12

Commonwealth Times, 1969-

No abstract provided.

Role Of Rock And Pkc In Regulation Of Contraction Of Permeabilized Femoral Arterial Smooth Muscle, Brendan Browne

Theses and Dissertations

KCl is traditionally used as a stimulus to examine the role of increases in cytosolic Ca2+ on the regulation of smooth muscle contraction. KCl bypasses GPCR activation, thereby avoiding activation of additional cell signaling systems, such as phospholipase C and PKC that are inherent to Gaq and Ga12/13 stimulation. GPCR activation causes Ca2+ sensitization (greater force for a given increase in Ca2+) by a ROCK- and PKC-dependent inhibition of myosin light chain (MLC) phosphatase. Recent studies have demonstrated that KCl can also produce Ca2+ sensitization, implying that Ca2+ itself may induce Ca2+ sensitization. To test the hypothesis that Ca2+ can …

Commonwealth Times 2009-02-09

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2009-02-02

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2009-01-29

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2009-01-26

Commonwealth Times, 1969-

No abstract provided.

Mutations In Many Genes Affect Aggressive Behavior In Drosophila Melanogaster, Alexis C. Edwards, Liesbeth Zwarts, Akihiko Yamamota, Patrick Callaerts, Trudy F.C. Mackay

Psychiatry Publications

Background Aggressive behavior in animals is important for survival and reproduction. Identifying the underlying genes and environmental contexts that affect aggressive behavior is important for understanding the evolutionary forces that maintain variation for aggressive behavior in natural populations, and to develop therapeutic interventions to modulate extreme levels of aggressive behavior in humans. While the role of neurotransmitters and a few other molecules in mediating and modulating levels of aggression is well established, it is likely that many additional genetic pathways remain undiscovered. Drosophila melanogaster has recently been established as an excellent model organism for studying the genetic basis of aggressive …

In Silico Whole Genome Association Scan For Murine Prepulse Inhibition, Bradley Todd Webb, Joseph L. Mcclay, Cristina Vargas-Irwin, Timothy P. York, Edwin J. C. G. Van Den Oord

Biomarker Research and Personalized Medicine Publications

Background

The complex trait of prepulse inhibition (PPI) is a sensory gating measure related to schizophrenia and can be measured in mice. Large-scale public repositories of inbred mouse strain genotypes and phenotypes such as PPI can be used to detect Quantitative Trait Loci (QTLs) in silico. However, the method has been criticized for issues including insufficient number of strains, not controlling for false discoveries, the complex haplotype structure of inbred mice, and failing to account for genotypic and phenotypic subgroups.

Methodology/Principal Findings

We have implemented a method that addresses these issues by incorporating phylogenetic analyses, multilevel regression with mixed …

Menorah Review (No. 70, Winter/Spring, 2009)

Menorah Review

A Poem by Richard E. Sherwin -- Believing Christian... Agnostic Believer -- From the Classics -- New and Notable Books -- Oy Vey Is Mir -- The Ancient Grudge: The Merchant of Venice and Shylock's Christian Problem

Severe Lactic Acidosis In A Patient With B-Cell Lymphoma: A Case Report And Review Of The Literature, Farn Huei Chan, Daniel Carl, Laurel J. Lyckholm

Internal Medicine Publications

Lactic acidosis is commonly observed in clinical situations such as shock and sepsis, as a result of tissue hypoperfusion and hypoxia. Lymphoma and leukemia are among other clinical situations where lactic acidosis has been reported. We present a case of a 59-year-old female with lactic acidosis who was found to have aggressive B-cell lymphoma. There have been 29 cases of lymphoma induced lactic acidosis reported thus far; however all reported cases have abnormal vital signs or concomitant medical conditions that may lead to lactic acidosis. The pathogenesis of malignancy-induced lactic acidosis is not well understood; however associated factors include increased …

Estrogen Exposure, Obesity And Thyroid Disease In Women With Severe Pulmonary Hypertension, Lori Sweeney, Norbert F. Voelkel

Internal Medicine Publications

Severe pulmonary hypertension is a lethal group of disorders which preferentially afflicts women. It appears that in recent years the patient profile has shifted towards older, obese, and postmenopausal women, suggesting that endocrine factors may be important. Several studies have revealed an increased prevalence of thyroid disease in these patients, but no studies have evaluated for a coexistence of endocrine factors. In particular, no studies have attempted to evaluate for concurrent thyroid disease, obesity and long-term estrogen exposure in patients.

88 patients attending the Pulmonary Hypertension Association 8th International meeting completed a questionnaire and were interviewed. Information was collected regarding …

Hypoxia Regulates Human Lung Fibroblast Proliferation Via P53-Dependent And -Independent Pathways, Shiro Mizuno, Herman J. Bogaard, Norbert F. Voelkel, Yukihiro Umeda, Maiko Kadowaki, Shingo Ameshima, Isamu Miyamori, Takeshi Ishizaki

Internal Medicine Publications

Background Hypoxia induces the proliferation of lung fibroblasts in vivo and in vitro. However, the subcellular interactions between hypoxia and expression of tumor suppressor p53 and cyclin-dependent kinase inhibitors p21 and p27 remain unclear.

Methods Normal human lung fibroblasts (NHLF) were cultured in a hypoxic chamber or exposed to desferroxamine (DFX). DNA synthesis was measured using bromodeoxyuridine incorporation, and expression of p53, p21 and p27 was measured using real-time RT-PCR and Western blot analysis.

Results DNA synthesis was increased by moderate hypoxia (2% oxygen) but was decreased by severe hypoxia (0.1% oxygen) and DFX. Moderate hypoxia decreased p21 synthesis without …

The Importance Of Saccular Function To Motor Development In Children With Hearing Impairments, Mary S. Shall

Physical Therapy Publications

Children with hearing deficits frequently have delayed motor development. The purpose of this study was to evaluate saccular function in children with hearing impairments using the Vestibular Evoked Myogenic Potential (VEMP). The impact of the saccular hypofunction on the timely maturation of normal balance strategies was examined using the Movement Assessment Battery for Children (Movement ABC). Thirty-three children with bilateral severe/profound hearing impairment between 4 and 7 years of age were recruited from a three-state area. Approximately half of the sample had one or bilateral cochlear implants, one used bilateral hearing aids, and the rest used no amplification. Parents reported …

Apoptotic Engulfment Pathway And Schizophrenia, Xiangning Chen, Cuie Sun, Qi Chen, F. Anthony O'Neill, Dermot Walsh, Ayman H. Fanous, Kodavali V. Chowdari, Vishwajit L. Nimgaonkar, Adrian Scott, Sibylle G. Schwab, Dieter B. Wildenauer, Ronglin Che, Wei Tang, Yongyong Shi, Lin He, Xiong-Jian Luo, Bing Su, Todd L. Edwards, Zhongming Zhao, Kenneth S. Kendler

Human and Molecular Genetics Publications

Background

Apoptosis has been speculated to be involved in schizophrenia. In a previously study, we reported the association of the MEGF10 gene with the disease. In this study, we followed the apoptotic engulfment pathway involving the MEGF10, GULP1, ABCA1 and ABCA7 genes and tested their association with the disease.

Methodology/Principal Findings

Ten, eleven and five SNPs were genotyped in the GULP1, ABCA1 and ABCA7 genes respectively for the ISHDSF and ICCSS samples. In all 3 genes, we observed nominally significant associations. Rs2004888 at GULP1 was significant in both ISHDSF and ICCSS samples (p = 0.0083 and …

Staphylococcus Aureus Immunodominant Surface Antigen B Is A Cell-Surface Associated Nucleic Acid Binding Protein, Nicole M. Mackey-Lawrence, Denise E. Potter, Nuno Cerca, Kimberly K. Jefferson

Microbiology and Immunology Publications

Background

Staphylococcus aureus immunodominant surface antigen B (IsaB) elicits an immune response during septicemia and is generally classified as a virulence factor, but its biological function remains completely undefined. In an attempt to identify staphylococcal RNA-binding proteins, we designed an RNA Affinity Chromatography assay and subsequently isolated IsaB.

Results

Western analysis indicated that IsaB was both secreted and cell-surface associated. Gel Shift analysis confirmed the RNA binding activity but revealed that IsaB bound to any nucleic acid without sequence specificity. IsaB exhibited the highest affinity for double-stranded DNA followed by single-stranded DNA and RNA. Because extracellular DNA has been shown …

Diagnosis Of Infections Caused By Pathogenic Free-Living Amoebae, Bruno Da Rocha-Azevedo, Herbert B. Tanowitz, Francine Marciano-Cabral

Microbiology and Immunology Publications

Naegleria fowleri, Acanthamoeba spp., Balamuthia mandrillaris, and Sappinia sp. are pathogenic free-living amoebae. N. fowleri causes Primary Amoebic Meningoencephalitis, a rapidly fatal disease of the central nervous system, whileAcanthamoeba spp. and B. mandrillaris cause chronic granulomatous encephalitis.Acanthamoeba spp. also can cause cutaneous lesions and Amoebic Keratitis, a sight-threatening infection of the cornea that is associated with contact lens use or corneal trauma. Sappinia pedata has been identified as the cause of a nonlethal case of amoebic encephalitis. In view of the potential health consequences due to infection with these amoebae, rapid diagnosis is critical for early treatment. Microscopic examination and …

Virginia Commonwealth University Undergraduate Bulletin Courses [2009], Virginia Commonwealth University

VCU Bulletins

Listing of undergraduate courses for 2009-2010.

Virginia Commonwealth University Graduate And Professional Programs Bulletin Courses [2009], Virginia Commonwealth University

VCU Bulletins

Listing of professional and graduate courses for 2009-2010.

Life-Centered Ethics And The Human Future In Space, Michael Noah Mautner

Chemistry Publications

In the future, human destiny may depend on our ethics. In particular, biotechnology and expansion in space can transform life, raising profound questions. Guidance may be found in Life-centered ethics, as biotic ethics that value the basic patterns of organic gene/protein life, and as panbiotic ethics that always seek to expand life. These life-centered principles can be based on scientific insights into the unique place of life in nature, and the biological unity of all life. Belonging to life then implies a human purpose: to safeguard and propagate life. Expansion in space will advance this purpose but will also raise …

Mast Cell Regulation Of The Immune Response, John J. Ryan, Johanna K. Morales, Yves T. Falanga, Josephine Fa Fernando, Matthew R. Macey

Biology Publications

Mast cells are well known as principle effector cells of type I hypersensitivity responses. Beyond this role in allergic disease, these cells are now appreciated as playing an important role in many inflammatory conditions. This review summarizes the support for mast cell involvement in resisting bacterial infection, exacerbating autoimmunity and atherosclerosis, and promoting cancer progression. A commonality in these conditions is the ability of mast cells to elicit migration of many cell types, often through the production of inflammatory cytokines such as tumor necrosis factor. However, recent data also demonstrates that mast cells can suppress the immune response through interleukin-10 …

Endothelial Cells And Pulmonary Arterial Hypertension: Apoptosis, Proliferation, Interaction And Transdifferentiation, Seiichiro Sakao, Koichiro Tatsumi, Norbert F. Voelkel

VCU Health Publications

Severe pulmonary arterial hypertension, whether idiopathic or secondary, is characterized by structural alterations of microscopically small pulmonary arterioles. The vascular lesions in this group of pulmonary hypertensive diseases show actively proliferating endothelial cells without evidence of apoptosis. In this article, we review pathogenetic concepts of severe pulmonary arterial hypertension and explain the term "complex vascular lesion ", commonly named "plexiform lesion", with endothelial cell dysfunction, i.e., apoptosis, proliferation, interaction with smooth muscle cells and transdifferentiation.

Menorah Review (No. 71, Summer/Fall, 2009)

Menorah Review

Abraham: A Seminal Personality -- Author's Reflections -- Books in Brief: New and Notable -- Soviet History as it Unfolds -- The Talmud Revisited: Tragedy and "The Oven of Aknai" -- Tourist Heaven -- Traduttore, Traditore?

Synchronization Of Pancreatic Islet Oscillations By Intrapancreatic Ganglia: A Modeling Study, B. Fendler, M. Zhang, L. Satin, R. Bertram

Pharmacology and Toxicology Publications

Abstract

Plasma insulin measurements from mice, rats, dogs, and humans indicate that insulin levels are oscillatory, reflecting pulsatile insulin secretion from individual islets. An unanswered question, however, is how the activity of a population of islets is coordinated to yield coherent oscillations in plasma insulin. Here, using mathematical modeling, we investigate the feasibility of a potential islet synchronization mechanism, cholinergic signaling. This hypothesis is based on well-established experimental evidence demonstrating intrapancreatic parasympathetic (cholinergic) ganglia and recent in vitro evidence that a brief application of a muscarinic agonist can transiently synchronize islets. We demonstrate using mathematical modeling that periodic pulses of …